Cell Microencapsulation

Author : Jose Luis Pedraz,Gorka Orive
Publisher : Springer Science & Business Media
Page : 167 pages
File Size : 47,5 Mb
Release : 2010-12-31
Category : Medical
ISBN : 9781441957863

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Therapeutic Applications of Cell Microencapsulation by Jose Luis Pedraz,Gorka Orive Pdf

The advancement of science is ever more contingent upon the interaction of experts vast amount of scientific information being gathered every day that exceeds the ability of any one scientist to acquire. As an illustration of the frantic pace of scientific disc- more acute in the case of scientific fields at the interface of different and seemingly distant areas of study. Amidst these, the field of cell encapsulation brings together an array of diverse disciplines such as molecular biology and biopolymers, gene therapy and inorganic membranes, stem cell biology and physicochemistry, immunology and nanotechnology. Clearly, such range of topics is too broad for any individual scientist the state-of-the-art in the field of cell encapsulation. At the core of this technology, there is an interaction of physicochemical and biological elements forming three distinct layers of complexity. First, the chemistry of the biopolymer dictates the degree of protein adsorption, vascularization, tox- ity and biocompatibility of the microcapsules. Advances in biopolymer science are providing solutions to overcome existing challenges and to improve microcapsules as delivery vehicles. Second, the choice of cells, and more precisely the plethora of in determining the immune response elicited by the host to implanted microcapsules.

Author : Emmanuel C. Opara
Publisher : Humana
Page : 366 pages
File Size : 47,6 Mb
Release : 2018-06-08
Category : Science
ISBN : 1493981773

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Cell Microencapsulation by Emmanuel C. Opara Pdf

This volume provides a unique forum to review cell microencapsulation in a broad sense by exploring various cell types that have been encapsulated for different purposes, different approaches and devices used for microencapsulation, the biomaterials used in cell microencapsulation, the challenges to the technology, and the current status of its application in different clinical situations. This book is divided in five sections: Section I is an introductory part that discusses historical developments of the technology and its current challenges, as well as the various applications of cell microencapsulation; Section II discusses the main approaches and devices currently used in cell microencapsulation; Section III presents an overview of the various polymeric materials currently in use for cell microencapsulation and the enabling technologies to either monitor or enhance encapsulated cell function; Section IV gives specific examples of the methods used to encapsulate various cell types; and Section V provides an overview of the different clinical situations in which cell microencapsulation has been applied. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and practical, Cell Microencapsulation: Methods and Protocols is a valuable reference for researchers, engineers, clinicians, and other healthcare professionals, as well as food technologists who will find detailed descriptions of methods for the microencapsulation of specific cell types and their current of potential clinical and industrial applications. This volume also includes detailed information about the design and manufacture of different devices including large-scale production devices for use in cell microencapsulation.

Author : Willem_M. Kühtreiber,Robert P. Lanza,William L. Chick
Publisher : Springer Science & Business Media
Page : 457 pages
File Size : 48,5 Mb
Release : 2013-12-01
Category : Medical
ISBN : 9781461215868

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Cell Encapsulation Technology and Therapeutics by Willem_M. Kühtreiber,Robert P. Lanza,William L. Chick Pdf

The concept of using encapsulation for the immunoprotection of transplanted cells was introduced for the first time in the 1960s. "[Microencapsulated cells] might be protected from destruction and from partici pation in immunological processes, while the enclosing membrane would be permeable to small molecules of specific cellular product which could then enter the general extracellular compartment of the recipient. For instance, encapsulated endocrine cells might survive and maintain an effective supply of hormone." (Chang, Ph. D. Thesis, McGill University, 1965; Chang et aI., Can J Physiol PharmacoI44:115-128, 1966). We asked Connaught Laboratories, Ltd., in Toronto to put this concept into practice. In 1980, Lim and Sun from Connaught Laboratories reported on the successful implantation of poly-I-Iysine-alginate encapsu lated rat islets into a foreign host. [Lim and Sun, Science 210:908-909, 1980]. Now many groups around the world are making tremendous progress in the encapsulation of a multitude of cell types. Kiihtreiber, Lanza, and Chick have invited many cell encapsulation groups from around the world to contribute to this book. The result is a very useful reference book in this rapidly growing area. With so many excellent au thors describing in detail the different areas of cell encapsulation, my role here will be to briefly discuss a few points.

