Tumour Microenvironment In Cancer Research And Drug Discovery

Tumour Microenvironment In Cancer Research And Drug Discovery Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Tumour Microenvironment In Cancer Research And Drug Discovery book. This book definitely worth reading, it is an incredibly well-written.

Tumour microenvironment in cancer research and drug discovery

Syed Mahmood ,Nur Akmarina Mohd Said ,Kenneth K. W. To
Tumour microenvironment in cancer research and drug discovery Book PDF

Author : Syed Mahmood ,Nur Akmarina Mohd Said ,Kenneth K. W. To
Publisher : Frontiers Media SA
Page : 173 pages
File Size : 50,8 Mb
Release : 2024-05-10
Category : Science
ISBN : 9782832548851

Get Book

Tumour microenvironment in cancer research and drug discovery by Syed Mahmood ,Nur Akmarina Mohd Said ,Kenneth K. W. To Pdf

The implication of tumour microenvironment (TME) on cancer progression and therapeutic response has profoundly shifted the paradigms of molecular cancer research and drug discovery. The intricate networks of immune-inflammatory cells and signalling, cancer-associated fibroblasts, endothelial cells and adipose cells are extensively researched for diagnostics, therapeutics and predictive values. This includes siRNA and miRNA nanotherapeutics targeting these molecular components, owing to their powerful gene-silencing properties. Despite the concerted effort in the development of drug targeting TME, such as BLZ945 (a colony-stimulating factor-1 receptor inhibitor), there is a void in clinically satisfactory drug to target this intricate factor, thus far.

The Tumor Microenvironment

Rebecca G. Bagley
The Tumor Microenvironment Book PDF

Author : Rebecca G. Bagley
Publisher : Springer Science & Business Media
Page : 765 pages
File Size : 41,8 Mb
Release : 2010-09-02
Category : Medical
ISBN : 9781441966155

Get Book

The Tumor Microenvironment by Rebecca G. Bagley Pdf

The fact that tumors are composed of both tumor cells and host cells has long been known. These tumor-associated cells include vascular endothelial cells and pe- cytes, as well as inflammatory cells such as neutrophils, monocytes, macrophages, mast cells and eosinophils, and lymphocytes. The tumor cells also interact with stromal cells and with elements of the tissue extracellular matrix. What has been less appreciated is the role that these cells could have in modulating the growth, invasion, and metastasis of the tumor. Early on, the elements of what we now call the tumor microenvironment were considered to be more or less innocent bysta- ers to the role of the tumor cells as they grew and invaded local sites. Today, there is an increased understanding of the critical role of the tumor microenvironment as dramatically influencing the course of tumor development and dissemination. This volume represents a superb compilation of the latest thoughts and data regarding the role of each essential component of the tumor microenvironment in cancer development and progression. Perhaps, the earliest recognition of the role of nonmalignant cells as cancer re- lators was the recognition that lymphocytes can participate in what was termed “immune surveillance” in the 1960s. Our understanding of tumor immunity has improved markedly since then, and there are now successful clinical studies sh- ing the potential use of immune-based therapies in cancer treatment.

Tumor Microenvironment

Constantinos Koumenis,Lisa M. Coussens,Amato Giaccia,Ester Hammond
Tumor Microenvironment Book PDF

Author : Constantinos Koumenis,Lisa M. Coussens,Amato Giaccia,Ester Hammond
Publisher : Springer
Page : 297 pages
File Size : 52,8 Mb
Release : 2016-06-20
Category : Medical
ISBN : 9783319266664

Get Book

Tumor Microenvironment by Constantinos Koumenis,Lisa M. Coussens,Amato Giaccia,Ester Hammond Pdf

This volume covers the topics presented at the 3rd International Conference on Tumor Microenvironment and Cellular Stress by an international community of researchers. The conference brings together scientists to discuss different cellular and animal models of tumor microenvironment study and identify common pathways that are candidates for therapeutic intervention; stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology (e.g., HIF regulation) and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery; and critically evaluate novel targets for imaging or therapeutic intervention that would be of use to the tumor microenvironment community and pharmaceutical industry.

