Streptococcal Superantigens

Author : Anshu Babbar
Publisher : Springer
Page : 41 pages
File Size : 46,6 Mb
Release : 2015-07-24
Category : Science
ISBN : 9783319224558

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Streptococcal Superantigens by Anshu Babbar Pdf

This book provides ample knowledge and better understanding of Streptococcus pyogenes and their superantigens. Many illustrations make this a highly informative book. This book elucidates briefly Streptococcus pyogenes as a strict human pathogen possessing an array of virulence factors. These help in evading host immune responses such as by the activation of non-specific T-cell subpopulations by producing superantigens. This book mainly focuses on streptococcal superantigens and explains how they are different from conventional antigens. Moreover, it elaborates those diseases in which superantigens are actively involved. Useful aspects of superantigens and different therapeutic interventions to eradicate superantigens induced diseased are also discussed.

Author : Leung
Publisher : CRC Press
Page : 626 pages
File Size : 42,7 Mb
Release : 1997-02-20
Category : Medical
ISBN : 0824798139

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Superantigens by Leung Pdf

This up-to-date sourcebook covers viral and bacterial superantigens (SAgs) from molecular structure and immunological processes to pathology and treatment of superantigen-mediated human diseases. Discusses diseases beyond Toxic Shock Syndrome, such as autoimmune and inflammatory skin conditions, as well as the role of superantigens in other infectious diseases. Illustrated with molecular structures of superantigens.

Author : Anna Norrby-Teglund,Mattias Svensson,Steinar Skrede
Publisher : Springer Nature
Page : 212 pages
File Size : 53,7 Mb
Release : 2020-10-20
Category : Medical
ISBN : 9783030576165

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Necrotizing Soft Tissue Infections by Anna Norrby-Teglund,Mattias Svensson,Steinar Skrede Pdf

This volume aims to enhance the current understanding of clinical features, treatment and pathogenic aspects in necrotizing soft tissue infections. Various representative case studies are discussed to enhance the readers’ understanding of these complex diseases. Necrotizing soft tissue infections are rapidly spreading infections that may cause extensive soft tissue or limb loss, multiorgan failure and are associated with a considerable fatality rate. It is undisputed that rapid diagnosis and prompt intervention is directly related to survival. The initial presentation may be limited to unspecific symptoms such as tenderness, swelling, erythema and pain. Thus, diagnosis and management are challenging due to heterogeneity in clinical presentation, in co-morbidities, in microbiological aetiology, as well as in the pathogenic mechanisms. An international and multidisciplinary consortium, INFECT, has for the last 6 years been pursuing research aimed to advance the understanding of the clinical and pathogenic aspects of these infections. A central part has been to create a comprehensive clinical registry and associated biobank which have also formed the basis for the experimental studies. Using the INFECT patient cohort, as well as an integrated systems biology approach in patients and clinically relevant experimental models, an advanced insight of diagnostic features, causative microbial agents, treatment strategies, and pathogenic mechanisms (host and bacterial disease traits and their underlying interaction network) has been obtained.

Author : Jacques Thibodeau,Rafick-Pierre Sékaly
Publisher : Unknown
Page : 272 pages
File Size : 44,7 Mb
Release : 1995
Category : Antigens
ISBN : UCLA:L0073499477

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Bacterial Superantigens by Jacques Thibodeau,Rafick-Pierre Sékaly Pdf

Although the field of superantigens (SAgs) has boomed in recent years, the function of these proteins in bacterial infection remains elusive. This volume begins with a brief introduction, followed by 15 chapters. Among the topics are structural studies of streptococcal pyrogenic exotoxin superantigens; Yersinia infection--the virulence determinants and SAgs they produce; structural features of T cell receptor recognition of SAgs; the pathophysiology of bacterial SAgs in vivo; and antibody targeted SAgs in experimental tumor therapy. Annotation copyright by Book News, Inc., Portland, OR

Author : Gianni Marone
Publisher : Karger Medical and Scientific Publishers
Page : 259 pages
File Size : 49,7 Mb
Release : 2007-01-01
Category : Medical
ISBN : 9783805582667

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Superantigens and Superallergens by Gianni Marone Pdf

Superantigens constitute a growing family of bacterial and viral proteins that share the capacity of inducing massive activation of the immune system. This volume contains contributions from leaders in the field of classical T cell superantigens and sheds light on relevant B cell superantigens at the molecular and biochemical levels. This is the first volume to put together basic and clinical aspects of the classical T cell superantigens, B cell superantigens and superallergens. It will therefore be indispensable reading to basic and clinical immunologists, microbiologists, virologists and specialists in allergic and immune disorders.