Author : T. M. S. Chang
Publisher : Springer Science & Business Media
Page : 304 pages
File Size : 49,7 Mb
Release : 2012-12-06
Category : Technology & Engineering
ISBN : 9781461251828

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Microencapsulation and Artificial Cells by T. M. S. Chang Pdf

Author : Eva Maria Brandtner,John Austin Dangerfield
Publisher : Bentham Science Publishers
Page : 195 pages
File Size : 52,8 Mb
Release : 2013-05-31
Category : Medical
ISBN : 9781608057207

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Bioencapsulation of Living Cells for Diverse Medical Applications by Eva Maria Brandtner,John Austin Dangerfield Pdf

Bioencapsulation (or microencapsulation) of cells and their implantation into a body of immunoprotected cells allows researchers to revive a missing or defective function in the cells. Microencapsulated cells have reached the clinic where they have been shown to be safe and efficacious in numerous clinical trials. Cell types that have been encapsulated for therapeutic purposes include hybridomas, islet cells, "platform" cell lines e.g. HEK293 and CHO cells as well as an increasing focus on the encapsulation of stem cells. This e-book explains the different methods used for achieving cell bioencapsulation based on different polymers e.g. alginate, cellulose sulphate and agarose. Other chapters in this book subsequently describe the use of cell encapsulation in cancer therapy to improve on existing chemotherapies by reducing doses and thus side effects while increasing efficacy for long term in vivo production of (i) tumoricidal or virus neutralising antibodies, (ii) insulin to achieve a self regulating treatment for diabetes and (iii) neuron nurturing factors to treat CNS diseases such as epilepsy, disorders like Parkinson's disease, Alzheimer, Amyotrophic lateral sclerosis, Huntington's disease and pathologies caused by trauma and/or ischemic processes. The book also includes a chapter reviewing the genetic engineering of cells to allow controlled production of biotherapeutics from encapsulated cells. This is a unique and timely book which brings together contributions from some of the leading researchers in the field of cell encapsulation. Interested readers are provided an overview of the exciting developments and clinical experiences of researchers with cell bioencapsulation.

Author : Jan E. Vandegaer
Publisher : Springer Science & Business Media
Page : 183 pages
File Size : 41,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468407396

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Microencapsulation by Jan E. Vandegaer Pdf

of McGill University of Montreal, Canada, who talks about artifi cial cells prepared from semipermeable microcapsules. Also illustrative of this method is a contribution on microencapsulated pesticides by C. B. Desavigny and E. E. Ivy of Pennwalt Corporation. Another method of polymerization in situ is micro encapsulation by vapor deposition, the subject of W. M. Jayne of Union Carbide Corporation. The more mechanical methods of microencapsulation are represented by two techniques, one involving a fluidized bed the other involving mainly a centrifugal method. The fluidized bed method is covered in a paper by H. Hall and T. M. Hinkes of the Wisconsin Alumini Research Foundation. The centrifugal and other related methods are treated by Mr. J. E. Goodwin and Mr. Sommerville of the Southwest Research Institute of San Antoni~ Texas. Dr. G. Baxter of Moore Business Forms, studied capsules made by mechanical methods as well as by chemical methods. Mr. Russell G. Arnold of the Bureau of Veteranary Medicine of the Food and Drug Administration draws our attention to the procedures to be used for securing approval of a new animal drug application for the marketing of microencapsulated products. And last but not least, we have a contribution by Mr. G. O. Fanger on "Micro encapsulation a Brief History and Introduction, whose title speaks for itself.

