Drug Monitoring And Clinical Chemistry

Author : Georg Hempel
Publisher : Elsevier
Page : 379 pages
File Size : 43,6 Mb
Release : 2004-05-15
Category : Science
ISBN : 9780080530543

Get Book

Drug Monitoring and Clinical Chemistry by Georg Hempel Pdf

Drug Monitoring and Clinical Chemistry, the 5th volume in the Handbook of Analytical Separations series, gives an overview about methods to analyse drugs in biological fluids. The most widely used methods to analyse drugs in biological fluids. i.e. chromatographic methods, CE and immunoassays are described in detail. For important drugs, an overview about the methods available and a comparison of the techniques should be given to enable the reader to choose the right method depending on laboratory equipment, staff, the aim of the investigation etc. Other general aspects important for conducting therapeutic drug monitoring or pharmacokinetics studies are also covered, i.e. sample preparation, validation of the analytical methods and pharmacokinetic methods for interpreting the data. Areas where therapeutic drug monitoring is used frequently such as antibiotics, immunosuppressant drugs, antipsychotic and anticancer drugs will be discussed in detail. In addition, the important field of phenotyping and genotyping for therapy optimisation with special focus on real-life applications is also covered. The book contains important information for analyst working on drug analysis in clinical chemistry, hospital pharmacists involved in therapeutic drug monitoring, other pharmacists, chemists or physicians working on pharmacokinetic studies in industry or academia. In contrast to other books in this field, this book provides up-to-date information regarding both methodology and clinical applications. For the applications, only fields are described where therapeutic drug monitoring is used in clinical routine and provides benefit to the patients. Overview of all important field where therapeutic drug monitoring is applied All relevant analytical and computational methods are discussed Written by experts with a lot of practical experience in the field

Author : Amitava Dasgupta
Publisher : CRC Press
Page : 475 pages
File Size : 45,7 Mb
Release : 2009-10-06
Category : Medical
ISBN : 9781420067590

Get Book

Advances in Chromatographic Techniques for Therapeutic Drug Monitoring by Amitava Dasgupta Pdf

For drugs with a narrow therapeutic index, therapeutic drug monitoring methods are essential for patient management. Although immunoassays are commercially available for many drugs and most laboratories use these assays for routine therapeutic monitoring, they have many limitations which hinder their efficacy. Providing practical guidelines for imp

Author : William Clarke,Amitava Dasgupta
Publisher : Elsevier
Page : 376 pages
File Size : 47,7 Mb
Release : 2016-07-21
Category : Medical
ISBN : 9780128020524

Get Book

Clinical Challenges in Therapeutic Drug Monitoring by William Clarke,Amitava Dasgupta Pdf

Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics focuses on critical issues in therapeutic drug monitoring including special requirements of therapeutic drug monitoring important to special populations (infants and children, pregnant women, elderly patients, and obese patients). The book also covers issues of free drug monitoring and common interferences in using immunoassays for therapeutic drug monitoring. This book is essential reading for any clinician, fellow, or trainee who wants to gain greater insight into the process of therapeutic drug monitoring for individual dosage adjustment and avoiding drug toxicity for certain drugs within a narrow therapeutic window. The book is written specifically for busy clinicians, fellows, and trainees who order therapeutic drug monitoring and need to get more familiar with testing methodologies, issues of interferences, and interpretation of results in certain patient populations. Offers busy clinicians, pathologists, and trainees a concise resource on the key aspects and critical issues in therapeutic drug monitoring Focuses on patient populations such as infants and children, pregnant women, elderly patients, and obese patients, who have special requirements in therapeutic drug monitoring Explores special topics in therapeutic drug monitoring including free drug monitoring and common immunoassay interference Explains how individual dosage adjustments can prevent drug toxicity for certain drugs within a narrow therapeutic window

Author : Anonim
Publisher : Unknown
Page : 414 pages
File Size : 46,8 Mb
Release : 1982
Category : Chemotherapy
ISBN : UCLA:31158009743732

Get Book

Applied Therapeutic Drug Monitoring by Anonim Pdf

Author : Amitava Dasgupta,Matthew Krasowski
Publisher : Academic Press
Page : 382 pages
File Size : 48,6 Mb
Release : 2019-09-14
Category : Science
ISBN : 9780128158500

