Advances In Targeted Cancer Therapy

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Advances in Targeted Cancer Therapy

Richard M. Schultz
Advances in Targeted Cancer Therapy Book PDF

Author : Richard M. Schultz
Publisher : Springer Science & Business Media
Page : 303 pages
File Size : 40,5 Mb
Release : 2006-01-24
Category : Medical
ISBN : 9783764374143

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Advances in Targeted Cancer Therapy by Richard M. Schultz Pdf

There have been tremendous advances in our understanding of molecular and tumor biology during the past few years. In the field of cancer therapeutics, it is expected that cytotoxic drug approaches will be gradually replaced with treatments based on biological targeted approaches. Hopefully these new targeted therapies will significantly increase efficacy and lack the devastating and troublesome side effects elicited by cytotoxic chemotherapy. This volume is the first book to cover the general topic of targeted cancer therapy. It presents a range of targets such as tumor angiogenesis, cell cycle control and cell signalling, COX-2, apoptosis/cell survival, invasion and metastasis and approaches like kinase inhibitors, antisense, and antibody-based therapeutics. The emphasis is on preclinical development, including target validation, development of biomarkers, strategies for combination approaches, and development of resistance. The particular challenges involved in translating these data to clinical application are discussed. This volume should be of broad general interest to researchers and clinicians involved in cancer therapy as well as other scientists interested in current strategies for cancer treatment.

Advances in Cancer Treatment

Iago Dillion Lima Cavalcanti,José Cleberson Santos Soares
Advances in Cancer Treatment Book PDF

Author : Iago Dillion Lima Cavalcanti,José Cleberson Santos Soares
Publisher : Springer Nature
Page : 109 pages
File Size : 50,9 Mb
Release : 2021-02-24
Category : Medical
ISBN : 9783030683344

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Advances in Cancer Treatment by Iago Dillion Lima Cavalcanti,José Cleberson Santos Soares Pdf

This work covers the pathophysiology of cancer, exploring the difficulty of optimal treatment due to the complexity and diversity of cancer types. The search for distinctive molecular biology characteristics of tumor cells is especially relevant in the identification of overexpressed receptors and proteins that can be used as a target for cancer treatment. We highlight the main therapeutic modalities, particularly conventional systemic chemotherapy, addressing its mechanisms of action, therapeutic classes and even the toxic effects. We also describe the main tumor markers, their importance in the diagnosis and treatment of cancer, and the specificity of tumor cells. The first chapters serve as an introduction to the central topic of this book, targeted therapy. Key aspects of target therapy, such as classes of drugs, immunotherapy, monoclonal antibodies, checkpoint inhibitors, cancer vaccines and tyrosine kinase inhibitors are presented, and, for each one, the benefits, as well as the adverse effects are reported. Chapter 6 compares conventional systemic chemotherapy and targeted therapy, identifies the risks and benefits and also the eligibility criteria for patient care. The possibility of targeted therapy replacing conventional chemotherapy is discussed while reviewing studies that demonstrate the benefits of combining both types of treatment. Finally, the introduction of pharmaceutical nanotechnology to improve antineoplastic agents is addressed in the last chapter and sets the direction for future research in cancer treatment. This is a valuable resource for many health professionals including physicians, pharmacists, nurses, researchers and students interested in the field of oncology.

Successes and Limitations of Targeted Cancer Therapy

S. Peters,R.A. Stahel
Successes and Limitations of Targeted Cancer Therapy Book PDF

Author : S. Peters,R.A. Stahel
Publisher : Karger Medical and Scientific Publishers
Page : 124 pages
File Size : 42,9 Mb
Release : 2014-02-19
Category : Medical
ISBN : 9783318025422

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Successes and Limitations of Targeted Cancer Therapy by S. Peters,R.A. Stahel Pdf

The treatment of patients with advanced malignancies has undergone remarkable change in the last few years. While in the past decisions about systemic therapy were largely based on the performance status of a patient, oncologists today also take into account the pathological and molecular characteristics of the patient’s tumor. Targeting specific molecular pathways important for tumorigenesis has become the preferred way of treatment for many types of malignancies. With these advances come new challenges including the optimization of therapy, recognizing and dealing with side effects and, importantly, the development of resistance. This book provides an up-to-date overview of the advances and limitations of targeted therapy for several tumor entities including breast cancer, colon cancer, gastrointestinal stromal tumors, lung cancer, melanoma, ovarian cancer and renal cell carcinoma. Written by over a dozen internationally renowned scientists, the book is suitable for advanced students, postdoctoral researchers, scientists and clinicians who wish to update their knowledge of the latest approaches to targeted cancer therapies.

