Environmental Endocrinology And Endocrine Disruptors

Author : Rosario Pivonello,Evanthia Diamanti-Kandarakis
Publisher : Springer Nature
Page : 532 pages
File Size : 43,5 Mb
Release : 2023-04-20
Category : Medical
ISBN : 9783030390440

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Environmental Endocrinology and Endocrine Disruptors by Rosario Pivonello,Evanthia Diamanti-Kandarakis Pdf

This book describes how exposure to various classes of endocrine disruptors, as well as other environmental chemicals targeting the endocrine system by alternative non-endocrine mechanisms, impact on endocrinological and endocrinological-related diseases. It includes comprehensive reviews of all aspects of environmental endocrinology, ranging from sources and patterns of exposure and identification of endocrine targets to direct endocrine disruptive mechanisms and indirect actions on the endocrine system, the latter including endocrine cell-directed cytotoxicity, oxidative damage, and genetic and epigenetic aberrations resulting in endocrine damage. It also examines the causal pathways and offers an extensive overview of downstream endocrinological and endocrinological-related disorders. In addition, several chapters focus on transgenerational actions, which are a topic of particular interest. Lastly, evidence from preclinical and clinical studies provides the basis for an in-depth, critical discussion of each topic. The book is part of the SpringerReference program, which provides access to ‘living editions’ that are constantly updated using a dynamic peer-review publishing process.

Author : A Crain,L J GuilletteJr
Publisher : CRC Press
Page : 432 pages
File Size : 52,6 Mb
Release : 2000-08-17
Category : Medical
ISBN : 9781135466008

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Environmental Endocrine Disruptors by A Crain,L J GuilletteJr Pdf

Addresses many aspects of endocrine disruption by environmental encountered toxic substances. Initial chapters provide essential background information whilst later chapters address specific aspects of endocrine disrupting contaminants (EDC)

Author : Sushil K. Khetan
Publisher : John Wiley & Sons
Page : 410 pages
File Size : 52,6 Mb
Release : 2014-06-23
Category : Technology & Engineering
ISBN : 9781118852934

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Endocrine Disruptors in the Environment by Sushil K. Khetan Pdf

Endocrine Disruptors in the Environment A concise and engaging overview of endocrine disruption phenomena that brings complex concepts within the reach of non-specialists For most of the last decade, the science of endocrine disruption has evolved with more definitive evidence of its damaging potential to health and environment. This book lists the major environmental chemicals of concern and their mechanism of endocrine disruption including remedial measures for them. Divided into three parts, Endocrine Disruptors in the Environment begins with an overview of the endocrine system and endocrine disruptors, discussing their salient features and presenting a historical perspective of endocrine disruption phenomena. It then goes on to cover hormone- signaling mechanisms, followed by various broad classes of putative endocrine disruptors, before introducing readers to environmental epigenetic modifications. Part two of the book focuses on removal processes of various EDCs by biotic and abiotic transformation/degradation. The last section consists of four chapters embracing themes on finding solutions to environmental EDCs—including their detection, regulation, replacement, and remediation. Endocrine Disruptors in the Environment is the first book to detail the endocrine effects of several known environmental contaminants and their mechanism of endocrine disruption. Additionally, it: Covers both the chemistry and biology of endocrine disruption and compiles almost all the known endocrine disrupting environmental chemicals and their mechanisms of toxicity Addresses policy and regulatory issues relevant to EDCs including scientific uncertainty and precautionary policy Brings forth the use of Green Chemistry principles in avoiding endocrine disruption in the designing and screening for safer chemicals and remediation of the EDCs in aquatic environment Includes a useful glossary of technical terms, a list of acronyms, topical references, and a subject index Endocrine Disruptors in the Environment is an ideal book for environmental chemists and endocrine toxicologists, developmental biologists, endocrinologists, epidemiologists, environmental health scientists and advocates, and regulatory officials tasked with risk assessment in environment and health areas.

Author : I. Assenmacher,D.S. Farner
Publisher : Springer Science & Business Media
Page : 344 pages
File Size : 48,7 Mb
Release : 2013-03-07
Category : Medical
ISBN : 9783642669811

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Environmental Endocrinology by I. Assenmacher,D.S. Farner Pdf

From 11 to 15 July 1977 about 60 physiologists, endo crinologists, ecologists and other biologists from 14 countries convened at the University Montpellier for a symposium on Environmental Endocrinology. This meet ing was organized as a Satellite Symposium of the 27th International Congress of Physiological Sciences, Paris, 18-23 July 1977. This volume is a record of the com munications presented at the symposium. The objectives of the program were to examine the role of the endocrine system in a wide spectrum of adjustments and adaptations to changes in environmental conditions by various spe cies of animals, including man, and to promote an ex change of ideas among investigators who have approached these functions from diverse aspects. The diversity of the information and ideas communicated is great. Of necessity, they represent only an extremely modest se lection of the many facets of endocrine function in the interaction of animals with their environments. Be yond the usefulness of the communications individually, we hope that they collectively demonstrate the substan tial heuristic value of the concept of environmental endocrinology as it was perceived by the participants. We acknowledge gratefully the kindness and sympathy of Professor Jaques ROUZAUD, President of the University of Montpellier II, for his generous extension of the hospitality of the University to the Symposium. We are most grateful to Mrs. Monique VIEU who effected so well the secretarial organization of the Sympos.

Author : Lawrence H. Keith,Tammy L. Jones-Lepp,Larry L. Needham
Publisher : Unknown
Page : 188 pages
File Size : 44,8 Mb
Release : 1999
Category : MEDICAL
ISBN : 084121753X

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Analysis of Environmental Endocrine Disruptors by Lawrence H. Keith,Tammy L. Jones-Lepp,Larry L. Needham Pdf

Author : Gerald T. Ankley
Publisher : Unknown
Page : 60 pages
File Size : 47,5 Mb
Release : 1998
Category : Endocrine disrupting chemicals
ISBN : MINN:31951D01809280M

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Research Plan for Endocrine Disruptors by Gerald T. Ankley Pdf

Author : R M Harrison,R E Hester
Publisher : Royal Society of Chemistry
Page : 167 pages
File Size : 52,7 Mb
Release : 2007-10-31
Category : Science
ISBN : 9781847550743

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Endocrine Disrupting Chemicals by R M Harrison,R E Hester Pdf

Long-term environmental effects of chemical exposure have long been of concern and, more recently, chemicals which cause changes to the sexual development of exposed organisms have been identified. It is thought that low-level exposure to a wide range of chemicals may be affecting endocrine function, leading to a reduction in fertility and an increase in reproductive cancers. Endocrine Disrupting Chemicals reviews the scientific evidence and attempts to put the subject into context. Along with an overview of the issue, there is discussion of the specialised aspects in relation to wildlife; environmental oestrogens and male reproduction; and naturally occurring oestrogenic substances. With contributions from representatives of the Medical Research Council's Institute for Environment and Health and the US Environmental Protection Agency, the articles provide a comprehensive and detailed review of current issues. This book will be of interest to a wide readership, including industrial and environmental scientists, managers and policy makers.

Author : Evanthia Diamanti-Kandarakis,Andrea C. Gore
Publisher : Springer Science & Business Media
Page : 378 pages
File Size : 53,7 Mb
Release : 2011-12-01
Category : Medical
ISBN : 1607615614

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Endocrine Disruptors and Puberty by Evanthia Diamanti-Kandarakis,Andrea C. Gore Pdf

Endocrine disruption represents one of the most controversial environmental issues of our time. Mounting evidence stemming from more than 10 years of experimental, epidemiological and clinical studies has transformed the once generally discounted subject of endocrine disruptors into an issue of tremendous concern not only within the scientific community but among society as a whole. Following initial evidence from basic research, endocrine disruption in humans has now emerged as a major medical challenge. In this respect, puberty, a crucial developmental stage, has been definitively identified as a key window of vulnerability with regard to endocrine disruptors. Written by leading authorities in the field, Endocrine Disruptors and Puberty offers an engaging and comprehensive overview of this fascinating and rapidly growing problem. An indispensable resource for all clinicians and scientists interested in this challenging endocrinologic topic, Endocrine Disruptors and Puberty is a timely contribution that will help navigate a path toward understanding the problem and developing solutions.

