Translational Research In Biomedical Sciences Recent Progress And Future Prospects

Author : Krupakar Parthasarathy,Radhakrishnan Manikkam
Publisher : Springer
Page : 0 pages
File Size : 42,6 Mb
Release : 2024-09-06
Category : Business & Economics
ISBN : 9819717760

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Translational Research in Biomedical Sciences: Recent Progress and Future Prospects by Krupakar Parthasarathy,Radhakrishnan Manikkam Pdf

The main objective of translational health science is to concentrate on discovering healthcare products for all people where care gaps exist. This book examines the applications of translational research, identifies its difficulties, outlines its essential characteristics, considers healthcare management strategies, and examines the public's perspectives today. This book assists aspiring implementation scientists in researching this area because the discipline is still relatively young for the wide range of researchers tackling the challenge of clinical and translational science, a field dedicated to examining human health and disease, interventions, and outcomes to develop new treatment approaches, devices, and modalities to improve health. This book Edition is the most authoritative and timely resource that introduces new physiological and therapeutic processes to engage the fastest-growing scientific outcomes from academic and industrial research. The chapters in this book give insights into perspectives on the field of clinical and translational science and discuss artificial intelligence in drug development and conventional and novel clinical trial designs. There is a lot of hope that using artificial intelligence (AI) will significantly advance all facets of healthcare, from diagnosis to therapy. AI is prepared to assist medical staff with various duties, including administrative workflow, clinical documentation, patient outreach, and specialist support like image analysis, medical device automation, and patient monitoring. Some of the most important uses of AI in healthcare will be covered in this book by eminent Scientists, Academicians, and Industrial persons from both clinical and non-clinical fields.

Author : Francesco Chiapelli,Nicole Balenton
Publisher : Unknown
Page : 0 pages
File Size : 44,7 Mb
Release : 2018
Category : Medical care
ISBN : 153614598X

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Translational Research by Francesco Chiapelli,Nicole Balenton Pdf

The future of healthcare lies in the continued progress and acceleration of adopting translational science. The two principal constructs, translational research and translational effectiveness, collectively strive towards patient-centered, effectiveness-focused and evidence-based care. Translational research is the application of scientific methods into healthcare decision-making and practice. Through these applications and methods used on the patient, translational research obtains new information that directly benefits that patient in return. This bench-to-bedside approach is specifically designed to improve health outcomes and standards of practice in healthcare to better serve the patients. It is through the utilization, dissemination, and implementation of the best evidence-based practices that will help in the understanding of intervention effectiveness. The chapters in this book highlight the transfer of basic science discovered and cutting-edge developments into clinical applications. Emphasis on continuing research, increasing transparency and accelerating the adoption of translational science into clinical practice is needed to provide the best possible care. The chapters focus on the future direction of all fields of healthcare which lies on the bench-to-bedside approach from medicine to dentistry to nursing. Translational research is at the forefront of efforts to improve patient care and is the engine of change for bringing new decision-making, practice, and technology into the field of healthcare in this new age.

Author : Barbara Alving,Kerong Dai,Samuel H. H. Chan
Publisher : Karger Medical and Scientific Publishers
Page : 136 pages
File Size : 47,5 Mb
Release : 2012-12-01
Category : Science
ISBN : 9783318022841

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Translational Medicine - What, Why and How by Barbara Alving,Kerong Dai,Samuel H. H. Chan Pdf

This book is the first to provide an aerial view, as well as detailed information, on 'how' activities in translational medicine are under development in countries such as the USA, China, the UK, and Taiwan. Institutions in each country are training investigators to work as sophisticated interdisciplinary teams. Investigators from 11 US academic health centers explain how they are incentivizing collaborations through pilot project programs, forming partnerships with business schools to promote efficient management of basic and clinical research, creating ethical, high- value public-private (industry) partnerships, improving efficiency with utilization of informatics, and engaging the community in research. The essential role of evaluation is explained in a clear and concise manner. The readers will also learn about the role of private funding in Taiwan and the vision of the government in China in developing multiple translational research centers. The UK is developing methodical approaches to patient needs across their lifespans; ongoing innovation is encouraged through incubator programs. With the emphasis on open innovation and sharing, the concepts and practice of translational medicine are spreading rapidly on an international scale.