Author : Willem M. Kühtreiber,Robert Paul Lanza,William Louis Chick
Publisher : Unknown
Page : 450 pages
File Size : 49,5 Mb
Release : 1999
Category : Animal cell biotechnology
ISBN : 376434010X

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Cell Encapsulation Technology and Therapeutics by Willem M. Kühtreiber,Robert Paul Lanza,William Louis Chick Pdf

Encapsulated cells offer enormous potential for the treatment of human disease. This work includes detailed descriptions of chemical properties of encapsulation materials, purification, biocompatibility issues and experimental protocols.

Author : Farshid Sefat,Gholamali Farzi,Masoud Mozafari
Publisher : Woodhead Publishing
Page : 510 pages
File Size : 47,7 Mb
Release : 2022-10-13
Category : Medical
ISBN : 9780323859431

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Principles of Biomaterials Encapsulation: Volume One by Farshid Sefat,Gholamali Farzi,Masoud Mozafari Pdf

Principles of Biomaterials Encapsulation: Volume One, provides an expansive and in-depth resource covering the key principles, biomaterials, strategies and techniques for encapsulation. Volume One begins with an introduction to encapsulation, with subsequent chapters dedicated to a broad range of encapsulation principles and techniques, including spray chilling and cooling, microemulsion, polymerization, extrusion, cell microencapsulation and much more. This book methodically details each technique, assessing the advantages and disadvantages of each, allowing the reader to make an informed decision when using encapsulation in their research. Principles of Biomaterials Encapsulation: Volume One enables readers to learn about the various strategies and techniques available for encapsulation of a wide selection of biomedical substrates, such as drugs, cells, hormones, growth factors and so on. Written and edited by well-versed materials scientists with extensive clinical, biomedical and regenerative medicine experience, this book offers a deeply interdisciplinary look at encapsulation in translational medicine. As such, this book will provide a useful resource to a broad readership, including those working in the fields of materials science, biomedical engineering, regenerative and translational medicine, pharmacology, chemical engineering and nutritional science. Details the various biomaterials available for encapsulation, as well as advantages and disadvantages of conventional and contemporary biomaterials for encapsulations Describes a broad range of applications in regenerative medicine, uniquely bringing encapsulation into the worlds of translational medicine and tissue engineering Written and edited by well-versed materials scientists with extensive clinical, biomedical and regenerative medicine experience, offering an interdisciplinary approach

Author : Shimon Efrat
Publisher : Springer Science & Business Media
Page : 294 pages
File Size : 49,5 Mb
Release : 2009-12-01
Category : Medical
ISBN : 9781607613664

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Stem Cell Therapy for Diabetes by Shimon Efrat Pdf

Stem Cell Therapy for Diabetes, one of the latest installments of the Stem Cell Biology and Regenerative Medicine series, reviews the three main approaches for generation of sufficient numbers of insulin-producing cells for restoration of an adequate beta-cell mass: beta-cell expansion, stem-cell differentiation, and nuclear reprogramming. Adeptly collecting the research of the leading scientists in the field, Stem Cell Therapy for Diabetes compares the merits of employing autologous versus banked allogeneic cell sources for generation of surrogate beta cells, and addresses tissue engineering and ways for cell protection from recurring autoimmunity and graft rejection. Stem Cell Therapy for Diabetes provides essential reading for those especially interested in tracking the progress in applying of one of the most exciting new developments in bio-medicine towards a cure for diabetes.

Author : Bartosz Tylkowski,Marta Giamberini,Susana Fernandez Prieto
Publisher : Walter de Gruyter GmbH & Co KG
Page : 433 pages
File Size : 48,7 Mb
Release : 2020-04-06
Category : Technology & Engineering
ISBN : 9783110641950

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Microencapsulation by Bartosz Tylkowski,Marta Giamberini,Susana Fernandez Prieto Pdf

Microencapsulations may be found in a number of fields like medicine, drug delivery, biosensing, agriculture, catalysis, intelligent microstructures and in many consumer goods. This new edition of Microencapsulation revises chapters to address the newest innovations in fields and adds three new chapters on the uses of microencapsulations in medicine, agriculture, and consumer products.

