Articular Cartilage

Author : Kyriacos A. Athanasiou,Eric M. Darling,Jerry C. Hu,Grayson D. DuRaine,A. Hari Reddi
Publisher : CRC Press
Page : 442 pages
File Size : 49,9 Mb
Release : 2013-03-21
Category : Medical
ISBN : 9781439853245

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Articular Cartilage by Kyriacos A. Athanasiou,Eric M. Darling,Jerry C. Hu,Grayson D. DuRaine,A. Hari Reddi Pdf

Well-known for their inability to heal, articular cartilage injuries often degenerate inexorably to disastrous impairment. Multitudes of treatments have been devised for this problem, but no satisfactory long-term solutions have been established. Written by world-class experts, Articular Cartilage covers the latest research and advancements related to biology, development, pathology, clinical applications, and tissue engineering. This book is useful for rheumatologists, orthopaedic surgeons, cartilage biologists, and cartilage engineers as well as for professionals working in the orthopaedic and other musculoskeletal industries. This book also belongs in the library of primary care physicians, gerontologists, physical therapists, kinesiologists, and chiropractors. Written at a level that allows accessibility to a wide audience, it provides an interdisciplinary approach that encompasses the breadth and depth of basic science, bioengineering, translational science, and detailed methodologic approaches. The authors examine the major events and signaling molecules that lead to development of articular cartilage from precursor cells, and the changes in cartilage as it matures and ages. They focus on the epidemiology, etiopathogenesis, and therapeutic approaches for cartilage injury and the major arthritides that affect cartilage and the synovial joints such as osteoarthritis, rheumatoid arthritis, and gout. They supply an up-to-date overview of the field of tissue engineering as applied to articular cartilage repair. They examine a number of methods used to assess structure, composition, biology, and biomechanical function. Each chapter contains extensive references to enhance additional study. The book’s comprehensive focus on multiple aspects of articular cartilage sets it apart from other tissue engineering or developmental biology-based books available. It includes important discussions and perspectives on many of the remaining challenges and opportunities in the development and translation of new approaches for treating diseases of articular cartilage. It also provides detailed working protocols for many of the methods used to study articular cartilage, coverage of current treatment options, and business and regulatory aspects of the development of cartilage products. It provides a deeper understanding that will help with the development of new products and clinical applications.

Author : David W. Smith,Bruce S. Gardiner,Lihai Zhang,Alan J. Grodzinsky
Publisher : Springer
Page : 738 pages
File Size : 41,6 Mb
Release : 2018-11-19
Category : Technology & Engineering
ISBN : 9789811314742

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Articular Cartilage Dynamics by David W. Smith,Bruce S. Gardiner,Lihai Zhang,Alan J. Grodzinsky Pdf

This book explains the anatomy and physiology of cartilage tissue in an integrated way. The emphasis is on how cartilage tissue functions and maintains homeostasis in a challenging mechanical environment. Supported by hundreds of references, the book posts new hypotheses explaining how cartilage adapts and achieves homeostasis in vivo, and tests them against available data. This exploratory approach creates a sense of discovery that the reader can join, or perhaps test themselves through their own research. The main benefit will be obtained by research students and professors looking to understand the deeper concepts that will further their own research, or clinicians (including health professionals and surgeons) who want to gain a deeper physiological understanding of cartilage tissue, which can then serve as a basis for more rational clinical decision-making they need to make on a daily basis. To help bridge the gap between basic science and clinically relevant joint disease, applications and interpretations of key physiological concepts are discussed in the context of osteoarthritis at the end of most chapters.

Author : Kyriacos A. Athanasiou,Eric M. Darling,Jerry C. Hu,Grayson D. DuRaine,A. Hari Reddi
Publisher : CRC Press
Page : 442 pages
File Size : 42,9 Mb
Release : 2017-01-06
Category : Medical
ISBN : 9781351722322

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Articular Cartilage by Kyriacos A. Athanasiou,Eric M. Darling,Jerry C. Hu,Grayson D. DuRaine,A. Hari Reddi Pdf