Get Book

Therapeutic Drug Monitoring Data by Amitava Dasgupta,Matthew Krasowski Pdf

Therapeutic Drug Monitoring Data: A Concise Guide, Fourth Edition serves as a ready resource of information on commonly monitored drugs that will help readers make decisions relating to the monitoring and interpretation of results. It is an easy-to-read source of information on intended use, pharmacokinetics, therapeutic range, and toxic concentrations, as well as bioavailability, disposition, metabolism and the excretion of commonly monitored therapeutic drugs. This fully updated fourth edition includes sections on new anticonvulsants, anti-depressant and anti-HIV drugs, new drugs for advanced cancer treatment, and thoroughly updated chapters that address new pitfalls and problems in the lab. Serves as a ready resource of information for commonly monitored drugs Presents a useful, quick guide for those making decisions related to monitoring and interpretation of results Provides concise, easily digestible content for clinical laboratory scientists, toxicologists and clinicians

Author : Mike Hallworth,Nigel Capps
Publisher : AACC Press
Page : 0 pages
File Size : 44,6 Mb
Release : 1993
Category : Biochemistry
ISBN : 0902429051

Get Book

Therapeutic Drug Monitoring and Clinical Biochemistry by Mike Hallworth,Nigel Capps Pdf

This text considers the close inter-relationship of therapeutic drug monitoring and clinical biochemistry. It covers principles of TDM, looking at drug dosage and effect; clinical monitoring and pharmacokinetics; interpretation and response; and near-patient testing. It also includes information on methodology, dosage prediction, drug structure, sampling requirements and target range. The drugs covered include anti-convulsants; aminoglycosides; lithium; anti-arrythmics; xanthines; cyclosporine; methotrexate; and tricyclics. The work also contains case studies.

Author : Daniel M. Baer,William R. Dito
Publisher : Unknown
Page : 418 pages
File Size : 54,7 Mb
Release : 1981
Category : Medical
ISBN : UOM:39015006016458

Get Book

Interpretations in Therapeutic Drug Monitoring by Daniel M. Baer,William R. Dito Pdf

Author : Therapeutic Drug Monitoring and Toxicology Laboratory Improvement Program Committee,American Association for Clinical Chemistry
Publisher : Amer Assn for Clinical Chemistry
Page : 143 pages
File Size : 40,7 Mb
Release : 1994-01-01
Category : Drug monitoring
ISBN : 0915274701

Get Book

Drug Monitoring Data Pocket Guide II by Therapeutic Drug Monitoring and Toxicology Laboratory Improvement Program Committee,American Association for Clinical Chemistry Pdf

The AACC DRUG MONITORING DATA POCKET GUIDE is an up-to-date, easy-to-use source of information on the most commonly measured therapeutic drugs in today's clinical laboratory. It provides a quick reference to drug pharmacokinetics, analysis & sample handling. References are provided for those needing more detail. The guide will be very useful for clinical scientists involved in therapeutic drug monitoring & as an education aid. 1994, 4 1/2 x 6 Softcover, ISBN 0-915274-70-1, $15, Order #625.

Author : Amitava Dasgupta
Publisher : Academic Press
Page : 469 pages
File Size : 55,5 Mb
Release : 2012-06-07
Category : Medical
ISBN : 9780123854681

Get Book

Therapeutic Drug Monitoring by Amitava Dasgupta Pdf

Therapeutic Drug Monitoring: Newer Drugs and Biomarkers features timely topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This reference also discusses the limitations of current commercially available immunoassays for therapeutic monitoring. It presents new and sophisticated techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs. Written by leading international experts and geared toward clinical pathologists, toxicologists, clinical chemists, laboratory professionals and physicians, this book is an essential resource on the current practice of therapeutic drug monitoring in improving patient safety. Includes both the technical and clinical issues associated with therapeutic drug monitoring Discusses the utility of therapeutic drug monitoring of newer drugs such as antiretroviral agents, anticonvulsants, antidepressants etc. Provides up-to-date information on issues in pharmacogenomics and personalized medicine with emphasis on therapy with warfarin, certain anticancer drugs and antidepressants Covers important content on the limitations of commercially available immunoassays (chemical tests) for therapeutic drug monitoring and additional analytical techniques

Author : Mike Hallworth,Ian D. Watson,Karen H. Poyser,Roy A. Sherwood
Publisher : Unknown
Page : 0 pages
File Size : 51,7 Mb
Release : 2008
Category : Biochemistry
ISBN : 0902429426

Get Book

Therapeutic Drug Monitoring and Laboratory Medicine by Mike Hallworth,Ian D. Watson,Karen H. Poyser,Roy A. Sherwood Pdf

Author : Seth Kwabena Amponsah,Yashwant V. Pathak
Publisher : Springer Nature
Page : 384 pages
File Size : 45,7 Mb
Release : 2022-10-25
Category : Medical
ISBN : 9783031123986

Get Book

Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology by Seth Kwabena Amponsah,Yashwant V. Pathak Pdf

