Articular Cartilage And Osteoarthritis

Author : Kyriacos A. Athanasiou,Eric M. Darling,Jerry C. Hu,Grayson D. DuRaine,A. Hari Reddi
Publisher : CRC Press
Page : 442 pages
File Size : 44,7 Mb
Release : 2017-01-06
Category : Medical
ISBN : 9781351722322

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Articular Cartilage by Kyriacos A. Athanasiou,Eric M. Darling,Jerry C. Hu,Grayson D. DuRaine,A. Hari Reddi Pdf

Well-known for their inability to heal, articular cartilage injuries often degenerate inexorably to disastrous impairment. Multitudes of treatments have been devised for this problem, but no satisfactory long-term solutions have been established. Written by world-class experts, Articular Cartilage covers the latest research and advancements related to biology, development, pathology, clinical applications, and tissue engineering. This book is useful for rheumatologists, orthopaedic surgeons, cartilage biologists, and cartilage engineers as well as for professionals working in the orthopaedic and other musculoskeletal industries. This book also belongs in the library of primary care physicians, gerontologists, physical therapists, kinesiologists, and chiropractors. Written at a level that allows accessibility to a wide audience, it provides an interdisciplinary approach that encompasses the breadth and depth of basic science, bioengineering, translational science, and detailed methodologic approaches. The authors examine the major events and signaling molecules that lead to development of articular cartilage from precursor cells, and the changes in cartilage as it matures and ages. They focus on the epidemiology, etiopathogenesis, and therapeutic approaches for cartilage injury and the major arthritides that affect cartilage and the synovial joints such as osteoarthritis, rheumatoid arthritis, and gout. They supply an up-to-date overview of the field of tissue engineering as applied to articular cartilage repair. They examine a number of methods used to assess structure, composition, biology, and biomechanical function. Each chapter contains extensive references to enhance additional study. The book’s comprehensive focus on multiple aspects of articular cartilage sets it apart from other tissue engineering or developmental biology-based books available. It includes important discussions and perspectives on many of the remaining challenges and opportunities in the development and translation of new approaches for treating diseases of articular cartilage. It also provides detailed working protocols for many of the methods used to study articular cartilage, coverage of current treatment options, and business and regulatory aspects of the development of cartilage products. It provides a deeper understanding that will help with the development of new products and clinical applications.

Author : Klaus E. Kuettner
Publisher : Lippincott Williams & Wilkins
Page : 808 pages
File Size : 47,7 Mb
Release : 1992
Category : Health & Fitness
ISBN : UOM:39015025161202

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Articular Cartilage and Osteoarthritis by Klaus E. Kuettner Pdf

Author : Felix Bronner,Mary C. Farach-Carson
Publisher : Springer Science & Business Media
Page : 220 pages
File Size : 48,5 Mb
Release : 2007-09-26
Category : Medical
ISBN : 9781846287015

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Bone and Osteoarthritis by Felix Bronner,Mary C. Farach-Carson Pdf

The molecular and cellular approaches to the relationship of joint and bone problems distinguish this from other books on the topic. Advances in bone and joint biology enable practitioners to approach clinical problems more comprehensively. Emphasis on genetics and on newer viewpoints and approaches, exemplified by the possible effect of subchondral bone on osteoarthritis, gives a wider viewpoint to the reader and may enable novel approaches to solving a clinical problem.

Author : J.-Y. Reginster,J.-P. Pelletier,J. Martel-Pelletier,Y. Henrotin
Publisher : Springer Science & Business Media
Page : 790 pages
File Size : 54,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642600265

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Osteoarthritis by J.-Y. Reginster,J.-P. Pelletier,J. Martel-Pelletier,Y. Henrotin Pdf

Musculoskeletal diseases are rapidly becoming a major health concern. The incidence of osteoarthritis, the most common arthritic disorder, is increasing steadily due to the graying of the world population. This disease is responsible of human life, a time in for significant morbidity, particularly in the second half which the quality of life is of primary importance. The aim of this publication is to bring to physicians and scientists a comprehensive overview of the field, from molecules to men. The direct costs related to osteoarthritis have been increasing steadily over the years and will soon be comparable to those of other major illnesses, such as cardiovascular diseases. This, of course, does not take into account all of the other costs related to the disease which often cannot be simply calculated in dollars and cents. There has been a great deal of renewed interest in osteoarthritis in the last few decades. This has been brought on by the need to improve our knowledge of all aspects of the disease, especially with regard to its etiopathogenesis and treatment. The most recent findings and developments on the structural, bio chemical, biomechanical and molecular changes observed in clinical and ex perimental osteoarthritis are presented in this book.

