Complement Regulatory Proteins

Author : B. Paul Morgan,Andrew L. Harris
Publisher : Academic Press
Page : 382 pages
File Size : 52,5 Mb
Release : 1999-02-18
Category : Medical
ISBN : 0080529569

Get Book

Complement Regulatory Proteins by B. Paul Morgan,Andrew L. Harris Pdf

From small beginnings in the early 1970s, the study of complement regulatory proteins has grown in the last decade to the point where it dominates the complement field. This growth has been fueled by the discovery of new regulators, the cloning of old and new regulators, the discovery that many of the regulators are structurally and evolutionarily related to each other and the development of recombinant forms for use in therapy. There are now more proteins known to be involved in controlling the complement system than there are components of the system and the list continues to grow. The time is ripe for a comprehensive review of our current knowledge of these intriguing proteins. This book does just that. The first few chapters discuss the "nuts-and-bolts" of the complement regulators, describing their structures, functional roles and modes of action. The roles of the complement regulators in vivo are then described, focusing on the consequences of deficiency, roles in the reproductive system, interactions with pathogens and exploitation for therapy. The interesting developments in defining the complement regulators expressed in other species are also discussed. The book is written as a monograph, albeit by two people. The text is as readable as possible without compromising on scientific accuracy and completeness. The conversational style very evident in some sections is deliberate! Placing all references in a single bibliography at the end of the text further improves readability. The reader will go to the book to discover a specific fact but be persuaded to read more and derive pleasure from the process. The authors' enthusiasm for the subject comes over strongly in the text, and this enthusiasm proves infectious. Complement regulators--structure, functional roles and mode of action Comprehensive reviews of each of the individual regulators Roles of Complement regulators in vivo,in health and disease: Consequences of deficiency Roles in the reproductive system Interactions with pathogens Exploitation for therapy Complement regulators in other species

Author : Janos Szebeni
Publisher : Springer Science & Business Media
Page : 565 pages
File Size : 55,6 Mb
Release : 2007-05-08
Category : Medical
ISBN : 9781402080562

Get Book

The Complement System by Janos Szebeni Pdf

As a phylogenetically old system complement is now regarded as a part of innate immunity. But it is much more than that. It bridges innate and adapted immunity, participates not only in host defense but also in many essential physiological processes, old and new diseases and adverse conditions. Indeed, complement became a term that almost defies categorization. What was for a long time a subject for a limited number of specialists has now moved into the mainstream of experimental and clinical immunology. In 1973 I visited the Basel Institute of Immunology and met its director, the eminent scientist and Nobel laureate Nils Jerne. When I entered his office he greeted me with the following words: “Complement, does that really exist?” I was never certain whether he wanted only to tease me or whether he sincerely believed that the complement system was an unimportant biological curiosity, a misstep of evolution. But, of course, missteps do not survive the evolutionary process. Little did I foresee the dramatic developments of recent years when Hans J. Müller-Eberhard and I started to unravel the specifics of the action of the cobra venom factor on the complement system in 1968 and defined a new pathway to its activation. An elucidation of the role of the system in diseases and its control for therapeutic reasons is now getting closer to actual realization in the clinic although many problems, in particular those of highly specificinhibition free of side effects, have still to be resolved.

Author : Marcel Christian Pasch
Publisher : Unknown
Page : 125 pages
File Size : 46,5 Mb
Release : 2000
Category : Electronic
ISBN : 9090135707

Get Book

Regulation of Expression of Complement Components, Complement Regulatory Proteins, and Chemokines in Keratinocytes by Marcel Christian Pasch Pdf

Author : John D. Lambris
Publisher : Springer Science & Business Media
Page : 254 pages
File Size : 43,6 Mb
Release : 2013-03-12
Category : Medical
ISBN : 9783642749773