Author : Thea Horaud,Anne Bouvet,Roland Leclercq,Henri de Montclos,Michel Sicard
Publisher : Springer Science & Business Media
Page : 939 pages
File Size : 46,8 Mb
Release : 2013-11-08
Category : Medical
ISBN : 9781489918253

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Streptococci and the Host by Thea Horaud,Anne Bouvet,Roland Leclercq,Henri de Montclos,Michel Sicard Pdf

Streptococci and enterococci are the etiologic agents of infectious diseases that rank among the most severe in human pathology. The diagnosis, antibiotherapy, and prevention of the streptococcal diseases have improved considerably. However, the reemergence of severe streptococcal and enterococcal diseases constitutes a growing public health con cern, which remains open to scientific and medical debate. The XIII'h Lancefield International Symposium on Streptococci and Streptococcal Diseases, held at Institut Pasteur, Paris, France, September 16---2el, 1996, attracted 505 par ticipants from 43 countries. Twenty-two percent of the participants were students, a clear sign of the intense interest in this field. Of the 390 presentations made at the symposium, 260 were submitted as manuscripts for the Proceedings; we have included 249 of these in this volume. This symposium provided a forum for the presentation of the most recent findings and approaches to understanding several important fields, such as new aspects of infec tion, bacteria~host interactions, epidemiology, and molecular genetics of streptococci and enterococci. Over the last three years, the study of these subjects has expanded as increas ingly sophisticated methods of molecular analysis have been applied to investigate the bi ology of pathogenic streptococci and enterococci. Virulence, vaccine strategies, genetics, antibiotic resistance, epidemiology, and immunology are now being examined through the lens of molecular biology. The application of recently developed techniques to this field will continue to yield insight into the mechanism by which these organisms cause disease.

Author : Bernhard Fleischer
Publisher : S Karger Ag
Page : 0 pages
File Size : 46,9 Mb
Release : 1992
Category : Medical
ISBN : 3805555873

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Biological Significance of Superantigens by Bernhard Fleischer Pdf

Author : Rafick P. Sékaly
Publisher : Unknown
Page : 128 pages
File Size : 54,9 Mb
Release : 1993
Category : Electronic
ISBN : OCLC:60099594

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Bacterial Superantigens by Rafick P. Sékaly Pdf

Author : Dennis L. Stevens,Edward L. Kaplan
Publisher : Oxford University Press, USA
Page : 474 pages
File Size : 43,9 Mb
Release : 2000
Category : Streptococcal infectinons
ISBN : 0195099214

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Streptococcal Infections by Dennis L. Stevens,Edward L. Kaplan Pdf

Streptococcal Infections: Clinical Aspects, Microbiology, and Molecular Pathogenesis offers an in-depth examination of the spectrum of hemolytic streptococcal infections and their complications. Additionally, the volume incorporates and discusses aspects of pneumococcal, entrococcal, and oral streptococcal disease. The recent resurgence of rheumatic fever, concomitant outbreaks of severe systemic group A streptococcal infections (often accompanied by toxic shock), an increasing incidence of multiple antibiotic resistance among streptococcal species, and an intensified effort to develop effective streptococcal vaccines have brought renewed attention to the continuing role of streptococci for causing significant medical and public health problems in both industrialized and developing countries. Addressing clinical and epidemiological aspects, and microbiological and other approaches of the research scientist, this volume is the first to comprehensively address these clinically important organisms in many years. The contributors are internationally recognized for their expertise, making this book invaluable for infectious disease physicians, (internists, pediatricians, and family physicians, microbiologists, epidemiologists, and basic scientists with an interest in streptococcal infections and their complications.

Author : Teresa Krakauer
Publisher : Springer Science & Business Media
Page : 259 pages
File Size : 47,6 Mb
Release : 2008-02-05
Category : Medical
ISBN : 9781592593675

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Superantigen Protocols by Teresa Krakauer Pdf

Leading researchers in the biological, chemical, and physical investigation of superantigens describe in step-by-step detail their best experimental techniques to assess the physical characteristics and biological effects of superantigens. Their protocols range from those for investigating the interactions of superantigens with cellular receptors to those for the analysis of their immunological and biological effects, including methods for using BIOcore to determine binding kinetics and establishing various lymphocyte cell culture systems. There are also accounts of such methods as the RNase protection assay, cytokine ELISA, FACS analysis, and cytokine production at the single cell level..

