Biased Signaling In Physiology Pharmacology And Therapeutics

Author : Brian J Arey
Publisher : Elsevier
Page : 316 pages
File Size : 53,6 Mb
Release : 2014-06-05
Category : Medical
ISBN : 9780124115071

Get Book

Biased Signaling in Physiology, Pharmacology and Therapeutics by Brian J Arey Pdf

Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective. Offers a unique and valuable resource on biased receptor signaling that provides a global view for better understanding pharmacology across many receptor families Integrates biased receptor signaling, physiology, and pharmacology to place this emerging science within the context of treating disease Includes important chapters on both the pharmaceutical and therapeutic implications of biased signaling

Author : Beata Jastrzebska,Paul S.H. Park
Publisher : Academic Press
Page : 0 pages
File Size : 44,6 Mb
Release : 2019-09-12
Category : Science
ISBN : 0128162287

Get Book

GPCRs by Beata Jastrzebska,Paul S.H. Park Pdf

GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric modulation, biased signaling through protein partners, deorphanization of GPCRs, and novel GPCR-targeting ligands that could lead to the development of new therapeutics against human diseases. GPCR association with, and possible therapeutic pathways for, retinal degenerative diseases, Alzheimer's disease, Parkinson's disease, cancer and diabetic nephropathy, among other illnesses, are examined in-depth.

Author : Vinood B. Patel,Victor R Preedy,Colin R Martin
Publisher : Elsevier
Page : 602 pages
File Size : 50,8 Mb
Release : 2023-06-02
Category : Psychology
ISBN : 9780323908788

Get Book

Neurobiology and Physiology of the Endocannabinoid System by Vinood B. Patel,Victor R Preedy,Colin R Martin Pdf

Neurobiology and Physiology of the Endocannabinoid System offers readers a comprehensive reference on the neurobiology of this system and the use of cannabimimetic compounds to induce neurological changes and confer symptom relief. With sections on both natural and synthetic compounds, the book's broad coverage allows readers to learn about their use with multiple conditions, as well as the working biology of the endocannabinoid system, its receptors and its ligands. This volume provides a platform for research on the effects of this system and its modulation in brain function and neurological dysfunction. Summarizes research on the working neurobiology of the endocannabinoid system Contains chapter abstracts, key facts, a dictionary and a summary Covers both natural cannabinoids and synthetic or exogenous cannabimimetics Includes conditions like headache, anxiety, stress and neuroinflammation Discusses system modulation in the context of pain, traumatic brain injury and obesity

Author : Ya-Xiong Tao
Publisher : Elsevier
Page : 440 pages
File Size : 49,9 Mb
Release : 2014-06-11
Category : Medical
ISBN : 9780124172067

Get Book

Pharmacology and Therapeutics of Constitutively Active Receptors by Ya-Xiong Tao Pdf

Volume 70 of Advances in Pharmacology presents the pharmacology and therapeutics of constitutively active receptors. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists, and biochemists alike. Advances in Pharmacology provides a rich collection of reviews on timely topics. The series places emphasis on the molecular bases of drug action, both applied and experimental. Contributions from the best authors in the field An essential resource for pharmacologists, immunologists, and biochemists

Author : Michel Dojat,Jan G. Bjaalie,Emmanuel L. Barbier
Publisher : Frontiers Media SA
Page : 111 pages
File Size : 44,6 Mb
Release : 2021-07-14
Category : Science
ISBN : 9782889668656

Get Book

APPNING: Animal Population Imaging by Michel Dojat,Jan G. Bjaalie,Emmanuel L. Barbier Pdf

Author : João Simões,George Stilwell
Publisher : Springer Nature
Page : 297 pages
File Size : 44,9 Mb
Release : 2021-08-28
Category : Medical
ISBN : 9783030681685