Author : Fabien Salaün
Publisher : BoD – Books on Demand
Page : 142 pages
File Size : 55,9 Mb
Release : 2019-10-02
Category : Technology & Engineering
ISBN : 9781838818692

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Microencapsulation by Fabien Salaün Pdf

This book is intended to provide an overview and review of the latest developments in microencapsulation processes and technologies for various fields of applications. The general theme and purpose are to provide the reader with a current and general overview of the existing microencapsulation systems and to emphasize various methods of preparation, characterization, evaluation, and potential applications in various fields such as medicine, food, agricultural, and composites. The book targets readers, including researchers in materials science processing and/or formulation and microencapsulation science, engineers in the area of microcapsule development, and students in colleges and universities.

Author : Nedal Abu-Thabit
Publisher : BoD – Books on Demand
Page : 292 pages
File Size : 45,8 Mb
Release : 2021-01-27
Category : Science
ISBN : 9781839683480

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Nano- and Microencapsulation by Nedal Abu-Thabit Pdf

Nano- or micro-encapsulation is used in many different fields and industries, including pharmaceuticals, cosmetics, food, and agrochemicals. It offers advantages for various applications, especially drug delivery. Nano-encapsulation can help extend and control the release of drugs as well as increase drug bioavailability and efficacy. It improves the precision of targeted drug delivery and allows for fabricating nano-encapsulated drugs for diagnostic and theranaostic applications. This book covers recent advances in fabricating nano-/micro-capsules using natural carriers for therapeutic and diagnostic drug delivery applications as well as rheology and formulations of micro-emulsions for diverse applications. This book is essential for scientists and researchers with diverse backgrounds in chemistry, engineering, material sciences, pharmaceuticals, and drug delivery.

Author : Franklin Lim
Publisher : CRC Press
Page : 169 pages
File Size : 46,9 Mb
Release : 2019-06-12
Category : Medical
ISBN : 9780429522604

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Biomedical Applications of Microencapsulation by Franklin Lim Pdf

Published in 1984: For this volume the publishers at CRC Press have chosen to present information on just one important area, namely the biomedical field, where much progress in the application of microencapsulation has been made in recent years.

Author : Satya Prakash,Dominique Shum-Tim
Publisher : World Scientific
Page : 569 pages
File Size : 50,7 Mb
Release : 2011
Category : Medical
ISBN : 9789812837899

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Stem Cell Bioengineering and Tissue Engineering Microenvironment by Satya Prakash,Dominique Shum-Tim Pdf

This is a comprehensive review of the current state of stem cell bioengineering from authorities in the field. The first part of the book includes the basic research work on stem cells and bioengineering carried out by various laboratories. The second part consists of a review of the current development of various microcapsules in stem cell therapy. The last part will summarize the overall clinical trials on stem cell therapy and myocardial regeneration as well as the most updated personal experience recently completed by well-known experts in this field.

Author : S Prakash
Publisher : Elsevier
Page : 544 pages
File Size : 55,6 Mb
Release : 2007-05-31
Category : Science
ISBN : 9781845693077

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Artificial Cells, Cell Engineering and Therapy by S Prakash Pdf

Artificial cells, cell engineering and therapy are emerging technologies which will make a significant impact on the future of medicine and healthcare. However, research within the field is vast. This unique book provides a comprehensive study of the most recent advances in the field and its practical applications. The first part of the book offers the reader an introduction to the basics of artificial cell technology with chapters on its origins, design, current status within medicine and future prospects. Part two covers apoptosis, the use of bone marrow stromal cells in myocardial regeneration together with signalling and tissue engineering. Part three discusses artificial cells for therapy, procedures for various clinical conditions and the current status of the discipline within the field. The book concludes with a final section on the role of artificial cells in medicine with particular focus on the use of artificial cells as blood substitutes and their potential use in myocardial regeneration, drug delivery and in treating kidney and bowel diseases, diabetes and cancer. Artificial cells, cell engineering and therapy is a valuable reference for researchers, students and practitioners within the field. Introduces the basics of artificial cell technology Provides a comprehensive study of the most recent advances in artificial cells, cell engineering and cell therapy Discusses the design, engineering and uses of artificial cells