Author : David Robertson,Gordon H. Williams
Publisher : Academic Press
Page : 812 pages
File Size : 41,9 Mb
Release : 2016-11-25
Category : Science
ISBN : 9780128021118

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Clinical and Translational Science by David Robertson,Gordon H. Williams Pdf

Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science. Introduces novel physiological and therapeutic strategies for engaging the fastest growing scientific field in both the private sector and academic medicine Brings insights from international leaders into the discipline of clinical and translational science Addresses drug discovery, drug repurposing and development, innovative and improved approaches to go/no-go decisions in drug development, and traditional and innovative clinical trial designs

Author : Rakesh K. Srivastava
Publisher : World Scientific
Page : 766 pages
File Size : 43,6 Mb
Release : 2014
Category : Medical
ISBN : 9789814489072

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Lost in Translation by Rakesh K. Srivastava Pdf

This book is all about the definition and finding ways to prioritize and accelerate translation research in biomedical sciences and rapidly turning new knowledge into first-in-human studies. It represents an effort to bring together scientists active in various areas of translational research to share science and, hopefully, generate new ideas and potential collaborations. The book provides a comprehensive overview of translational work that includes significant discoveries and pioneering contributions, e.g., in immunology, gene therapy, stem cells and population sciences. It may be used as an advanced textbook by graduate students and even ambitious undergraduates in biomedical sciences. It is also suitable for non-experts, i.e. medical doctors, who wish to have an overview of some of the fundamental models in translational research. Managing the translational enterprise remains a work in progress. The world is changing rapidly, and the scientific world needs to seek new ways to ensure that discoveries get translated for patients efficiently and as quickly as possible. In addition, everyone expects the investment in biomedical research should pay dividends through effective therapeutic solutions. This unique project provides a broad collaborative approach of the international scientific team to present its view and opinion how to cross barriers to incentives for translational research in medical sciences. Contributing to the book is an international team of prominent co-authors. The book consists of unique and widely treated topics, and includes new hypotheses, data and analyses. Sample Chapter(s). Foreword (41 KB). Chapter 1: Translational Research: Lost in Complexity (305 KB). Contents: Barriers to Incentives for Translational Research; Integrating Emerging Science into Clinical Practice; Organization, Prioritization, Review and Funding for the Translational Research; Translational Sciences in Cancer Research; Translational Science in Infectious Diseases; Translation Research in Endocrinology and Nutrition; Translation Research and Neuroscience; Stem Cells and Translation Research; The Role of Translational Research in Public Health and Behavioral Sciences; Translational Epidemiology, Biostatistics and Informatics; Translational Research Outcomes and Resources. Readership: Graduate students and researchers in cancer research, pharmacology/drug discovery/pharmaceuticals, immunology, infectious diseases and public health.

Author : James Mittra,Christopher-Paul Milne
Publisher : CRC Press
Page : 290 pages
File Size : 53,8 Mb
Release : 2016-04-19
Category : Mathematics
ISBN : 9789814364843

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Translational Medicine by James Mittra,Christopher-Paul Milne Pdf

This book brings together a range of academic, industry and practitioner perspectives on translational medicine (TM). It enhances conceptual and practical understanding of the emergence and progress of the field and its potential impact on basic research, therapeutic development, and institutional infrastructure. In recognition of the various impli

Author : National Research Council,Division on Earth and Life Studies,Institute of Medicine,National Cancer Policy Board,Committee on Large-Scale Science and Cancer Research
Publisher : National Academies Press
Page : 297 pages
File Size : 48,5 Mb
Release : 2003-07-19
Category : Medical
ISBN : 9780309089128

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Large-Scale Biomedical Science by National Research Council,Division on Earth and Life Studies,Institute of Medicine,National Cancer Policy Board,Committee on Large-Scale Science and Cancer Research Pdf

The nature of biomedical research has been evolving in recent years. Technological advances that make it easier to study the vast complexity of biological systems have led to the initiation of projects with a larger scale and scope. In many cases, these large-scale analyses may be the most efficient and effective way to extract functional information from complex biological systems. Large-Scale Biomedical Science: Exploring Strategies for Research looks at the role of these new large-scale projects in the biomedical sciences. Though written by the National Academies' Cancer Policy Board, this book addresses implications of large-scale science extending far beyond cancer research. It also identifies obstacles to the implementation of these projects, and makes recommendations to improve the process. The ultimate goal of biomedical research is to advance knowledge and provide useful innovations to society. Determining the best and most efficient method for accomplishing that goal, however, is a continuing and evolving challenge. The recommendations presented in Large-Scale Biomedical Science are intended to facilitate a more open, inclusive, and accountable approach to large-scale biomedical research, which in turn will maximize progress in understanding and controlling human disease.

