Vaccine Delivery Technology

Author : Blaine Pfeifer,Andrew Hill
Publisher : Humana
Page : 591 pages
File Size : 55,9 Mb
Release : 2020-11-19
Category : Science
ISBN : 1071607944

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Vaccine Delivery Technology by Blaine Pfeifer,Andrew Hill Pdf

This volume discusses the vaccine development process and the role delivery concepts contribute to a global goal of effective health outcomes. The chapters in this book cover a wide range of topics such as antigen discovery methods; genetic and protein antigen preparation; preparation of viral vaccines as VLPs; viral and non-viral gene delivery; needle-less or non-invasive delivery technology; vaccine storage; and vaccine administration and assessment. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics; lists of the necessary materials and reagents; step-by-step, readily reproducible laboratory protocols; and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Vaccine Delivery Technology: Methods and Protocols is a valuable resource for both novice and expert researchers, in and outside the field, who would like to gain insight into the impactful field of vaccines. Chapter 7 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Author : Manmohan Singh
Publisher : Springer Science & Business Media
Page : 369 pages
File Size : 55,9 Mb
Release : 2013-03-03
Category : Medical
ISBN : 9781461453802

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Novel Immune Potentiators and Delivery Technologies for Next Generation Vaccines by Manmohan Singh Pdf

Development of new-generation vaccines is now more challenging than ever, as identifying, purifying and evaluating vaccine antigens is a complex undertaking. Most importantly, once the relevant antigens have been identified, key focus then shifts to the development of suitable delivery systems and formulations to achieve maximum in vivo potency with minimum potential side effects. These novel formulations—many of which will be nanoparticulates—can deliver the antigens to the desired site, to the relevant antigen presenting cells, and prevent systemic exposure of the immune potentiators. The proposed book will outline all the critical steps that need to be considered for successful development of various types of nanoparticulate delivery systems for vaccine antigens. These contributions from leading experts in the area of vaccine formulation and delivery systems will tie in what is the most current status, including clinical evaluations with these novel vaccine technologies.​

Author : Blaine A. Pfeifer,Andrew Hill
Publisher : Unknown
Page : 128 pages
File Size : 44,5 Mb
Release : 2021
Category : Drug delivery systems
ISBN : 1071607952

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Vaccine Delivery Technology by Blaine A. Pfeifer,Andrew Hill Pdf

Author : Camilla Foged,Thomas Rades,Yvonne Perrie,Sarah Hook
Publisher : Springer
Page : 433 pages
File Size : 54,7 Mb
Release : 2014-11-22
Category : Medical
ISBN : 9781493914173

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Subunit Vaccine Delivery by Camilla Foged,Thomas Rades,Yvonne Perrie,Sarah Hook Pdf

This comprehensive volume compiles the concepts essential for the understanding of the pharmaceutical science and technology associated with the delivery of subunit vaccines. Twenty-one chapters are divided into four main parts: (I) Background; (2) Delivery Systems for Subunit Vaccines; (3) Delivery Routes, Devices and Dosage Forms; and (4) Pharmaceutical Analysis and Quality Control of Vaccines. Part one provide a basic background with respect to immunology and general vaccine classification. In part two, it presents representative types of vaccine delivery systems individually with focus on the physicochemical properties of the systems and their significance for the immune response they stimulate. These delivery systems include aluminum adjuvants, emulsions, liposomes, bilosomes, cubosomes/hexosomes, ISCOMs, virus-like particles, polymeric nano- and microparticles, gels, implants and cell-based delivery systems. Following these chapters, part three addresses the challenges associated with vaccine delivery via specific routes of administration—in particular subcutaneous, intramuscular, oral, nasal, pulmonary, transdermal and vaginal administration. Furthermore, the specific administration routes are discussed in combination with device technologies relevant for the respective routes as well as dosage forms appropriate for the device technology. Finally, the fourth part concerns pharmaceutical analysis and quality control of subunit vaccines.

