Animal Models For The Development Of Cancer Immunotherapy

Animal Models For The Development Of Cancer Immunotherapy Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Animal Models For The Development Of Cancer Immunotherapy book. This book definitely worth reading, it is an incredibly well-written.

Animal Models for the Development of Cancer Immunotherapy

Seng-Lai Tan
Animal Models for the Development of Cancer Immunotherapy Book PDF

Author : Seng-Lai Tan
Publisher : John Wiley & Sons
Page : 324 pages
File Size : 42,6 Mb
Release : 2022-08-08
Category : Medical
ISBN : 9781119535317

Get Book

Animal Models for the Development of Cancer Immunotherapy by Seng-Lai Tan Pdf

Animal Models for the Development of Cancer Immunotherapy Provides readers with a clear understanding of the value and challenges of using common and emerging preclinical models in cancer immunotherapy research and development. Animal models are essential tools for studying a range of issues in preclinical and clinical research on therapies targeting cancerous tumors. As clinical trials of advances in cancer immunotherapy are predicted to outpace preclinical research in the near future, there remains an urgent need to develop better animal models for preclinical evaluation of novel modulators. Animal Models for the Development of Cancer Immunotherapy provides a detailed overview of different preclinical model systems for development of novel cancer immunotherapies while highlighting how key aspects of individual models translate into clinical findings. Covering the introduction, development, and therapeutic applications of animal models for cancer immunotherapy, this comprehensive volume helps pharmacologists identify suitable animal models, design pharmacological or translational studies, and advance their mechanistic understanding of therapeutic agents, and increase the possibility of success for novel immunotherapies in clinical settings. Chapters written by prominent leaders in the field address specific models that evaluate immuno-oncology drugs are supported by in-depth case studies and extensive references throughout. Emphasizes the importance of modeling tumor metastasis in preclinical models for efficient translation of findings into the clinic Explores recently discovered mechanisms of resistance and their preclinical modeling Highlights the unique characteristics and features of autologous and allogeneic approaches for humanization of mouse models Reviews development of bone marrow-liver-thymus (BLT) immune humanized mice and emerging alternative models such as genetically engineered mouse models (GEMM) Discusses alternative animal models for cancer research such as severe combined immunodeficiency (SCID) pigs Animal Models for the Development of Cancer Immunotherapy is an essential resource for scientists and researchers in the pharmaceutical and biotechnology industries, medicinal chemists and biochemists, cell and molecular biologists, pharmacologists, immunologists, and clinicians.

Animal Models in Cancer Drug Discovery

Asfar Azmi,Ramzi M. Mohammad
Animal Models in Cancer Drug Discovery Book PDF

Author : Asfar Azmi,Ramzi M. Mohammad
Publisher : Academic Press
Page : 470 pages
File Size : 50,6 Mb
Release : 2019-04-16
Category : Business & Economics
ISBN : 9780128147054

Get Book

Animal Models in Cancer Drug Discovery by Asfar Azmi,Ramzi M. Mohammad Pdf

Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field. Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid systems, humanized and other models in modern biology paradigms that are enhancing research in the field of drug discover Covers the use of these models in personalized medicine, immunotherapy, toxicology, pre-IND assessments and related drug development arenas Presents protocols, procedures, and a comprehensive glossary to help new readers understand technical terms and specialized nomenclature

Animal Models for Human Cancer

Marianne I. Martic-Kehl,Pius August Schubiger
Animal Models for Human Cancer Book PDF

Author : Marianne I. Martic-Kehl,Pius August Schubiger
Publisher : John Wiley & Sons
Page : 272 pages
File Size : 54,5 Mb
Release : 2016-05-18
Category : Medical
ISBN : 9783527695911

Get Book

Animal Models for Human Cancer by Marianne I. Martic-Kehl,Pius August Schubiger Pdf

Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results. Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the book describes correct study design as well as the handling and housing of animals. It then goes on to describe the animal models available for different cancer types, from natural cancer models in mice and dogs to humanized animals. An evaluation of previously unpublished long-term data from the Swiss canine and feline cancer registry is also included. The final part of the book reviews the lessons learned over the last decade on how to interpret data from animal studies for improving human therapy and gives recommendations for future drug development.

