Tumor Immunology And Immunotherapy Resistance

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Tumor Immunology and Immunotherapy Resistance

Subree Subramanian,Timothy K Starr,Xianda Zhao
Tumor Immunology and Immunotherapy Resistance Book PDF

Author : Subree Subramanian,Timothy K Starr,Xianda Zhao
Publisher : Mdpi AG
Page : 0 pages
File Size : 55,9 Mb
Release : 2023-09-06
Category : Medical
ISBN : 3036587020

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Tumor Immunology and Immunotherapy Resistance by Subree Subramanian,Timothy K Starr,Xianda Zhao Pdf

In recent years, cancer immunotherapy has made remarkable progress, revolutionizing cancer treatment. Our Special Issue "Cancer Immunology" in the journal Cancers showcased cutting-edge research and reviews. Building on that success, this new Special Issue explores recent advancements, technologies, and future prospects in cancer immunology, pre-clinical assessments, and clinical trials. While immune checkpoint inhibitors have been transformative, addressing limited response remains crucial. Strategies to overcome resistance, such as combination therapies and targeted pathways, are discussed in the issue. Chimeric antigen receptor (CAR) T cell therapy is an important area of immunotherapy, with exciting findings for enhancing CAR persistence and efficacy. Conventional treatments and monoclonal antibodies also activate immunological mechanisms, boosting cytotoxic efficacy against specific cancers. Identifying biomarkers associated with treatment response is vital for personalized cancer immunotherapy. Potential biomarkers like immune cell densities and estrogen receptor expression are explored in this Issue. The review articles cover advancements in CAR T cell therapy, tumor metabolic alterations, immune suppressive cells, and the role of bacteria in cancer immunotherapy. This Special Issue is a valuable resource for researchers, clinicians, and industry professionals, guiding future developments towards more effective and personalized cancer immunotherapies.

Tumor Immunology and Immunotherapy

Robert C. Rees
Tumor Immunology and Immunotherapy Book PDF

Author : Robert C. Rees
Publisher : Oxford University Press, USA
Page : 469 pages
File Size : 55,7 Mb
Release : 2014
Category : Medical
ISBN : 9780199676866

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Tumor Immunology and Immunotherapy by Robert C. Rees Pdf

A comprehensive account of cancer immunity and immunotherapy, examining recent results, current areas of interest and the specific issues that are affecting the research and development of vaccines. It provides insight into how these problems may be overcome as viewed by leaders in the field.

Cancer Immunotherapy Principles and Practice, Second Edition

Lisa H. Butterfield, PhD,Howard L. Kaufman, MD, FACS,Francesco M. Marincola, MD, FACS
Cancer Immunotherapy Principles and Practice Second Edition Book PDF

Author : Lisa H. Butterfield, PhD,Howard L. Kaufman, MD, FACS,Francesco M. Marincola, MD, FACS
Publisher : Springer Publishing Company
Page : 1339 pages
File Size : 49,8 Mb
Release : 2021-08-25
Category : Medical
ISBN : 9780826137432

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Cancer Immunotherapy Principles and Practice, Second Edition by Lisa H. Butterfield, PhD,Howard L. Kaufman, MD, FACS,Francesco M. Marincola, MD, FACS Pdf

Thoroughly updated to reflect major advances in the field of immuno-oncology, this second edition of Cancer Immunotherapy Principles and Practice, from the Society for Immunotherapy of Cancer (SITC), remains the definitive resource for information on tumor immunology and cancer immunotherapy treatments. An essential reference for both novice and experienced cancer researchers, oncologists, and related practitioners alike, the book not only guides readers through the fundamental scientific principles of the field all the way to translational and practical clinical applications for treating and managing oncologic disease, but also provides a comprehensive understanding of the regulatory processes that support the safe and effective delivery of immunotherapy to patients with cancer. The expanded and updated second edition now spans 68 chapters, including 12 new chapters, covering major topics and innovations that have shaped the rapid development of immunotherapy and its ascension into the standard of care as first-line treatment for a growing number of disease settings. New to this edition are chapters with deeper insight into our understanding of cancer genomics and determinants of response, immunogenic cell death, cancer and stromal cell-intrinsic pathways of immune resistance, cancer immune exclusion, adoptive cell therapy, metabolomics, tumor mutation burden, immunotherapy in combination with radiation therapy, synthetic biology, and more. Complete with detailed illustrations, tables, and key points for targeted reference, Cancer Immunotherapy Principles and Practice, Second Edition is the most comprehensive and authoritative resource for scientists and clinicians looking to expand their knowledge base of this dynamic field. Key Features: Offers key insights and perspectives on cancer immunology and immunotherapy treatments from renowned experts in the field Covers the basic principles and science behind cancer immunotherapy and tumor immunology Includes treatment strategies for a vast array of available immunotherapy classes and agents, such as cytokine therapies, oncolytic viruses, cancer vaccines, CAR T therapies, and combination immunotherapies Provides essential information on FDA-approved immunotherapies, including clinical management and outcome data related to response rates, risks, and toxicities Discusses special considerations for immunotherapy in the context of specific disease settings, including skin cancers, genitourinary cancers, gastrointestinal cancers, hepatocellular carcinomas, gynecologic malignancies, breast cancers, lung cancers, head and neck cancers, brain tumors, sarcomas, pediatric cancers, and treatments combined with radiation therapy Clarifies the complex regulatory aspects behind the development and approval of immunotherapy drugs

