Intercellular Communication In Cancer

Author : Mustapha Kandouz
Publisher : Springer
Page : 366 pages
File Size : 52,5 Mb
Release : 2015-11-20
Category : Medical
ISBN : 9789401773805

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Intercellular Communication in Cancer by Mustapha Kandouz Pdf

Cells are by nature compelled to live in groups. They develop dependence over signaling cues received from their microenvironment, in particular from other cells, whether of their own “kind” or of a different type. Therefore, communicating with these cells is a critical aspect of their behavior and fate, as they live and die normally or as they undergo disease-related pathological changes, with dramatic repercussions. In this book, we have asked expert researchers in the field of Intercellular Communication in Cancer to provide chapters on different aspects of interaction between neighboring cells, in the context of cancer diseases. We have specifically focused our efforts on membrane-to-membrane contact-based rather than growth factors-mediated modes of intercellular communications. The contributing authors provide an extensive overview of their respective area of specialization, with an in-depth discussion of the molecular mechanisms of cell-cell interactions, the impact on tumor progression and response to therapies, as well as the cancer diagnostic value of this scientific information. This book aims to introduce essential aspects of the normal and pathological cellular fate and homeostasis to both scientists and clinicians, and also to provide established researchers with an update on the novelties and future directions this expanding field is witnessing.

Author : Mustapha Kandouz
Publisher : Unknown
Page : 128 pages
File Size : 51,5 Mb
Release : 2015
Category : Electronic
ISBN : 9401773815

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Intercellular Communication in Cancer by Mustapha Kandouz Pdf

Cells are by nature compelled to live in groups. They develop dependence over signaling cues received from their microenvironment, in particular from other cells, whether of their own "kind" or of a different type. Therefore, communicating with these cells is a critical aspect of their behavior and fate, as they live and die normally or as they undergo disease-related pathological changes, with dramatic repercussions. In this book, we have asked expert researchers in the field of Intercellular Communication in Cancer to provide chapters on different aspects of interaction between neighboring cells, in the context of cancer diseases. We have specifically focused our efforts on membrane-to-membrane contact-based rather than growth factors-mediated modes of intercellular communications. The contributing authors provide an extensive overview of their respective area of specialization, with an in-depth discussion of the molecular mechanisms of cell-cell interactions, the impact on tumor progression and response to therapies, as well as the cancer diagnostic value of this scientific information. This book aims to introduce essential aspects of the normal and pathological cellular fate and homeostasis to both scientists and clinicians, and also to provide established researchers with an update on the novelties and future directions this expanding field is witnessing.

Author : Huang-Ge Zhang
Publisher : Springer Science & Business Media
Page : 223 pages
File Size : 44,6 Mb
Release : 2012-09-06
Category : Medical
ISBN : 9781461436973

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Emerging Concepts of Tumor Exosome–Mediated Cell-Cell Communication by Huang-Ge Zhang Pdf

In multicellular organisms, communication between cells involves secretion of proteins that bind to receptors on neighboring cells. While this has been well documented, another mode of intercellular communication has recently become the subject of increasing interest: the release of exosomes. In cancer, tumor exosomes are involved in various aspects of pathogenesis, including proliferation, immunosuppression, and metastasis. Given the ability of exosomes to export unneeded endogenous molecules from cells, these structures hold great potential as anticancer therapeutic agents. They are also being studied as prognostic markers for cancer.

Author : Walmor DeMello
Publisher : Springer Science & Business Media
Page : 262 pages
File Size : 54,7 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781468422832

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Intercellular Communication by Walmor DeMello Pdf

Progress made in the last 20 years clearly indicates that the cell surface is an extremely dynamic structure involved in fundamental processes such as cell motility, innervation, and cell adhesion. Of particular interest is the finding that, in several tissues, the cell surface is differen tiated at the intercellular region, thereby providing communicating chan nels between apposing cells. Although our actual knowledge of the precise structures and mecha in the complex process of intercellular communication is still nisms involved scanty, evidence has been presented that ions and molecules diffuse from cell to cell, establishing a physiological continuum. Embryonic differentia tion, cell growth, neoplasia, electrical synchronization in nerve and mus cles, as well as immune response seem to be related to ceIl communication. In organizing this volume, it has been our intention to provide the reader with an actual review of the processes involved in intercellular communication in normal tissues as well as in neoplasia. We sincerely believe that the opinions and experiences described herein will be of help in establishing new perspectives for the future of this exciting new field of cell biology. We wish to thank all the colleagues who joined us in the organization of this volume, as well as Plenum Publishing Corporation for making its appearance possible.

