Dynamics And Kinetics In Structural Biology

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Dynamics and Kinetics in Structural Biology

Keith Moffat,Eaton E. Lattman
Dynamics and Kinetics in Structural Biology Book PDF

Author : Keith Moffat,Eaton E. Lattman
Publisher : John Wiley & Sons
Page : 292 pages
File Size : 42,5 Mb
Release : 2024-01-03
Category : Science
ISBN : 9781119696285

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Dynamics and Kinetics in Structural Biology by Keith Moffat,Eaton E. Lattman Pdf

Understand the latest experimental tools in structural biology with this pioneering work Structural biology seeks to understand the chemical mechanisms and functions of biological molecules, such as proteins, based on their atomic structures. Until recently, these structures have been studied only statically, using procedures which deliberately freeze atomic motion. However, freezing eliminates the rapid structural motions so essential to biological activity and function; the molecules are inactive. But with the recent development of X-ray free electron laser (XFEL) sources, efforts to conduct dynamic experiments have expanded using the principles of dynamics and kinetics to capture active biological molecules as they function. Dynamics and Kinetics in Structural Biology promotes the development of these experiments and their successful application. It grounds readers in the foundational principles of dynamics and kinetics; proceeds through extended discussions of experimental procedures, data analysis techniques; and explores experimental frontiers in structural dynamics. The book will aid researchers to gather and interpret cutting-edge data on the dynamic structure of biological molecules, under conditions where they retain their biological functions. Dynamics and Kinetics in Structural Biology offers readers: Authorship by founding figures in the field In-depth presentation of time-resolved X-ray crystallography, solution scattering, and more A pioneering contribution to a rapidly developing field of study Dynamics and Kinetics in Structural Biology is essential reading for graduate students, scientists, researchers and industry professionals engaged in structural studies of biological systems. Industry professionals considering dynamic studies in the development of new product lines will also benefit.

Mass Spectrometry in Structural Biology and Biophysics

Igor A. Kaltashov,Stephen J. Eyles
Mass Spectrometry in Structural Biology and Biophysics Book PDF

Author : Igor A. Kaltashov,Stephen J. Eyles
Publisher : John Wiley & Sons
Page : 312 pages
File Size : 54,6 Mb
Release : 2012-04-03
Category : Science
ISBN : 9780470937792

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Mass Spectrometry in Structural Biology and Biophysics by Igor A. Kaltashov,Stephen J. Eyles Pdf

The definitive guide to mass spectrometry techniques in biology and biophysics The use of mass spectrometry (MS) to study the architecture and dynamics of proteins is increasingly common within the biophysical community, and Mass Spectrometry in Structural Biology and Biophysics: Architecture, Dynamics, and Interaction of Biomolecules, Second Edition provides readers with detailed, systematic coverage of the current state of the art. Offering an unrivalled overview of modern MS-based armamentarium that can be used to solve the most challenging problems in biophysics, structural biology, and biopharmaceuticals, the book is a practical guide to understanding the role of MS techniques in biophysical research. Designed to meet the needs of both academic and industrial researchers, it makes mass spectrometry accessible to professionals in a range of fields, including biopharmaceuticals. This new edition has been significantly expanded and updated to include the most recent experimental methodologies and techniques, MS applications in biophysics and structural biology, methods for studying higher order structure and dynamics of proteins, an examination of other biopolymers and synthetic polymers, such as nucleic acids and oligosaccharides, and much more. Featuring high-quality illustrations that illuminate the concepts described in the text, as well as extensive references that enable the reader to pursue further study, Mass Spectrometry in Structural Biology and Biophysics is an indispensable resource for researchers and graduate students working in biophysics, structural biology, protein chemistry, and related fields.