Advances in Tumor Immunology and Immunotherapy

Joseph D. Rosenblatt,Eckhard R. Podack,Glen N. Barber,Augusto Ochoa
Advances in Tumor Immunology and Immunotherapy Book PDF

Author : Joseph D. Rosenblatt,Eckhard R. Podack,Glen N. Barber,Augusto Ochoa
Publisher : Springer Science & Business Media
Page : 371 pages
File Size : 47,6 Mb
Release : 2013-10-25
Category : Medical
ISBN : 9781461488095

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Advances in Tumor Immunology and Immunotherapy by Joseph D. Rosenblatt,Eckhard R. Podack,Glen N. Barber,Augusto Ochoa Pdf

Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumor immunity and tumor evasion. In addition to emerging understanding of tumor evasion, new immune targets such as CTLA4 blockade, NK stimulatory receptors, manipulation of the antigen processing and presentation, cytokine and costimulatory responses all provide new possibilities for enhancing anti-tumor immunity even in tumors previously felt to be resistant to immune attack. Several of these strategies have already been realized in the clinic. The volume will explore evolving paradigms in antigen presentation, dendritic cell biology, the innate response and immunosuppressive mechanisms, and emerging strategies for manipulation of the immune system for therapeutic benefit that have realized success in neuroblastoma, leukemia, melanoma, lung cancer, and allogeneic transplantation. Early successes as well as failures will be highlighted to provide a snapshot of the state of clinical immunotherapy with an eye to future possibilities such as combination therapies, adoptive T-cell transfer, and the retargeting of immune cells via T-cell receptor engineering.

Tumor Immunology and Immunotherapy - Integrated Methods Part A

Anonim
Tumor Immunology and Immunotherapy Integrated Methods Part A Book PDF

Author : Anonim
Publisher : Academic Press
Page : 344 pages
File Size : 44,5 Mb
Release : 2020-02-28
Category : Science
ISBN : 9780128188750

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Tumor Immunology and Immunotherapy - Integrated Methods Part A by Anonim Pdf

Tumor Immunology and Immunotherapy Integrated Methods - Part A, Volume 635 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Specific chapters to this release include Deconvolution of the immunological contexture of mouse tumors with multiplexed immunohistochemistry, High-dimensional multiplexed immunohistochemical characterization of immune contexture in human cancers, Multiplex assay by IHC for melanoma tumor microenvironment evaluation, Characterization of the tumor immune microenvironment by multispectral image analysis of multiplex immunofluorescence images, Phenotyping of immune cells in situ using multispectral imaging quantification, and much more. Authored by leaders in the field of enzymology Provides a comprehensiveness level of discussion on the field Presents a highly specialized group of topics that delve deep into new updates and future prospects

Cancer Immunology and Immunotherapy

Glenn Dranoff
Cancer Immunology and Immunotherapy Book PDF

Author : Glenn Dranoff
Publisher : Springer Science & Business Media
Page : 306 pages
File Size : 48,6 Mb
Release : 2011-04-11
Category : Medical
ISBN : 9783642141362

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Cancer Immunology and Immunotherapy by Glenn Dranoff Pdf

The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment.