Get Book

The Third Component of Complement by John D. Lambris Pdf

The third component of complement, C3, is one of the most versatile proteins and an important participant in immune surveillance and immune response pathways. Its multifunctio nality is based on its ability to interact specifically with multiple serum complement proteins, cell surface receptors, and mem brant;-associated regulatory proteins. One of its most intriguing strategies of interaction with cell surfaces is the covalent binding of activated C3 through the internal thioester. The field has expanded over the past 10 years and a wealth of information has accumulated. C3 from various species and many of the human C3 binding proteins have been cloned and expressed. Numerous cellular responses mediated by the diffe rent fragments of C3 have been described. The findings that C3 interacts in a ligand-receptor-like fashion with proteins of nonself origin such as the gC of herpes simplex virus, a 70-kDa protein from Candida albicans, proteins from Epstein-Barr virus, etc. has opened a new field of investigation. The papers assembled in this volume summarize the wealth of data on the various aspects of the C3 interactions; together they bring to the reader new information on the chemistry, molecular gene tics, biology, and pathophysiology of C3 and C3-binding proteins. Emphasis is given to structural features as they relate to functions. Spring 1989 JOHN D. LAMBRIS, HANS J. MULLER-EBERHARD Table of Contents J. E. VOLANAKIS: Participation of C3 and Its Ligands in Complement Activation . . . . . . . . . . . 1 S. R. BARNUM, G. FEY, and B. F. TACK: Biosynthesis and Genetics of C3 . . . . . . . . . . . . .

Author : B. Paul Morgan
Publisher : Unknown
Page : 128 pages
File Size : 40,6 Mb
Release : 1999-01-01
Category : Science
ISBN : 0412133814

Get Book

Human Complement Regulatory Molecules by B. Paul Morgan Pdf

Author : Barbara Rolfe,Ruben Pio,Trent M. Woodruff,Maciej M. Markiewski,Helga D. Manthey
Publisher : Frontiers Media SA
Page : 107 pages
File Size : 54,8 Mb
Release : 2020-03-23
Category : Electronic
ISBN : 9782889635764

Get Book

The Role of Complement in Tumors by Barbara Rolfe,Ruben Pio,Trent M. Woodruff,Maciej M. Markiewski,Helga D. Manthey Pdf

Author : Charles J. Parker
Publisher : Springer Science & Business Media
Page : 193 pages
File Size : 51,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642770142

Get Book

Membrane Defenses Against Attack by Complement and Perforins by Charles J. Parker Pdf

In this volume a comprehensive review of membrane proteins that regulate complement and perforin-mediated cytolysis is presented. A detailed analysisis provided of the biochemical, molecular, and functional features of these proteins; the glycosyl phosphatidylinositol linked proteins are covered, with emphasis placed on the functional importance of this type of membrane anchor. Further chapters include reviews of the effects of complement activation on cells that are metabolically active, and of the regulation of cell killing by cytotoxic lymphocytes, considering the similarities and disparities between the complement and perforin systems. The therapeutic use of recombinant CR1 for immune-mediated pathophysiological processes is discussed in a separate section.

Author : Scott R. Barnum
Publisher : Academic Press
Page : 237 pages
File Size : 53,5 Mb
Release : 1999-10-28
Category : Medical
ISBN : 9780080529554

Get Book

The Complement FactsBook by Scott R. Barnum Pdf

The Complement FactsBook contains entries on all components of the Complement System, including C1q and Lectins, C3 Family, Serine Proteases, Serum Regulators of Complement Activation, Cell Surface Proteins, and Terminal Pathway Proteins. Domain Structure diagrams are incorporated to clearly illustrate the relationships between all the complement proteins, both within families and between families. The FactsBook also includes the cDNA sequences, marked with intron/exon boundaries, which will facilitate genetic studies. Includes the cDNA sequences, marked with intron/exon boundaries, facilitating genetic studies Presents detailed structural information including cDNA and gene structure for all proteins Introduces complement function, simply described for each function Data is as up-to-date as possible, including unpublished work from many contributors Incorporates domain structures diagrams, which beautifully illustrate the relationship between all the complement proteins, both within, and between, familiesEach chapter has been written by an expert in the field Data is as up-to-date as possible, including unpublished work from many contributors Entries provide information on: Alternative nomenclature, Physiochemical properties, Structure and function, Tissue distribution and regulation expression, Protein sequence/modules, Chromosomal location, Genomic structure, Database accession numbers, Deficiency and polymorphic variants, Key references