Tumor Microenvironment

Alexander Birbrair
Tumor Microenvironment Book PDF

Author : Alexander Birbrair
Publisher : Springer Nature
Page : 178 pages
File Size : 44,9 Mb
Release : 2020-08-26
Category : Medical
ISBN : 9783030484576

Get Book

Tumor Microenvironment by Alexander Birbrair Pdf

Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components of the tumor microenvironment during cancer development. Furthermore, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include elastin, decorin, syndecan-1, versican, lipoproteins, brevican, thrombospondin, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Extracellular Matrix Components – Part B updates us on what we know about the different aspects of the tumor microenvironment, as well as apprises us on the future advances in the field. For the newest generation of researchers, this volume serves as a useful introduction to the history of scientists’ focus on the tumor microenvironment, and explores how this knowledge is currently applied in cancer treatments. The book is an essential text for advanced cell biology and cancer biology students, as well as for scientists seeking an update on the developments in tumor microenvironment research. All of the chapters authors are renowned international experts in the field of cancer biology, and in the specific subfields that are the focus of their chapters.

Tumor Microenvironment

Alexander Birbrair
Tumor Microenvironment Book PDF

Author : Alexander Birbrair
Publisher : Springer Nature
Page : 189 pages
File Size : 55,6 Mb
Release : 2020-04-07
Category : Medical
ISBN : 9783030401467

Get Book

Tumor Microenvironment by Alexander Birbrair Pdf

Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components of the tumor during cancer development. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include heparan sulphate, hyaluronan, fibronectin, perlecan, glypican, matrix metalloproteinases, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Extracellular Matrix Components – Part A updates us on what we know about the different aspects of the tumor microenvironment, as well as apprises us on the future advances in the field. For the newest generation of researchers, this volume serves as a useful introduction to the history of scientists’ focus on the tumor microenvironment, and explores how this knowledge is currently applied in cancer treatments. The book is an essential text for advanced cell biology and cancer biology students, as well as for scientists seeking an update on the developments in tumor microenvironment research. All of the chapter authors are renowned international experts in the field of cancer biology, and in the specific subfields that are the focus of their chapters.

Tumor Microenvironment and Cellular Stress

Constantinos Koumenis,Ester Hammond,Amato Giaccia
Tumor Microenvironment and Cellular Stress Book PDF

Author : Constantinos Koumenis,Ester Hammond,Amato Giaccia
Publisher : Springer Science & Business Media
Page : 293 pages
File Size : 44,9 Mb
Release : 2013-11-23
Category : Medical
ISBN : 9781461459156

Get Book

Tumor Microenvironment and Cellular Stress by Constantinos Koumenis,Ester Hammond,Amato Giaccia Pdf

The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.

Ex Vivo Engineering of the Tumor Microenvironment

Amir R. Aref,David Barbie
Ex Vivo Engineering of the Tumor Microenvironment Book PDF

Author : Amir R. Aref,David Barbie
Publisher : Springer
Page : 135 pages
File Size : 55,7 Mb
Release : 2016-12-09
Category : Medical
ISBN : 9783319453972

Get Book

Ex Vivo Engineering of the Tumor Microenvironment by Amir R. Aref,David Barbie Pdf

This volume will outline how to recreate the tumor microenvironment, to culture primary tumors without the need for developmental priming factors, and to deliver targeted therapeutics in a manner that recapitulates pharmacokinetics in vivo. Much of what may be learned from this volume will aid in understanding many aspects of the enhanced study of tumor cell biology in a physiologic context, open new avenues for drug screening and biomarker development, and accelerate the preclinical evaluation of novel personalized medicine strategies for patients in real time.

Animal Models in Cancer Drug Discovery

Asfar Azmi,Ramzi M. Mohammad
Animal Models in Cancer Drug Discovery Book PDF

Author : Asfar Azmi,Ramzi M. Mohammad
Publisher : Academic Press
Page : 470 pages
File Size : 46,9 Mb
Release : 2019-04-16
Category : Business & Economics
ISBN : 9780128147054

Get Book

Animal Models in Cancer Drug Discovery by Asfar Azmi,Ramzi M. Mohammad Pdf

Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field. Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid systems, humanized and other models in modern biology paradigms that are enhancing research in the field of drug discover Covers the use of these models in personalized medicine, immunotherapy, toxicology, pre-IND assessments and related drug development arenas Presents protocols, procedures, and a comprehensive glossary to help new readers understand technical terms and specialized nomenclature

