Calcium In Drug Actions

Author : Peter F. Baker
Publisher : Springer Science & Business Media
Page : 579 pages
File Size : 52,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642718069

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Calcium in Drug Actions by Peter F. Baker Pdf

The Editorial Board and the Publishers of the Handbook of Experimental Pharmacology wish to express their profound grief at the untimely death of Professor Peter Baker. Aware of his international recognition as an expert on the ubiquitous role of calcium in physiological processes and their pharma cological control, the Board was gratified when Professor Baker accepted its invitation to edit a new Handbook volume on "Calcium in Drug Actions". He went about this task with his usual energy and effectiveness so that, in the few months before his unexpected death, Professor Baker had mustered his distinguished contributors, got them to provide their manuscripts, and seen almost the entire material into the press. This achievement is all the more remarkable when one bears in mind the extraordinary number of his other commitments during the same time; they are mentioned in Sir Alan Hodgkin's preface to this volume. With so many other professional and personal responsibilities upon him, the Board of the Handbook wishes to record its grateful appreciation for the admirable way in which Professor Baker took on and carried out the additional work of bringing this fine book into existence; and the Board wishes it to be dedicated to the memory of Professor Peter Frederick Baker. The Editorial Board: G. V. R. BORN, P. CUATRECASAS, H. HERKEN, A.

Author : G. B. Weiss
Publisher : Springer Science & Business Media
Page : 366 pages
File Size : 47,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468433548

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Calcium in Drug Action by G. B. Weiss Pdf

Anyone surveying physiological and pharmacological journals can readily see that the biological actions of calcium ion are of increasingly widespread current interest. The scope of investi gated actions and reactions in which a role for calcium ion is of some importance is so numerous as to convey the impression that calcium ion is everywhere and interacts with everything. This being so, the challenge in contemporary research is to focus on investigation of those actions of calcium ion which, in some manner, influence either significant physiological parameters or the manner in which pharmacological agents act. This multi-authored book originated from a more limited Symposium on "Importance of Calcium as a Primary Locus of Drug Action" co-chaired by myself and Dr. Frank R. Goodman at the April, 1977 FASEB meeting in Chicago. This Symposium was organized in response to a perceived need for increased communication among 2 workers in different areas of Ca +-related research. In the pro cess of selecting the maximum of six areas for presentation within the format provided, it soon became apparent that this would result in only a limited sampling of current research efforts. Expansion of the number of areas to fourteen within a book format appeared to be the most logical mechanism to provide a more coherent inter disciplinary approach to consideration of various aspects of the 2 roles of Ca + in drug action. This is not to imply that all rele 2 vant Ca +-related areas are surveyed within this volume.

Author : Michael Denborough
Publisher : Pergamon
Page : 208 pages
File Size : 54,8 Mb
Release : 1987
Category : Medical
ISBN : UOM:39015012458801

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The Role of Calcium in Drug Action by Michael Denborough Pdf

The role of the calcium ion is central to many homeostatic processes and as a result any perturbation in the concentration can cause profound metabolic effects. Disorders of red blood cells, platelets, the heart, bone, hypertension and asthma are all linked by this common factor and this book describes the effects of the drugs currently used in the control of calcium concentration. In describing the actions of these drugs on calcium metabolism, this volume of the International Encyclopedia of Pharmacology & Therapeutics will provide a greater understanding of the processes at work, and will undoubtedly lead to greater, more effective control of calcium concentration. It should thus be invaluable reading for those dealing with both the clinical and experimental control of calcium metabolism.