Get Book

Calving Management and Newborn Calf Care by João Simões,George Stilwell Pdf

This comprehensive textbook provides detailed information on calving management in dairy and beef cattle. Enriched with diverse learning opportunities, it conveys the fundamentals of reproductive anatomy and physiology, parturition, birth complications and various obstetrical manoeuvres, as well as dam and calf care. In order to promote best practices in this specialized subject, the book covers all significant points from conception to calving and the perinatal period. Clear chapter structures, a wealth of illustrations and videos, obstetrical case studies, and question-and-answer lists round out the reading experience, making the book a unique source of information on how to support mother cows and obtain viable offspring. In addition, readers can download the free Springer Nature Flashcards App and benefit from 77 digital study questions to test their knowledge. Calving is a significant event in terms of providing care and nutrition for mother cows and calves. The reproductive health status in cattle farms is crucial to immediately initiate lactation and new conception. Assistance by technical personnel, dystocia and stillbirth occurrences can reach ca. 50%, 14% and 6% of parturitions, respectively. Hence, zootechnical and veterinary management of calving is of great importance for animal welfare. This textbook makes a valuable contribution to teaching and everyday practice in cattle medicine and obstetrics. Veterinary students, residents, practitioners and technical personnel will discover it to be a rich learning and reference resource.

Author : Mohammad Ashrafuzzaman
Publisher : CRC Press
Page : 603 pages
File Size : 41,8 Mb
Release : 2023-12-15
Category : Science
ISBN : 9781003821649

Get Book

Introduction to Modern Biophysics by Mohammad Ashrafuzzaman Pdf

This textbook provides an introduction to the fundamental and applied aspects of biophysics for advanced undergraduate and graduate students of physics, chemistry, and biology. The application of physics principles and techniques in exploring biological systems has long been a tradition in scientific research. Biological systems hold naturally inbuilt physical principles and processes which are popularly explored. Systematic discoveries help us understand the structures and functions of individual biomolecules, biomolecular systems, cells, organelles, tissues, and even the physiological systems of animals and plants. Utilizing a physics- based scientific understanding of biological systems to explore disease is at the forefront of applied scientific research. This textbook covers key breakthroughs in biophysics whilst looking ahead to future horizons and directions of research. It contains models based on both classical and quantum mechanical treatments of biological systems. It explores diseases related to physical alterations in biomolecular structures and organizations alongside drug discovery strategies. It also discusses the cutting- edge applications of nanotechnologies in manipulating nanoprocesses in biological systems. Key Features: • Presents an accessible introduction to how physics principles and techniques can be used to understand biological and biochemical systems. • Addresses natural processes, mutations, and their purposeful manipulation. • Lays the groundwork for vitally important natural scientific, technological, and medical advances. Mohammad Ashrafuzzaman, a biophysicist and condensed matter scientist, is passionate about investigating biological and biochemical processes utilizing physics principles and techniques. He is a professor of biophysics at King Saud University’s Biochemistry Department in the College of Science, Riyadh, Saudi Arabia; the co- founder of MDT Canada Inc., and the founder of Child Life Development Institute, Edmonton, Canada. He has authored Biophysics and Nanotechnology of Ion Channels, Nanoscale Biophysics of the Cell, and Membrane Biophysics. He has also published about 50 peer- reviewed articles and several patents, edited two books, and has been serving on the editorial boards of Elsevier and Bentham Science journals. Dr. Ashrafuzzaman has held research and academic ranks at Bangladesh University of Engineering & Technology, University of Neuchatel (Switzerland), Helsinki University of Technology (Finland), Weill Medical College of Cornell University (USA), and University of Alberta (Canada). During 2013– 2018 he also served as a Visiting Professor at the Departments of Oncology, and Medical Microbiology and Immunology, of the University of Alberta. Dr. Ashrafuzzaman earned his highest academic degree, Doctor of Science (D.Sc.) in condensed matter physics from the University of Neuchatel, Switzerland in 2004.