This book gives an overview of therapeutic drug monitoring (TDM) and its clinical application. It also highlights recent advances in toxicological studies, as they relate to therapeutic drug monitoring. This is one of the few books available on the market that covers TDM. Therapeutic drug monitoring (TDM) is a clinical decision-making tool that enables dosage regimen adjustments based on clinical and laboratory measurements. TDM not only involves the measuring of drug concentrations but also interpretation of the results. There is a strong correlation between drug concentrations in body fluids and outcome than between dose and outcome. The chapters include coverage of analytical techniques, pharmacokinetics, therapeutic indices, artificial intelligence and recent advances in toxicological studies. The book fills a gap in published literature and provides reliable information on; Analytical techniques in TDM and clinical toxicology TDM and pharmacokinetic studies TDM of drugs with narrow therapeutic indices Artificial intelligence in TDM and clinical toxicology Future directions and challenges

Author : Steven H.Y. Wong
Publisher : Routledge
Page : 673 pages
File Size : 41,9 Mb
Release : 2017-09-19
Category : Medical
ISBN : 9781351408462

Get Book

Therapeutic Drug Monitoring and Toxicology by Liquid Chromatography by Steven H.Y. Wong Pdf

First Published in 2017. Routledge is an imprint of Taylor & Francis, an Informa company.

Author : Georg Hempel
Publisher : Elsevier
Page : 380 pages
File Size : 45,9 Mb
Release : 2019-10-17
Category : Science
ISBN : 9780444640673

Get Book

Methods of Therapeutic Drug Monitoring Including Pharmacogenetics by Georg Hempel Pdf

Methods of Therapeutic Drug Monitoring Including Pharmacogenetics, Second Edition, Volume Seven in the Handbook of Analytical Separations series, covers all aspects of drug monitoring, including laboratory work, pharmacokinetic analysis and clinical aspects, thus enabling readers from different fields to understand the whole process of therapeutic drug monitoring and how to avoid common pitfalls. The book contains analytical techniques for the quantification of drugs, along with pharmacogenetic and pharmacogenomic methods. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. In addition, the book includes new drugs, such as tyrosine kinase inhibitors and the monitoring of immunosuppressant drugs. Presents a unique, interdisciplinary approach that appeals to a wide range of users Written by authors from international labs, providing a global perspective that can be applied in various regulatory environments Features additional therapeutic drugs to reflect the rising number of immunocompromised patients Includes a new mass spectroscopic methods chapter to capture the frequent use in TDM and the improved availability of LC-MS across laboratories

Author : Amitava Dasgupta
Publisher : John Wiley & Sons
Page : 355 pages
File Size : 41,6 Mb
Release : 2012-07-02
Category : Science
ISBN : 9781118347850

Get Book

Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring by Amitava Dasgupta Pdf

The tools for detecting false positives, false negatives, and interference in interactions when testing and monitoring therapeutic drug use For physicians monitoring a patient's progress, efficacy of treatment is often linked to a patient's response to medication. Determining whether a patient is taking the prescribed amount, the drug or dosage is effective, or the prescribed medication is interacting with other drugs can be determined through drug testing. Written as a guide for toxicologists, chemists, and health professionals involved in patient care, Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring provides an up-to-date introduction to the tests and methodologies used in a toxicology lab as well as the sources of testing error that can lead to false positives, false negatives, and unreliable conclusions of drug abuse or under use. Covering a host of common therapeutic drugs as well as specific types of interference in immunoassays used in drug testing, the book details a number of possible testing scenarios and problems as well as solutions: False positive results in immunoassays for drugs in abuse testing Interferences in immunoassays used for monitoring anticonvulsants, tricyclic antidepressants, and digoxin False positive alcohol tests using breath analyzers and automated analyzers When a toxicology report is negative in a suspected overdose patient: the world of designer drugs Effects of drug-herb interactions on therapeutic drug monitoring Pharmacogenomics and the general principles of genetic analysis Approaches for eliminating interference/discordant specimen in therapeutic drug monitoring and drugs in abuse testing What to do in case there is no readily available method for testing Complete with easy-to-read tables and flowcharts, this book helps toxicologists, clinical chemists, clinical pathologists, and forensic pathologists develop accurate, unbiased drug monitoring and toxicology reports. Health care professionals involved in patient care, especially of critically ill patients, will find this guide indispensable in making sure lab tests are reliable enough to provide high-quality care. An indispensable handbook to the entire suite of toxicology lab tests, as well as all the possible sources of testing error, Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring offers clear remedies for eliminating and preventing testing error.

Author : T. Moyer,R. Boeckx
Publisher : Unknown
Page : 128 pages
File Size : 49,9 Mb
Release : 1984-10-01
Category : Chemotherapy.
ISBN : 0915274272

Get Book

Applied Tdm by T. Moyer,R. Boeckx Pdf