Tumor Immunology and Immunotherapy - Cellular Methods Part B

Anonim
Tumor Immunology and Immunotherapy Cellular Methods Part B Book PDF

Author : Anonim
Publisher : Academic Press
Page : 588 pages
File Size : 53,8 Mb
Release : 2020-01-29
Category : Science
ISBN : 9780128186763

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Tumor Immunology and Immunotherapy - Cellular Methods Part B by Anonim Pdf

Tumor Immunology and Immunotherapy – Cellular Methods Part B, Volume 632, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Topics covered include Quantitation of calreticulin exposure associated with immunogenic cell death, Side-by-side comparisons of flow cytometry and immunohistochemistry for detection of calreticulin exposure in the course of immunogenic cell death, Quantitative determination of phagocytosis by bone marrow-derived dendritic cells via imaging flow cytometry, Cytofluorometric assessment of dendritic cell-mediated uptake of cancer cell apoptotic bodies, Methods to assess DC-dependent priming of T cell responses by dying cells, and more. Contains content written by authorities in the field Provides a comprehensive view on the topics covered Includes a high level of detail

Cancer Immunology

Nima Rezaei
Cancer Immunology Book PDF

Author : Nima Rezaei
Publisher : Springer Nature
Page : 600 pages
File Size : 54,9 Mb
Release : 2020-12-12
Category : Medical
ISBN : 9783030579494

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Cancer Immunology by Nima Rezaei Pdf

This book explains the immunology of organ-specific malignancies and discusses novel immunotherapy strategies for their treatment. Since the first, very successful edition of the book was published in 2015, a number of entirely new chapters have been included. The range of cancers considered has accordingly been extended, with coverage of the latest immunotherapy approaches for cancers in different organs. In addition, the original chapters have been updated to document the latest advances in immunotherapy for pediatric solid tumors, hematologic malignancies, gastrointestinal tumors, bone tumors, central nervous tumors, lung cancer, genitourinary tract tumors, and breast cancer, among others. The book is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Other volumes in the series address the translational medicine context and bench to bedside immunotherapy. Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors will be of special value to clinical immunologists, hematologists, and oncologists.

General Principles of Tumor Immunotherapy

Howard L. Kaufman,Jedd D. Wolchok
General Principles of Tumor Immunotherapy Book PDF

Author : Howard L. Kaufman,Jedd D. Wolchok
Publisher : Springer Science & Business Media
Page : 502 pages
File Size : 45,6 Mb
Release : 2007-10-22
Category : Medical
ISBN : 9781402060861

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General Principles of Tumor Immunotherapy by Howard L. Kaufman,Jedd D. Wolchok Pdf

This book brings together the world’s leading authorities on tumor immunology. This book describes the basic immunology principles that form the foundation of understanding how the immune system recognizes and rejects tumor cells. The role of the innate and adaptive immune responses is discussed and the implications of these responses for the design of clinical strategies to combat cancer are illustrated.

Tumor Immunology

A. G. Dalgleish,M. J. Browning
Tumor Immunology Book PDF

Author : A. G. Dalgleish,M. J. Browning
Publisher : Cambridge University Press
Page : 382 pages
File Size : 51,6 Mb
Release : 1996-06-13
Category : Medical
ISBN : 0521472377

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Tumor Immunology by A. G. Dalgleish,M. J. Browning Pdf

This 1996 volume reviewed advances in the field of human tumour immunology for an audience of clinicians and researchers.

Successes and Challenges of NK Immunotherapy

Benjamin Bonavida,Anahid Jewett
Successes and Challenges of NK Immunotherapy Book PDF

Author : Benjamin Bonavida,Anahid Jewett
Publisher : Academic Press
Page : 540 pages
File Size : 42,8 Mb
Release : 2021-06-23
Category : Science
ISBN : 9780128243961

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Successes and Challenges of NK Immunotherapy by Benjamin Bonavida,Anahid Jewett Pdf

Successes and Challenges of NK Immunotherapy: Increasing Anti-tumor Efficacy describes the unique therapeutic applications of NK cells to fight cancers and eliminate the bulk and subset of cancer stem cells responsible for metastasis, relapse and recurrences. The book provides information on the development, engineering, mechanisms of action, response to various preclinical models, and applications in various clinical trials. Sections cover the development of highly engineered cytotoxic NK cells, their mechanisms of action, preclinical and clinical applications, the development and application of CAR-NK cells, and new NK-drug conjugates, also emphasizing that activated NK cells can target and kill highly resistant cancer stem cells. Written by the leading experts on NK immunotherapy worldwide, this is a valuable resource for researchers, clinicians and members of the biomedical field who are interested in understanding novel and efficient therapies to fight cancers. Discusses the unique developmental applications of NK immunotherapy against cancers, which differs greatly from other types of immunotherapies Provides up-to-date and highly relevant information through chapters written by the leading researchers in the field Presents a significant number of schematic diagrams for easy understanding and reproducibility

