Superantigens

Author : Leung
Publisher : CRC Press
Page : 626 pages
File Size : 46,5 Mb
Release : 1997-02-20
Category : Medical
ISBN : 0824798139

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Superantigens by Leung Pdf

This up-to-date sourcebook covers viral and bacterial superantigens (SAgs) from molecular structure and immunological processes to pathology and treatment of superantigen-mediated human diseases. Discusses diseases beyond Toxic Shock Syndrome, such as autoimmune and inflammatory skin conditions, as well as the role of superantigens in other infectious diseases. Illustrated with molecular structures of superantigens.

Author : Gianni Marone
Publisher : Karger Medical and Scientific Publishers
Page : 259 pages
File Size : 42,7 Mb
Release : 2007-01-01
Category : Medical
ISBN : 9783805582667

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Superantigens and Superallergens by Gianni Marone Pdf

Superantigens constitute a growing family of bacterial and viral proteins that share the capacity of inducing massive activation of the immune system. This volume contains contributions from leaders in the field of classical T cell superantigens and sheds light on relevant B cell superantigens at the molecular and biochemical levels. This is the first volume to put together basic and clinical aspects of the classical T cell superantigens, B cell superantigens and superallergens. It will therefore be indispensable reading to basic and clinical immunologists, microbiologists, virologists and specialists in allergic and immune disorders.

Author : Kyuhei Tomonari
Publisher : CRC Press
Page : 284 pages
File Size : 53,9 Mb
Release : 1997-05-30
Category : Medical
ISBN : 0849376882

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Viral Superantigens by Kyuhei Tomonari Pdf

Since the discovery of viral superantigens in 1991, immunologists have made a number of new discoveries. The discoveries, especially those relating to the interplay between the immune system and viruses producing superantigens, have had a great impact on immunology and virology, as it appears that some diseases are triggered or exacerbated by viral superantigens. Viral Superantigens presents a complete review of this new area of study. Edited by a leading researcher and authored by a distinguished team of contributors, this comprehensive analysis covers every aspect of viral superantigens and related subjects, including critical topics such as effects on the T cell repertoire and viral superantigen-mediated diseases. Immunologists and virologists, clinical practitioners, and graduate students will find this book an invaluable resource to encourage further advances in research.

Author : Anshu Babbar
Publisher : Springer
Page : 41 pages
File Size : 54,7 Mb
Release : 2015-07-24
Category : Science
ISBN : 9783319224558

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Streptococcal Superantigens by Anshu Babbar Pdf

This book provides ample knowledge and better understanding of Streptococcus pyogenes and their superantigens. Many illustrations make this a highly informative book. This book elucidates briefly Streptococcus pyogenes as a strict human pathogen possessing an array of virulence factors. These help in evading host immune responses such as by the activation of non-specific T-cell subpopulations by producing superantigens. This book mainly focuses on streptococcal superantigens and explains how they are different from conventional antigens. Moreover, it elaborates those diseases in which superantigens are actively involved. Useful aspects of superantigens and different therapeutic interventions to eradicate superantigens induced diseased are also discussed.

Author : Bernhard Fleischer,Hans O. Sjögren
Publisher : Springer Science & Business Media
Page : 144 pages
File Size : 54,6 Mb
Release : 2013-03-09
Category : Medical
ISBN : 9783642509988

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Superantigens by Bernhard Fleischer,Hans O. Sjögren Pdf

This volume of Current Topics in Microbiology and Immunology is concerned with a class of molecules that are the most potent polyclonal stimulators of T lymphocytes of several species. These molecules have been named "superantigens" because they use a mechanism of T cell stimulation closely mimicking MHC-restricted recognition of specific antigen: they act on variable parts of T cell antigen receptors and are presented by MHC class II molecules. Prototypes of these molecules are the pyrogenic exotoxins produced by S. aureus and S. pyogenes, of which the staphylococcal enterotoxins and the toxic shock syndrome toxin are the best known. Superantigens also occur endogen ously in mice, most notably the enigmatic Mis determinants, that have withstood characterization for nearly 20 years. Only very recently was it found that Mis is probably encoded by endogenous retroviruses. The list of candidates that are implicated as being superantigens is growing. In many cases, however, the proof that a given molecule indeed falls into this category is still missing.

