Bioencapsulation Of Living Cells For Diverse Medical Applications

Author : Eva Maria Brandtner,John Austin Dangerfield
Publisher : Bentham Science Publishers
Page : 195 pages
File Size : 43,7 Mb
Release : 2013-05-31
Category : Medical
ISBN : 9781608057207

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Bioencapsulation of Living Cells for Diverse Medical Applications by Eva Maria Brandtner,John Austin Dangerfield Pdf

Bioencapsulation (or microencapsulation) of cells and their implantation into a body of immunoprotected cells allows researchers to revive a missing or defective function in the cells. Microencapsulated cells have reached the clinic where they have been shown to be safe and efficacious in numerous clinical trials. Cell types that have been encapsulated for therapeutic purposes include hybridomas, islet cells, "platform" cell lines e.g. HEK293 and CHO cells as well as an increasing focus on the encapsulation of stem cells. This e-book explains the different methods used for achieving cell bioencapsulation based on different polymers e.g. alginate, cellulose sulphate and agarose. Other chapters in this book subsequently describe the use of cell encapsulation in cancer therapy to improve on existing chemotherapies by reducing doses and thus side effects while increasing efficacy for long term in vivo production of (i) tumoricidal or virus neutralising antibodies, (ii) insulin to achieve a self regulating treatment for diabetes and (iii) neuron nurturing factors to treat CNS diseases such as epilepsy, disorders like Parkinson's disease, Alzheimer, Amyotrophic lateral sclerosis, Huntington's disease and pathologies caused by trauma and/or ischemic processes. The book also includes a chapter reviewing the genetic engineering of cells to allow controlled production of biotherapeutics from encapsulated cells. This is a unique and timely book which brings together contributions from some of the leading researchers in the field of cell encapsulation. Interested readers are provided an overview of the exciting developments and clinical experiences of researchers with cell bioencapsulation.

Author : Munmaya Mishra
Publisher : CRC Press
Page : 2954 pages
File Size : 55,9 Mb
Release : 2018-12-17
Category : Science
ISBN : 9781351019415

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Encyclopedia of Polymer Applications, 3 Volume Set by Munmaya Mishra Pdf

Undoubtedly the applications of polymers are rapidly evolving. Technology is continually changing and quickly advancing as polymers are needed to solve a variety of day-to-day challenges leading to improvements in quality of life. The Encyclopedia of Polymer Applications presents state-of-the-art research and development on the applications of polymers. This groundbreaking work provides important overviews to help stimulate further advancements in all areas of polymers. This comprehensive multi-volume reference includes articles contributed from a diverse and global team of renowned researchers. It offers a broad-based perspective on a multitude of topics in a variety of applications, as well as detailed research information, figures, tables, illustrations, and references. The encyclopedia provides introductions, classifications, properties, selection, types, technologies, shelf-life, recycling, testing and applications for each of the entries where applicable. It features critical content for both novices and experts including, engineers, scientists (polymer scientists, materials scientists, biomedical engineers, macromolecular chemists), researchers, and students, as well as interested readers in academia, industry, and research institutions.

Author : Farshid Sefat,Gholamali Farzi,Masoud Mozafari
Publisher : Elsevier
Page : 806 pages
File Size : 55,9 Mb
Release : 2023-04-10
Category : Medical
ISBN : 9780323853309

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Principles of Biomaterials Encapsulation: Volume Two by Farshid Sefat,Gholamali Farzi,Masoud Mozafari Pdf