Author : Ulrich Dirnagl,Bernd Elger
Publisher : Springer Science & Business Media
Page : 248 pages
File Size : 40,6 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9783662054260

Get Book

Neuroinflammation in Stroke by Ulrich Dirnagl,Bernd Elger Pdf

The successful treatment of acute stroke remains one of the major challenges in clinical medicine. Over the last decades, the understanding of stroke pathophysiology has greatly improved, while the therapeutic options in stroke therapy remain very limited. Today, hyperacute mechanisms of damage, such as excitotoxicity, can be discriminated from delayed ones, such as inflammation and apoptosis. Targeting of inflammation has already been successfully applied in various stroke models, but translation into a clinically efficacious strategy has not been achieved so far. In this book, leading experts in basic cerebrovascular research as well as stroke treatment review the current evidence for and against an important role for inflammation in stroke, and explore the potential of treating or modulating inflammation in stroke therapy.

Author : M. Benczur,Anna Erdei,A. Falus,G. Füst,G.A. Medgyesi,G.G. Petranyi,Eva Rajnavölgyi
Publisher : Springer
Page : 926 pages
File Size : 42,9 Mb
Release : 2013-12-21
Category : Medical
ISBN : 9783642514791

Get Book

Progress in Immunology Vol. VIII by M. Benczur,Anna Erdei,A. Falus,G. Füst,G.A. Medgyesi,G.G. Petranyi,Eva Rajnavölgyi Pdf

At this congress there were again numereous reports of progress in immunology. The new technologies are continuing to have an immense impact: gene isolation, mutation, transfection and expression, protein structure andpeptide synthesis, cell cloning, hybridization and monoclonal antibodies, CD serology, SCID and transgenic mice, modern immunomodulation and vaccines. A trmendous mass of data has accumulated over the last years. The reports are up-to-date and outstanding,to a degree no journal will ever achieve, and the results are presented in a concise and lucid way. This report will serve as a guideline for the years to came, because it is a treasure trove of explorations, making it exciting reading. This progress presents outstanding contributions. Immunology is exhibited at its best: an exciting research area and a rewarding subject to study for the benefit of mankind - today more than ever.

Author : Gene V. Ball,Barri J. Fessler,S. Louis Bridges
Publisher : Oxford University Press, USA
Page : 690 pages
File Size : 50,6 Mb
Release : 2014
Category : Medical
ISBN : 9780199659869

Get Book

Oxford Textbook of Vasculitis by Gene V. Ball,Barri J. Fessler,S. Louis Bridges Pdf

A comprehensive review of inflammatory syndromes and diseases that affect the blood vessels, this volume draws upon authors from all over the world to present informed discussions on all types of vasculitis and related conditions.

Author : Holger Heine
Publisher : Springer Science & Business Media
Page : 248 pages
File Size : 52,5 Mb
Release : 2007-12-07
Category : Science
ISBN : 9783540739302

Get Book

Innate Immunity of Plants, Animals and Humans by Holger Heine Pdf

This book has been cunningly designed to provide an overview of our current knowledge about the innate immune systems of these three types of organisms. It not only covers the innate immune mechanisms and responses of such diverse organisms as plants, Cnidaria, Drosophila, urochordates and zebrafish, but also the major receptor systems in mammalians and humans. It delves too into the central defense mechanisms, antimicrobial peptides and the complement system.