Well-known for their inability to heal, articular cartilage injuries often degenerate inexorably to disastrous impairment. Multitudes of treatments have been devised for this problem, but no satisfactory long-term solutions have been established. Written by world-class experts, Articular Cartilage covers the latest research and advancements related to biology, development, pathology, clinical applications, and tissue engineering. This book is useful for rheumatologists, orthopaedic surgeons, cartilage biologists, and cartilage engineers as well as for professionals working in the orthopaedic and other musculoskeletal industries. This book also belongs in the library of primary care physicians, gerontologists, physical therapists, kinesiologists, and chiropractors. Written at a level that allows accessibility to a wide audience, it provides an interdisciplinary approach that encompasses the breadth and depth of basic science, bioengineering, translational science, and detailed methodologic approaches. The authors examine the major events and signaling molecules that lead to development of articular cartilage from precursor cells, and the changes in cartilage as it matures and ages. They focus on the epidemiology, etiopathogenesis, and therapeutic approaches for cartilage injury and the major arthritides that affect cartilage and the synovial joints such as osteoarthritis, rheumatoid arthritis, and gout. They supply an up-to-date overview of the field of tissue engineering as applied to articular cartilage repair. They examine a number of methods used to assess structure, composition, biology, and biomechanical function. Each chapter contains extensive references to enhance additional study. The book’s comprehensive focus on multiple aspects of articular cartilage sets it apart from other tissue engineering or developmental biology-based books available. It includes important discussions and perspectives on many of the remaining challenges and opportunities in the development and translation of new approaches for treating diseases of articular cartilage. It also provides detailed working protocols for many of the methods used to study articular cartilage, coverage of current treatment options, and business and regulatory aspects of the development of cartilage products. It provides a deeper understanding that will help with the development of new products and clinical applications.

Author : E. Carlos Rodrìguez-Merchán
Publisher : Springer Science & Business Media
Page : 117 pages
File Size : 54,7 Mb
Release : 2012-10-19
Category : Medical
ISBN : 9788847027275

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Articular Cartilage Defects of the Knee by E. Carlos Rodrìguez-Merchán Pdf

This book reviews current knowledge on the diagnosis and treatment (surgical and non-surgical) of cartilage defects at the knee joint. In the discussion of diagnosis, the focus is primarily on imaging findings, particularly those obtained with MRI. The remainder of the book is devoted to the full range of current conservative and surgical treatments, with attention to both treatment indications and results as reported in the recent literature. In reviewing non-surgical treatment, oral and intra-articular medical management is evaluated and rehabilitation and physical therapy are also considered. The three main types of surgical technique – microfracture surgery and similar procedures, mosaicplasty and related techniques, and autologous chondrocyte transplantation – are then extensively discussed in a series of highly informative chapters. This book will be of great practical value for clinicians, assisting in daily decision making.

Author : Kyriacos A. Athanasiou,Eric M. Darling,Jerry C. Hu
Publisher : Morgan & Claypool Publishers
Page : 183 pages
File Size : 51,9 Mb
Release : 2010
Category : Medical
ISBN : 9781598298758

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Articular Cartilage Tissue Engineering by Kyriacos A. Athanasiou,Eric M. Darling,Jerry C. Hu Pdf

Cartilage injuries in children and adolescents are increasingly observed, with roughly 20% of knee injuries in adolescents requiring surgery. In the US alone, costs of osteoarthritis (OA) are in excess of $65 billion per year (both medical costs and lost wages). Comorbidities are common with OA and are also costly to manage. Articular cartilage's low friction and high capacity to bear load makes it critical in the movement of one bone against another, and its lack of a sustained natural healing response has necessitated a plethora of therapies. Tissue engineering is an emerging technology at the threshold of translation to clinical use. Replacement cartilage can be constructed in the laboratory to recapitulate the functional requirements of native tissues. This book outlines the biomechanical and biochemical characteristics of articular cartilage in both normal and pathological states, through development and aging. It also provides a historical perspective of past and current cartilage treatments and previous tissue engineering efforts. Methods and standards for evaluating the function of engineered tissues are discussed, and current cartilage products are presented with an analysis on the United States Food and Drug Administration regulatory pathways that products must follow to market. This book was written to serve as a reference for researchers seeking to learn about articular cartilage, for undergraduate and graduate level courses, and as a compendium of articular cartilage tissue engineering design criteria. Table of Contents: Hyaline Articular Cartilage / Cartilage Aging and Pathology / In Vitro / Bioreactors / Future Directions

Author : Harpal K. Gahunia,Allan E. Gross,Kenneth P.H. Pritzker,Paul S. Babyn,Lucas Murnaghan
Publisher : Springer
Page : 0 pages
File Size : 52,6 Mb
Release : 2020-05-10
Category : Medical
ISBN : 1493975854

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Articular Cartilage of the Knee by Harpal K. Gahunia,Allan E. Gross,Kenneth P.H. Pritzker,Paul S. Babyn,Lucas Murnaghan Pdf