Principles of Biomaterials Encapsulation: Volume Two provides an expansive and in-depth resource covering the key principles, biomaterials, techniques and applications of encapsulation in translational medicine. The book details the various biomaterials available for encapsulation, including polymers, natural and synthetic biomaterials, porous materials, and more. The advantages and disadvantages of conventional and contemporary biomaterials for encapsulations are reviewed, along with advice on the most effective materials for both shell and core. The final part of the book describes a broad range of applications in regenerative medicine, uniquely bringing encapsulation into the worlds of translational medicine and tissue engineering. This book enables readers to learn about the pros and cons of different biomaterials for encapsulation, as well as how they can be utilized in many bodily systems and tissues, such as the respiratory, digestive, endocrine and cardiovascular systems. Written and edited by well-versed materials scientists with extensive clinical, biomedical and regenerative medicine experience, this book offers a deeply interdisciplinary look at encapsulation in translational medicine. Details the various biomaterials available for encapsulation, as well as the advantages and disadvantages of conventional and contemporary biomaterials for encapsulations Describes a broad range of applications in regenerative medicine, uniquely bringing encapsulation into the worlds of translational medicine and tissue engineering Written and edited by well-versed materials scientists with extensive clinical, biomedical and regenerative medicine experience, offering an interdisciplinary approach

Author : Gerhard M. Artmann,Aysegül Artmann,Azhar A. Zhubanova,Ilya Digel
Publisher : Springer
Page : 481 pages
File Size : 47,5 Mb
Release : 2018-04-11
Category : Technology & Engineering
ISBN : 9789811079047

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Biological, Physical and Technical Basics of Cell Engineering by Gerhard M. Artmann,Aysegül Artmann,Azhar A. Zhubanova,Ilya Digel Pdf

This book presents and discusses recent scientific progress on Cell and Stem Cell Engineering. It predominantly focuses on Biological, Physical and Technical Basics, and features new trends of research reaching far into the 21st century.

Author : Valentin I. Popa
Publisher : Walter de Gruyter GmbH & Co KG
Page : 496 pages
File Size : 53,9 Mb
Release : 2020-07-06
Category : Technology & Engineering
ISBN : 9783110659214

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Pulp Production and Processing by Valentin I. Popa Pdf

This book presents the aspects of cellulose obtained in correlation with its integration into the new concept of biorefining. The authors detail the individual steps of pulp manufacture as well as properties and fiber characterization techniques for paper, cellulose derivatives and processing by-products. This book is of interest to scientists and advanced students working in the fields of renewable resources and biorefining.

Author : Jose Luis Pedraz,Gorka Orive
Publisher : Springer Science & Business Media
Page : 167 pages
File Size : 47,6 Mb
Release : 2010-12-31
Category : Medical
ISBN : 9781441957863

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Therapeutic Applications of Cell Microencapsulation by Jose Luis Pedraz,Gorka Orive Pdf

The advancement of science is ever more contingent upon the interaction of experts vast amount of scientific information being gathered every day that exceeds the ability of any one scientist to acquire. As an illustration of the frantic pace of scientific disc- more acute in the case of scientific fields at the interface of different and seemingly distant areas of study. Amidst these, the field of cell encapsulation brings together an array of diverse disciplines such as molecular biology and biopolymers, gene therapy and inorganic membranes, stem cell biology and physicochemistry, immunology and nanotechnology. Clearly, such range of topics is too broad for any individual scientist the state-of-the-art in the field of cell encapsulation. At the core of this technology, there is an interaction of physicochemical and biological elements forming three distinct layers of complexity. First, the chemistry of the biopolymer dictates the degree of protein adsorption, vascularization, tox- ity and biocompatibility of the microcapsules. Advances in biopolymer science are providing solutions to overcome existing challenges and to improve microcapsules as delivery vehicles. Second, the choice of cells, and more precisely the plethora of in determining the immune response elicited by the host to implanted microcapsules.

Author : Rebecca Lim,Jessica E. Frith,Gina D. Kusuma,Christopher G. Sobey
Publisher : Frontiers Media SA
Page : 142 pages
File Size : 55,8 Mb
Release : 2021-02-03
Category : Science
ISBN : 9782889664481

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Stem Cells as Targeted Drug Delivery Vehicles by Rebecca Lim,Jessica E. Frith,Gina D. Kusuma,Christopher G. Sobey Pdf

Topic Editor RL is a patent inventor on exosome-related patents, PCT/AU2017/050821 and PCT/AU2016/050468. All other Topic Editors declare no competing interests with regards to the Research Topic subject.