Author : Anonim
Publisher : Springer
Page : 230 pages
File Size : 41,9 Mb
Release : 2012-09-07
Category : Electronic
ISBN : 1461436982

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Emerging Concepts of Tumor Exosome-Mediated Cell-Cell Communication by Anonim Pdf

Author : Paul Harris O'Lague
Publisher : Unknown
Page : 428 pages
File Size : 41,6 Mb
Release : 1969
Category : Cancer cells
ISBN : CORNELL:31924003156043

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An Electrophysiological and Scanning Electron Microscopic Investigation of Intercellular Communication Between Normal and Between Cancer Cells in Tissue Culture by Paul Harris O'Lague Pdf

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 44,9 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : H. Acker,J. Carlsson,R. Durand,R.M. Sutherland
Publisher : Springer Science & Business Media
Page : 328 pages
File Size : 55,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642823404

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Spheroids in Cancer Research by H. Acker,J. Carlsson,R. Durand,R.M. Sutherland Pdf

Malignant growth of cells is often characterized by disorganization of tissue structure, abnormal blood vessel development, and insuffi cient vascular supply. As a consequence, the cancer cells grow in a three-dimensional pattern in atypical microenvironments which include physical, chemical, and nutritional stresses. Necrosis often develops some distance away from the blood vessels. In association with an inherent instability in malignant cell populations, and also because of the changing micromilieu, significant cellular heteroge neity emerges with regard to various phenotypic characteristics. Both biological behavior and responses to therapeutic agents can be affected. A variety of in vitro and in vivo experimental models exist for research on properties of cancer cells during growth. The multicell spheroid model was developed as a system of intermediate complexity in which three dimensional growth of cells enhances cell-cell interactions and creates micro environments that simulate the conditions in intervascular microregions of tumors or microme tastatic foci. Spheroids may change their cellular characteristics with changing environments during growth. These can be studied under controlled conditions in vitro. Interest in details of experimental methods for this model system stimulated the organization of the First International Conference in Rochester, NY in 1980, the Proceedings of which were summarized in Cancer Research in 1981. Since then there has been a rapid increase in the use of this model system, and increased research on the significance of cell-cell and cell-microenvironment interactions in biology in general.

Author : Alecsandru Ioan Baba,Cornel Cătoi
Publisher : Unknown
Page : 787 pages
File Size : 50,7 Mb
Release : 2007
Category : Electronic books
ISBN : 9732714573

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Comparative Oncology by Alecsandru Ioan Baba,Cornel Cătoi Pdf

Author : Mansoor M. Amiji,Rajagopal Ramesh
Publisher : Academic Press
Page : 0 pages
File Size : 43,7 Mb
Release : 2018-05-11
Category : Medical
ISBN : 0128127740

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Diagnostic and Therapeutic Applications of Exosomes in Cancer by Mansoor M. Amiji,Rajagopal Ramesh Pdf

Diagnostic and Therapeutic Applications of Exosomes in Cancer evaluates the potential of exosome content manipulation in the development of novel therapeutics. In recent years, exosomes, the small vesicles produced by all cell types, have been identified as contributors to cancer growth and metastasis. However, due to their unique biophysical properties, they are also being tested for use in therapeutic design and delivery, as well as in diagnostics. This book presents a comprehensive analysis on exosomes, with a main emphasis on their biogenesis and signaling, use as biomarkers, and as tools for imaging, drug delivery and the treatment of cancer.

Author : Y. Kanno,K. Kataoka,Y. Shiba,Y. Shibata,T. Shimazu
Publisher : Newnes
Page : 474 pages
File Size : 53,5 Mb
Release : 1995-02-09
Category : Science
ISBN : 9780444599520

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Intercellular Communication through Gap Junctions by Y. Kanno,K. Kataoka,Y. Shiba,Y. Shibata,T. Shimazu Pdf

Research on intercellular communication through gap junctions has continued to expand, and the meeting on which this book is based brought together many scientists from many different countries and disciplines. In line with the objective of the meeting, this volume focuses on the biological meaning of intercellular communication through gap junctions in various organs. The most recent up-to-date findings have been included in this extensive volume, valuable to all those interested in this rapidly expanding field.