Author : Biological Council. Co-ordinating Committee for Symposia on Drug Action
Publisher : Raven Press (ID)
Page : 416 pages
File Size : 44,7 Mb
Release : 1985
Category : Medical
ISBN : UCAL:B4494614

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Control and Manipulation of Calcium Movement by Biological Council. Co-ordinating Committee for Symposia on Drug Action Pdf

Author : International Society for Heart Research. American Section. Meeting
Publisher : Springer
Page : 376 pages
File Size : 52,7 Mb
Release : 1984-05-31
Category : Medical
ISBN : UOM:39015006699881

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Calcium Antagonists by International Society for Heart Research. American Section. Meeting Pdf

From the Proceedings of the Meeting of the American Section of the International Society for Heart Research (ISHR) at Hilton Head, South Carolina, September 21-24, 1983

Author : Institute of Medicine,Division of Health Care Services,VA Pharmacy Formulary Analysis Committee
Publisher : National Academies Press
Page : 280 pages
File Size : 41,8 Mb
Release : 2000-10-03
Category : Medical
ISBN : 9780309183536

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Description and Analysis of the VA National Formulary by Institute of Medicine,Division of Health Care Services,VA Pharmacy Formulary Analysis Committee Pdf

The VA National Formulary generated controversy, which motivated congressional scrutiny and a directive to the VA to commission this report reviewing the experience with the National Formulary and formulary system. This Institute of Medicine committee was pleased to assist the Congress with this review, in part because the committee saw in the VHA example an opportunity to understand and anticipate problems that all publicly funded programs are likely to encounter in this new age of pharmaceuticals. The Congress asked the committee to review the restrictiveness of the National Formulary, its impact on the costs and quality of care in the VHA, and how it compared to formularies and drug management practices in the private sector and in other public programs, especially Medicaid. Detailed in the pages that follow, the committee's findings and conclusions on these questions are, the committee believes, highly instructive, though not always in the ways that we anticipated.

Author : Anonim
Publisher : Academic Press
Page : 307 pages
File Size : 43,8 Mb
Release : 2013-07-24
Category : Science
ISBN : 9780124079380

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Store-Operated Calcium Channels by Anonim Pdf

Store-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful. The volume provides a comprehensive overview of the mechanisms and functions of store-operated calcium channels Contributors are authoritative researchers who have produced important advances in the field The volume is well-illustrated with cartoons and data to facilitate easy comprehension of the subject

Author : Institute of Medicine,Food and Nutrition Board,Committee on Military Nutrition Research
Publisher : National Academies Press
Page : 172 pages
File Size : 54,6 Mb
Release : 2002-01-07
Category : Medical
ISBN : 9780309082587

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Caffeine for the Sustainment of Mental Task Performance by Institute of Medicine,Food and Nutrition Board,Committee on Military Nutrition Research Pdf

This report from the Committee on Military Nutrition Research reviews the history of caffeine usage, the metabolism of caffeine, and its physiological effects. The effects of caffeine on physical performance, cognitive function and alertness, and alleviation of sleep deprivation impairments are discussed in light of recent scientific literature. The impact of caffeine consumption on various aspects of health, including cardiovascular disease, reproduction, bone mineral density, and fluid homeostasis are reviewed. The behavioral effects of caffeine are also discussed, including the effect of caffeine on reaction to stress, withdrawal effects, and detrimental effects of high intakes. The amounts of caffeine found to enhance vigilance and reaction time consistently are reviewed and recommendations are made with respect to amounts of caffeine appropriate for maintaining alertness of military personnel during field operations. Recommendations are also provided on the need for appropriate labeling of caffeine-containing supplements, and education of military personnel on the use of these supplements. A brief review of some alternatives to caffeine is also provided.

Author : Mutschler,Hartmut Derendorf
Publisher : CRC Press
Page : 830 pages
File Size : 44,9 Mb
Release : 1995
Category : Medical
ISBN : 0849377749

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Drug Actions by Mutschler,Hartmut Derendorf Pdf

The most highly acclaimed pharmacology and toxicology text/reference used in Europe is now available in English. This excellent translation of Mutschler's Arzneimittelwirkungen combines a clear, informative narrative with 255 figures, 261 diagrams, and 198 tables to appeal to both new students and experts in pharmacy, pharmacology, and therapeutics. Drug structure and activity relationships are emphasized as an important dimension that is sometimes lacking in other pharmacology texts. Drug Actions is organized into three major sections covering general drug action and dosing principles, specific drug therapeutics, and toxicology. The first section provides an integrated overview of basic principles in pharmacology with chapters addressing pharmacokinetics, pharmacodynamics, drug side effects, drug interactions, chronopharmacology, rational and irrational drug combinations as well as drug developments and drug trials. The second section systematically describes specific drug actions with pharmacology, clinical indications, standard doses side effects, and contraindications described for each approved drug category. The third section addresses toxicology where specific drug toxicities are identified and treatment options for accidental and drug associated poisoning are presented. Topics covered include environmental, occupational, and nutritional exposure to toxins.