Deterministic Kinetics in Chemistry and Systems Biology

Gábor Lente
Deterministic Kinetics in Chemistry and Systems Biology Book PDF

Author : Gábor Lente
Publisher : Springer
Page : 135 pages
File Size : 55,9 Mb
Release : 2015-03-09
Category : Science
ISBN : 9783319154824

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Deterministic Kinetics in Chemistry and Systems Biology by Gábor Lente Pdf

This book gives a concise overview of the mathematical foundations of kinetics used in chemistry and systems biology. The analytical and numerical methods used to solve complex rate equations with the widely used deterministic approach will be described, with primary focus on practical aspects important in designing experimental studies and the evaluation of data. The introduction of personal computers transformed scientific attitudes in the last two decades considerably as computational power ceased to be a limiting factor. Despite this improvement, certain time-honored approximations in solving rate equations such as the pre-equilibrium or the steady-state approach are still valid and necessary as they concern the information content of measured kinetic traces. The book shows the role of these approximations in modern kinetics and will also describe some common misconceptions in this field.

Structural Biology in Drug Discovery

Jean-Paul Renaud
Structural Biology in Drug Discovery Book PDF

Author : Jean-Paul Renaud
Publisher : John Wiley & Sons
Page : 1367 pages
File Size : 41,9 Mb
Release : 2020-01-09
Category : Medical
ISBN : 9781118900505

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Structural Biology in Drug Discovery by Jean-Paul Renaud Pdf

With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Protein Folding Kinetics

Bengt Nölting
Protein Folding Kinetics Book PDF

Author : Bengt Nölting
Publisher : Springer Science & Business Media
Page : 222 pages
File Size : 49,8 Mb
Release : 2005-12-05
Category : Science
ISBN : 9783540272786

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Protein Folding Kinetics by Bengt Nölting Pdf

First methods book which includes many detailed descriptions Absolutely needed and thus timely for the scientific community Comprises 15% more content and includes the mentioned special features

Kinetics and Dynamics

Piotr Paneth,Agnieszka Dybala-Defratyka
Kinetics and Dynamics Book PDF

Author : Piotr Paneth,Agnieszka Dybala-Defratyka
Publisher : Springer
Page : 530 pages
File Size : 50,7 Mb
Release : 2010-11-04
Category : Science
ISBN : 9048130352

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Kinetics and Dynamics by Piotr Paneth,Agnieszka Dybala-Defratyka Pdf

"Kinetics and Dynamics" on molecular modeling of dynamic processes opens with an introductory overview before discussing approaches to reactivity of small systems in the gas phase. Then it examines studies of systems of increasing complexity up to the dynamics of DNA. This title has interdisciplinary character presenting wherever possible an interplay between the theory and the experiment. It provides basic information as well as the details of theory and examples of its application to experimentalists and theoreticians interested in modeling of dynamic processes in chemical and biochemical systems. All contributing authors are renowned experts in their fields and topics covered in this volume represent the forefront of today’s science.

Self-Organized Biological Dynamics and Nonlinear Control

Jan Walleczek
Self Organized Biological Dynamics and Nonlinear Control Book PDF

Author : Jan Walleczek
Publisher : Cambridge University Press
Page : 444 pages
File Size : 54,5 Mb
Release : 2006-04-20
Category : Science
ISBN : 9781139427593

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Self-Organized Biological Dynamics and Nonlinear Control by Jan Walleczek Pdf

The growing impact of nonlinear science on biology and medicine is fundamentally changing our view of living organisms and disease processes. This book introduces the application to biomedicine of a broad range of interdisciplinary concepts from nonlinear dynamics, such as self-organization, complexity, coherence, stochastic resonance, fractals and chaos. It comprises 18 chapters written by leading figures in the field and covers experimental and theoretical research, as well as the emerging technological possibilities such as nonlinear control techniques for treating pathological biodynamics, including heart arrhythmias and epilepsy. This book will attract the interest of professionals and students from a wide range of disciplines, including physicists, chemists, biologists, sensory physiologists and medical researchers such as cardiologists, neurologists and biomedical engineers.

Fundamentals of Molecular Structural Biology

Subrata Pal
Fundamentals of Molecular Structural Biology Book PDF

Author : Subrata Pal
Publisher : Academic Press
Page : 518 pages
File Size : 47,7 Mb
Release : 2019-08-13
Category : Science
ISBN : 9780128148563

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Fundamentals of Molecular Structural Biology by Subrata Pal Pdf

Fundamentals of Molecular Structural Biology reviews the mathematical and physical foundations of molecular structural biology. Based on these fundamental concepts, it then describes molecular structure and explains basic genetic mechanisms. Given the increasingly interdisciplinary nature of research, early career researchers and those shifting into an adjacent field often require a "fundamentals" book to get them up-to-speed on the foundations of a particular field. This book fills that niche. Provides a current and easily digestible resource on molecular structural biology, discussing both foundations and the latest advances Addresses critical issues surrounding macromolecular structures, such as structure-based drug discovery, single-particle analysis, computational molecular biology/molecular dynamic simulation, cell signaling and immune response, macromolecular assemblies, and systems biology Presents discussions that ultimately lead the reader toward a more detailed understanding of the basis and origin of disease

Deterministic Kinetics in Chemistry and Systems Biology

Gábor Lente
Deterministic Kinetics in Chemistry and Systems Biology Book PDF

Author : Gábor Lente
Publisher : Unknown
Page : 128 pages
File Size : 47,9 Mb
Release : 2015
Category : Electronic
ISBN : 3319154834

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Deterministic Kinetics in Chemistry and Systems Biology by Gábor Lente Pdf

This book gives a concise overview of the mathematical foundations of kinetics used in chemistry and systems biology. The analytical and numerical methods used to solve complex rate equations with the widely used deterministic approach will be described, with primary focus on practical aspects important in designing experimental studies and the evaluation of data. The introduction of personal computers transformed scientific attitudes in the last two decades considerably as computational power ceased to be a limiting factor. Despite this improvement, certain time-honored approximations in solving rate equations such as the pre-equilibrium or the steady-state approach are still valid and necessary as they concern the information content of measured kinetic traces. The book shows the role of these approximations in modern kinetics and will also describe some common misconceptions in this field.

Advances in Protein Molecular and Structural Biology Methods

Timir Tripathi,Vikash Kumar Dubey
Advances in Protein Molecular and Structural Biology Methods Book PDF

Author : Timir Tripathi,Vikash Kumar Dubey
Publisher : Academic Press
Page : 716 pages
File Size : 50,8 Mb
Release : 2022-01-14
Category : Science
ISBN : 9780323902656

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Advances in Protein Molecular and Structural Biology Methods by Timir Tripathi,Vikash Kumar Dubey Pdf

Advances in Protein Molecular and Structural Biology Methods offers a complete overview of the latest tools and methods applicable to the study of proteins at the molecular and structural level. The book begins with sections exploring tools to optimize recombinant protein expression and biophysical techniques such as fluorescence spectroscopy, NMR, mass spectrometry, cryo-electron microscopy, and X-ray crystallography. It then moves towards computational approaches, considering structural bioinformatics, molecular dynamics simulations, and deep machine learning technologies. The book also covers methods applied to intrinsically disordered proteins (IDPs)followed by chapters on protein interaction networks, protein function, and protein design and engineering. It provides researchers with an extensive toolkit of methods and techniques to draw from when conducting their own experimental work, taking them from foundational concepts to practical application. Presents a thorough overview of the latest and emerging methods and technologies for protein study Explores biophysical techniques, including nuclear magnetic resonance, X-ray crystallography, and cryo-electron microscopy Includes computational and machine learning methods Features a section dedicated to tools and techniques specific to studying intrinsically disordered proteins

Structural Biology of the Complement System

Dimitrios Morikis,John D. Lambris
Structural Biology of the Complement System Book PDF

Author : Dimitrios Morikis,John D. Lambris
Publisher : CRC Press
Page : 449 pages
File Size : 41,5 Mb
Release : 2005-03-29
Category : Medical
ISBN : 9781000612080

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Structural Biology of the Complement System by Dimitrios Morikis,John D. Lambris Pdf

Of recent, the structure of the complement system has received considerable attention, including the publication of several three-dimensional structures of complement proteins. This has led to the need for an authoritative resource to provide a complete overview of the basics, as well as an explanation of the cutting-edge work being accomplished in

Computational Structural Biology

Torsten Schwede
Computational Structural Biology Book PDF

Author : Torsten Schwede
Publisher : World Scientific
Page : 790 pages
File Size : 47,5 Mb
Release : 2008
Category : Science
ISBN : 9789812778789

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Computational Structural Biology by Torsten Schwede Pdf

This is a comprehensive introduction to Landau-Lifshitz equations and Landau-Lifshitz-Maxwell equations, beginning with the work by Yulin Zhou and Boling Guo in the early 1980s and including most of the work done by this Chinese group led by Zhou and Guo since. The book focuses on aspects such as the existence of weak solutions in multi dimensions, existence and uniqueness of smooth solutions in one dimension, relations with harmonic map heat flows, partial regularity and long time behaviors. The book is a valuable reference book for those who are interested in partial differential equations, geometric analysis and mathematical physics. It may also be used as an advanced textbook by graduate students in these fields.

Methods in Molecular Biophysics

Igor N. Serdyuk,Nathan R. Zaccai,Joseph Zaccai,Giuseppe Zaccai
Methods in Molecular Biophysics Book PDF

Author : Igor N. Serdyuk,Nathan R. Zaccai,Joseph Zaccai,Giuseppe Zaccai
Publisher : Cambridge University Press
Page : 709 pages
File Size : 54,7 Mb
Release : 2017-05-18
Category : Medical
ISBN : 9781107056374

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Methods in Molecular Biophysics by Igor N. Serdyuk,Nathan R. Zaccai,Joseph Zaccai,Giuseppe Zaccai Pdf

A comprehensive graduate textbook explaining key physical methods in biology, reflecting the very latest research in this fast-moving field.

Dynamics of Proteins and Nucleic Acids

Anonim
Dynamics of Proteins and Nucleic Acids Book PDF

Author : Anonim
Publisher : Elsevier
Page : 368 pages
File Size : 53,8 Mb
Release : 2013-08-14
Category : Science
ISBN : 9780124116276

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Dynamics of Proteins and Nucleic Acids by Anonim Pdf

Published continuously since 1944, Advances in Protein Chemistry and Structural Biology has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. Covers reviews of methodology and research in all aspects of protein chemistry Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics

Advanced Spectroscopic Methods to Study Biomolecular Structure and Dynamics

Prakash Saudagar,Timir Tripathi
Advanced Spectroscopic Methods to Study Biomolecular Structure and Dynamics Book PDF

Author : Prakash Saudagar,Timir Tripathi
Publisher : Elsevier
Page : 560 pages
File Size : 43,7 Mb
Release : 2022-09-28
Category : Science
ISBN : 9780323993661

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Advanced Spectroscopic Methods to Study Biomolecular Structure and Dynamics by Prakash Saudagar,Timir Tripathi Pdf

Advanced Spectroscopic Methods to Study Biomolecular Structure and Dynamics presents the latest emerging technologies in spectroscopy and advances in established spectroscopic methods. The book presents a guide to research methods in biomolecular spectroscopy, providing comprehensive coverage of developments in the spectroscopic techniques used to study protein structure and dynamics. Seventeen chapters from leading researchers cover key aspects of spectroscopic methods, with each chapter covering structure, folding, and dynamics. This title will help researchers keep up-to-date on the latest novel methods and advances in established methods. Presents current, emerging, and evolving advances and applications of spectroscopic techniques in the study of biomolecules, including proteins and nucleic acids Discusses contemporary spectroscopic techniques used to study biomolecular structure, interaction, and dynamics