Author : Kyriacos Athanasiou,Eric M. Darling,Jerry C. Hu
Publisher : Springer Nature
Page : 174 pages
File Size : 48,8 Mb
Release : 2022-06-01
Category : Science
ISBN : 9783031025785

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Articular Cartilage Tissue Engineering by Kyriacos Athanasiou,Eric M. Darling,Jerry C. Hu Pdf

Cartilage injuries in children and adolescents are increasingly observed, with roughly 20% of knee injuries in adolescents requiring surgery. In the US alone, costs of osteoarthritis (OA) are in excess of $65 billion per year (both medical costs and lost wages). Comorbidities are common with OA and are also costly to manage. Articular cartilage's low friction and high capacity to bear load makes it critical in the movement of one bone against another, and its lack of a sustained natural healing response has necessitated a plethora of therapies. Tissue engineering is an emerging technology at the threshold of translation to clinical use. Replacement cartilage can be constructed in the laboratory to recapitulate the functional requirements of native tissues. This book outlines the biomechanical and biochemical characteristics of articular cartilage in both normal and pathological states, through development and aging. It also provides a historical perspective of past and current cartilage treatments and previous tissue engineering efforts. Methods and standards for evaluating the function of engineered tissues are discussed, and current cartilage products are presented with an analysis on the United States Food and Drug Administration regulatory pathways that products must follow to market. This book was written to serve as a reference for researchers seeking to learn about articular cartilage, for undergraduate and graduate level courses, and as a compendium of articular cartilage tissue engineering design criteria. Table of Contents: Hyaline Articular Cartilage / Cartilage Aging and Pathology / In Vitro / Bioreactors / Future Directions

Author : Bruce M. Rothschild
Publisher : BoD – Books on Demand
Page : 606 pages
File Size : 53,8 Mb
Release : 2012-02-22
Category : Medical
ISBN : 9789535100638

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Principles of Osteoarthritis by Bruce M. Rothschild Pdf

This volume addresses the nature of the most common form of arthritis in humans. If osteoarthritis is inevitable (only premature death prevents all of us from being afflicted), it seems essential to facilitate its recognition, prevention, options, and indications for treatment. Progress in understanding this disease has occurred with recognition that it is not simply a degenerative joint disease. Causative factors, such as joint malalignment, ligamentous abnormalities, overuse, and biomechanical and metabolic factors have been recognized as amenable to intervention; genetic factors, less so; with metabolic diseases, intermediate. Its diagnosis is based on recognition of overgrowth of bone at joint margins. This contrasts with overgrowth of bone at vertebral margins, which is not a symptomatic phenomenon and has been renamed spondylosis deformans. Osteoarthritis describes an abnormality of joints, but the severity does not necessarily produce pain. The patient and his/her symptoms need to be treated, not the x-ray.

Author : Joseph A. Buckwalter,Martin K. Lotz,J. F. Stoltz
Publisher : IOS Press
Page : 316 pages
File Size : 47,5 Mb
Release : 2007
Category : Health & Fitness
ISBN : 9781586037734

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Osteoarthritis, Inflammation and Degradation by Joseph A. Buckwalter,Martin K. Lotz,J. F. Stoltz Pdf

Osteoarthritis is a public health issue due to its impact in term of handicap. Regarded as a multi-factorial disease, mechanistic and inflammatory theories are no more opposed but, on the contrary, are framed within the same continuum: osteoarthritis, inflammation and degeneration. This book helps readers understand the secrets of this disease.

Author : Massimo Sabatini,Philippe Pastoureau,FrTdTric De Ceuninck
Publisher : Springer Science & Business Media
Page : 362 pages
File Size : 48,8 Mb
Release : 2008-02-01
Category : Medical
ISBN : 9781592598106

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Cartilage and Osteoarthritis by Massimo Sabatini,Philippe Pastoureau,FrTdTric De Ceuninck Pdf

Osteoarthritis (OA), the most common form of arthritis, is generally characterized by a slowly progressive degeneration of articular cartilage, particularly in the weight-bearing joints. It has a stronger prevalence in women, and its incidence increases with age. OA is a major and growing health concern in developed countries, owing to steadily increasing life expectancy and the demand for better quality of life. Because of its chronic nature and nonfatal outcome, OA affects the growing population of the elderly over an increasing time span. Moreover, despite its relatively benign character, OA is one of the most disabling diseases; it is responsible for increasing financial and social burdens in terms of medical treatments, forced inactivity, loss of mobility, and dependence. Despite a growing awareness of OA as a medical problem that has yet to reach its maximum impact on society, there is a surprising absence of effective medical treatments beyond pain control and surgery. So far, only symptom-modifying drugs are available, while there remains a major demand for disease-modifying treatments of proven clinical efficacy. This demand will hopefully be met in the future by some of the drugs that have been pressed into development and are now at different stages of clinical investigation. Nevertheless, the current lack of effective treatments reflects a still insufficient knowledge of cartilage with respect to its metabolism, interactions with other joint tissues, and causes and mechanisms (possibly of very different nature) leading to failure of its turnover.