Author : Peter F Zipfel
Publisher : Springer Science & Business Media
Page : 236 pages
File Size : 46,5 Mb
Release : 2006-03-09
Category : Medical
ISBN : 9783764374280

Get Book

Complement and Kidney Disease by Peter F Zipfel Pdf

The understanding how complement relates to glomerular diseases has evolved considerably during the last years. Substantial evidence has accumulated that explain how a defective or deregulated complement system results in kidney diseases. The combination and close interaction of basic research with clinical medicine has demonstrated an important role of complement effector and regulatory proteins in pathological settings of the kidney. A large panel of distinct human kidney diseases such as hemolytic uremic syndrome (HUS), membrano proliferative glomerulonephritis (MPGN), systemic lupus erythematosus (SLE) and in ischemic reperfusions injury and transplantation are caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms already allowed to establish new diagnostic and novel promising therapeutic approaches for several human kidney diseases.

Author : John D. Lambris
Publisher : Springer
Page : 251 pages
File Size : 44,8 Mb
Release : 2011-12-09
Category : Medical
ISBN : 364274978X

Get Book

The Third Component of Complement by John D. Lambris Pdf

The third component of complement, C3, is one of the most versatile proteins and an important participant in immune surveillance and immune response pathways. Its multifunctio nality is based on its ability to interact specifically with multiple serum complement proteins, cell surface receptors, and mem brant;-associated regulatory proteins. One of its most intriguing strategies of interaction with cell surfaces is the covalent binding of activated C3 through the internal thioester. The field has expanded over the past 10 years and a wealth of information has accumulated. C3 from various species and many of the human C3 binding proteins have been cloned and expressed. Numerous cellular responses mediated by the diffe rent fragments of C3 have been described. The findings that C3 interacts in a ligand-receptor-like fashion with proteins of nonself origin such as the gC of herpes simplex virus, a 70-kDa protein from Candida albicans, proteins from Epstein-Barr virus, etc. has opened a new field of investigation. The papers assembled in this volume summarize the wealth of data on the various aspects of the C3 interactions; together they bring to the reader new information on the chemistry, molecular gene tics, biology, and pathophysiology of C3 and C3-binding proteins. Emphasis is given to structural features as they relate to functions. Spring 1989 JOHN D. LAMBRIS, HANS J. MULLER-EBERHARD Table of Contents J. E. VOLANAKIS: Participation of C3 and Its Ligands in Complement Activation . . . . . . . . . . . 1 S. R. BARNUM, G. FEY, and B. F. TACK: Biosynthesis and Genetics of C3 . . . . . . . . . . . . .

Author : G. Opelz,W.A. Buurman,J.P. van Hooff,P. MacMaster,J. Wallwork
Publisher : Springer Science & Business Media
Page : 733 pages
File Size : 51,9 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9783642774232

Get Book

Transplant International Official Journal of the European Society for Organ Transplantation by G. Opelz,W.A. Buurman,J.P. van Hooff,P. MacMaster,J. Wallwork Pdf

This supplement to Transplant International contains the Proceedings of the successful 5th Congress of the European Society for Organ Transplantation held in Maastricht from 7-10 October 1991. Of 827 abstracts submitted to the congress, 548 were selected by the Scien tific Committee for either oral or poster presentation. Of these 548 presenta tions, the guest editors selected 212 full papers for publication in this book. Two aspects are important where proceedings are concerned-the quality of the papers and the speed of publication. I thank our authors and guest editors, whose combined expertise has given us a guarantee of quality. I also thank our editorial and production teams for their tremendous efforts to hasten editing, proofreading, printing, and publication. In particular, I would like to express my gratitude to Maurits Booster, M.D., and Sylvia van Roosmalen for their assist ance and support in seeing this supplement through to completion. As a concession to time, we have waived some of our stringent rules of style and limited our correspondence with authors by, for example, page proofs being reviewed and corrected in house only. This enables us to publish two months earlier but has the disadvantage that, given the allotted time, we have not been able to ensure that each and every article has an abstract, nor that every "i" has been dotted in the reference lists or in the addresses/institute affiliations of all the authors.