Author : Brigitte T. Huber,Ed Palmer
Publisher : CSHL Press
Page : 198 pages
File Size : 40,6 Mb
Release : 1993
Category : Medical
ISBN : 0879693983

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Superantigens by Brigitte T. Huber,Ed Palmer Pdf

Superantigens are microbial products that defy the conventional notion of lymphocyte activation to produce an unusually vigorous, genetically unrestricted response among many subsets of antigen-specific T cells. Bacterial toxins and certain viral gene products behave as superantigens, deleting T cells in vivo and stimulating their proliferation in vitro. These observations raise many fascinating questions about the nature of T-cell activation and microbial pathogenesis. This volume is an up-to-date, wide-ranging examination of the function and significance of superantigens in virology, biochemistry, and cell and stuctural biology as well as immunology. The book will interest graduate students and postdoctoral fellows in a wide range of biomedical sciences.

Author : Teresa Krakauer
Publisher : Springer Science & Business Media
Page : 259 pages
File Size : 42,9 Mb
Release : 2008-02-05
Category : Medical
ISBN : 9781592593675

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Superantigen Protocols by Teresa Krakauer Pdf

Leading researchers in the biological, chemical, and physical investigation of superantigens describe in step-by-step detail their best experimental techniques to assess the physical characteristics and biological effects of superantigens. Their protocols range from those for investigating the interactions of superantigens with cellular receptors to those for the analysis of their immunological and biological effects, including methods for using BIOcore to determine binding kinetics and establishing various lymphocyte cell culture systems. There are also accounts of such methods as the RNase protection assay, cytokine ELISA, FACS analysis, and cytokine production at the single cell level..

Author : Carel J. van Oss
Publisher : CRC Press
Page : 316 pages
File Size : 47,5 Mb
Release : 1997-03-19
Category : Medical
ISBN : 0824700929

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Immunological and Molecular Diagnosis of Infectious Disease by Carel J. van Oss Pdf

Written by world-renowned experts, this book addresses immunological and molecular methodologies of diagnosis as well as clinical aspects of diseases. It book discusses DNA and RNA amplification methods, explains ELISA approaches, and introduces rapid diagnosis techniques, biosensors, and flow cytometry. The book examines bacterial and parasitic infections, including M. tuberculosis, Borrelia burgdorferi, Streptococcus pyogenes, chlamydia and schistosomes, and describe viral infections such as hantaviruses, hepatitis C., cytomegalovirus, herpes virus, and HIV. It also covers syndromes with infections origins, including prions, chronic fatigue syndrome, and superantigens, and much more.

Author : C. Vaman Rao
Publisher : Alpha Science Int'l Ltd.
Page : 436 pages
File Size : 54,8 Mb
Release : 2005
Category : Biological response modifiers
ISBN : 1842652559

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Immunology by C. Vaman Rao Pdf

In 'Immunology' Rao presents recent concepts and ideas with regard to innate and acquired immunity. Topics covered include the mucosal immune system, the activation, maturation and development of T- and B-cells, the role of the T-cell receptor, and the role of Class I MHC in auto-immune disease.

Author : Bernhard Fleischer
Publisher : S Karger Ag
Page : 0 pages
File Size : 47,7 Mb
Release : 1992
Category : Medical
ISBN : 3805555873

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Biological Significance of Superantigens by Bernhard Fleischer Pdf

Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 44,8 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570

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Janeway's Immunobiology by Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter Pdf

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Author : H. Redl
Publisher : Springer
Page : 377 pages
File Size : 48,7 Mb
Release : 2013-03-11
Category : Medical
ISBN : 9783034887557