Author : Gerald Werner Zamponi,Norbert Weiss
Publisher : Springer Nature
Page : 705 pages
File Size : 49,6 Mb
Release : 2022-11-07
Category : Science
ISBN : 9783031088810

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Voltage-Gated Calcium Channels by Gerald Werner Zamponi,Norbert Weiss Pdf

This book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing. Finally, the book also provides an overview of the updated research on calcium channel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for academic researchers at all levels in neuroscience, biophysics, cell biology and drug discovery.

Author : Jae Y. Choe
Publisher : Mcgraw-hill
Page : 768 pages
File Size : 42,6 Mb
Release : 2011-02-14
Category : Medical
ISBN : 0071634754

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Drug Actions and Interactions by Jae Y. Choe Pdf

The quick reference guide you need to avoid harmful interactions between prescription drugs, over-the-counter medications, and dietary supplements 4 STAR DOODY'S REVIEW! "This will serve as an invaluable guide for various medical professionals and basic scientists, as well as pharmacology students with an interest in understanding the relevance of drug interactions to pharmacotherapy....The book is extremely useful as a quick yet thorough guide through the wealth of information that exists for the most common drug therapies....this [book] is unique in its careful consideration of the relevance of dietary supplements to the discussion of drug interactions."--Doody's Review Service Drug Actions and Interactions is a handy easy-to-access guide to understanding what major drugs are available for specific diseases, how selected drugs produce therapeutic benefits, side effects that may occur when taking these drugs, and which drugs and supplements should not be taken in combination with each other. Applying the 300 most often prescribed drugs in the United States to more than 80 common disorders, Drug Actions and Interactions discusses each drug’s mechanism of action, side effects, and interactions with other drugs. Molecular structures of medications are also included to help you understand their mechanisms of action. Coverage includes drugs that act on the major systems (cardiovascular, respiratory, gastrointestinal, genitourinary, endocrine, neuronal); bone, muscle, skin, and joints; and general health. You will also find an appendix listing major drugs currently in use in each therapeutic classification. Thirty-two additional appendices detail interaction between a therapeutic group of drugs and an individual drug or group of drugs, such as interactions of beta-blockers, alpha-blockers, calcium-blockers, etc.

Author : Institute of Medicine,Food and Nutrition Board,Standing Committee on the Scientific Evaluation of Dietary Reference Intakes
Publisher : National Academies Press
Page : 449 pages
File Size : 44,8 Mb
Release : 1999-10-17
Category : Medical
ISBN : 9780309064033

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Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride by Institute of Medicine,Food and Nutrition Board,Standing Committee on the Scientific Evaluation of Dietary Reference Intakes Pdf