Covering both pediatric and adult populations, this comprehensive text covers the diverse topics related to the health, disease and therapy of articular cartilage of the knee, from basic principles to future directions for research. This vast array of information is arranged into eight sections, encompassing a number of relevant disciplines and covering, in turn, normal articular cartilage, aging and degeneration, evaluation and assessment, non-surgical approaches, surgical approaches, qualitative and quantitative assessment of repair, research into cartilage repair and engineering, and future prospects for therapy. Each chapter is amply referenced and self-contained for independent study and reference. Scoring systems for knee cartilage assessment are included in four appendices as well, rounding out the presentation. A multidisciplinary collection of basic, translational and clinical material, Articular Cartilage of the Knee is a singular resource for orthopedic surgeons, rheumatologists, pathologists and the broad spectrum of professionals working with articular cartilage.

Author : Aaron J. Krych,Leela C. Biant,Andreas H. Gomoll,João Espregueira-Mendes,Alberto Gobbi,Norimasa Nakamura
Publisher : Springer Nature
Page : 345 pages
File Size : 48,7 Mb
Release : 2021-08-31
Category : Medical
ISBN : 9783030780517

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Cartilage Injury of the Knee by Aaron J. Krych,Leela C. Biant,Andreas H. Gomoll,João Espregueira-Mendes,Alberto Gobbi,Norimasa Nakamura Pdf

Cartilage injuries of the knee are common, and diagnosis and treatment options have continued to evolve. This book focuses on current non-operative and surgical treatment strategies for articular cartilage injuries, highlighting the controversies and different approaches from an international perspective. This book includes information on the basic science of cartilage structure and function, expert perspectives on imaging and diagnosing, as well as work-up of athletes and patients presenting with acute or chronic cartilage injury. It also provides an evidence base for current cutting-edge cartilage repair and restoration. Written by leading experts in the field, the book, published in collaboration with ISAKOS and ICRS, is vital reading for orthopaedic and sports medicine surgeons, fellows and residents. It is also of interest to sports trainers, physiotherapists, medical students, postgraduate students, and physical medicine and rehabilitation specialists.

Author : James P. Stannard,James L. Cook,Jack Farr
Publisher : Thieme
Page : 364 pages
File Size : 51,9 Mb
Release : 2013-04-15
Category : Medical
ISBN : 9781604068597

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Articular Cartilage Injury of the Knee: Basic Science to Surgical Repair by James P. Stannard,James L. Cook,Jack Farr Pdf

Articular Cartilage Injury of the Knee is a comprehensive reference that combines the basic scientific knowledge of articular cartilage as it relates to patient health and disease with patient-focused diagnosis and treatment options. This book emphasizes the importance of bridging the divide between basic science and clinical applications in order to select the best possible treatment when injuries occur. Key Features: Provides clinically-relevant information on each topic that can easily be applied in practice Showcases the latest techniques in transplantation and scaffolds for cartilage repair Includes a focused chapter on assessment outcomes after cartilage repair of the knee Written and edited by leading orthopedic surgeons and basic science experts who represent the most current philosophy of effective management of articular cartilage injury of the knee Orthopedic surgeons specializing in the lower extremity will find this book to be an excellent resource that they can consult to guide them in the treatment of patients with articular cartilage injury of the knee.

Author : J. F. Stoltz
Publisher : IOS Press
Page : 460 pages
File Size : 53,7 Mb
Release : 2006
Category : Medical
ISBN : 1586036483

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Mechanobiology by J. F. Stoltz Pdf

Over recent years, there has been increasing interest in the fundamental role played by local mechanical parameters in chondrocyte regulation and cartilage dysfunction as a first step in the development of osteoarthritis. This is how the idea of mechanobiology and the concept of mechanotransduction were born in the 90's. Indeed, a broad diversity of physiological phenomena is induced by mechanical stimuli (hearing, orientation to gravity, touch, tissue remodeling...) but the mechanism by which mechanical forces may regulate a physiological response is still unknown. In other respects, the concept of regenerative medicine has recently developed in parallel to this. Regenerative medicine is an emerging multidisciplinary field involving medicine, biology, chemistry, mechanics and engineering that is likely to revolutionize the ways we improve the health and quality of life by restoring, maintaining or enhancing tissue and organ functions. Indeed, human tissues do not regenerate spontaneously and healing is only a stopgap that may be associated with contraction which in turn may prevent regeneration. interesting alternative. Today, the in vitro preparation of biological tissues such as cartilage, bone, tendon, vessel, heart muscle, skin, brings out major expectations for the next decade. However, to each type of tissue correspond a large number of potential methods related to the support, the cells used (tissular cells or stem cells) and to the conditions of the environment (culture medium and mechanical forces). The aim of this publication is to provide a thoughtful and balanced view on new crucial concepts with clinical implications.