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,Board on Health Sciences Policy,Roundtable on Genomics and Precision Health,National Cancer Policy Forum,Forum on Neuroscience and Nervous System Disorders,Forum on Drug Discovery, Development, and Translation
Publisher : National Academies Press
Page : 143 pages
File Size : 45,8 Mb
Release : 2020-05-28
Category : Medical
ISBN : 9780309663496

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Enhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,Board on Health Sciences Policy,Roundtable on Genomics and Precision Health,National Cancer Policy Forum,Forum on Neuroscience and Nervous System Disorders,Forum on Drug Discovery, Development, and Translation Pdf

Sharing knowledge is what drives scientific progress - each new advance or innovation in biomedical research builds on previous observations. However, for experimental findings to be broadly accepted as credible by the scientific community, they must be verified by other researchers. An essential step is for researchers to report their findings in a manner that is understandable to others in the scientific community and provide sufficient information for others to validate the original results and build on them. In recent years, concern has been growing over a number of studies that have failed to replicate previous results and evidence from larger meta-analyses, which have pointed to the lack of reproducibility in biomedical research. On September 25 and 26, 2019, the National Academies of Science, Engineering, and Medicine hosted a public workshop in Washington, DC, to discuss the current state of transparency in the reporting of preclinical biomedical research and to explore opportunities for harmonizing reporting guidelines across journals and funding agencies. Convened jointly by the Forum on Drug Discovery, Development, and Translation; the Forum on Neuroscience and Nervous System Disorders; the National Cancer Policy Forum; and the Roundtable on Genomics and Precision Health, the workshop primarily focused on transparent reporting in preclinical research, but also considered lessons learned and best practices from clinical research reporting. This publication summarizes the presentation and discussion of the workshop.

Author : R.C. Sobti,Naranjan S. Dhalla
Publisher : Springer Nature
Page : 597 pages
File Size : 49,5 Mb
Release : 2022-07-28
Category : Medical
ISBN : 9789811692321

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Biomedical Translational Research by R.C. Sobti,Naranjan S. Dhalla Pdf

This book, which is the third volume of Biomedical translational research, focuses on the fundamental role of biomedical research in developing new medicinal products. It emphasizes the importance of understanding biological and pathophysiological mechanisms underlying the disease to discover and develop new biological agents. The book uniquely explores the genomic computational integrative approach for drug repositioning. Further, it discusses the health benefits of nutraceuticals and their application in human diseases. Further, the book comprehensively reviews different computational approaches that employ GWAS data to guide drug repositioning. Finally, it summarizes the major challenges in drug development and the strategies for the rational design of the next generation more effective but less toxic therapeutic agents.

Author : James Lyons-Weiler
Publisher : World Scientific Publishing Company
Page : 0 pages
File Size : 48,6 Mb
Release : 2016
Category : Medical innovations
ISBN : 9814730149

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Cures Vs. Profits by James Lyons-Weiler Pdf

Did you ever wonder whether doctors want cures, or just treatments?Did you know ... This book reviews recent key, hard-won successes and findings from recent biomedical research. Written by one of the most ardent defenders of the public trust in science, it provides an accessible, detailed look at successes in translational biomedical and clinical research. The author provides an optimistic, forward-looking view for the possibility of change for the public good, cutting through the controversy and gets to very core of each topic. The public can be optimistic about the future of medicine, but only if they learn the facts of these advances, and learn what their doctors should be expected to know.Highly referenced, and filled with interviews from experts and people directly involved in the research behind the new facts in each chapter, this book is a rich source of information on advances in biomedicine that you will want to share with your family & friends.

Author : Mieczyslaw Pokorski
Publisher : Springer Nature
Page : 122 pages
File Size : 48,9 Mb
Release : 2020-02-28
Category : Science
ISBN : 9783030412197

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Trends in Biomedical Research by Mieczyslaw Pokorski Pdf

This book addresses hot issues in the research and management of difficult-to-treat medical disorders that are commonly encountered, but for which the underlying mechanisms are often unknown. These include the adverse effects of hemodialysis and its biocompatibility in chronic kidney insufficiency, particularly related to malnutrition and inflammation, or the vulnerability of cancer patients to bacterial meningitis, the infection that remains underdiagnosed due to limited expression of symptoms. The book also covers other key topics, such as the psychological care of lung cancer patients; difficulties in the diagnosis of diffuse axonal injury in traumatic brain injury – a disorder with a poor prognosis and high mortality rate; and the virological aspects of seasonal influenza epidemic outbreaks – a perennial modern scourge. Further, it addresses recent developments in targeted drug delivery from titanium implants and a novel integrated thermal approach to rehabilitation of neurodegeneration-related disabilities. Featuring the latest interdisciplinary trends in biomedicine, this book connects research, theory and practice to help alleviate suffering caused by a variety of diseases. It is a resource for medical professionals, including academics, practitioners and all allied healthcare workers.

Author : Weili Fu,Yin Fang,Chao Zhao,Dong Jiang
Publisher : Frontiers Media SA
Page : 298 pages
File Size : 55,5 Mb
Release : 2022-10-06
Category : Science
ISBN : 9782832501740

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Bioengineering and Translational Research for Bone and Joint Diseases by Weili Fu,Yin Fang,Chao Zhao,Dong Jiang Pdf

Author : Jose Luis Pedraz Muñoz,Laura Saenz del Burgo Martínez,Gustavo Puras Ochoa,Jon Zarate Sesma
Publisher : CRC Press
Page : 353 pages
File Size : 47,6 Mb
Release : 2023-09-27
Category : Medical
ISBN : 9781000957600

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3D Printing and Bioprinting for Pharmaceutical and Medical Applications by Jose Luis Pedraz Muñoz,Laura Saenz del Burgo Martínez,Gustavo Puras Ochoa,Jon Zarate Sesma Pdf

The increasing availability and decreasing costs of 3D printing and bioprinting technologies are expanding opportunities to meet medical needs. 3D Printing and Bioprinting for Pharmaceutical and Medical Applications discusses emerging approaches related to these game-changer technologies in such areas as drug development, medical devices, and bioreactors. Key Features: Offers an overview of applications, the market, and regulatory analysis Analyzes market research of 3D printing and bioprinting technologies Reviews 3D printing of novel pharmaceutical dosage forms for personalized therapies and for medical devices, as well as the benefits of 3D printing for training purposes Covers 3D bioprinting technology, including the design of polymers and decellularized matrices for bio-inks development, elaboration of 3D models for drug evaluation, and 3D bioprinting for musculoskeletal, cardiovascular, central nervous system, ocular, and skin applications Provides risk-benefit analysis of each application Highlights bioreactors, regulatory aspects, frontiers, and challenges This book serves as an ideal reference for students, researchers, and professionals in materials science, bioengineering, the medical industry, and healthcare.

Author : Sanju Bala Dhull,Aarti Bains,Prince Chawla,Pardeep Kumar Sadh
Publisher : CRC Press
Page : 544 pages
File Size : 52,6 Mb
Release : 2022-08-10
Category : Technology & Engineering
ISBN : 9781000602500

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Wild Mushrooms by Sanju Bala Dhull,Aarti Bains,Prince Chawla,Pardeep Kumar Sadh Pdf

Many wild varieties of mushrooms are consumed by people around the world, yet many species remain unexplored, their nutritional as well as pharmacological significance yet to be discovered for many of them. Wild Mushrooms: Characteristics, Nutrition, and Processing informs readers about different unexplored wild mushrooms, their methods of cultivation, nutritional values, pharmaceutical values, and possible utilization for human wellbeing. The book represents a comprehensive assessement of current knowledge about the edible mushrooms commercialization, especially as nutraceuticals and dietary supplement formulation, mineral supplementation and source of quality proteins in foods and diet. The health benefits of edible mushrooms, nature and chemistry of bioactive components and in-vitro and in-vivo bioactivity of edible mushrooms are also highlighted in different chapters. By bringing diverse areas such as oxidative stress and longevity, techniques of mushroom analysis, toxicology and extracellular enzymes of wild mushrooms, it lays the groundwork for striking expansion in our understanding of these important biochemicals and their role in health and disease prevention. Key Features: Explores major preservation and processing technologies for wild mushrooms and their effects on bioavailability and nutritional value of mushrooms Presents the classical taxonomy and genetic classification of mushrooms Discusses the different components present in mushrooms and their biological activities and the health attribute of mushrooms due to these bioactive components Reviews the applications of mushrooms in environmental pollution reduction Covers different cultivation strategies of edible and medicinal mushrooms The book also explores the role of mushrooms in the degradation of harmful xenobiotic compounds as well as reduction of pesticides. It discusses the utilization of wild mushrooms in waste management and cultivation of wild mushroom using lignocellulosic biomass-based residue as a substrate. This book should be of interest to a large and varied audience of researchers in academia, industry, nutritionists, dietitian, food scientists, agriculturists and regulators.

Author : R.C. Sobti,Naranjan S. Dhalla
Publisher : Springer
Page : 0 pages
File Size : 47,5 Mb
Release : 2022-07-29
Category : Medical
ISBN : 9811692319

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Biomedical Translational Research by R.C. Sobti,Naranjan S. Dhalla Pdf

This book, which is the third volume of Biomedical translational research, focuses on the fundamental role of biomedical research in developing new medicinal products. It emphasizes the importance of understanding biological and pathophysiological mechanisms underlying the disease to discover and develop new biological agents. The book uniquely explores the genomic computational integrative approach for drug repositioning. Further, it discusses the health benefits of nutraceuticals and their application in human diseases. Further, the book comprehensively reviews different computational approaches that employ GWAS data to guide drug repositioning. Finally, it summarizes the major challenges in drug development and the strategies for the rational design of the next generation more effective but less toxic therapeutic agents.