Recent Advances in Cancer Research and Therapy

Xin-Yuan Liu,Sidney Pestka,Yu-Fang Shi
Recent Advances in Cancer Research and Therapy Book PDF

Author : Xin-Yuan Liu,Sidney Pestka,Yu-Fang Shi
Publisher : Elsevier
Page : 700 pages
File Size : 53,9 Mb
Release : 2012-05-18
Category : Medical
ISBN : 9780123978363

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Recent Advances in Cancer Research and Therapy by Xin-Yuan Liu,Sidney Pestka,Yu-Fang Shi Pdf

Cancer continues to be one of the major causes of death throughout the developed world, which has led to increased research on effective treatments. Because of this, in the past decade, rapid progress in the field of cancer treatment has been seen. Recent Advances in Cancer Research and Therapy reviews in specific details some of the most effective and promising treatments developed in research centers worldwide. While referencing advances in traditional therapies and treatments such as chemotherapy, this book also highlights advances in biotherapy including research using Interferon and Super Interferon, HecI based and liposome based therapy, gene therapy, and p53 based cancer therapy. There is also a discussion of current cancer research in China including traditional Chinese medicine. Written by leading scientists in the field, this book provides an essential insight into the current state of cancer therapy and treatment. Includes a wide range of research areas including a focus on biotherapy and the development of novel cancer therapeutic strategies. Formatted for a broad audience including all working in researching cancer treatments and therapies. Discusses special traits and results of Chinese cancer research.

Targeted Therapies in Breast Cancer

Gw Sledge,George W. Sledge (Jr.)
Targeted Therapies in Breast Cancer Book PDF

Author : Gw Sledge,George W. Sledge (Jr.)
Publisher : Clinical Pub
Page : 0 pages
File Size : 43,5 Mb
Release : 2012-06
Category : Breast
ISBN : 1846920663

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Targeted Therapies in Breast Cancer by Gw Sledge,George W. Sledge (Jr.) Pdf

This new volume updates the reader on selected areas of targeted therapy in breast cancer, with special emphasis on chemoprevention strategies, drug resistance, biomarkers, combination chemotherapy, angiogenesis inhibition and pharmacogenomics in the context of clinical efficacy. This selected review of targeted therapies will guide the reader on effective treatment as part of an integrated programme of patient management.

Advanced Drug Delivery Systems in the Management of Cancer

Kamal Dua,Meenu Mehta,Terezinha de Jesus Andreoli Pinto,Lisa G. Pont,Kylie A. Williams,Michael Rathbone
Advanced Drug Delivery Systems in the Management of Cancer Book PDF

Author : Kamal Dua,Meenu Mehta,Terezinha de Jesus Andreoli Pinto,Lisa G. Pont,Kylie A. Williams,Michael Rathbone
Publisher : Elsevier
Page : 572 pages
File Size : 54,8 Mb
Release : 2021-06-24
Category : Business & Economics
ISBN : 9780323900799

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Advanced Drug Delivery Systems in the Management of Cancer by Kamal Dua,Meenu Mehta,Terezinha de Jesus Andreoli Pinto,Lisa G. Pont,Kylie A. Williams,Michael Rathbone Pdf

Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems

Targeted Cancer Therapy

Razelle Kurzrock,Maurie Markman
Targeted Cancer Therapy Book PDF

Author : Razelle Kurzrock,Maurie Markman
Publisher : Springer Science & Business Media
Page : 446 pages
File Size : 49,9 Mb
Release : 2008-03-07
Category : Medical
ISBN : 9781603274241

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Targeted Cancer Therapy by Razelle Kurzrock,Maurie Markman Pdf

Emerging technologies in target identification, drug discovery, molecular markers, and imaging are rapidly changing the face of cancer. This book provides a foundation of knowledge in targeted cancer therapeutics. The treatment of cancer is increasingly being individualized, based on an understanding of underlying biologic mechanisms. Poised to change the landscape in oncology, this volume provides a state-of-the-art overview. It will be valuable to practicing and academic physicians, fellows, residents and students, as well as basic scientists, interested in the cancer field.

Targeted Therapies for Solid Tumors

Antonio Russo,Rafael Rosell,Christian Rolfo
Targeted Therapies for Solid Tumors Book PDF

Author : Antonio Russo,Rafael Rosell,Christian Rolfo
Publisher : Humana Press
Page : 269 pages
File Size : 52,6 Mb
Release : 2015-03-11
Category : Medical
ISBN : 9781493920471

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Targeted Therapies for Solid Tumors by Antonio Russo,Rafael Rosell,Christian Rolfo Pdf

This volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers some of the newest developments in cancer therapy that are not adequately covered by any current available literature. Written by recognized experts in the field, Targeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment provides a unique and valuable resource in the field of molecular oncology, both for those currently in training, and for those already in clinical or research practice.

Handbook of Targeted Cancer Therapy

Daniel D. Karp,Gerald S. Falchook
Handbook of Targeted Cancer Therapy Book PDF

Author : Daniel D. Karp,Gerald S. Falchook
Publisher : Lippincott Williams & Wilkins
Page : 288 pages
File Size : 42,5 Mb
Release : 2014-09-09
Category : Medical
ISBN : 9781469894584

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Handbook of Targeted Cancer Therapy by Daniel D. Karp,Gerald S. Falchook Pdf

Make optimal use of the latest personalized therapeutic strategies with Handbook of Targeted Cancer Therapy! This concise, practical oncology reference examines more than 140 targeted therapy agents for which clinical trial data are available, and explains when and how you can use them to most effectively combat cancer. Approach clinical challenges from any direction with separate sections on Targets by Organ Site, Carcinogenesis from the Perspective of Targeted Therapy, Molecular Targets and Pathways, and Targeted Therapy Agents. Find information easily thanks to a color-coded format and an intuitive organization. Access the complete contents online and on mobile devices, with regular updates to include newly approved treatments. Important state of the art cancer information for caregivers, researchers, other health care professionals, and even patients

Targeted Therapy in Translational Cancer Research

Apostolia-Maria Tsimberidou,Razelle Kurzrock,Kenneth C. Anderson
Targeted Therapy in Translational Cancer Research Book PDF

Author : Apostolia-Maria Tsimberidou,Razelle Kurzrock,Kenneth C. Anderson
Publisher : John Wiley & Sons
Page : 320 pages
File Size : 54,8 Mb
Release : 2015-10-14
Category : Medical
ISBN : 9781118468661

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Targeted Therapy in Translational Cancer Research by Apostolia-Maria Tsimberidou,Razelle Kurzrock,Kenneth C. Anderson Pdf

Targeted Therapy in Translational Cancer Research for the Translational Oncology series provides a comprehensive overview of recent developments in our understanding of tumor biology, elucidates the roles of targets and pathways involved in carcinogenesis, and describes current state-of-the-art anticancer therapy, as well as the most promising areas of translational research and targeted therapy. Introduces cutting-edge ‘bench to bedside and back’ breakthroughs which have transformed the diagnosis, prognosis, and treatment of cancer Covers basic principles of targeted therapy, including immunotherapy and the roles of cancer stem cells, the microenvironment, angiogenesis, epigenetics, microRNAs, and functional imaging in precision medicine Summarises major advances in therapeutic management of hematologic malignancies and solid tumors using conventional therapy, targeted therapy, immunotherapy, or novel treatment modalities

Targeted Radionuclide Therapy

Tod W. Speer
Targeted Radionuclide Therapy Book PDF

Author : Tod W. Speer
Publisher : Lippincott Williams & Wilkins
Page : 564 pages
File Size : 53,9 Mb
Release : 2012-03-28
Category : Medical
ISBN : 9781451153262

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Targeted Radionuclide Therapy by Tod W. Speer Pdf

Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.

Nanomedicine and Cancer Treatment: Advances in Targeted Therapy and Diagnosis

Aliasghar Tabatabaei Mohammadi,Erfan Ghanbarzadeh,Hajar Hoveizavi,Seyedehyasamin Habibiabhari,Sajjad Alimohammadvand,Sepideh Kianian,Navid Naghsh,Shaghayegh Abbasi,Negar Jahani
Nanomedicine and Cancer Treatment Advances in Targeted Therapy and Diagnosis Book PDF

Author : Aliasghar Tabatabaei Mohammadi,Erfan Ghanbarzadeh,Hajar Hoveizavi,Seyedehyasamin Habibiabhari,Sajjad Alimohammadvand,Sepideh Kianian,Navid Naghsh,Shaghayegh Abbasi,Negar Jahani
Publisher : Nobel Sciences
Page : 58 pages
File Size : 48,9 Mb
Release : 2023-08-29
Category : Medical
ISBN : 8210379456XXX

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Nanomedicine and Cancer Treatment: Advances in Targeted Therapy and Diagnosis by Aliasghar Tabatabaei Mohammadi,Erfan Ghanbarzadeh,Hajar Hoveizavi,Seyedehyasamin Habibiabhari,Sajjad Alimohammadvand,Sepideh Kianian,Navid Naghsh,Shaghayegh Abbasi,Negar Jahani Pdf

Chapter 1: Cancer biology Chapter 2: Histone deacetylase inhibitors Chapter 3: Nanomedicine based cancer treatments: Abraxane Chapter 4: Nanomedicine based cancer treatments: Doxil

Current Challenges in Personalized Cancer Medicine

Anonim
Current Challenges in Personalized Cancer Medicine Book PDF

Author : Anonim
Publisher : Academic Press
Page : 576 pages
File Size : 45,7 Mb
Release : 2012-12-31
Category : Medical
ISBN : 9780123984838

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Current Challenges in Personalized Cancer Medicine by Anonim Pdf

For this volume of Advances in Pharmacology we have brought together some of the foremost basic science and clinical researchers to discuss some of the new frontiers in the development of targeted cancer therapy. Although still in its formative stages, the development of targeted cancer therapies has already shown incredible promise in a limited number of cancer types. As basic cancer research and drug development continues, we expect this number to grow and more patients to benefit from these exciting advances. Through better patient selection and novel strategies to manage resistance, a future can be envisaged in which cancer can be reduced to the level of a chronic, manageable disease. Brought together some of the foremost basic science and clinical researchers Part of the renowned Advances in Pharmacology Serial Discussion of some of the new frontiers in the development of targeted cancer therapy

Targeted Therapies in Oncology, Second Edition

Giuseppe Giaccone,Jean-Charles Soria
Targeted Therapies in Oncology Second Edition Book PDF

Author : Giuseppe Giaccone,Jean-Charles Soria
Publisher : CRC Press
Page : 500 pages
File Size : 52,7 Mb
Release : 2013-10-21
Category : Medical
ISBN : 9781842145456

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Targeted Therapies in Oncology, Second Edition by Giuseppe Giaccone,Jean-Charles Soria Pdf

Since the last edition of this book, major advances have been made in our understanding of key pathways that control tumor progression. This has led to the development of new anticancer agents that have the ability to block the activity of proteins involved in neoplastic cell development and proliferation. Targeted Therapies in Oncology, Second Edition provides a concise timely panorama of existing targeted therapies and progress into future anticancer treatments. These therapies notably include: Targeted agents of immune checkpoints Signal-transduction inhibitors Antiangiogenic agents Vascular-disrupting agents Apoptosis modulators Stem cell inhibitors Tumor profiling for drug development The book emphasizes the biology behind this new class of drugs as well as the clinical achievements obtained. The contributors to this volume stand at the cutting edge of cancer research and treatment around the world.

Targeted Therapies in Cancer

Manfred Dietel
Targeted Therapies in Cancer Book PDF

Author : Manfred Dietel
Publisher : Springer
Page : 0 pages
File Size : 46,7 Mb
Release : 2014-11-23
Category : Medical
ISBN : 3642432433

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Targeted Therapies in Cancer by Manfred Dietel Pdf

From its introduction, oncological chemotherapy has been encumbered by poor selectivity because antiproliferative drugs are often toxic not only to tumor cells but also to important populations of the body’s non-neoplastic cells. Modern targeted therapies interact with defined molecules present on cancer cells, adding increased selectivity to their toxic effects. This book presents an integrated critical view on the theories, mechanisms, problems and pitfalls of the targeted therapy approach.