Handbook of Animal Models and its Uses in Cancer Research

Surajit Pathak,Antara Banerjee,Atil Bisgin
Handbook of Animal Models and its Uses in Cancer Research Book PDF

Author : Surajit Pathak,Antara Banerjee,Atil Bisgin
Publisher : Springer Nature
Page : 1158 pages
File Size : 41,7 Mb
Release : 2023-01-31
Category : Medical
ISBN : 9789811938245

Get Book

Handbook of Animal Models and its Uses in Cancer Research by Surajit Pathak,Antara Banerjee,Atil Bisgin Pdf

This reference book compiles together different animal models in cancer research. It provides knowledge and a better understanding of the advancement of the molecular and cellular mechanisms associated with the progression, formation, and clinical results of various types of cancer from the evidence collected from animal models utilized for cancer research. It discusses animal models for screening anti-cancer drugs and exploration of gene therapy. It presents different methods used to construct cancer animal models and the progress of each animal model in tumor research. The book also highlights the applications of genetic engineering, including CRISP/Cas9, in designing and developing animal models for cancer research. Further, it discusses strategies for modeling animals for investigating growth, metastasis, tumor-associated inflammation and microenvironment, cancer stem cells, tumor heterogeneity, and therapeutic resistance. This book is s a valuable resource for basic and translational cancer researchers, clinicians, and health care.

Immunodeficient Animals

Wolfgang Arnold,Petra Köpf-Maier,Burkhard Micheel
Immunodeficient Animals Book PDF

Author : Wolfgang Arnold,Petra Köpf-Maier,Burkhard Micheel
Publisher : S. Karger AG (Switzerland)
Page : 252 pages
File Size : 47,8 Mb
Release : 1996
Category : Medical
ISBN : UOM:39015037798371

Get Book

Immunodeficient Animals by Wolfgang Arnold,Petra Köpf-Maier,Burkhard Micheel Pdf

The classic immunodeficient mutants nude, scid and rnu have an important function in experimental cancer research: they allow unique methods of investigation and provide data of clinical relevance. This volume presents the state of the art of research work based on the use of these immunodeficient animal models. One section is dedicated to the biological aspects and immunological properties of immunodeficient mutants. Another part includes articles on xenogenous transplantation of human tumors, focusing on the establishment of transplantable lines, growth characteristics and tumor markers. Special attention is given to new approaches in the fields of chemotherapy, radiation therapy and immunotherapy. Various contributors consider in vitro methods as alternative models. In addition to current data, this publication contains useful technical and methodological information and is therefore valuable not only for specialists but also for scientists entering the field of experimental cancer research.

Animal Models for the Study of Human Disease

JoEllen Welsh
Animal Models for the Study of Human Disease Book PDF

Author : JoEllen Welsh
Publisher : Elsevier Inc. Chapters
Page : 1108 pages
File Size : 55,8 Mb
Release : 2013-05-29
Category : Medical
ISBN : 9780128072301

Get Book

Animal Models for the Study of Human Disease by JoEllen Welsh Pdf

Breast cancer is one of the most frequently diagnosed malignancies, and despite extensive molecular and cellular research, the mortality rate remains high. Preclinical testing of new strategies to prevent the emergence of invasive disease and to effectively treat existing disease is dependent on appropriate in vivo models. The challenges with modeling breast cancer in animals include species differences in mammary gland development and sensitivity to carcinogens as well as the molecular heterogeneity of human breast cancer. This chapter focuses on the plethora of animal models that have been developed in rodents, including chemically induced protocols, transplantable and graft models, and transgenic and knockout approaches. Although no single model is suitable for all research purposes, genomic profiling has enabled the identification of rodent tumors that display molecular similarity to specific subtypes of human breast cancer. Practical aspects and key issues involved in choosing an animal model are discussed, along with the advantages and limitations of the most commonly utilized rodent models of breast cancer.

Animal Models for the Development of Cancer Immunotherapy

Seng-Lai Tan
Animal Models for the Development of Cancer Immunotherapy Book PDF

Author : Seng-Lai Tan
Publisher : John Wiley & Sons
Page : 324 pages
File Size : 48,7 Mb
Release : 2022-08-23
Category : Medical
ISBN : 9781119535287

Get Book

Animal Models for the Development of Cancer Immunotherapy by Seng-Lai Tan Pdf

Animal Models for the Development of Cancer Immunotherapy Provides readers with a clear understanding of the value and challenges of using common and emerging preclinical models in cancer immunotherapy research and development. Animal models are essential tools for studying a range of issues in preclinical and clinical research on therapies targeting cancerous tumors. As clinical trials of advances in cancer immunotherapy are predicted to outpace preclinical research in the near future, there remains an urgent need to develop better animal models for preclinical evaluation of novel modulators. Animal Models for the Development of Cancer Immunotherapy provides a detailed overview of different preclinical model systems for development of novel cancer immunotherapies while highlighting how key aspects of individual models translate into clinical findings. Covering the introduction, development, and therapeutic applications of animal models for cancer immunotherapy, this comprehensive volume helps pharmacologists identify suitable animal models, design pharmacological or translational studies, and advance their mechanistic understanding of therapeutic agents, and increase the possibility of success for novel immunotherapies in clinical settings. Chapters written by prominent leaders in the field address specific models that evaluate immuno-oncology drugs are supported by in-depth case studies and extensive references throughout. Emphasizes the importance of modeling tumor metastasis in preclinical models for efficient translation of findings into the clinic Explores recently discovered mechanisms of resistance and their preclinical modeling Highlights the unique characteristics and features of autologous and allogeneic approaches for humanization of mouse models Reviews development of bone marrow-liver-thymus (BLT) immune humanized mice and emerging alternative models such as genetically engineered mouse models (GEMM) Discusses alternative animal models for cancer research such as severe combined immunodeficiency (SCID) pigs Animal Models for the Development of Cancer Immunotherapy is an essential resource for scientists and researchers in the pharmaceutical and biotechnology industries, medicinal chemists and biochemists, cell and molecular biologists, pharmacologists, immunologists, and clinicians.

