Author : Bernardo L. Rapoport ,Giancarlo Troncone ,Fernando Schmitt ,Simon Nayler
Publisher : Karger Medical and Scientific Publishers
Page : 109 pages
File Size : 46,9 Mb
Release : 2020-10-20
Category : Medical
ISBN : 9783318068184
Fast Facts: Comprehensive Genomic Profiling by Bernardo L. Rapoport ,Giancarlo Troncone ,Fernando Schmitt ,Simon Nayler Pdf
Cancer is a multifaceted disease in which genetic changes induce uncontrolled tumor growth. Genomic characterization of cancer is now leading to better diagnostic, prognostic and predictive biomarkers, and effective individualized management. 'Fast Facts: Comprehensive Genomic Profiling' provides a crash course in the science, methods and application of genomic profiling. Assuming only the most basic knowledge – or memory – of cell biology, the authors provide an overview of DNA and RNA biology and next-generation sequencing. This sets in context the descriptions of prognostic and predictive biomarkers for different cancer types and genomic-based treatments. Finally, but importantly, some of the practicalities of gaining and interpreting genomic information are described. Whether you need a primer or a refresher, this short colorful book demystifies this complex subject. Contents: • Genetic mutations and biomarkers • Understanding next-generation sequencing • Elements of comprehensive genomic profiles • Role in precision oncology • Predictive and prognostic biomarkers • Overcoming barriers to genotype-directed therapy