Author : Oliana Carnevali,Gary Hardiman
Publisher : Elsevier
Page : 394 pages
File Size : 54,8 Mb
Release : 2023-05-30
Category : Medical
ISBN : 9780323859325

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Environmental Contaminants and Endocrine Health by Oliana Carnevali,Gary Hardiman Pdf

Environmental Contaminants and Endocrine Health focuses specifically on contaminants with hormonal disrupting activities. The book provides insights into the multiple effects of endocrine-disrupting chemicals (EDCs) and their mechanism of action (MoA) on metabolism, reproduction and the multiple physiological roles of the endocannabinoid system which has recently been indicated as new target. The content systematically covers EDC sources and effects, EDCs as sources of disease and health impairment in laboratory models, EDCs as the cause of disease and health impairment in humans and wild species, and the removal of hazardous pollutants from wastewaters to highlight intervention, mitigation and adaptation for reduced threat. This content will be a foundational resource for academic and research staff in endocrinology and hormone toxicology as well as for professors, researchers and students in these areas. Includes important foundational coverage of the endocrine system, definitions of EDC sources and descriptions, model examples and mechanisms of action biological effects Provides coverage of EDC effects in humans and animals, from metabolic alterations to epidemiological studies of fertility and metabolism Presents insights into the confirmed and suspected human diseases spectrum with origins linked to EDC exposure, including cancers, intellectual disabilities, autism, birth defects of the urethra (hypospadias), decreased sperm count, increased rates of miscarriage, obesity, type 2 diabetes, and more

Author : Heather B. Patisaul,Scott M. Belcher
Publisher : Oxford University Press
Page : 336 pages
File Size : 44,9 Mb
Release : 2017-04-10
Category : Psychology
ISBN : 9780199935741

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Endocrine Disruptors, Brain, and Behavior by Heather B. Patisaul,Scott M. Belcher Pdf

Our world and bodies are becoming increasingly polluted with chemicals capable of interfering with our hormones and thus, possibly, our present and future neural and mental health. As authors Heather Patisaul and Scott Belcher outline, there is a large lack of data and evidence in this causal relationship, which begs a need for further study to accelerate progress in the endocrinology and neuroendocrinology fields. Endocrine Disruptors, Brain, and Behavior focuses on if and how these chemicals, known as endocrine disrupting compounds (EDCs), affect the development and function of the brain and might be contributing to neural disorders rapidly rising in prevalence. The book provides an overall synthesis of the EDC field, including its historical roots, major hypotheses, key findings, and research gaps. The authors explain why even the concept of endocrine disruption is controversial in some circles, how differing definitions of endocrine disruption and what constitutes an "adverse" outcome on the brain shape public policy, and where the current capacity by different stakeholders (industry, academia, regulatory agencies) to evaluate chemicals for safety in a regulatory context begins and ends. The book concludes with suggestions for future research needs and a summary of emerging technology which might prove capable of more effectively evaluating existing and emerging chemicals for endocrine disrupting properties. As such, it provides the context for interdisciplinary and innovative input from a broad spectrum of fields, including those well-schooled in neuroscience, evolutionary biology, brain, behavior, sex differences, and neuroendocrinology.

Author : Younis Ahmad Hajam,Rouf Ahmad Bhat,Khalid Rehman Hakeem,Rajesh Kumar
Publisher : CRC Press
Page : 429 pages
File Size : 44,6 Mb
Release : 2023-08-04
Category : Medical
ISBN : 9781000779448

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Environmental Endocrine Toxicants by Younis Ahmad Hajam,Rouf Ahmad Bhat,Khalid Rehman Hakeem,Rajesh Kumar Pdf

Highlighting cutting-edge research on human exposure to endocrine toxicants and the related harmful effects, this book focuses on the challenges of dealing with increasing pollution levels, increased use of synthetic chemicals, and environmental endocrine disruptors that endanger the human endocrine system and its hormones. Found in manmade and natural substances and materials, these toxicants include pesticides, herbicides, industrial chemicals, solvents and byproducts, phytoestrogens, nanomaterials, and chemicals used in personal care products. They may mimic or interfere with the body’s hormones and are linked with developmental, reproductive, brain, immune, and other problems. The volume discusses the chemical nature and mechanisms of endocrine disruptors, their sources, the impact of endocrine toxicants on a sustainable environment, and the effect of endocrine toxicants on human health, such as on thyroid glands, on human reproduction, etc. The volume also looks at the therapeutic effects of medicinal plants on endocrine disorders in humans.