Alternatives to Animal Testing

Hajime Kojima,Troy Seidle,Horst Spielmann
Alternatives to Animal Testing Book PDF

Author : Hajime Kojima,Troy Seidle,Horst Spielmann
Publisher : Springer
Page : 130 pages
File Size : 51,6 Mb
Release : 2018-12-27
Category : Medical
ISBN : 9789811324475

Get Book

Alternatives to Animal Testing by Hajime Kojima,Troy Seidle,Horst Spielmann Pdf

This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0.

Animal Models of Brain Tumors

Ricardo Martínez Murillo,Alfredo Martínez
Animal Models of Brain Tumors Book PDF

Author : Ricardo Martínez Murillo,Alfredo Martínez
Publisher : Humana Press
Page : 0 pages
File Size : 40,7 Mb
Release : 2012-11-05
Category : Medical
ISBN : 1627032088

Get Book

Animal Models of Brain Tumors by Ricardo Martínez Murillo,Alfredo Martínez Pdf

Although the available models, whether at the cellular, tissue, or animal level, do not exactly represent the biology of human brain tumors, animal models can offer significant insights into these tumors, providing a better understanding of biological mechanisms underlying tumor generation, growth, angiogenesis, invasion, and metastasis. Animal Models of Brain Tumors brings together developments and discoveries in “in vivo” experimental tumor research that have provided advances in our understanding of the cellular and molecular mechanisms involved in the generation, progression, and clinical outcome of brain neoplasms. Broken into convenient sections, this thorough volume includes topics such as animal model insights into human brain neoplasms, the cellular, molecular, and genetic basis of brain tumors, therapies in the treatment of malignant glioma, as well as imaging technologies in animal tumor models, i.e. measuring brain tumor growth and metabolism. Written for the popular Neuromethods series, chapters include the kind of detailed description and implementation advice that is essential for achieving successful results. Authoritative and cutting-edge, Animal Models of Brain Tumors provides the key methods needed to validate, compare, and contrast the animal model with its proposed human counterpart and further the understanding of our own serious ailments.

Transgenic Mouse Methods and Protocols

Marten H. Hofker,Jan van Deursen
Transgenic Mouse Methods and Protocols Book PDF

Author : Marten H. Hofker,Jan van Deursen
Publisher : Springer Science & Business Media
Page : 382 pages
File Size : 43,9 Mb
Release : 2008-02-04
Category : Science
ISBN : 9781592593408

Get Book

Transgenic Mouse Methods and Protocols by Marten H. Hofker,Jan van Deursen Pdf

Marten Hofker and Jan van Deursen have assembled a multidisciplinary collection of readily reproducible methods for working with mice, and particularlyfor generating mouse models that will enable us to better understand gene function. Described in step-by-step detail by highly experienced investigators, these proven techniques include new methods for conditional, induced knockout, and transgenic mice, as well as for working with mice in such important research areas as immunology, cancer, and atherosclerosis. Such alternative strategies as random mutagenesis and viral gene transduction for studying gene function in the mouse are also presented.

Patient Derived Tumor Xenograft Models

Rajesh Uthamanthil,Peggy Tinkey,Elisa de Stanchina
Patient Derived Tumor Xenograft Models Book PDF

Author : Rajesh Uthamanthil,Peggy Tinkey,Elisa de Stanchina
Publisher : Academic Press
Page : 486 pages
File Size : 46,5 Mb
Release : 2016-10-13
Category : Medical
ISBN : 9780128040614

Get Book

Patient Derived Tumor Xenograft Models by Rajesh Uthamanthil,Peggy Tinkey,Elisa de Stanchina Pdf

Patient Derived Tumor Xenograft Models: Promise, Potential and Practice offers guidance on how to conduct PDX modeling and trials, including how to know when these models are appropriate for use, and how the data should be interpreted through the selection of immunodeficient strains. In addition, proper methodologies suitable for growing different type of tumors, acquisition of pathology, genomic and other data about the tumor, potential pitfalls, and confounding background pathologies that occur in these models are also included, as is a discussion of the facilities and infrastructure required to operate a PDX laboratory. Offers guidance on data interpretation and regulatory aspects Provides useful techniques and strategies for working with PDX models Includes practical tools and potential pitfalls for best practices Compiles all knowledge of PDX models research in one resource Presents the results of first ever global survey on standards of PDX development and usage in academia and industry