Author : Nedal Abu-Thabit
Publisher : BoD – Books on Demand
Page : 292 pages
File Size : 49,6 Mb
Release : 2021-01-27
Category : Science
ISBN : 9781839683480

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Nano- and Microencapsulation by Nedal Abu-Thabit Pdf

Nano- or micro-encapsulation is used in many different fields and industries, including pharmaceuticals, cosmetics, food, and agrochemicals. It offers advantages for various applications, especially drug delivery. Nano-encapsulation can help extend and control the release of drugs as well as increase drug bioavailability and efficacy. It improves the precision of targeted drug delivery and allows for fabricating nano-encapsulated drugs for diagnostic and theranaostic applications. This book covers recent advances in fabricating nano-/micro-capsules using natural carriers for therapeutic and diagnostic drug delivery applications as well as rheology and formulations of micro-emulsions for diverse applications. This book is essential for scientists and researchers with diverse backgrounds in chemistry, engineering, material sciences, pharmaceuticals, and drug delivery.

Author : Severian Dumitriu
Publisher : CRC Press
Page : 1170 pages
File Size : 44,7 Mb
Release : 1998-05-12
Category : Science
ISBN : 0849335698

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Polysaccharides by Severian Dumitriu Pdf

Offers comprehensive coverage of the structural characterization of polysaccharides-emphasizing commercially available and potential exopolysaccharides as well as new applications. Presents the major chemical and physical properties of polysaccharides and derivatives.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 43,7 Mb
Release : 2024-06-30
Category : Electronic
ISBN : 9789814475815

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Artificial Cells by Anonim Pdf

Author : Thomas Ming Swi Chang
Publisher : World Scientific
Page : 482 pages
File Size : 47,7 Mb
Release : 2007
Category : Medical
ISBN : 9789812770370

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Artificial Cells by Thomas Ming Swi Chang Pdf

50th anniversary of artificial cells -- Basic principles -- Oxygen carriers based on nanobiotechnology -- A nanobiotechnologic therapeutic that transports oxygen and remove oxygen radicals: for stroke, hemorrhagic shock and related conditions -- Nanotechnology-based artificial red blood cells (RBC's) -- Use of enzyme artificial cells for genetic enzyme defects that increase systemic substrates to toxic levels -- Enzyme artificial cells in substrate-dependent tumors and activation of prodrug -- Artificial cells for cell encapsulation -- Artificial cells containing hepatocytes and/or stem cells in regenerative medicine -- Hemoperfusion in poisoning, kidney failure, liver failure, and immunology -- Perspectives on the future of artificial cells as suggested by past research.

Author : Thomas Ming Swi Chang,Binglan Yu
Publisher : Frontiers Media SA
Page : 148 pages
File Size : 40,5 Mb
Release : 2023-11-28
Category : Medical
ISBN : 9782832540022

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Innovative Medical Technology Based on Artificial Cells, Including its Different Configurations by Thomas Ming Swi Chang,Binglan Yu Pdf

Artificial Cells are not to reproduce biological cells but to prepare an artificial system for possible uses in medicine and other areas. Many of the ideas on artificial cells are being extensively applied and extended by researchers worldwide, resulting in rapid and exciting progress and discoveries. Different configurations include using emulsion methods and microfluidizers to form microscopic or nano dimension cells called artificial cells, synthetic cells, microcapsules, nanocapsules, liposomes, microparticles, nanoparticles, polymersomes, etc. Macro dimensions artificial cells are used for bioencapsulated cells. Soluble nanobiotherapeutics can be formed by crosslinking proteins and enzymes or by PEG conjugation. The principle of artificial cell has now evolved into nanomedicine, biotherapeutics, blood substitutes, drug delivery, enzyme/gene therapy, cancer therapy, cell/stem cell therapy, nanoparticles, liposomes, bioencapsulation, replicating synthetic cells, cell encapsulation, biosorbent/immunosorbent hemoperfusion/plasmapheresis, regenerative medicine, encapsulated microbe, COVID_19 vaccine, COVID_19 therapy, nanobiotechnology, nanotechnology and other areas.

