Biological Significance Of Superantigens

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Superantigens

Author : Leung
Publisher : CRC Press
Page : 626 pages
File Size : 42,7 Mb
Release : 1997-02-20
Category : Medical
ISBN : 0824798139

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Superantigens by Leung Pdf

This up-to-date sourcebook covers viral and bacterial superantigens (SAgs) from molecular structure and immunological processes to pathology and treatment of superantigen-mediated human diseases. Discusses diseases beyond Toxic Shock Syndrome, such as autoimmune and inflammatory skin conditions, as well as the role of superantigens in other infectious diseases. Illustrated with molecular structures of superantigens.

Superantigens

Author : Brigitte T. Huber,Ed Palmer
Publisher : CSHL Press
Page : 198 pages
File Size : 45,9 Mb
Release : 1993
Category : Medical
ISBN : 0879693983

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Superantigens by Brigitte T. Huber,Ed Palmer Pdf

Superantigens are microbial products that defy the conventional notion of lymphocyte activation to produce an unusually vigorous, genetically unrestricted response among many subsets of antigen-specific T cells. Bacterial toxins and certain viral gene products behave as superantigens, deleting T cells in vivo and stimulating their proliferation in vitro. These observations raise many fascinating questions about the nature of T-cell activation and microbial pathogenesis. This volume is an up-to-date, wide-ranging examination of the function and significance of superantigens in virology, biochemistry, and cell and stuctural biology as well as immunology. The book will interest graduate students and postdoctoral fellows in a wide range of biomedical sciences.

Streptococcal Superantigens

Author : Anshu Babbar
Publisher : Springer
Page : 41 pages
File Size : 55,6 Mb
Release : 2015-07-24
Category : Science
ISBN : 9783319224558

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Streptococcal Superantigens by Anshu Babbar Pdf

This book provides ample knowledge and better understanding of Streptococcus pyogenes and their superantigens. Many illustrations make this a highly informative book. This book elucidates briefly Streptococcus pyogenes as a strict human pathogen possessing an array of virulence factors. These help in evading host immune responses such as by the activation of non-specific T-cell subpopulations by producing superantigens. This book mainly focuses on streptococcal superantigens and explains how they are different from conventional antigens. Moreover, it elaborates those diseases in which superantigens are actively involved. Useful aspects of superantigens and different therapeutic interventions to eradicate superantigens induced diseased are also discussed.

Superantigen Protocols

Author : Teresa Krakauer
Publisher : Humana
Page : 259 pages
File Size : 54,7 Mb
Release : 2013-08-16
Category : Medical
ISBN : 1489938230

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Superantigen Protocols by Teresa Krakauer Pdf

Superantigen Protocols assembles experimental protocols that have proved useful for the study of superantigens. These techniques will allow researchers from various areas of cell biology, microbiology, immunology, biochemistry, and molecular biology to assess the physical characteristics and biological effects of well-known superantigens as well as of putative substances that might have superantigenic activities, and to explore therapies for superantig- induced effects. Microbial exotoxins have been studied for decades as virulence factors because of their pathogenic effects. The term “superantigen” was coined by Marrack and Kappler a decade ago for some of these molecules because of their potent T-cell stimulatory activities. In recent years, advances in mole- lar biology provide recombinant as well as natural superantigens in highly purified form for physical characterization. Superantigens are now used extensively as tools to study interactions between receptors on cells of the immune system as they bind to major histocompatibility complex class II m- ecules on antigen-presenting cells and V regions of T-cell receptors. The b- ? logical effects that result from these interactions are studied both in vitro and in vivo. The intent of this book is, therefore, to bring together up-to-date te- niques developed by experts in the field of biochemistry, immunology, and molecular biology for the study of superantigens. Superantigen Protocols begins with an overview of the field to provide background information on the various classes of superantigens and their str- ture.

Bacterial Superantigens

Author : Jacques Thibodeau,Rafick-Pierre Sékaly
Publisher : Unknown
Page : 272 pages
File Size : 40,5 Mb
Release : 1995
Category : Antigens
ISBN : UCLA:L0073499477

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Bacterial Superantigens by Jacques Thibodeau,Rafick-Pierre Sékaly Pdf

Although the field of superantigens (SAgs) has boomed in recent years, the function of these proteins in bacterial infection remains elusive. This volume begins with a brief introduction, followed by 15 chapters. Among the topics are structural studies of streptococcal pyrogenic exotoxin superantigens; Yersinia infection--the virulence determinants and SAgs they produce; structural features of T cell receptor recognition of SAgs; the pathophysiology of bacterial SAgs in vivo; and antibody targeted SAgs in experimental tumor therapy. Annotation copyright by Book News, Inc., Portland, OR

Superantigens and Superallergens

Author : Gianni Marone
Publisher : Karger Medical and Scientific Publishers
Page : 259 pages
File Size : 54,8 Mb
Release : 2007-01-01
Category : Medical
ISBN : 9783805582667

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Superantigens and Superallergens by Gianni Marone Pdf

Superantigens constitute a growing family of bacterial and viral proteins that share the capacity of inducing massive activation of the immune system. This volume contains contributions from leaders in the field of classical T cell superantigens and sheds light on relevant B cell superantigens at the molecular and biochemical levels. This is the first volume to put together basic and clinical aspects of the classical T cell superantigens, B cell superantigens and superallergens. It will therefore be indispensable reading to basic and clinical immunologists, microbiologists, virologists and specialists in allergic and immune disorders.