Since 1941, Recommended Dietary Allowances (RDAs) has been recognized as the most authoritative source of information on nutrient levels for healthy people. Since publication of the 10th edition in 1989, there has been rising awareness of the impact of nutrition on chronic disease. In light of new research findings and a growing public focus on nutrition and health, the expert panel responsible for formulation RDAs reviewed and expanded its approachâ€"the result: Dietary Reference Intakes. This new series of references greatly extends the scope and application of previous nutrient guidelines. For each nutrient the book presents what is known about how the nutrient functions in the human body, what the best method is to determine its requirements, which factors (caffeine or exercise, for example) may affect how it works, and how the nutrient may be related to chronic disease. The first volume of Dietary Reference Intakes includes calcium, phosphorus, magnesium, vitamin D, and fluoride. The second book in the series presents information about thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. Based on analysis of nutrient metabolism in humans and data on intakes in the U.S. population, the committee recommends intakes for each age groupâ€"from the first days of life through childhood, sexual maturity, midlife, and the later years. Recommendations for pregnancy and lactation also are made, and the book identifies when intake of a nutrient may be too much. Representing a new paradigm for the nutrition community, Dietary Reference Intakes encompasses: Estimated Average Requirements (EARs). These are used to set Recommended Dietary Allowances. Recommended Dietary Allowances (RDAs). Intakes that meet the RDA are likely to meet the nutrient requirement of nearly all individuals in a life-stage and gender group. Adequate Intakes (AIs). These are used instead of RDAs when an EAR cannot be calculated. Both the RDA and the AI may be used as goals for individual intake. Tolerable Upper Intake Levels (ULs). Intakes below the UL are unlikely to pose risks of adverse health effects in healthy people. This new framework encompasses both essential nutrients and other food components thought to pay a role in health, such as dietary fiber. It incorporates functional endpoints and examines the relationship between dose and response in determining adequacy and the hazards of excess intake for each nutrient.

Author : Francesco Clementi,Guido Fumagalli
Publisher : John Wiley & Sons
Page : 784 pages
File Size : 52,8 Mb
Release : 2015-07-01
Category : Medical
ISBN : 9781118768594

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General and Molecular Pharmacology by Francesco Clementi,Guido Fumagalli Pdf

With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action – the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics. • Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students • Discusses the relevance of pharmacokinetics and drug development for the clinical application of drugs • Presents material from the perspective of drug targets and interaction, the theoretical basis of drug action analysis, and drug properties • Focuses on structure-function relationships of drug targets – informing about their biochemical and physiologic functions and experimental and clinical pathways for drug discovery and development • Has a companion website that offers a host of resources: short additional chapters about methodology, topics at the forefront of research, and all figures and tables from the book

Author : Christopher J. Coulson
Publisher : Columbia University Press
Page : 314 pages
File Size : 40,7 Mb
Release : 1994-02-03
Category : Medical
ISBN : 0748400680

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Molecular Mechanisms Of Drug Action by Christopher J. Coulson Pdf

Brings together the state of knowledge with respect to drug action in an accessible form. The text emcompasses the modes of action of drugs for infectious disease and those for endogenous conditions.

Author : Maria A. Hernandez, Ph.D.,Appu Rathinavelu, Ph.D.
Publisher : Routledge
Page : 388 pages
File Size : 44,8 Mb
Release : 2017-07-12
Category : Medical
ISBN : 9781351989114

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Basic Pharmacology by Maria A. Hernandez, Ph.D.,Appu Rathinavelu, Ph.D. Pdf

Intended for use in an introductory pharmacology course, Basic Pharmacology: Understanding Drug Actions and Reactions provides an in-depth discussion of how to apply the chemical and molecular pharmacology concepts, a discussion students need for more advanced study. The textbook introduces the principles of chemistry and biology necessary to understand drug interactions at the cellular level. The authors highlight chemical and physical properties of drugs, drug absorption and distribution, drug interactions with cellular receptors, and drug metabolism and elimination. The book begins with a review of chemical principles as they apply to drug molecules, focusing mainly on those for commonly prescribed drugs. The authors use drug structures to illustrate the chemical concepts learned in general and organic chemistry courses. They cover the dynamics of receptors in mediating the pharmacological effects of drugs. They clarify theories, drawn from the scientific literature, which explain drug-receptor interactions and the quantitative relationship between drug binding and its effects at the cellular level. The authors’ extensive use of drug structures for teaching chemical and molecular pharmacology principles, and their emphasis on the relevance of these principles in future professional life makes this book unique. It provides the framework for better understanding of advanced pharmacology and therapeutics topics. Blending medicinal chemistry and pharmacodynamics aspects, this textbook clearly elucidates the essential concepts that form the cornerstone for further work in pharmacology.