Author : Anonim
Publisher : Unknown
Page : 164 pages
File Size : 48,8 Mb
Release : 2009
Category : Vaccines
ISBN : 1858223814

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Advances in vaccine technology & delivery by Anonim Pdf

Author : Martin J. D'Souza
Publisher : CRC Press
Page : 244 pages
File Size : 42,8 Mb
Release : 2015-06-01
Category : Medical
ISBN : 9789814613316

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Nanoparticulate Vaccine Delivery Systems by Martin J. D'Souza Pdf

Recent years have seen the development of novel technologies that use nanoparticles and microparticles to deliver vaccines by the oral and microneedle-based transdermal route of administration. These new technologies enable the formulation of vaccine particles containing vaccine antigens, without loss of their biological activity during the formulation process. Also, multiple antigens, targeting ligands, and adjuvants can all be encapsulated within the same particle. When administered orally, these particles are designed to withstand the acidic environment of the stomach and are targeted to Peyer’s patches and the gut-associated mucosal immune system. Since these vaccines are particulate in nature, they are readily taken up by phagocytic antigen-presenting cells, such as M cells, dendritic cells, and macrophages in Peyer’s patches of the intestines, resulting in a strong immune response and antibody production. Since no needles are required for oral vaccines, this method of vaccine delivery is inexpensive and suitable for mass vaccination in the developing world as well as the developed world. This book discusses studies conducted on a wide array of vaccines, including vaccines for infectious diseases such as tuberculosis, typhoid, influenza, pneumonia, meningitis, human papillomavirus, and hepatitis B. It also discusses recent studies on vaccines for cancers such as melanoma and ovarian, breast, and prostate cancer.

Author : Ning Wang,Ting Wang
Publisher : BoD – Books on Demand
Page : 124 pages
File Size : 44,8 Mb
Release : 2018-11-28
Category : Medical
ISBN : 9781789845389

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Immunization by Ning Wang,Ting Wang Pdf

Immunization plays a key role in maintaining human health and each year, saves millions of lives from lethal pathogens and other fatal diseases in the most economical way, thanks to the advanced development of model vaccines. Subunit vaccines are regarded as a safer product than the whole microbe based-conventional vaccines and can be entrapped in various nanocarriers to form a vaccine adjuvant-delivery system (VADS) able to further boost their immunostimulatory activity. In this book, six groups of authors introduce immunization advances in VADSs designed for infection prophylaxis and cancer immunotherapy, problems and their resolution in both human and poultry immunization, and also, the mathematical model for assay of the basic immunization problem (BIP) understood from a finance point of view.

Author : Lene Jorgensen,Hanne Morck Nielson
Publisher : John Wiley & Sons
Page : 442 pages
File Size : 42,7 Mb
Release : 2009-10-23
Category : Science
ISBN : 9780470688403

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Delivery Technologies for Biopharmaceuticals by Lene Jorgensen,Hanne Morck Nielson Pdf

Advances in biotechnology have provided scientists with an increasing number of biopharmaceuticals such as novel peptide and protein drugs as well as nucleic acid based drugs for gene therapy. However, successful delivery of these biopharmaceuticals is a major challenge because their molecular properties lead to poor physical and chemical stability in the body and limited membrane permeability. Therefore researchers are developing a range of new delivery technologies and materials to enable these new drugs to be delivered intact to their target sites. Delivery Technologies for Biopharmaceuticals describes strategies to overcome the main barriers for successful delivery of therapeutic peptides, proteins, and nucleic acid-based drugs or vaccines related to the site of administration and the target site. Many of the approaches described are reported in formulations in current clinical trials as well as in marketed products. Contents include: challenges in delivery of biopharmaceuticals novel formulation approaches for peptide and protein injectables non-viral chemical vectors and viral technology for delivery of nucleic acid based drugs immune response, adjuvants and delivery systems for vaccines several examples of delivery systems for different biopharmaceuticals a critical assessment of delivery technologies for biopharmaceuticals Delivery Technologies for Biopharmaceuticals is an essential single-volume introduction to the technologies used by researchers to ensure efficient delivery of this exciting new class of drugs. It will be of value to researchers and students working in drug delivery, formulation, biopharmaceuticals, medicinal chemistry, and new materials development.

Author : Igor S Lukashevich,Haval Shirwan
Publisher : Springer
Page : 393 pages
File Size : 43,5 Mb
Release : 2014-11-13
Category : Medical
ISBN : 9783709118184

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Novel Technologies for Vaccine Development by Igor S Lukashevich,Haval Shirwan Pdf

This book presents a detailed overview of the development of new viral vector-based vaccines before discussing two major applications: preventive vaccines for infectious diseases and therapeutic cancer vaccines. Viral vector-based vaccines hold a great potential for development into successful pharmaceutical products and several examples at the advanced pre-clinical or clinical stage are presented. Nevertheless, the most efforts were focused on novel and very innovative technologies for new generation of vector-based vaccines. Furthermore, specific topics such as delivery and adjuvant and protection strategies for cell-mediated-based vaccines are presented. Given its scope, the book is a “must read” for all those involved in vaccine development, both in academia and industrial vaccine development.

Author : Bruno Gander,Hans P Merkle,Giampietro Corradin
Publisher : CRC Press
Page : 258 pages
File Size : 52,8 Mb
Release : 1998-01-29
Category : Medical
ISBN : 9057022672

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Antigen Delivery Systems by Bruno Gander,Hans P Merkle,Giampietro Corradin Pdf

This text presents an up-to-date overview of recent developments in this field, reviews new trends in vaccine development programs, and emphasizes the requirements and importance of varied vaccine delivery systems.

Author : Smadar Cohen,Howard Bernstein
Publisher : CRC Press
Page : 536 pages
File Size : 48,7 Mb
Release : 1996-08-23
Category : Science
ISBN : 0824797531

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Microparticulate Systems for the Delivery of Proteins and Vaccines by Smadar Cohen,Howard Bernstein Pdf

This practical guide offers concise coverage of the scientific and pharmaceutical aspects of protein delivery from controlled release microparticulate systems-emphasizing protein stability during encapsulation and release.

Author : Jennifer Hamborsky, MPH, MCHES,Andrew Kroger, MD, MPH,Charles (Skip) Wolfe
Publisher : Public Health Foundation
Page : 512 pages
File Size : 50,6 Mb
Release : 2015-10-19
Category : Health & Fitness
ISBN : 9780990449126

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Epidemiology and Prevention of Vaccine-Preventable Diseases, 13th Edition E-Book by Jennifer Hamborsky, MPH, MCHES,Andrew Kroger, MD, MPH,Charles (Skip) Wolfe Pdf

The Public Health Foundation (PHF) in partnership with the Centers for Disease Control and Prevention (CDC) is pleased to announce the availability of Epidemiology and Prevention of Vaccine-Preventable Diseases, 13th Edition or “The Pink Book” E-Book. This resource provides the most current, comprehensive, and credible information on vaccine-preventable diseases, and contains updated content on immunization and vaccine information for public health practitioners, healthcare providers, health educators, pharmacists, nurses, and others involved in administering vaccines. “The Pink Book E-Book” allows you, your staff, and others to have quick access to features such as keyword search and chapter links. Online schedules and sources can also be accessed directly through e-readers with internet access. Current, credible, and comprehensive, “The Pink Book E-Book” contains information on each vaccine-preventable disease and delivers immunization providers with the latest information on: Principles of vaccination General recommendations on immunization Vaccine safety Child/adult immunization schedules International vaccines/Foreign language terms Vaccination data and statistics The E-Book format contains all of the information and updates that are in the print version, including: · New vaccine administration chapter · New recommendations regarding selection of storage units and temperature monitoring tools · New recommendations for vaccine transport · Updated information on available influenza vaccine products · Use of Tdap in pregnancy · Use of Tdap in persons 65 years of age or older · Use of PCV13 and PPSV23 in adults with immunocompromising conditions · New licensure information for varicella-zoster immune globulin Contact [email protected] for more information. For more news and specials on immunization and vaccines visit the Pink Book's Facebook fan page

