Free Radicals In Synthesis And Biology

Author : F. Minisci
Publisher : Springer Science & Business Media
Page : 487 pages
File Size : 40,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789400908970

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Free Radicals in Synthesis and Biology by F. Minisci Pdf

Free-radical reactions have been for long time the domain of the physical chemists and the basic chemical industry (polymerization of vinyl monomers, oxidation by molecular oxygen, chlorination of methane etc.), where the use of simple molecules and the possibility of partial conversions without heavy problems of product separations makes less dramatic the aspects of regio and chemoselectivity. As synonym of unselectivity, free radical reactions were considered of poor use in the synthesis of fine chemicals or sophisticated molecules, where a high selectivity is an essential condition for the success, or in the involvement of biological processes. Within the last 15 years, however, an authentic explosion of synthetic applications of free radical reactions occurred; they have gained a remarkable position among the selective methods of synthesis. At the same time the great importance of free radical reactions in fundamental biological processes and in the metabolism of drugs has been recognized. Thus a specialized meeting on these topics was generally felt appropriate. I had the honour and the onus to organize this workshop because for more than 30 years I have been involved in the research of free radical reactions. Thanks to a generous grant from NATO Scientific Affairs Division and the financial support of CNR and chemical industry (Montedison, Enichem, Zambon) such a meeting among almost 50 specialists and 15 observers of sufficient standard to take advantage of the discussion, became possible at Bardolino (Italy).

Author : F Minisci
Publisher : Unknown
Page : 508 pages
File Size : 47,7 Mb
Release : 1988-12-31
Category : Electronic
ISBN : 9400908989

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Free Radicals in Synthesis and Biology by F Minisci Pdf

Author : Toshikazu Yoshikawa
Publisher : Unknown
Page : 560 pages
File Size : 50,7 Mb
Release : 2000
Category : Antioxidants
ISBN : STANFORD:36105025027470

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Free Radicals in Chemistry, Biology and Medicine by Toshikazu Yoshikawa Pdf

Author : Barry Halliwell,John M. C. Gutteridge
Publisher : Oxford University Press, USA
Page : 568 pages
File Size : 45,9 Mb
Release : 1989
Category : Biochemistry
ISBN : UCSC:32106009290187

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Free Radicals in Biology and Medicine by Barry Halliwell,John M. C. Gutteridge Pdf

"This latest edition has been comprehensively rewritten and updated (over 80% of the text is new), whilst maintaining the clarity of its predecessor. There is expanded coverage of isoprostanes and related compounds, mechanisms of oxidative damage to DNA and proteins (and the repair of such damage), the free radical theory of ageing and the roles played by reactive species in signal transduction, cell death, human reproduction, and other important biological events. Greater emphasis has also been placed on the methods available to measure reactive species and oxidative damage (and their potential pitfalls), as well as the importance of antioxidants in the human diet." "This book is recommended as a comprehensive introduction to the field for students, clinicians and researchers, and an invaluable companion to all those interested in the role of free radicals in the life and medical sciences."--BOOK JACKET.

Author : F. Minisci
Publisher : Springer Science & Business Media
Page : 496 pages
File Size : 54,5 Mb
Release : 2013-04-17
Category : Science
ISBN : 9789401716079

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Free Radicals in Biology and Environment by F. Minisci Pdf

Our understanding of the quantitative aspects of free radical chemistry and the involvement of radicals in such areas as biology, medicine, the environment, etc., has developed spectacularly over recent years, yet the various topics are commonly discussed separately, in specific meetings and specialised publications. Free Radicals in Biology and Environment draws together two important areas of free radical chemistry, using as a bridge the fundamental physical chemistry of free radicals (spectroscopic detection of free radicals, evaluation of absolute rate constants, elucidation of mechanisms of free radical reactions and catalysis, photochemical and radiation processes, etc.). The most relevant topics covered are the EPR detection of radicals in biochemical systems and in pollutant formation and degradation, oxidation processes in biology and in the troposphere, radiation and induced damage, and atmospheric pollutants arising from incomplete combustion. Also covered are the chemistry and biochemistry of nitric oxide and peroxynitrite, the chemistry and biochemistry of DNA radicals, the role of radicals in myeloperoxidase, lignineperoxidase, radicals and cardiovascular injury, radiation and the fragmentation of cells and tissues.