Cancer Microenvironment and Therapeutic Implications

Gianfranco Baronzio,Giammaria Fiorentini,Christopher R. Cogle
Cancer Microenvironment and Therapeutic Implications Book PDF

Author : Gianfranco Baronzio,Giammaria Fiorentini,Christopher R. Cogle
Publisher : Springer Science & Business Media
Page : 247 pages
File Size : 51,9 Mb
Release : 2009-04-10
Category : Medical
ISBN : 9781402095764

Get Book

Cancer Microenvironment and Therapeutic Implications by Gianfranco Baronzio,Giammaria Fiorentini,Christopher R. Cogle Pdf

In the post-genomic era, cancer is a genetic disease. However, cancer genotype does not always equal cancer phenotype. Cancers with the same genetic abnormalities don’t always behave the same. Understanding and eradicating cancers will require an appreciation for cancer’s ecology. This book is the first to comprehensively explore and critically appraise cancer microenvironments and host interactions with an eye towards exploiting our understanding for new treatments. The team of contributors share amongst them impressive experiences at the laboratory bench and in the clinic. These physician-scientists have dedicated themselves to the tension between the urgency for cures and the technical challenges of discovery. The target audience includes clinical oncologists, clinical hematologists, research oncologists, research hematologists, immunologists, stem cell researchers, oncology and hematology fellows (trainees), oncology educators (graduate and undergraduate levels), and course book for graduate students and undergraduate students.

Tumor Microenvironment

Dietmar W. Siemann
Tumor Microenvironment Book PDF

Author : Dietmar W. Siemann
Publisher : John Wiley & Sons
Page : 407 pages
File Size : 41,6 Mb
Release : 2011-06-24
Category : Science
ISBN : 9781119956921

Get Book

Tumor Microenvironment by Dietmar W. Siemann Pdf

The microenvironment in which a tumor originates plays a critical role in its initiation and progression. Tumor Microenvironment reviews the importance of tumor microenvironment in cancer management. Particular emphasis is placed on discussing how the unique characteristics of the tumor microenvironment not only impact disease progression and response to conventional anticancer therapies, but have also led to the identification of potential new therapeutic targets and treatment possibilities for cancer patients. Tumor Microenvironment also reviews the fundamental basis of target development, preclinical assessment, and the current clinical status of these therapies.

Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy

Pawel Kalinski
Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy Book PDF

Author : Pawel Kalinski
Publisher : Springer
Page : 264 pages
File Size : 44,6 Mb
Release : 2017-12-22
Category : Medical
ISBN : 9783319675770

Get Book

Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy by Pawel Kalinski Pdf

The tumor microenvironment has become a very important and hot topic in cancer research within the past few years. The tumor microenvironment is defined as the normal cells, molecules, and blood vessels that surround and feed a tumor cell. As many scientists have realized, studying the tumor microenvironment has become critical to moving the field forward, since there are many players in a tumor’s localized and surrounding area, which can significantly change cancer cell behavior. There is a dual relationship wherein the tumor can change its microenvironment and the microenvironment can affect how a tumor grows and spreads. Tumor Microenvironment in Cancer Progression and Cancer Therapy aims to shed light on the mechanisms, factors, and mediators that are involved in the cancer cell environment. Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics. Thus, the dual role of the tumor microenvironment is the integral focus of the volume. The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment. It also focuses on the three groups of the reactive tumor component: stromal cells, blood vessels and the infiltrating immune cells. These three groups are discussed under the lens of their role in promoting tumor growth, shielding the tumor from rejection and from standard forms of cancer therapies. They are emerging as targets and mediators of standard and new forms of potential therapy.

Frontiers in Anti-Cancer Drug Discovery

Atta-ur Rahman,M. Iqbal Choudhary
Frontiers in Anti Cancer Drug Discovery Book PDF

Author : Atta-ur Rahman,M. Iqbal Choudhary
Publisher : Bentham Science Publishers
Page : 181 pages
File Size : 46,9 Mb
Release : 2017-07-06
Category : Medical
ISBN : 9781681083896