Immunotherapy of Sarcoma

Sandra P. D'Angelo,Seth M. Pollack
Immunotherapy of Sarcoma Book PDF

Author : Sandra P. D'Angelo,Seth M. Pollack
Publisher : Springer
Page : 152 pages
File Size : 45,5 Mb
Release : 2018-11-27
Category : Medical
ISBN : 9783319935300

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Immunotherapy of Sarcoma by Sandra P. D'Angelo,Seth M. Pollack Pdf

This book describes recent progress in the development of immunotherapies for advanced sarcoma, paying special attention to the potential role of manipulations of the sarcoma tumor immune microenvironment in improving patient outcomes. Readers will find a thorough overview of the state of the art in tumor immunology and immunotherapy as they relate to sarcoma. Among the topics addressed are advances in vaccine therapy; cytokine therapies; natural killer cells; the development of adoptive T cell strategies; and the scope for use of checkpoint inhibitors in patients with sarcoma, mirroring the tremendous breakthroughs made in other malignancies. Detailed information is provided on laboratory and clinical research, with analysis of outcomes of recent trials and identification of key challenges. There is every reason to believe that more effective and less toxic therapies for metastatic sarcoma can be attained by deepening our understanding of cancer immunology and building on the advances in immunotherapy for other solid tumors. In this context, Immunotherapy of Sarcoma will be of high interest for all medical oncologists responsible for the treatment of sarcoma patients.

Combinatorial Approaches to Enhance Anti-Tumor Immunity: Focus on Immune Checkpoint Blockade Therapy

Patrik Andersson,Christian Ostheimer
Combinatorial Approaches to Enhance Anti Tumor Immunity Focus on Immune Checkpoint Blockade Therapy Book PDF

Author : Patrik Andersson,Christian Ostheimer
Publisher : Frontiers Media SA
Page : 316 pages
File Size : 41,7 Mb
Release : 2019-12-27
Category : Electronic
ISBN : 9782889631612

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Combinatorial Approaches to Enhance Anti-Tumor Immunity: Focus on Immune Checkpoint Blockade Therapy by Patrik Andersson,Christian Ostheimer Pdf

The immune system harbors great potential for controlling and eliminating tumors. Recent developments in the field of immuno-oncology has led to unprecedented clinical benefits for a broad spectrum of solid tumors. However, immunotherapy (IT) approaches currently have several limitations including (i) low response rate; (ii) development of resistance and (iii) causing severe immune-related adverse effects (IrAEs), which underline the importance of adequate patient selection. Importantly, IT holds promising synergistic potential when combined with standard-of-care chemotherapy, radiotherapy (RT) and anti-angiogenic therapy (AAT) as part of multi-modal oncologic treatment regimes. Published data suggest that there are potential synergy between RT and AAT, which ultimately could help potentiate the response to IT. However, the complex interactions between RT and IT and/or AAT remain poorly understood. Many research questions including optimal timing, scheduling and dosing, as well as patient selection and side effects of combined therapy approaches, remain to be addressed. This Research Topic aims to give a comprehensive overview of the current field with particular emphasis on the future outlook of RT and AAT as complementary approaches to improve IT in solid tumors.

Tumor Immunology and Cancer Therapy

R. H. Goldfarb
Tumor Immunology and Cancer Therapy Book PDF

Author : R. H. Goldfarb
Publisher : CRC Press
Page : 346 pages
File Size : 53,9 Mb
Release : 2020-07-24
Category : Medical
ISBN : 9781000148305

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Tumor Immunology and Cancer Therapy by R. H. Goldfarb Pdf

Based on a Tumor Immunology Symposium held in Pittsburgh, this work provides comprehensive coverage of the most important aspects of tumor immunology. It reveals novel approaches to the immunotherapy of cancer and presents complex issues in an accessible manner.

Cancer Immunology and Immunotherapy

Glenn Dranoff
Cancer Immunology and Immunotherapy Book PDF

Author : Glenn Dranoff
Publisher : Springer
Page : 306 pages
File Size : 49,9 Mb
Release : 2011-04-15
Category : Medical
ISBN : 3642141358

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Cancer Immunology and Immunotherapy by Glenn Dranoff Pdf

The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment.