Alternative Pre Mrna Splicing

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Alternative pre-mRNA Splicing

Stefan Stamm,Chris Smith,Reinhard Lührmann
Alternative pre mRNA Splicing Book PDF

Author : Stefan Stamm,Chris Smith,Reinhard Lührmann
Publisher : John Wiley & Sons
Page : 660 pages
File Size : 41,7 Mb
Release : 2012-08-01
Category : Science
ISBN : 9783527647989

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Alternative pre-mRNA Splicing by Stefan Stamm,Chris Smith,Reinhard Lührmann Pdf

This book was written for graduate and medical students, as well as clinicians and postdoctoral researchers. It describes the theory of alternative pre-mRNA splicing in twelve introductory chapters and then introduces protocols and their theoretical background relevant for experimental research. These 43 practical chapters cover: Basic methods, Detection of splicing events, Analysis of alternative pre-mRNA splicing in vitro and in vivo, Manipulation of splicing events, and Bioinformatic analysis of alternative splicing. A theoretical introduction and practical guide for molecular biologists, geneticists,clinicians and every researcher interested in alternative splicing. Website: www.wiley-vch.de/home/splicing

Pre-mRNA Processing

Angus I. Lamond
Pre mRNA Processing Book PDF

Author : Angus I. Lamond
Publisher : Springer Science & Business Media
Page : 230 pages
File Size : 42,5 Mb
Release : 2013-11-11
Category : Science
ISBN : 9783662223253

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Pre-mRNA Processing by Angus I. Lamond Pdf

he past fifteen years have seen tremendous growth in our understanding of T the many post-transcriptional processing steps involved in producing func tional eukaryotic mRNA from primary gene transcripts (pre-mRNA). New processing reactions, such as splicing and RNA editing, have been discovered and detailed biochemical and genetic studies continue to yield important new insights into the reaction mechanisms and molecular interactions involved. It is now apparent that regulation of RNA processing plays a significant role in the control of gene expression and development. An increased understanding of RNA processing mechanisms has also proved to be of considerable clinical importance in the pathology of inherited disease and viral infection. This volume seeks to review the rapid progress being made in the study of how mRNA precursors are processed into mRNA and to convey the broad scope of the RNA field and its relevance to other areas of cell biology and medicine. Since one of the major themes of RNA processing is the recognition of specific RNA sequences and structures by protein factors, we begin with reviews of RNA-protein interactions. In chapter 1 David Lilley presents an overview of RNA structure and illustrates how the structural features of RNA molecules are exploited for specific recognition by protein, while in chapter 2 Maurice Swanson discusses the structure and function of the large family of hnRNP proteins that bind to pre-mRNA. The next four chapters focus on pre-mRNA splicing.

Spliceosomal Pre-mRNA Splicing

Klemens J. Hertel
Spliceosomal Pre mRNA Splicing Book PDF

Author : Klemens J. Hertel
Publisher : Humana
Page : 0 pages
File Size : 45,7 Mb
Release : 2016-09-03
Category : Medical
ISBN : 149396044X

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Spliceosomal Pre-mRNA Splicing by Klemens J. Hertel Pdf

Providing a guide to classical experimental approaches to decipher splicing mechanisms and experimental strategies that rely on novel multi-disciplinary approaches, Spliceosomal Pre-mRNA Splicing: Methods and Protocols describes the theory of alternative pre-mRNA splicing in seven introductory chapters and then introduces protocols and their theoretical background relevant for a variety of experimental research. These protocol chapters cover basic methods to detect splicing events, analyses of alternative pre-mRNA splicing in vitro and in vivo manipulation of splicing events and high-throughput and bioinformatic analyses of alternative splicing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Spliceosomal Pre-mRNA Splicing: Methods and Protocols will aid newcomers and seasoned molecular biologists in understanding the fascinating world of alternative splicing with the ultimate goal of paving the way for many new discoveries to come.

Alternative pre-mRNA Splicing

Stefan Stamm,Chris Smith,Reinhard Lührmann
Alternative pre mRNA Splicing Book PDF

Author : Stefan Stamm,Chris Smith,Reinhard Lührmann
Publisher : John Wiley & Sons
Page : 660 pages
File Size : 43,9 Mb
Release : 2012-02-13
Category : Science
ISBN : 9783527326068

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Alternative pre-mRNA Splicing by Stefan Stamm,Chris Smith,Reinhard Lührmann Pdf

Der definitive Leitfaden zum RNA-Splicing - ideal für alle Kliniker, die sich mit genetischen Erkrankungen befassen, insbesondere natürlich für RNA-Forscher. Website: www.wiley-vch.de/home/splicing

Eukaryotic MRNA Processing

Adrian Krainer
Eukaryotic MRNA Processing Book PDF

Author : Adrian Krainer
Publisher : IRL Press
Page : 408 pages
File Size : 46,8 Mb
Release : 1997
Category : Language Arts & Disciplines
ISBN : STANFORD:36105020129602

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Eukaryotic MRNA Processing by Adrian Krainer Pdf

This volume focuses on the major aspects of post-transcriptional mRNA processing in the nucleus of eukaryotic cells. Each of the described mRNA reactions is required for proper gene expression and can also serve as a control point for regulating the expression of many genes, for example duringembryonic development or in different cell types. The different chapters review the assembly of newly synthesized nuclear mRNA transcripts into hnRNP particles and catalytically active spliceosomes; the structure and mechanism of action of small nuclear ribonucleoprotein particles and proteinfactors that catalyse pre-mRNA splicing in mammalian cells and in yeast; the regulation of gene expression and generation of protein isoform diversity by alternative splicing; the mechanisms of 3' end cleavage and polyadenylation; the architecture of the cell nucleus in relation to these processesand to the localization of the relevant substrates and factors; the diverse mechanisms of RNA processing by ribozymes and their potential relevance for nuclear mRNA processing; the mechanism of spliced-leader addition by trans-splicing in nematodes and trypanosomes; and the process ofinsertion/deletion mRNA editing in kinetoplasmid protozoa. In each chapter, leading researchers have provided detailed, critical reviews of the history, experimental approaches, major advances, current ideas and models, as well as future directions, for each of these active areas of research.

Regulation of Alternative Splicing

Philippe Jeanteur
Regulation of Alternative Splicing Book PDF

Author : Philippe Jeanteur
Publisher : Springer Science & Business Media
Page : 254 pages
File Size : 55,5 Mb
Release : 2013-03-14
Category : Science
ISBN : 9783662097281

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Regulation of Alternative Splicing by Philippe Jeanteur Pdf

The discovery in 1977 that genes are split into exons and introns has done away with the one gene - one protein dogma. Indeed, the removal of introns from the primary RNA transcript is not necessarily straightforward since there may be optional pathways leading to different messenger RNAs and consequently to different proteins. Examples of such an alternative splicing mechanism cover all fields of biology. Moreover, there are plenty of occurrences where deviant splicing can have pathological effects. Despite the high number of specific cases of alternative splicing, it was not until recently that the generality and extent of this phenomenon was fully appreciated. A superficial reading of the preliminary sequence of the human genome published in 2001 led to the surprising, and even deceiving to many scientists, low number of genes (around 32,000) which contrasted with the much higher figure around 150,000 which was previously envisioned. Attempts to make a global assessment of the use of alternative splicing are recent and rely essentially on the comparison of genomic mRNA and EST sequences as reviewed by Thanaraj and Stamm in the first chapter of this volume. Most recent estimates suggest that 40-60% of human genes might be alternatively spliced, as opposed to about 22% for C. elegans.

Spliceosomal Pre-mRNA Splicing

Klemens J. Hertel
Spliceosomal Pre mRNA Splicing Book PDF

Author : Klemens J. Hertel
Publisher : Unknown
Page : 427 pages
File Size : 52,9 Mb
Release : 2014
Category : Genetic engineering
ISBN : 1627039805

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Spliceosomal Pre-mRNA Splicing by Klemens J. Hertel Pdf

Providing a guide to classical experimental approaches to decipher splicing mechanisms and experimental strategies that rely on novel multi-disciplinary approaches, Spliceosomal Pre-mRNA Splicing: Methods and Protocols describes the theory of alternative pre-mRNA splicing in seven introductory chapters and then introduces protocols and their theoretical background relevant for a variety of experimental research. These protocol chapters cover basic methods to detect splicing events, analyses of alternative pre-mRNA splicing in vitro and in vivo, manipulation of splicing events, and high-throughput and bioinformatic analyses of alternative splicing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Spliceosomal Pre-mRNA Splicing: Methods and Protocols will aid newcomers and seasoned molecular biologists in understanding the fascinating world of alternative splicing with the ultimate goal of paving the way for many new discoveries to come.

Nuclear pre-mRNA Processing in Plants

A. S. N. Reddy,Maxim V. Golovkin
Nuclear pre mRNA Processing in Plants Book PDF

Author : A. S. N. Reddy,Maxim V. Golovkin
Publisher : Springer Science & Business Media
Page : 323 pages
File Size : 52,5 Mb
Release : 2008-04-16
Category : Science
ISBN : 9783540767763

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Nuclear pre-mRNA Processing in Plants by A. S. N. Reddy,Maxim V. Golovkin Pdf

During the last few years, tremendous progress has been made in understanding various aspects of pre-mRNA processing. This book, with contributions from leading scientists in this area, summarizes recent advances in nuclear pre-mRNA processing in plants. It provides researchers in the field, as well as those in related areas, with an up-to-date and comprehensive, yet concise, overview of the current status and future potential of this research in understanding plant biology.

Tropomyosin

Peter Gunning
Tropomyosin Book PDF

Author : Peter Gunning
Publisher : Springer Science & Business Media
Page : 323 pages
File Size : 47,5 Mb
Release : 2009-09-30
Category : Medical
ISBN : 9780387857664

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Tropomyosin by Peter Gunning Pdf

A recent review of one of my grant applications commented on the ‘rediscovery of tropomyosin’. I was tempted to write back in my rebuttal to the reviewer that I didn’t realise it had been lost. Uncharacteristic maturity prevailed and I resisted the temptation, but I was struck by the underlying observation that research on the str- ture and function of tropomyosin has been somewhat invisible, particularly in terms of the cytoskeleton isoforms. So, how can it be that one of the two major components of the actin filament has been so thoroughly overlooked? I suspect that the answer is disappointingly pedestrian. Whereas the biochemistry of the 1980s revealed the potential of tropomyosin isoforms to diversify the function of actin filaments, the subsequent disenchantment with isoform biology in general in the 1990s inhibited growth of this field. With the development of more sophisticated experimental - proaches we are now seeing a growing realisation of the importance of tropomyosin in regulating actin filaments beyond its pivotal role in muscle contraction. The opportunity to edit this book came at a time when we had written several reviews on different aspects of tropomyosin function and I had just finished the background reading for a comprehensive review of tropomyosin biology. I realised that the field was simply beyond the capacity of any one person to do the field j- tice.

Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension

Toshio Nakanishi,H. Scott Baldwin,Jeffrey R. Fineman,Hiroyuki Yamagishi
Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension Book PDF

Author : Toshio Nakanishi,H. Scott Baldwin,Jeffrey R. Fineman,Hiroyuki Yamagishi
Publisher : Springer Nature
Page : 374 pages
File Size : 50,9 Mb
Release : 2020-02-28
Category : Medical
ISBN : 9789811511851

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Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension by Toshio Nakanishi,H. Scott Baldwin,Jeffrey R. Fineman,Hiroyuki Yamagishi Pdf

This open access book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies. The book also presents recent advances in our understanding of the molecular mechanism of lung development, pulmonary hypertension and molecular regulation of the ductus arteriosus. As such, it is an ideal resource for physicians, scientists and investigators interested in the latest findings on the origins of congenital heart disease and potential future therapies involving pulmonary circulation/hypertension and the ductus arteriosus.

Brain Transcriptome

Anonim
Brain Transcriptome Book PDF

Author : Anonim
Publisher : Academic Press
Page : 365 pages
File Size : 52,8 Mb
Release : 2014-08-27
Category : Science
ISBN : 9780128013199

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Brain Transcriptome by Anonim Pdf

Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume, concentrates on the brain transcriptome. Brings together cutting-edge research on the brain transcriptome

Alzheimer’s and Parkinson’s Diseases

Israel Hanin,Mitsuo Yoshida,Abraham Fisher
Alzheimer s and Parkinson s Diseases Book PDF

Author : Israel Hanin,Mitsuo Yoshida,Abraham Fisher
Publisher : Springer Science & Business Media
Page : 690 pages
File Size : 47,6 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781475791457

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Alzheimer’s and Parkinson’s Diseases by Israel Hanin,Mitsuo Yoshida,Abraham Fisher Pdf

This book represents the third in a series of International Conferences related to Alzheimer's (AD) and Parkinson's (PD) diseases. The first one took place in Eilat, Israel, in 1985; and the second one in Kyoto, Japan, in 1989. This book contains the full text of oral and poster presentations from the Third International Conference on Alzheimer's and Parkinson's Diseases: Recent Developments, held in Chicago, Illinois, U.S.A. on November 1-6, 1993. The Chicago Conference was attended by 270 participants. The Scientific Program was divided into nine oral sessions, a keynote presentation, and a poster session. The conference culminated in a Round Table Discussion involving all of the participants in the conference. The four and one-half day meeting served as an excellent medium for surveying the current status of clinical and preclinical developments in AD and PD. There were 59 oral presentations and 93 posters. This book incorporates a majority of both.

Alternative Splicing and Disease

Philippe Jeanteur
Alternative Splicing and Disease Book PDF

Author : Philippe Jeanteur
Publisher : Springer Science & Business Media
Page : 265 pages
File Size : 51,9 Mb
Release : 2006-10-04
Category : Science
ISBN : 9783540344490

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Alternative Splicing and Disease by Philippe Jeanteur Pdf

Splicing of primary RNA transcript is a quasi-systematic step of gene expression in higher organisms. This is the first book to highlight the medical implications, i.e. diseases, caused by alternative splicing. Alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences. The book also outlines possible targets for therapy.

Alternative Splicing

Peter Scheiffele,Oriane Mauger
Alternative Splicing Book PDF

Author : Peter Scheiffele,Oriane Mauger
Publisher : Springer Nature
Page : 356 pages
File Size : 40,8 Mb
Release : 2022-07-27
Category : Science
ISBN : 9781071625217

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Alternative Splicing by Peter Scheiffele,Oriane Mauger Pdf

This detailed volume collects commonly used and cutting-edge methods to analyze alternative splicing, a key step in gene regulation. After an introduction of the alternative splicing mechanism and its targeting for therapeutic strategies, the book continues with techniques for analyzing alternative splicing profiles in complex biological systems, visualizing and localizing alternative spliced transcripts with cellular and sub-cellular resolution, probing regulators of alternative splicing, as well as assessing the functional consequences of alternative splicing. Written for the highly successful Methods in Molecular Biology series, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step, reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Alternative Splicing: Methods and Protocols serves as an ideal guide for both RNA aficionados that want to implement novel approaches in their labs and novices undertaking alternative splicing projects.

Alternative Splicing in the Postgenomic Era

Benjamin J. Blencowe,Brenton R. Graveley
Alternative Splicing in the Postgenomic Era Book PDF

Author : Benjamin J. Blencowe,Brenton R. Graveley
Publisher : Springer Science & Business Media
Page : 260 pages
File Size : 46,8 Mb
Release : 2008-01-23
Category : Medical
ISBN : 0387773738

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Alternative Splicing in the Postgenomic Era by Benjamin J. Blencowe,Brenton R. Graveley Pdf

Yet again Springer has reached the market before everyone. This is the first book that is solely dedicated to the topic of alternative splicing. The book contains chapters by experts in the field that cover nearly all aspects of this hugely important subject. The purpose of the text is to provide a single, authoritative source of information on alternative splicing that is accessible to researchers in diverse fields. It is suitable for beginners and experts alike.