Author : J. F. Stoltz
Publisher : IOS Press
Page : 372 pages
File Size : 51,8 Mb
Release : 2008
Category : Articular cartilage
ISBN : 158603927X

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Mechanobiology by J. F. Stoltz Pdf

This book covers the proceedings of the Fifth Symposium on Mechanobiology of Cartilage and Chondrocyte. Mechanobiology can be now considered as a vigorous branch of biomechanics, biorheology and physiology mainly concerned with the study of the influence of mechanical forces on cells and tissues and their clinical or therapeutical applications. As we are now in the age of proteomics, genomics and cell micro mechanical approaches, suing methods like laser tweezers or confocal microscopy, mechanobiology brings new challenges. With such new research, mechanobiology promises new diagnostic and therapeutic approaches. In other respect there has been increasing interest over recent years in the fundamental role played by local mechanical parameters in chondrocyte regulations and cartilage dysfunctions as a first step in the development of osteoarthritis. These proceedings are sub-divided into four parts: Theoretical approaches and mechanobiology of chondrocyte; Cartilage and chondrocyte studies; Osteoarthritis: inflammation degradation and clinical approaches; and, Cartilage engineering

Author : Roland W. Moskowitz
Publisher : Lippincott Williams & Wilkins
Page : 492 pages
File Size : 50,7 Mb
Release : 2007
Category : Medical
ISBN : 0781767075

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Osteoarthritis by Roland W. Moskowitz Pdf

Written by the foremost experts, this text is a comprehensive clinical reference on osteoarthritis. Chapters review current information on the epidemiology, etiopathogenesis, and pathology of osteoarthritis, the biochemistry and molecular and cell biology of articular cartilage, and experimental models of osteoarthritis. Major sections focus on clinical presentations, roentgenologic and laboratory diagnosis, and treatment, including pharmacologic treatment, intra-articular therapy, surgery, arthroscopy, and complementary and alternative medicine. The authors discuss the indications, outcomes, and complications of various orthopaedic procedures. Chapters present orthopaedic approaches to osteoarthritis of various joints—the shoulder, hand, wrist, elbow, hip, knee, foot, ankle, and cervical, thoracic, and lumbar spine.

Author : Nigel Arden,Francisco Blanco,C. Cooper,Ali Guermazi,Daichi Hayashi,David Hunter,M. Kassim Javaid,Francois Rannou,Frank Roemer,Jean-Yves Reginster
Publisher : Springer
Page : 99 pages
File Size : 49,6 Mb
Release : 2015-01-19
Category : Medical
ISBN : 9781910315163

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Atlas of Osteoarthritis by Nigel Arden,Francisco Blanco,C. Cooper,Ali Guermazi,Daichi Hayashi,David Hunter,M. Kassim Javaid,Francois Rannou,Frank Roemer,Jean-Yves Reginster Pdf

This Atlas provides an up-to-date and comprehensive overview of the historical and current perspectives on osteoarthritis, including the pathophysiology and epidemiology of the disease. Written by leading authors in the field of osteoarthritis, the book discusses classification, etiology and risk factors for osteoarthritis, the disease course and determinants of osteoarthritis progression, clinical features and diagnosis as well as imaging methods to assess joint damage. The Atlas of Osteoarthritis concludes with the latest treatment updates including both nonpharmacological and pharmacological treatments, as well as surgical recommendations for patients with the disease. Osteoarthritis is the most common form of joint disease causing joint pain, stiffness, and physical disability among adults. It is an important issue for both the individual and society with its impact on public health continuing to grow as a result of the aging population, the rising prevalence of obesity, and the lack of definitive treatments to prevent or halt the progress of the disease.

Author : H. G. Fassbender
Publisher : Hans Huber Pub
Page : 64 pages
File Size : 41,8 Mb
Release : 1983
Category : Articular cartilage
ISBN : 3456812515

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Articular Cartilage and Osteoarthrosis by H. G. Fassbender Pdf

Author : Wim B. van den Berg,Peter M. Kraan,Peter L. E. M. Lent
Publisher : Birkhauser
Page : 296 pages
File Size : 48,7 Mb
Release : 1993
Category : Health & Fitness
ISBN : UOM:39015029542175

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Joint Destruction in Arthritis and Osteoarthritis by Wim B. van den Berg,Peter M. Kraan,Peter L. E. M. Lent Pdf

Author : Susanne Grässel,Attila Aszódi
Publisher : Springer
Page : 261 pages
File Size : 54,7 Mb
Release : 2017-01-25
Category : Medical
ISBN : 9783319458038

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Cartilage by Susanne Grässel,Attila Aszódi Pdf

In three Volumes this mini book series presents current knowledge and new perspectives on cartilage as a specialized yet versatile tissue. This second volume is dedicated to basic pathologies of the two most common osteoarticular diseases affecting large segments of the Western population, osteoarthritis and chondrodysplasias. This book addresses Professors, researchers and PhD students who are interested in musculoskeletal and cartilage biology and pathobiology.

Author : Troy N. Trumble,Christopher R. Byron,Ali Mobasheri
Publisher : Frontiers Media SA
Page : 129 pages
File Size : 52,9 Mb
Release : 2021-09-15
Category : Medical
ISBN : 9782889713332

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One Step at a Time: Advances in Osteoarthritis by Troy N. Trumble,Christopher R. Byron,Ali Mobasheri Pdf