Author : Martha Robles-Flores
Publisher : Humana
Page : 300 pages
File Size : 43,7 Mb
Release : 2020-11-12
Category : Sports & Recreation
ISBN : 1071607588

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Cancer Cell Signaling by Martha Robles-Flores Pdf

This fully updated edition provides the most recent advances in cancer cell signaling knowledge combined with some discussion of the current challenges and prospects in cancer therapy. Beginning with an important section on cancer resistance, the main obstacle to effective cancer therapy, the book continues with chapters exploring state-of-the-art methods in epigenetic control of cancer, metastasis promotion, as well as a variety of new technologies in the study of cancer. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and timely, Cancer Cell Signaling: Methods and Protocols, Third Edition serves as an ideal guide to researchers seeking to overcome the challenges in the vital field of cancer cell signaling.

Author : Hong-Gang Wang
Publisher : Springer Science & Business Media
Page : 267 pages
File Size : 51,6 Mb
Release : 2013-03-30
Category : Medical
ISBN : 9781461465614

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Autophagy and Cancer by Hong-Gang Wang Pdf

With the explosion of information on autophagy in cancer, this is an opportune time to speed the efforts to translate our current knowledge about autophagy regulation into better understanding of its role in cancer. This book will cover the latest advances in this area from the basics, such as the molecular machinery for autophagy induction and regulation, up to the current areas of interest such as modulation of autophagy and drug discovery for cancer prevention and treatment. The text will include an explanation on how autophagy can function in both oncogenesis and tumor suppression and a description of its function in tumor development and tumor suppression through its roles in cell survival, cell death, cell growth as well as its influences on inflammation, immunity, DNA damage, oxidative stress, tumor microenvironment, etc. The remaining chapters will cover topics on autophagy and cancer therapy. These pages will serve as a description on how the pro-survival function of autophagy may help cancer cells resist chemotherapy and radiation treatment as well as how the pro-death functions of autophagy may enhance cell death in response to cancer therapy, and how to target autophagy for cancer prevention and therapy − what to target and how to target it. ​

Author : Gesellschaft zur Bekämpfung der Krebskrankheiten Nordrhein-Westfalen
Publisher : Unknown
Page : 384 pages
File Size : 42,9 Mb
Release : 1980
Category : Cancer
ISBN : UCLA:31158006337579

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Metastatic Tumor Growth by Gesellschaft zur Bekämpfung der Krebskrankheiten Nordrhein-Westfalen Pdf

Author : Rahul Jandial
Publisher : CRC Press
Page : 312 pages
File Size : 50,6 Mb
Release : 2013-08-08
Category : Medical
ISBN : 1587066599

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Metastatic Cancer: Clinical and Biological Perspectives by Rahul Jandial Pdf

Most cancer deaths are a result of metastasis. The spread of a primary tumor to colonize neighboring and distant organs is the relentless endgame that defines the neoplastic process. Patients who have been diagnosed with cancer are treated to prevent both the recurrence of the tumor at the site of origin and metastasis that would re-stage them as advanced stage IV cancer. Historically and still with some types of cancer, stage IV is perceived by patients as “terminal.” Fortunately, recent molecular therapies have extended the lives of patients with advanced cancer and reassuringly people living with metastatic disease increasingly visit our clinics. What is the path forward? Given that the consilience of science and medicine is a dynamic art from which therapies arise, it would be misguided to consider any single work adequate at capturing the horizon for research. So with humility we constructed this text as primer for scientists. It begins with a broad introduction to the clinical management of common cancers. This is intended to serve as a foundation for investigators to consider when developing basic science hypotheses. Unquestionably, medical and surgical care of cancer patients reveals biology and dictates how novel therapeutics will ultimately be evaluated in clinical trials. The second section of this text offers provocative and evolving insights that underscore the breadth of science involved in the elucidation of cancer metastasis biology. The text concludes with information that integrates scientific and clinical foundations to highlight translational research. This book serves as a framework for scientists to conceptualize clinical and translational knowledge on the complexity of disease that is metastatic cancer.