Author : Polyxeni Nicolopoulou-Stamati,Luc Hens,Vyvyan C. Howard
Publisher : Springer Science & Business Media
Page : 385 pages
File Size : 52,7 Mb
Release : 2013-03-14
Category : Medical
ISBN : 9789401597692

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Endocrine Disrupters by Polyxeni Nicolopoulou-Stamati,Luc Hens,Vyvyan C. Howard Pdf

During recent decades, millions of tonnes of man-made chemicals have been produced and released into the environment, with very little safety testing. Many of these chemical substances have been found to interfere with the endocrine system and modulate its function. This book not only overviews the effects of endocrine/disrupting substances on human health, but also addresses the regulatory problems from the point of view of international organisations, including the WHO, the EU, and the European Chlorine Industry. This volume contains the proceedings of a workshop held at the International Hippocrates Foundation on Kos Island, Greece, in September 1999. The workshop was part of the activities of the ASPIS project, which aims at raising awareness of environmental health impacts among multidisciplinary groups. The contributions to this volume are the result of the interaction of participants at the workshop. As such, it addresses the issue of endocrine disrupters from many different points of view and allows the subject to be approached by a multidisciplinary readership, including: decision makers, medical doctors, environmental experts, post/and undergraduate students, lawyers, engineers, and journalists.

Author : Andrea C. Gore
Publisher : Springer Science & Business Media
Page : 361 pages
File Size : 48,7 Mb
Release : 2007-06-08
Category : Medical
ISBN : 9781597451079

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Endocrine-Disrupting Chemicals by Andrea C. Gore Pdf

This book provides comprehensive coverage of the three most important themes in the field of Endocrine Disrupting Chemicals (EDC) research: the basic biology of EDCs, particularly their effects on reproductive systems; EDC effects on humans and wildlife, including biomedical considerations; and potential interventions and practical advice for dealing with the problem of EDCs.

Author : M. Metzler
Publisher : Springer
Page : 302 pages
File Size : 46,5 Mb
Release : 2002-01-01
Category : Medical
ISBN : 3540422803

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Endocrine Disruptors by M. Metzler Pdf

The field of endocrine disruption or endocrine active compounds (EACs), which is just emerging and still controversial, is comprehensively covered by leading experts in Volume 3, Subvolumes L (Part I) and M (the present volume, Part II). The major classes of endocrine active chemicals are discussed, as well as methods for their detection and their association with health disturbances in humans and wildlife. The etiology of several of the human diseases associated with endocrine disruptors, e.g. breast and prostate cancer, decreased fertility and malformations, is still poorly understood, and the current state of knowledge is presented. Since hormonally active agents appear to have the potential of both adverse and beneficial effects, the evidence of health benefits associated with endocrine active compounds in humans is also presented. Basic chapters on the mode of action of EACs and on the etiology of the associated diseases facilitate the understanding of this complex subject for non-medical readers.

Author : M. Metzler
Publisher : Springer
Page : 302 pages
File Size : 46,8 Mb
Release : 2006-03-02
Category : Medical
ISBN : 9783540482093

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Endocrine Disruptors by M. Metzler Pdf

The field of endocrine disruption or endocrine active compounds (EACs), which is just emerging and still controversial, is comprehensively covered by leading experts in Volume 3, Subvolumes L (Part I) and M (the present volume, Part II). The major classes of endocrine active chemicals are discussed, as well as methods for their detection and their association with health disturbances in humans and wildlife. The etiology of several of the human diseases associated with endocrine disruptors, e.g. breast and prostate cancer, decreased fertility and malformations, is still poorly understood, and the current state of knowledge is presented. Since hormonally active agents appear to have the potential of both adverse and beneficial effects, the evidence of health benefits associated with endocrine active compounds in humans is also presented. Basic chapters on the mode of action of EACs and on the etiology of the associated diseases facilitate the understanding of this complex subject for non-medical readers.