Author : Gary Stephens
Publisher : Springer Nature
Page : 540 pages
File Size : 45,7 Mb
Release : 2024-05-02
Category : Electronic
ISBN : 9783031521973

Get Book

Ion Channels as Targets in Drug Discovery by Gary Stephens Pdf

Author : M.A. Steiner,M. Yanagisawa,M. Clozel
Publisher : Karger Medical and Scientific Publishers
Page : 165 pages
File Size : 43,9 Mb
Release : 2021-05-28
Category : Health & Fitness
ISBN : 9783318068443

Get Book

The Orexin System. Basic Science and Role in Sleep Pathology by M.A. Steiner,M. Yanagisawa,M. Clozel Pdf

The orexin system, discovered in 1998, has emerged as a crucial player in regulating the sleep and wake balance inside our brain. This discovery has sparked a burst of novel and dynamic research on the physiology and pathology of sleep. The Orexin System: Basic Science and Role in Sleep Pathology honors this research and the authors share their ideas and perspectives on the novel developments within the field. The book examines the intricate role of the orexin system in regulating sleep and wake, and its interaction with other wake-regulating systems. The orexin system is dissected at the cellular and molecular level to explore the diversity of the orexin-producing neurons, their projections, and their signaling pathways. Additionally, the book discusses the diseases which are associated with a dysfunctional orexin system, such as narcolepsy, insomnia, substance abuse, and Alzheimer’s disease, and explores the new potential therapeutic applications derived from the burst of research around this fascinating system. This publication is essential reading for neurobiologists, neurologists, psychopharmacologists, sleep researchers, and other researchers and clinical scientists interested in sleep, sleep research, insomnia, and medicine in general.

Author : Heba Mohamed Mansour,Mahmoud Mohamed Khattab,Aiman Saad El-Khatib
Publisher : Elsevier
Page : 606 pages
File Size : 52,7 Mb
Release : 2023-06-06
Category : Medical
ISBN : 9780443186783

Get Book

Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders by Heba Mohamed Mansour,Mahmoud Mohamed Khattab,Aiman Saad El-Khatib Pdf

Overexpression of receptor tyrosine kinases (RTKs) has been implicated in cancer. Increasing evidence suggests that dysregulation of RTKs is reported in many neurodegenerative and psychiatric disorders. Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders provides a fundamental, pragmatic map of RTKs structure, activation, functions, mechanism of action, gene regulation, and signaling pathways in developing central nervous system (CNS), adult normal CNS, neurodegenerative and psychiatric disorders. Additionally, the structure, function, activation, and therapeutic potential of many growth factors have been covered. Here, international experts in the field offer a comprehensive discussion of results of pre-clinical and clinical studies of repositioning of anti-cancer receptor tyrosine kinase inhibitors (RTKIs) and other promising protein kinase inhibitors in various neurodegenerative disorders including, Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis, and psychiatric disorders including, anxiety, depression, alcohol use disorder, and schizophrenia. In addition, the book discusses the obstacles and opportunities for the potential repositioning of kinase inhibitors in neurodegenerative and psychiatric disorders. Provides a thorough overview of RTKs biology and their role in health and disease progression and modulation Highlights RTK families and the numerous receptors within each subfamily Examines RTKIs and other protein kinase inhibitors in pre-clinical and clinical trials in both neurodegenerative and psychiatric disorders Gives future directions of possible safe effective targeted RTKIs and other protein kinase inhibitors that may be repositioned in various neurodegenerative and psychiatric disorders Includes chapter contributions from renowned experts in biology, pharmacology, neurology, psychiatry, and oncology

Author : Marc J.M. Abadie,Mariana Pinteala,Alexandru Rotaru
Publisher : Springer Nature
Page : 371 pages
File Size : 49,7 Mb
Release : 2021-05-26
Category : Medical
ISBN : 9783030574567

Get Book

New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications by Marc J.M. Abadie,Mariana Pinteala,Alexandru Rotaru Pdf

