Dna Topoisomerases In Cancer

Author : Toshiwo Andoh
Publisher : Springer Science & Business Media
Page : 208 pages
File Size : 49,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461501411

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DNA Topoisomerases in Cancer Therapy by Toshiwo Andoh Pdf

In the mid 80's type I and II enzymes were found to be the intracellular targets of a number of efficacious anticancer drugs such as doxorubicin, mitoxantrone, etoposide and camptothecin as a result of a continued efforts of many investigators, especially Leroy Liu and his collaborators at Johns Hopkins University. Readers will find a series of chapters written by researchers actively engaged in the expanding field of topoisomerase and their inhibitors. The series of chapters cover review articles on pharmacology and the molecular mechanism of topoisomerase I- and II-targeting anticancer drugs in mammals and in the yeast Saccharomyces cerevisiae, which has proved to be a superb model organism for studies of anticancer drugs. This volume compiles up-to-date information on the topoisomerase-targeting compounds in clinical and preclinical development as a useful and important reference book for students and researchers in the field of pharmacology, toxicology, oncology and molecular biology.

Author : Yves Pommier
Publisher : Springer Science & Business Media
Page : 443 pages
File Size : 41,8 Mb
Release : 2011-09-21
Category : Medical
ISBN : 9781461403234

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DNA Topoisomerases and Cancer by Yves Pommier Pdf

DNA topoisomerases represent an essential family of DNA processing enzymes and a large number of topoisomerase inhibitors are used clinically for the treatment of various human cancers. Novels drugs are in clinical development both against type I and type II topoisomerases. The book will include basic biochemical and structural reviews for the cancer-relevant topoisomerases. It will describe how topoisomerase dysfunctions can damage the genome and increase the risk of cancers, and the involvement of topoisomerases in programmed cell death. The book will also present the various topoisomerase inhibitors in clinical use and development and their molecular and cellular mechanisms of action.

Author : Milan Potmesil,Kurt W. Kohn
Publisher : Oxford University Press, USA
Page : 364 pages
File Size : 44,8 Mb
Release : 1991
Category : Medical
ISBN : UOM:39015022015427

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DNA Topoisomerases in Cancer by Milan Potmesil,Kurt W. Kohn Pdf

DNA Topoisomerases are a unique class of enzymes that are responsible for the control and modification of DNA topology (tertiary structure); one example of their function is the transformation of chromosomes from a supercoiled condensed state to uncoiled strands and vice versa. They are of interest both for their intrinsic role in cell biology (i.e. control of cell division) and also because some anticancer drugs, such as camptothecin, act by inhibiting their action.

Author : Anonim
Publisher : Unknown
Page : 456 pages
File Size : 50,9 Mb
Release : 2011-09-21
Category : Electronic
ISBN : 1461403243

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DNA Topoisomerases and Cancer by Anonim Pdf

Author : Anonim
Publisher : Unknown
Page : 162 pages
File Size : 52,5 Mb
Release : 1987
Category : Antineoplastic agents
ISBN : UCR:31210007091620

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First Conference on DNA Topoisomerases in Cancer Chemotherapy by Anonim Pdf

Author : Toshiwo Andoh,Masao Oguro,Hideo Ikeda
Publisher : CRC Press
Page : 400 pages
File Size : 41,7 Mb
Release : 1992-10-26
Category : Medical
ISBN : 0849349702

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Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy by Toshiwo Andoh,Masao Oguro,Hideo Ikeda Pdf

Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy is based on conference proceedings from the International Symposium on DNA Topoisomerases in Chemotherapy, held in Nagoya, Japan, in November 1991. The book opens with a discussion of the structural and functional properties of various types of DNA topoisomerases identified in prokaryotes and eukaryotes, in addition to their roles as cellular targets of anticancer and antimicrobial agents. Other topics addressed include the genetics and biology of DNA topoisomerases, inhibitors of microbial DNA topoisomerases and drug resistance, inhibitors of mammalian DNA topoisomerases and drug resistance, and preclinical and clinical studies of DNA topoisomerase inhibitors. Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy will broaden the understanding of biology and genetics of DNA topoisomerases and contribute to the development of antimicrobial and anticancer agents-inhibitors of topoisomerases. It will be invaluable for oncologists, molecular biologists, cellular biologists, geneticists, biochemists, and pharmaceutical researchers.

Author : Duncan J. Clarke
Publisher : Methods in Molecular Biology
Page : 288 pages
File Size : 55,8 Mb
Release : 2009-09-25
Category : Medical
ISBN : UOM:39015075686447

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DNA Topoisomerases by Duncan J. Clarke Pdf

DNA topoisomerases and gyrases have been studied thoroughly from a biochemical perspective, and expanding research at the molecular and cellular level shows great promise. This book gives a compendium of protocols that extends into such new areas of research.

Author : Mark R. Kelley,Melissa L. Fishel
Publisher : Academic Press
Page : 464 pages
File Size : 41,7 Mb
Release : 2016-06-07
Category : Medical
ISBN : 9780128035993

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DNA Repair in Cancer Therapy by Mark R. Kelley,Melissa L. Fishel Pdf

DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment. Experts on DNA repair proteins from all areas of cancer biology research take readers from bench research to new therapeutic approaches. This book provides a detailed discussion of combination therapies, in other words, how the inhibition of repair pathways can be coupled with chemotherapy, radiation, or DNA damaging drugs. Newer areas in this edition include the role of DNA repair in chemotherapy induced peripheral neuropathy, radiation DNA damage, Fanconi anemia cross-link repair, translesion DNA polymerases, BRCA1-BRCA2 pathway for HR and synthetic lethality, and mechanisms of resistance to clinical PARP inhibitors. Provides a comprehensive overview of the basic and translational research in DNA repair as a cancer therapeutic target Includes timely updates from the earlier edition, including Fanconi Anemia cross-link repair, translesion DNA polymerases, chemotherapy induced peripheral neuropathy, and many other new areas within DNA repair and cancer therapy Saves academic, medical, and pharma researchers time by allowing them to quickly access the very latest details on DNA repair and cancer therapy Assists researchers and research clinicians in understanding the importance of the breakthroughs that are contributing to advances in disease-specific research

Author : Anonim
Publisher : Academic Press
Page : 337 pages
File Size : 55,9 Mb
Release : 1994-11-07
Category : Science
ISBN : 9780080581200

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DNA Topoisomearases: Biochemistry and Molecular Biology by Anonim Pdf

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.

Author : Bruce A. Chabner,Dan L. Longo
Publisher : Lippincott Williams & Wilkins
Page : 836 pages
File Size : 53,7 Mb
Release : 2011-12-07
Category : Medical
ISBN : 9781451148206

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Cancer Chemotherapy and Biotherapy by Bruce A. Chabner,Dan L. Longo Pdf

Updated to include the newest drugs and those currently in development, this Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition's introduction includes timely information on general strategies for drug usage, the science of drug discovery and development, economic and regulatory aspects of cancer drug development, and principles of pharmacokinetics. Eight new chapters have been added and more than twenty have been significantly revised. A companion website includes the fully searchable text and an image bank.

Author : Andrew D. Bates,Anthony Maxwell
Publisher : Oxford University Press, USA
Page : 224 pages
File Size : 46,7 Mb
Release : 2005
Category : Science
ISBN : 019856709X

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DNA Topology by Andrew D. Bates,Anthony Maxwell Pdf

"A key aspect of DNA is its ability to form a variety of structures, this book explains the origins and importance of such structures"--Provided by publisher.

Author : James C. Wang
Publisher : Unknown
Page : 252 pages
File Size : 48,9 Mb
Release : 2009
Category : DNA topoisomerases
ISBN : UOM:39015080851556

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Untangling the Double Helix by James C. Wang Pdf

The problem of unraveling two intertwined strands during the duplication of DNA was recognized shortly after the proposal of the DNA double helix structure in 1953. A group of enzymes called DNA topoisomerases solve this problem by breaking and rejoining DNA molecules in a controlled manner, thereby allowing strands to be passed through each other and thus untangled—not just during DNA replication, but also during many other basic cellular processes. Because of their intimate involvement in the workings of the cell, topoisomerases are also the logical targets of many antibiotics (including Cipro) and anticancer agents. This book, written by James Wang, the discoverer of the first topoisomerase and a leader in the field since, presents ten chapters covering the historical backdrop of the DNA entanglement problem and the discovery of the DNA topoisomerases, how DNA topoisomerases perform their magic in DNA replication, transcription, genetic recombination and chromosome condensation, and how they are targets of therapeutic agents. The book should appeal to readers from undergraduates upwards with interests in the biological and clinical aspects of topoisomerase function, or in the mathematics and physics of topology.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 43,8 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Anonim
Publisher : Unknown
Page : 149 pages
File Size : 46,8 Mb
Release : 1987
Category : Antineoplastic agents
ISBN : OCLC:16664216

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First Conference on DNA Topoisomerases in Cancer Chemotherapy by Anonim Pdf

Author : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Publisher : World Health Organization
Page : 536 pages
File Size : 49,8 Mb
Release : 2000
Category : Health & Fitness
ISBN : UOM:39015054424513

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Some Antiviral and Antineoplastic Drugs, and Other Pharmaceutical Agents by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans Pdf

Evaluates the carcinogenic risks to humans posed by the use of four antiretroviral agents four DNA topoisomerase II inhibitors used in the treatment of cancer and an additional three pharmaceutical agents (hydroxyures phenolphthalein and vitamin K substances). The volume marks the first IARC evaluation of nucleoside analogs that act as antiviral agents. The evaluation responds in part to recent findings that zidovudine (AZT) an effective antiretroviral agent now being given to pregnant HIV-infected women to prevent maternal-to-fetal transmission of the virus is a transplacental carcinogen in mice. The opening monograph evaluates the carcinogenicity to humans of the antiretroviral nucleoside analogs zidovudine (AZT) zalcitabine (ddC) and didanosine (ddI) and the antiherpesvirus drug aciclovir. Of these aciclovir and didanosine could not be classified on the basis of available data. For zidovudine transplacental administration to mice resulted in an increased incidence and multiplicity of lung and liver tumours and in an increased incidence of female reproductive tract tumours in one study but not in another involving treatment at a lower dose. Despite observation of toxic effects in some studies of humans human carcinogenicity data were judged to provide inadequate evidence of carcinogenicity in humans. Zidovudine was classified as possibly carcinogenic to humans. Similar weaknesses in human carcinogenicity data for zalcitabine which consistently induces thymic lymphomas in mice resulted in its classification as possibly carcinogenic to humans. The second monograph evaluates four DNA topoisomerase II inhibitors: etoposide teniposide mitoxantrone and amsacrine. Of these etoposide - one of the most widely used and effective cytotoxic drugs in combination therapy - was classified as probably carcinogenic to humans and etoposide in combination with cisplatin and bleomycin was judged to be carcinogenic to humans. Teniposide was classified as probably carcinogenic to humans and mitoxantrone and amsacrine were classified as possibly carcinogenic to humans. Of the three pharmaceutical agents evaluated in the final monograph hydroxyurea which is widely used in cancer treatment and increasingly in combination with didanosine in HIV infection could not be classified. Phenolphthalein a widely used laxative now being withdrawn from the market in many countries because of toxicological concerns was classified as possibly carcinogenic. Vitamin K substances could not be classified on the basis of available evidence.