Author : Milan Lazar
Publisher : CRC Press
Page : 322 pages
File Size : 47,7 Mb
Release : 1989-03-31
Category : Science
ISBN : 0849353874

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Free Radicals in Chemistry and Biology by Milan Lazar Pdf

Elementary radical reactions are described in terms of fundamental knowledge of organic chemistry and chemical physics in this valuable reference text. The complex radical processes of nonchain and chain mechanisms, such as dimerization, alkylation, polymerization, telomerization, halogenation pyrolysis, oxidation and combustion, are complemented by reactions in chemical lasers and in the cosmos, as well as by reactions in biological objects under normal or pathological metabolism. The text also provides the synthesis of facts from various fields of research and involves mechanisms where free radicals appear either as main or side intermediates in one of the several alternatives of the reaction pathway. Highlights include 38 tables and 39 figures.

Author : William Pryor
Publisher : Elsevier
Page : 304 pages
File Size : 51,7 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323156820

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Free Radicals in Biology V1 by William Pryor Pdf

Free Radicals in Biology, Volume 1, provides an introduction to some of the basic concepts of free radical biology. The book emerged from the President's Symposium of the American Society for Experimental Pathology held in Atlantic City in April 1970. The book's opening chapter introduces a mechanistic view of free radical reactions using examples from biological systems. This is followed by a discussion of autoxidative damage to lipids in membranes. Some of the special chemistry of lipid oxidation are presented, and a number of novel ideas are suggested. The third chapter deals with the uses of electron-spin resonance in biology. Spin labeling is also discussed, which is one of the most useful methods of probing the chemical and physical environment of molecules in cells. The remaining chapters cover free radicals which occur in photosynthesis and the importance of the enzyme, superoxide dismutase. The study of the occurrence and reactions of this enzyme provides an important and extensive body of data clearly pointing to the significance of free radicals in cellular chemistry.

Author : Roberfroid
Publisher : CRC Press
Page : 292 pages
File Size : 51,9 Mb
Release : 1994-12-14
Category : Medical
ISBN : 0824795873

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Free Radicals and Oxidation Phenomena in Biological Systems by Roberfroid Pdf

This work offers an analysis of the biological processes mediated by free radicals, from a toxicological point of view, providing easy access to information in an integrated, coherent presentation. The chemistry and biochemistry of all principal types of radical are explained, and the multiple forms in whch radicals participate in living organisms are investigated.;This work should be of use to biochemists, pharmacologists, pharmaceutical researchers, food scientists and technologists, nutritionists, toxicologists, chemists, biologists and graduate students in these disciplines.

Author : A.T. Diplock,M.C.R. Symons,C.A. Rice-Evans
Publisher : Elsevier
Page : 290 pages
File Size : 51,6 Mb
Release : 1991-12-11
Category : Science
ISBN : 0080858910

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Techniques in Free Radical Research by A.T. Diplock,M.C.R. Symons,C.A. Rice-Evans Pdf

Free radical species are generally short-lived due to their high reactivity and thus direct measurement and identification are often impossible. ESR is the only technique which has the potential for direct detection of radicals but in biological systems even these must be trapped by a spin-trapping agent. Thus most investigations involve recognition of indicators of the presence of radicals in vivo or "FOOTPRINTS" of radical-mediated damage. Techniques in Free Radical Research assembles and critically assesses the most relevant and reliable experimental approaches used towards the measurement of radicals and radical-mediated damage in chemical systems, in cells and in tissues under the following six headings: a) Footprints of DNA damage, b) Footprints of protein damage, c) Footprints of lipid peroxidation, d) Footprints of antioxidant consumption, e) Footprints via indirect radical assays, and f) Footprints via the availability of transition metal complexes.

Author : William A. Pryor
Publisher : Unknown
Page : 312 pages
File Size : 41,5 Mb
Release : 1976
Category : Science
ISBN : UOM:39015006046984

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Free Radicals in Biology by William A. Pryor Pdf

Free Radicals in Biology V5 ...

Author : William Pryor
Publisher : Elsevier
Page : 371 pages
File Size : 50,5 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323153720

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Free Radicals in Biology V4 by William Pryor Pdf

Free Radicals in Biology, Volume IV reviews diverse topics in free radical biology and covers topics ranging from radiation biology to lipid peroxidation, radical-mediated liver pathology, and chemical carcinogenesis. Radical mechanisms in prostaglandin biochemistry are also discussed, along with the use of electron spin resonance and spin trap methods to probe mechanisms of radical reactions in biological systems. Comprised of 10 chapters, this volume begins with an overview of the mechanisms of lipid peroxidation, focusing on the chemistry of fluorescent products from in vivo lipid peroxidation; the production of pentane in the expired breath of animals exposed to oxidative threats; and the chemistry of the enzyme glutathione peroxidase. The next chapter is devoted to the kinetic aspects of lipid peroxidation and the multiple ways in which autoxidants can react. The reader is then introduced to the mechanisms of hepatoxicity by synthetic chemicals present in the environment, together with direct mechanisms of radiation damage to nucleic acids. Subsequent chapters deal with spin trapping in biological systems; the role of free radicals in arylamine carcinogenesis and their influence on the structure and reactivity of melanins; and the involvement of vitamin ? and lipid antioxidants in free-radical-initiated reactions. This book will be of value to chemists, biologists, and physicians.

Author : Anonim
Publisher : BoD – Books on Demand
Page : 132 pages
File Size : 53,8 Mb
Release : 2020-07-15
Category : Science
ISBN : 9781789851434

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Free Radical Medicine and Biology by Anonim Pdf

Although free radicals perform some useful immune functions, they can also damage healthy cells through a process called oxidation. Antioxidants reduce the effect of free radicals by binding together with these harmful molecules, decreasing their destructive power. This book highlights various issues of free radical biology from the perspective of antioxidant defense mechanisms. It also provides useful information on gene modulation, radiation-generated reactive oxygen species-induced apoptosis in cancer, and environmental aspects associated with free radicals’ exposure on living systems.

Author : William Pryor
Publisher : Elsevier
Page : 468 pages
File Size : 46,5 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323149310

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Free Radicals in Biology V6 by William Pryor Pdf

Free Radicals in Biology, Volume VI covers the significant biological implications of arachidonic acid chemistry in free radical biology. This 11-chapter volume explores the biochemistry of the prostaglandins, leukotrienes, and other products from arachidonic acid. The introductory chapters describe the chemistry of the eicosanoids; the structures of prostaglandin and leukotriene compounds; the role of lipid hydroperoxides in controlling prostaglandin biosynthesis; and the oxidation of xenobiotics during prostaglandin H biosynthesis. The discussion then shifts to the effects of the so-called fatty acid paradoxes on cell proliferation, tumorigenesis, and metastasis, followed by chapters on arachidonic acid cascade process; the causes of lung injury conditions, such as hyperoxia; and the origin of low-level chemiluminescence in cells. This volume further deals with the oxy-radical involvement in parasitic diseases and the mechanisms for activation of aromatic amine carcinogens. The concluding chapters examine the controversial one- and two-electron mechanisms for activation of polynuclear hydrocarbon carcinogens and a hypothesis to rationalize the effects of radicals on the life span of mammals. These chapters propose that aging results from toxic by-products of metabolism, and longevity is determined by the ability of an organism to deal with these products. This book will be of great benefit to biochemists, biologists, and physicists.

Author : Hideo Togo
Publisher : Elsevier
Page : 270 pages
File Size : 49,7 Mb
Release : 2004-01-14
Category : Science
ISBN : 0080524257

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Advanced Free Radical Reactions for Organic Synthesis by Hideo Togo Pdf

Free radical reactions have become increasingly important and a very attractive tool in organic synthesis in the last two decades, due to their powerful, selective, specific, and mild reaction abilities. Advanced Free Radical Reactions for Organic Synthesis reviews information on all types of practical radical reactions, e.g. cyclizations, additions, hydrogen-atom abstractions, decarboxylation reactions. The book usefully provides experimental details for the most important reactions as well as numerous references to the original literature. By covering both the fundamentals and synthetic applications it is therefore suitable for both new and experienced researchers, chemists, biochemists, natural product chemists and graduate students. This title is the definitive guide to radical chemistry for all scientists. Introduces and reviews the use of radicals to perform synthetic transformations Practical details are provided for the most important methods Numerous references to the original literature

Author : Andrew F. Parsons
Publisher : Wiley-Blackwell
Page : 252 pages
File Size : 45,7 Mb
Release : 2000-11-30
Category : Science
ISBN : 0632052929

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An Introduction to Free Radical Chemistry by Andrew F. Parsons Pdf

The past twenty years has seen an explosion of interest in free radicals, as their pivotal role in both chemistry and biology has come to light. This introductory textbook aims to capture this excitement for advanced level undergraduates, with particular emphasis on the importance of radical reactions in organic synthesis. The book provides a gentle, stepwise introduction to the subject, taking the student from the basic principles of radical reactions through to their applications in industry and their role in biological and environmental processes, allowing the relevance of the subject to be grasped more easily. Suitable for advanced level undergraduates and postgraduates in chemistry and biochemistry, the book will also be invaluable for research level scientists requiring an update in the area.