This contributed volume applies the insights of supramolecular chemistry to biomedical applications such as ions/water transport through nano-scale channels, gene therapy, tissue engineering and drug delivery, to cite some of the major investigations.The challenge is to understand the mechanisms of transport through tissues particularly in the therapeutic treatment of a disease where the active drug must be delivered directly to diseased cells without affecting healthy cells. As a result, smaller quantities of active substances can be used to treat the disease. Another interest concerns new ways to administer gene therapy. If genes are often delivered to their target cells by adapted viruses, the supramolecular non-viral ‘vectors’ using dynamic nano-frameworks and nano-structures are presented. In addition, it is important to reconstruct damaged tissues by mimicking natural processes in cells and polymers, such as tissue engineering and self-healing. Different options are here discussed: e.g. hydrogels based on chitosan, a carbohydrate polymer, are proving especially promising for tissue engineering and drug delivery. For controlled delivery of drugs or other biologically active compounds, hydrogels sensitive to the most important stimuli in the human body, such as temperature, pH, ionic strength, glucose and biomolecules released by the organism in pathological conditions have been developed. Finally, to assist and validate the experimental studies, computer modelling and simulations of large-sized molecular structures and systems using different molecular dynamics and quantum mechanical techniques are developed based on the experimental and chemistry synthesis. This book is of great interest for graduate students, researchers and health professionals interested in acquiring a better understanding of the mechanisms of medical treatments. In addition, it provides numerous tools to develop better therapies for human diseases.

Author : Krishna C. Persaud,Santiago Marco,Agustin Gutierrez-Galvez
Publisher : CRC Press
Page : 237 pages
File Size : 50,6 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781439871720

Get Book

Neuromorphic Olfaction by Krishna C. Persaud,Santiago Marco,Agustin Gutierrez-Galvez Pdf

Many advances have been made in the last decade in the understanding of the computational principles underlying olfactory system functioning. Neuromorphic Olfaction is a collaboration among European researchers who, through NEUROCHEM (Fp7-Grant Agreement Number 216916)-a challenging and innovative European-funded project-introduce novel computing p

Author : Francesco Caciagli,Francisco Ciruela,Kjell Fuxe,Peter Illes,Henning Ulrich
Publisher : Frontiers Media SA
Page : 287 pages
File Size : 46,6 Mb
Release : 2021-10-29
Category : Science
ISBN : 9782889715701

Get Book

Purinergic Signaling 2020: the State-of-The-Art Commented by the Members of the Italian Purine Club by Francesco Caciagli,Francisco Ciruela,Kjell Fuxe,Peter Illes,Henning Ulrich Pdf

Author : Anne Feltz
Publisher : Garland Science
Page : 776 pages
File Size : 48,7 Mb
Release : 2020-04-09
Category : Science
ISBN : 9781000761559

Get Book

Physiology of Neurons by Anne Feltz Pdf

Thanks to tremendous technical advances in molecular biology and cellular imaging after those in electrophysiology, there is now a deep understanding of the physiology of nerve cells and their synaptic interconnections. The complexity of the brain emerges from the communication and interaction between billions of these elements. This book explores systematically and didactically the details of neuronal physiology, covering membrane biophysics, receptor physiology, sensory transduction and synaptic transmission with its selective pharmacology. Readers of the book will be fully equipped to understand the functions and possibilities of the key units of the brain’s parallel computations.

Author : Anonim
Publisher : Academic Press
Page : 492 pages
File Size : 53,5 Mb
Release : 2017-08-18
Category : Medical
ISBN : 9780128112335

Get Book

Cannabinoid Pharmacology by Anonim Pdf

Cannabinoid Pharmacology, Volume 80 is a new volume in the Advances in Pharmacology that presents reviews of recent breakthroughs. This volume aims to present current knowledge of the endogenous cannabinoid system, and looks at molecular, cellular, tissue and organismal effects of endogenous and exogenous cannabinoids. Topics of note in this new volume include Endocannabinoids and their congeners, Endocannabinoid turnover, Plant cannabinoids, Synthetic cannabinoids and ‘legal highs’, CB1 and CB2 cannabinoid receptors, Novel signaling modalities, Novel cannabinoid receptors, and Ion channel regulation by cannabinoids. There is a broad coverage of the essential elements associated with the cannabinoid system. The Editors have sought to include authors who represent authoritative voices on these themes, but have not previously worked together to allow a fresh approach to the individual aspects covered. Presents reviews of recent breakthroughs in the cannabinoid system Features chapters from the best authors in the field Provides an essential resource for scientists, advanced undergraduate students through to established faculty members