Cancer and the Environment

Institute of Medicine,Board on Health Sciences Policy,Roundtable on Environment Health Sciences, Research, and Medicine
Cancer and the Environment Book PDF

Author : Institute of Medicine,Board on Health Sciences Policy,Roundtable on Environment Health Sciences, Research, and Medicine
Publisher : National Academies Press
Page : 160 pages
File Size : 48,8 Mb
Release : 2002-08-01
Category : Science
ISBN : 9780309169240

Get Book

Cancer and the Environment by Institute of Medicine,Board on Health Sciences Policy,Roundtable on Environment Health Sciences, Research, and Medicine Pdf

The Roundtable on Environmental Health Sciences, Research, and Medicine wanted to address the link between environmental factors and the development of cancer in light of recent advances in genomics. They asked what research tools are needed, how new scientific information can be applied in a timely manner to reduce the burden of cancer, and how this can be flexible enough to treat the individual.

Tumor Microenvironment

Jacinta Serpa
Tumor Microenvironment Book PDF

Author : Jacinta Serpa
Publisher : Springer Nature
Page : 430 pages
File Size : 54,6 Mb
Release : 2020-03-04
Category : Medical
ISBN : 9783030340254

Get Book

Tumor Microenvironment by Jacinta Serpa Pdf

The way a cell undergoes malignant transformation should meet their capacity of surviving in the microenvironment of the organ where the cancer will develop. Metabolic adaptation is for sure one of the criteria that must be accomplished, driven by metabolic plasticity that allows the adaptation of cancer cells to the availability of energy and biomass sources that will sustain cell survival and proliferation. Each human organ has a particular microenvironment which depends on several cell types and in some cases also on symbiotic microorganisms. These biological partners are constantly sharing organic compounds and signaling molecules that will control mitogenesis, cell death and differentiation, accounting for the organ's function. Nevertheless, cancer cells are capable of taking advantage of this metabolic and signaling microenvironmental dynamics. In this book, we intend to present the different components of the microenvironment driving the metabolic fitness of cancer cells. The metabolic changes required for establishing a tumor in a given microenvironment and how these metabolic changes limit the response to drugs will generally be the major items addressed. It is important to mention not only aspects of the microenvironment that stimulate metabolic changes and that select better adapted tumor cells, but also how this regulation of cell plasticity is made. Thus, the signaling pathways that orchestrate and are orchestrated throughout this panoply of metabolic rearrangements will also be addressed in this book. The subjects will be presented from the conceptual point of view of the cross-cancer mechanisms and also particularizing some models that can be examples and enlightening within the different areas.

Cancer Models

Michael Breitenbach,Jens Hoffmann
Cancer Models Book PDF

Author : Michael Breitenbach,Jens Hoffmann
Publisher : Frontiers Media SA
Page : 176 pages
File Size : 55,8 Mb
Release : 2019-02-05
Category : Electronic
ISBN : 9782889457014

Get Book

Cancer Models by Michael Breitenbach,Jens Hoffmann Pdf

Cancer research, like research on other diseases, highly depends on representative and reliable model systems. In the Research Topic “Cancer Models”, we collected original papers and review articles addressing the topic of tumor modeling from molecular biology, biochemistry, microorganisms, cells and organoids, fishes, animals and xenografts, up to computational cancer models and patient data analysis. This representative eBook describes that there is not a single molecular defined tumor but rather a heterogenic and highly variable complex of different individual diseases. This is what makes research on cancer so difficult, expensive, and explains the broad number of models needed for research. Our authors describe new next-generation sequencing-based methods to analyze complex patterns of chromosomal aberrations in order to understand the molecular biology of tumorigenesis as well as the role of cellular senescence and dormancy in the aetiology of tumor formation and development of therapy resistance of tumors. The current developments on 3D cultures are thoroughly reviewed, as these models help to overcome the current limitations of cell cultures and allow a more accurate mimicry of the native cancer tissue, including cellular heterogeneity and restore specific biochemical and morphological. Reviews about tumor models in zebrafish, different transgenic mouse strains and pigs conclude the book. In the final two chapters of this volume, the authors discuss the theoretical and mathematical models developed in cancer research.

Hepatocellular Carcinoma

Yujin Hoshida
Hepatocellular Carcinoma Book PDF

Author : Yujin Hoshida
Publisher : Springer
Page : 366 pages
File Size : 48,9 Mb
Release : 2019-08-05
Category : Medical
ISBN : 9783030215408

Get Book

Hepatocellular Carcinoma by Yujin Hoshida Pdf

This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.