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Cytokines in Severe Sepsis and Septic Shock by H. Redl Pdf

t Heinz Red! and Gunther Sch!ag Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria The word "sepsis" derives from the Greek meaning decay or rottenness. Tradition ally this term has been used to describe the process of infection accompanied by the host's systemic inflammatory response. Based on that understanding, previous clin ical studies have been designed to include only patients with positive blood cultures [1, 2]. However, the frequent occurrence of a septic response without the demon stration of microorganisms in the circulation has led to a new definition and under standing of sepsis, mainly as the systemic response of the host to an often unde tectable microbiological or non-microbiological process [3]. The general consensus is that cytokines are central to the inflammatory response, particularly in sepsis. It is now known that not only Gram-negative but also Gram positive, viral, and fungal infections initiate the complex cascades of cytokine release. Probably the most important aspect of bacterial action is the release of toxic bacterial products. In particular endotoxin from Gram-negative bacteria (see chap ter by Schade) and super antigens (see chapter by Neumann and Holzmann), as well as pore-forming toxins [4] from Gram-positive bacteria, induce cytokine formation. The importance of this cytokine release is evident from both diagnostic and thera peutic (mostly experimental) studies, and the action of cytokines may be the key to our understanding of the pathophysiology of the sepsis syndrome.

Author : Fred J. Stucker,Chris de Souza,Guy S. Kenyon,Timothy S. Lian,Wolfgang Draf,Bernhard Schick
Publisher : Springer Science & Business Media
Page : 909 pages
File Size : 41,9 Mb
Release : 2009-03-28
Category : Medical
ISBN : 9783540743804

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Rhinology and Facial Plastic Surgery by Fred J. Stucker,Chris de Souza,Guy S. Kenyon,Timothy S. Lian,Wolfgang Draf,Bernhard Schick Pdf

Georg von Bekesey was awarded the Nobel Prize for his seminal everyone all over the world. In other words it is directed toward work on hearing. It was, however, 43 years later in 2004 that evolving a common scientifc language that is spoken uniformly Linda Buck and Richard Axel were awarded the Nobel Prize for and consistently all over the world. Universality, so that norms, their work on olfaction. Tis is indicative of how the science of staging systems, etc., can be applied anywhere in the world with rhinology is only now coming into its own. For quite some time, equal validity. Tis can only be achieved through consensus. rhinology was thought to be limited in scope. It is now appreci- Tis book contains not only the genesis and pathogenesis of ated that the nose is not only an organ of aesthetic appeal, but rhinologic disease, but also what all surgeons want and that is one that carries out several important, complex functions. Te operative steps to bring about successful resolution of disease, tremendous surge in medical literature in recent times bears with the return of normal function.

Author : Jacques Thibodeau,Rafick-Pierre Sékaly
Publisher : Unknown
Page : 272 pages
File Size : 48,7 Mb
Release : 1995
Category : Antigens
ISBN : UCLA:L0073499477

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Bacterial Superantigens by Jacques Thibodeau,Rafick-Pierre Sékaly Pdf

Although the field of superantigens (SAgs) has boomed in recent years, the function of these proteins in bacterial infection remains elusive. This volume begins with a brief introduction, followed by 15 chapters. Among the topics are structural studies of streptococcal pyrogenic exotoxin superantigens; Yersinia infection--the virulence determinants and SAgs they produce; structural features of T cell receptor recognition of SAgs; the pathophysiology of bacterial SAgs in vivo; and antibody targeted SAgs in experimental tumor therapy. Annotation copyright by Book News, Inc., Portland, OR

Author : Sakari Reitamo,Thomas A. Luger,Martin Steinhoff
Publisher : CRC Press
Page : 285 pages
File Size : 55,8 Mb
Release : 2008-05-01
Category : Medical
ISBN : 9780203091449

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Textbook of Atopic Dermatitis by Sakari Reitamo,Thomas A. Luger,Martin Steinhoff Pdf

Atopic dermatitis or atopic eczema is an extremely common skin disease characterized by red patches, dry, scaling or crusting skin, and intense itch. It frequently develops in children during the first year of life and can become severe, with a consequently major impact on health-related quality of life. This text from international experts draws t