Author : Vasso Apostolopoulos,Lalitkumar K. Vora,Vivek P. Chavda
Publisher : Elsevier
Page : 530 pages
File Size : 41,7 Mb
Release : 2024-03-25
Category : Medical
ISBN : 9780443185656

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Advanced Vaccination Technologies for Infectious and Chronic Diseases by Vasso Apostolopoulos,Lalitkumar K. Vora,Vivek P. Chavda Pdf

The role of vaccines is emerging and even critical to ending infectious and chronic diseases and pandemics alike. The design and development of new vaccines could lead to improved health. Handbook on Advanced Vaccination Technologies for Infectious and Chronic Disease discusses these new developments and introduces the reader to the current state of the science and the outlook going forward from the discovery of vaccines to the clinical trials of personalized vaccines. Handbook on Advanced Vaccination Technologies for Infectious and Chronic Diseases is a valuable reference for occupational health professionals whose role involves supervision of immunization programs such as those working in the National Health Service, some sectors of higher education and the pharmaceutical industry. Offers comprehensive coverage of different vaccine platforms and their development Includes information on the regulatory perspective of vaccine development Describes different delivery approaches for vaccinology Explains the clinical development of vaccines along with novel platforms Covers all recent developments of vaccine production technologies, new types of vaccines, and ongoing research that could prevent future pandemics

Author : Mariusz Skwarczynski,Istvan Toth
Publisher : William Andrew
Page : 460 pages
File Size : 44,6 Mb
Release : 2016-09-20
Category : Medical
ISBN : 9780323400299

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Micro- and Nanotechnology in Vaccine Development by Mariusz Skwarczynski,Istvan Toth Pdf

This book provides a comprehensive overview of how use of micro- and nanotechnology (MNT) has allowed major new advance in vaccine development research, and the challenges that immunologists face in making further progress. MNT allows the creation of particles that exploit the inherent ability of the human immune system to recognize small particles such as viruses and toxins. In combination with minimal protective epitope design, this permits the creation of immunogenic particles that stimulate a response against the targeted pathogen. The finely tuned response of the human immune system to small particles makes it unsurprising that many of the lead adjuvants and vaccine delivery systems currently under investigation are based on nanoparticles. Provides a comprehensive and unparalleled overview of the role of micro- and nanotechnology in vaccine development Allows researchers to quickly familiarize themselves with the broad spectrum of vaccines and how micro- and nanotechnologies are applied to their development Includes a combination of overview chapters setting out general principles, and focused content dealing with specific vaccines, making it useful to readers from a variety of disciplines

Author : Selene Baschieri
Publisher : Springer Science & Business Media
Page : 294 pages
File Size : 42,7 Mb
Release : 2012-07-20
Category : Medical
ISBN : 9789400745438

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Innovation in Vaccinology by Selene Baschieri Pdf

Prevention of infectious diseases by vaccination is one of the most significant achievements of modern medicine. During the 20th century, the average human life span in the developed world was about 70 years and it is expected to increase, with a significant portion of this increase directly attributed to vaccination. Since the first empiric vaccination trials, knowledge and technology have enormously evolved and new vaccination strategies are emerging on the market. Indeed, in spite of the great success, conventional vaccination strategies sometimes may result ineffective and, above all, may raise safety concerns. The aim of this book is to provide an overview of some of the technology platforms that have been realized or are currently under development to try to address unsolved and new issues in the field of vaccine development. Common denominator of all thematic areas described herein is the multidisciplinary teamwork. Most of the enabling technologies have been established by putting in the “melting pot” expertise in fields that, at first glance, may appear very far apart. I hope that this collection of articles will make the readers aware that vaccinology is rapidly taking a new direction, ceasing to be an empirical science.