Superantigens

Author : Amanda J. Brosnahan
Publisher : Humana Press
Page : 228 pages
File Size : 55,9 Mb
Release : 2019-03-29
Category : Medical
ISBN : 1493980262

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Superantigens by Amanda J. Brosnahan Pdf

This volume combines protocols that encompass the true variety of investigation done on superantigens in the fields of microbiology, immunology, molecular biology, biochemistry, and cellular biology, with a strong focus on disease models utilized to determine the role of superantigens in human disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Superantigens: Methods and Protocols contains a detailed and wide breadth of subject coverage that any scientist, clinician, or industry professional interested in this field will find valuable.

Superantigens

Author : Malak Kotb,John D. Fraser
Publisher : Unknown
Page : 0 pages
File Size : 55,9 Mb
Release : 2007
Category : Superantigens
ISBN : 1555814247

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Superantigens by Malak Kotb,John D. Fraser Pdf

A comprehensive book on superantigen biology. It combines many aspects of superantigen biology from the basic molecular mechanisms of superantigen action to the clinical consequences of superantigen intoxication, superantigen related diseases, and measures to combat superantigen toxicity.

Janeway's Immunobiology

Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 42,5 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570

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Janeway's Immunobiology by Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter Pdf

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Adverse Effects of Vaccines

Author : Institute of Medicine,Board on Population Health and Public Health Practice,Committee to Review Adverse Effects of Vaccines
Publisher : National Academies Press
Page : 894 pages
File Size : 52,9 Mb
Release : 2012-04-26
Category : Medical
ISBN : 9780309214353

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Adverse Effects of Vaccines by Institute of Medicine,Board on Population Health and Public Health Practice,Committee to Review Adverse Effects of Vaccines Pdf

In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children. Adverse Effects of Vaccines reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma. Adverse Effects of Vaccines will be of special interest to the National Vaccine Program Office, the VICP, the Centers for Disease Control and Prevention, vaccine safety researchers and manufacturers, parents, caregivers, and health professionals in the private and public sectors.

Molecular Biology of The Cell

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 50,5 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Encyclopedic Reference of Immunotoxicology

Author : Hans-Werner Vohr
Publisher : Springer
Page : 0 pages
File Size : 47,9 Mb
Release : 2005-06-01
Category : Medical
ISBN : 3540441727

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Encyclopedic Reference of Immunotoxicology by Hans-Werner Vohr Pdf

This work provides rapid access to focused information on topics of Immunotoxicology not only for scientists and those dealing with laboratory aspects but also for lecturers and advanced students. Over 200 contributing authors – including many of the world’s top specialists – have contributed full essays on all relevant topics, supplemented by keyword definitions of related terms. Full essays are structured uniformly to provide reader-friendly information on all aspects of Immunotoxicology, including methods of testing and analysis, characteristics of substances, the regulatory environment and the relevance of these to humans. The single A–Z format of both types of entry makes this reference book very easy to use. The Encyclopedic Reference of Immunotoxicology is intended to be a comprehensive work of reference which will provide easy access to relevant information in the fast-growing field of Immunotoxicology.

Viral Superantigens

Author : Kyuhei Tomonari
Publisher : CRC Press
Page : 284 pages
File Size : 41,9 Mb
Release : 1997-05-30
Category : Medical
ISBN : 0849376882

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Viral Superantigens by Kyuhei Tomonari Pdf

Since the discovery of viral superantigens in 1991, immunologists have made a number of new discoveries. The discoveries, especially those relating to the interplay between the immune system and viruses producing superantigens, have had a great impact on immunology and virology, as it appears that some diseases are triggered or exacerbated by viral superantigens. Viral Superantigens presents a complete review of this new area of study. Edited by a leading researcher and authored by a distinguished team of contributors, this comprehensive analysis covers every aspect of viral superantigens and related subjects, including critical topics such as effects on the T cell repertoire and viral superantigen-mediated diseases. Immunologists and virologists, clinical practitioners, and graduate students will find this book an invaluable resource to encourage further advances in research.

The Comprehensive Sourcebook of Bacterial Protein Toxins

Author : Joseph E. Alouf,Daniel Ladant,Michel R. Popoff
Publisher : Elsevier
Page : 1072 pages
File Size : 53,5 Mb
Release : 2005-12-20
Category : Science
ISBN : 9780080456980

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The Comprehensive Sourcebook of Bacterial Protein Toxins by Joseph E. Alouf,Daniel Ladant,Michel R. Popoff Pdf

This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates. Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology Includes the major toxins of both basic and clinical interest are described in depth Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology Evolutionary and functional aspects of bacterial toxins evaluated and summarized Toxin applications in cell biology presented Therapy (cancer therapy, dystonias) discussed Vaccines (native and genetically engineered vaccines) featured Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.