Author : Emmanuel C. Opara
Publisher : Humana
Page : 0 pages
File Size : 48,5 Mb
Release : 2016-10-14
Category : Science
ISBN : 1493963627

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Cell Microencapsulation by Emmanuel C. Opara Pdf

This volume provides a unique forum to review cell microencapsulation in a broad sense by exploring various cell types that have been encapsulated for different purposes, different approaches and devices used for microencapsulation, the biomaterials used in cell microencapsulation, the challenges to the technology, and the current status of its application in different clinical situations. This book is divided in five sections: Section I is an introductory part that discusses historical developments of the technology and its current challenges, as well as the various applications of cell microencapsulation; Section II discusses the main approaches and devices currently used in cell microencapsulation; Section III presents an overview of the various polymeric materials currently in use for cell microencapsulation and the enabling technologies to either monitor or enhance encapsulated cell function; Section IV gives specific examples of the methods used to encapsulate various cell types; and Section V provides an overview of the different clinical situations in which cell microencapsulation has been applied. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and practical, Cell Microencapsulation: Methods and Protocols is a valuable reference for researchers, engineers, clinicians, and other healthcare professionals, as well as food technologists who will find detailed descriptions of methods for the microencapsulation of specific cell types and their current of potential clinical and industrial applications. This volume also includes detailed information about the design and manufacture of different devices including large-scale production devices for use in cell microencapsulation.

Author : M. Raafat El-Gewely
Publisher : Elsevier
Page : 422 pages
File Size : 47,8 Mb
Release : 2006-08-08
Category : Science
ISBN : 9780080465463

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Biotechnology Annual Review by M. Raafat El-Gewely Pdf

Biotechnology is a diverse, complex and rapidly evolving field. Students and experienced researchers alike face the challenges of staying on top of developments in their field of specialty and maintaining a broader overview of the field as a whole. Volumes containing competent reviews on a diverse range of topics in the field fulfill the dual role of broadening and updating biotechnologists’ knowledge. The current volume is an excellent example of such a book. The topics covered range from classical issues in biotechnology - such as, recent advances in all-protein chromophore technology- to topics that are focused on coencapsulation of hepatocytes and bone marrow cell. The information presented in this book will therefore will be of great value to both experienced biotechnologists and biotechnologists in training. Includes over 80 illustrations and photographs Discusses the recent developments in biodegradable synthetic polymers Offers a detailed discussion on emerging options in protein bioseparation

Author : Guillermo R. Castro,Ashok Kumar Nadda,Tuan Anh Nguyen,Swati Sharma,Ram K. Gupta
Publisher : Elsevier
Page : 298 pages
File Size : 40,9 Mb
Release : 2022-09-30
Category : Technology & Engineering
ISBN : 9780323913973

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Smart Nanomaterials for Bioencapsulation by Guillermo R. Castro,Ashok Kumar Nadda,Tuan Anh Nguyen,Swati Sharma,Ram K. Gupta Pdf

Smart Nanomaterials for Bioencapsulation focuses on the fundamentals, synthesis methods and matrix design for the encapsulation of drugs, drug release, food and nutraceuticals, mechanisms of nano- encapsulated drugs on liposomes, micelles, silica composites, carbon nanotubes, dendrimers, and protein inorganic nanohybrids. Providing detailed information on the encapsulation of food and drug derivatives, the book helps create new and modern approaches for both pharmaceutical and nutritional science. The target delivery of pharmacological agents, as well as food additives under various conditions is covered, including sections on systemic release of drug molecules, minimum loss at non-target sites, the accumulation of diseased tissue or organs, and more. Smart nanomaterial-based nanocarriers protect the loaded molecules from premature degradation in the biological environment and enhance bioavailability for cellular uptake. The tuned properties of smart nanomaterials, such as porosity, pore-volume, surface area-to-volume ratio, coating with inert and labile materials, and more help determine the in vivo performance of the bioencapsulated food and drug derivatives. Outlines the major design principles surrounding the encapsulation of drugs, drug release, food and nutraceuticals at the nanoscale Discusses the pros and cons of different bioencapsulation methods for different application areas Outlines the major challenges of applying nanobioencapsulation at an industrial scale