Author : Dr. Scott Dougherty,Jonathan Carapetis,Liesl Zuhlke,Nigel Wilson
Publisher : Elsevier Health Sciences
Page : 364 pages
File Size : 54,9 Mb
Release : 2020-02-22
Category : Medical
ISBN : 9780323754606

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Acute Rheumatic Fever and Rheumatic Heart Disease by Dr. Scott Dougherty,Jonathan Carapetis,Liesl Zuhlke,Nigel Wilson Pdf

Acute Rheumatic Fever and Rheumatic Heart Disease is a concise, yet comprehensive, clinical resource highlighting must-know information on rheumatic heart disease and acute rheumatic fever from a global perspective. Covering the major issues dominating the field, this practical resource presents sufficient detail for a deep and thorough understanding of the latest treatment options, potential complications, and disease management strategies to improve patient outcomes. Divided into four distinct sections for ease of navigation: Acute Rheumatic Fever, Rheumatic Heart Disease, Population-Based Strategies for Disease Control, and Acute and Emergency Presentations. International editors and chapter authors ensure a truly global perspective. Covers all clinical aspects, including epidemiology, pathophysiology, clinical features, diagnosis, management, and treatment. Includes key topics on population-based measures for disease control for effective primary, secondary, and tertiary prevention. Consolidates today’s available information and guidance into a single, convenient resource.

Author : Peter Altmeyer,Klaus Hoffmann,Stephan el Gammal,Jerry Hutchinson
Publisher : Springer Science & Business Media
Page : 717 pages
File Size : 54,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642778827

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Wound Healing and Skin Physiology by Peter Altmeyer,Klaus Hoffmann,Stephan el Gammal,Jerry Hutchinson Pdf

On the occasion of the European Congress on Wound Healing and Skin Physiology (Bochum, Germany, November 1992), an international team of scientists and clinicians discussed the core topics in this important field of dermatological and surgical research. Themes include morphology and physiology, microcirculation and angiogenesis, biochemistry and immunology, microbiology and wound infection, non-invasive measurement techniques, wound repair, surgical treatment, dressings, and agents that promote wound healing.

Author : Anonim
Publisher : ScholarlyEditions
Page : 114 pages
File Size : 54,6 Mb
Release : 2012-12-10
Category : Medical
ISBN : 9781464972133

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Streptococcal Infections: New Insights for the Healthcare Professional: 2012 Edition by Anonim Pdf

Streptococcal Infections: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Strep Infections. The editors have built Streptococcal Infections: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Strep Infections in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Streptococcal Infections: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Joseph E. Alouf,Daniel Ladant,Michel R. Popoff
Publisher : Elsevier
Page : 1072 pages
File Size : 47,6 Mb
Release : 2005-12-20
Category : Science
ISBN : 9780080456980

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The Comprehensive Sourcebook of Bacterial Protein Toxins by Joseph E. Alouf,Daniel Ladant,Michel R. Popoff Pdf

This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates. Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology Includes the major toxins of both basic and clinical interest are described in depth Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology Evolutionary and functional aspects of bacterial toxins evaluated and summarized Toxin applications in cell biology presented Therapy (cancer therapy, dystonias) discussed Vaccines (native and genetically engineered vaccines) featured Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.

Author : Malak Kotb,Thierry Calandra
Publisher : Springer Science & Business Media
Page : 425 pages
File Size : 51,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781592593095

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Cytokines and Chemokines in Infectious Diseases Handbook by Malak Kotb,Thierry Calandra Pdf

A comprehensive review of what is known about the role of cytokines and chemokines in a variety of human infectious diseases, including gram-negative and -positive infections, listeriosis, mycobacterial infections, lyme arthritis, pneumonia, fungal infections, HIV, leishmaniasis, and sepsis. The authors demonstrate the different cytokine and chemokine production profiles in response to a wide variety of pathogens and the importance of host genetic factors in determining the type and magnitude of responses to a given microorganism. They also critically evaluate the use of cytokines and anticytokines in the treatment of infectious diseases and show how knowledge of cytokine pleiotropic effects, redundancy, and the complexity of the cytokine network has led to better design and better outcomes in cytokine-based therapies for specific infections.