Author : Klaus E. Kuettner
Publisher : Lippincott Williams & Wilkins
Page : 808 pages
File Size : 51,5 Mb
Release : 1992
Category : Health & Fitness
ISBN : UOM:39015025161202

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Articular Cartilage and Osteoarthritis by Klaus E. Kuettner Pdf

Author : Michael Alexander Reykers Freeman
Publisher : Unknown
Page : 364 pages
File Size : 53,9 Mb
Release : 1974
Category : Medical
ISBN : UOM:39015000806797

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Adult Articular Cartilage by Michael Alexander Reykers Freeman Pdf

Author : Joseph Leidy
Publisher : Unknown
Page : 36 pages
File Size : 45,9 Mb
Release : 1849
Category : Cartilage
ISBN : BSB:BSB10368783

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On the Intimate Structure and History of the Articular Cartilages by Joseph Leidy Pdf

Author : Carlos Rodriguez-Merchan
Publisher : Springer Science & Business Media
Page : 117 pages
File Size : 51,7 Mb
Release : 2012-10-20
Category : Medical
ISBN : 9788847027268

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Articular Cartilage Defects of the Knee by Carlos Rodriguez-Merchan Pdf

This book reviews current knowledge on the diagnosis and treatment (surgical and non-surgical) of cartilage defects at the knee joint. In the discussion of diagnosis, the focus is primarily on imaging findings, particularly those obtained with MRI. The remainder of the book is devoted to the full range of current conservative and surgical treatments, with attention to both treatment indications and results as reported in the recent literature. In reviewing non-surgical treatment, oral and intra-articular medical management is evaluated and rehabilitation and physical therapy are also considered. The three main types of surgical technique – microfracture surgery and similar procedures, mosaicplasty and related techniques, and autologous chondrocyte transplantation – are then extensively discussed in a series of highly informative chapters. This book will be of great practical value for clinicians, assisting in daily decision making.

Author : Brian J. Cole,M. Mike Malek
Publisher : Springer Science & Business Media
Page : 346 pages
File Size : 55,5 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9780387215532

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Articular Cartilage Lesions by Brian J. Cole,M. Mike Malek Pdf

Drs. Cole and Malek, recognized leaders in the field, wrote this cutting-edge text to fill the void in the literature regarding the management of articular cartilage disease and meniscal deficiency. The book enables orthopedic surgeons to develop an evidence-based decision-making framework that guides the management of articular cartilage lesions. Carefully chosen contributors provide readers with a practical background in articular lesions, patient assessment, and management strategies. Subsequent chapters address the gamut of current surgical techniques, from arthroscopy and debridement to unicondylar arthroplasty, in a step-by-step manner. More than 500 detailed illustrations, many in color, help readers understand and master treatments. Case studies, which include preoperative planning and postoperative outcomes, reinforce the decision-making process. Nearly every permutation and treatment option is covered, making this text a prime resource for surgeons committed to exercising sound judgement.

Author : Christian Hendrich,Ulrich Nöth,Jochen Eulert
Publisher : Springer Science & Business Media
Page : 230 pages
File Size : 44,5 Mb
Release : 2003-04-28
Category : Medical
ISBN : 3540010548

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Cartilage Surgery and Future Perspectives by Christian Hendrich,Ulrich Nöth,Jochen Eulert Pdf

Tissue engineering as a technology and as a therapeutic has captured worldwide attention and commitmentbecause it has such potential in the care of humanity. Because we are not as yet able to craft robust three dimensional vascular and ductal structures to support the development of complex parenchymal organs, the initial focus of the field has been on thin tissues that can be nourished by diffusion alone.The best example of this class is cartilage. Thought by some to be a relatively simple tissue in the early days of tissue engineering, deep study of this tissue has shown it to manifest great complexity.Yearsof experimental and clinical effort have begun to untangle the clues that will allow us to reproducibly characterize, gener ate and clinically apply engineered cartilage with positive effects.World wide researchers and clinicians are intently focused on this goal and it has come time to step back and make a good assessment of our progress.