Get Book

Frontiers in Anti-Cancer Drug Discovery by Atta-ur Rahman,M. Iqbal Choudhary Pdf

Frontiers in Anti-Cancer Drug Discovery is a book series devoted to publishing the latest and the most important advances in anti-cancer drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The book series should prove to be of interest to all pharmaceutical scientists involved in research in anti-cancer drug design and discovery. Each volume is devoted to the major advances in anti-cancer drug design and discovery. The book series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field. The eighth volume of the series features chapters covering the following topics: - T cells in gastrointestinal cancers - The pharmacology of adjudin – a male contraceptive with anti-cancer properties - Manipulating the tumor microenvironment - Treatment of hepatocellular carcinoma - Gold-based compounds as potential anti-cancer drug candidates - Oral nanostructure drug delivery for anti-cancer treatment

Tumor Microenvironment

Alexander Birbrair
Tumor Microenvironment Book PDF

Author : Alexander Birbrair
Publisher : Springer Nature
Page : 548 pages
File Size : 41,5 Mb
Release : 2021-10-18
Category : Medical
ISBN : 9783030731199

Get Book

Tumor Microenvironment by Alexander Birbrair Pdf

This volume discusses novel concepts in cancer biology, focusing on different factors that affect the tumor microenvironment. Topics covered include sex-based differences in the tumor microenironment, dormancy in the tumor microenvironment, the influence of obesity on the tumor microenvironment, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Novel Concepts covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.

Hypoxia and Cancer

Giovanni Melillo
Hypoxia and Cancer Book PDF

Author : Giovanni Melillo
Publisher : Springer Science & Business Media
Page : 362 pages
File Size : 44,7 Mb
Release : 2013-11-09
Category : Medical
ISBN : 9781461491675

Get Book

Hypoxia and Cancer by Giovanni Melillo Pdf

​​​The imbalance between rapidly proliferating tumor cells and inadequate and inefficient tumor vasculature leads to a decrease in oxygen levels (hypoxia and/or anoxia) in tumor tissues. Intra-tumor hypoxia profoundly affects the biological behavior of cancer cells, which become resistant to conventional therapies and acquire a more invasive and metastatic phenotype. Hypoxia is a hallmark of the malignant phenotype and a key feature of the tumor microenvironment. Hypoxia Inducible Factor 1 (HIF-1) is a master regulator of the transcriptional response to oxygen deprivation. HIF triggers the expression of genes whose products induce angiogenesis, decrease oxygen consumption, switch metabolism to glycolysis, maintain a stem cell phenotype and select for more invasive and metastatic cells. Therapeutic approaches targeting HIF, directly or downstream mediators of its transcriptional activity, are being developed. Intra-tumor hypoxia is a topic has been gaining scientific interest over the last few years for its wide involvement in many physiological and pathological processes. This volume will cover the latest research and translational aspects associated with intra-tumor hypoxia, along with opportunities for drug development offered by this unique feature of the tumor microenvironment. The ongoing efforts to translate our understanding of the biology underlying intra-tumor hypoxia in viable therapeutic options face many challenges, but this book will provide an opportunity for an in-depth analysis of the fundamental mechanisms implicated in the adaption to low oxygen levels and will scrutinize the potential for opportunities that are being pursued in both research and the drug development industry.

Lipid Metabolism in Tumor Immunity

Yongsheng Li
Lipid Metabolism in Tumor Immunity Book PDF

Author : Yongsheng Li
Publisher : Springer Nature
Page : 211 pages
File Size : 46,8 Mb
Release : 2021-03-19
Category : Medical
ISBN : 9789813367852

Get Book

Lipid Metabolism in Tumor Immunity by Yongsheng Li Pdf

This book focuses on lipid metabolism in tumor immunity, covering the application of lipidomics in tumor immunity and all aspects of lipid metabolism in tumor microenvironment. During the progression of tumors, tumor cells and immune cells interact in a dynamic microenvironment. Targeting the immune system has a high potential for treating cancer. However, due to the high heterogeneity of the tumor microenvironment, only a small percentage of patients experience such clinical benefits of tumor immunotherapy. Therefore, understanding the tumor microenvironment is crucial for tumor immunity. Recently, lipid metabolism is an emerging research direction and contributes to cell survival and biofunctions in tumor microenvironment, which is of great interest and significance to be elucidated. This book provides the doctors, researchers, and scientists with a cutting-edge overview of the lipid metabolism and its role in tumor immunity. It also yields benefits for pharmaceutical companies regarding drug discovery.