Functional Genomics And Proteomics In The Clinical Neurosciences

Author : Scott E. Hemby,Sabine Bahn
Publisher : Elsevier
Page : 329 pages
File Size : 52,9 Mb
Release : 2006-10-09
Category : Science
ISBN : 9780080465630

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Functional Genomics and Proteomics in the Clinical Neurosciences by Scott E. Hemby,Sabine Bahn Pdf

The purpose of this work is to familiarize neuroscientists with the available tools for proteome research and their relative abilities and limitations. To know the identities of the thousands of different proteins in a cell, and the modifications to these proteins, along with how the amounts of both of these change in different conditions would revolutionize biology and medicine. While important strides are being made towards achieving the goal of global mRNA analysis, mRNA is not the functional endpoint of gene expression and mRNA expression may not directly equate with protein expression. There are many potential applications for proteomics in neuroscience: determination of the neuro-proteome, comparative protein expression profiling, post-translational protein modification profiling and mapping protein-protein interactions, to name but a few. Functional Genomics and Proteomics in Clinical Neuroscience will comment on all of these applications, but with an emphasis on protein expression profiling. This book combines the basic methodology of genomics and proteomics with the current applications of such technologies in understanding psychiatric illnesses. * Introduction of basic methodologies in genomics and proteomics and their integration in psychiatry* Development of the text in sections related to methods, application and future directions of these rapidly advancing technologies* Use of actual data to illustrate many principles of functional genomics and proteomics. * Introduction to bioinformatics and database management techniques

Author : S. E. Hemby,S. Bahn
Publisher : Unknown
Page : 317 pages
File Size : 53,6 Mb
Release : 2006
Category : Genomics
ISBN : 0444801049

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Functional Genomics and Proteomics in the Clinical Neurosciences by S. E. Hemby,S. Bahn Pdf

Author : James D Clelland
Publisher : Springer Science & Business Media
Page : 598 pages
File Size : 52,6 Mb
Release : 2010-12-03
Category : Medical
ISBN : 9781441971975

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Genomics, Proteomics, and the Nervous System by James D Clelland Pdf

This newest volume of Advances in Neurobiology discusses the utilization of genomic and proteomic technologies, to address facets of neurobiology including development and epigenetic regulation, functions in learning and memory, and changes associated with neurological and psychiatric disorders.

Author : Scott E. Hemby,Sabine Bahn
Publisher : Elsevier Science
Page : 402 pages
File Size : 54,8 Mb
Release : 2006-12-22
Category : Science
ISBN : 0444518533

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Functional Genomics and Proteomics in the Clinical Neurosciences by Scott E. Hemby,Sabine Bahn Pdf

The purpose of this work is to familiarize neuroscientists with the available tools for proteome research and their relative abilities and limitations. To know the identities of the thousands of different proteins in a cell, and the modifications to these proteins, along with how the amounts of both of these change in different conditions would revolutionize biology and medicine. While important strides are being made towards achieving the goal of global mRNA analysis, mRNA is not the functional endpoint of gene expression and mRNA expression may not directly equate with protein expression. There are many potential applications for proteomics in neuroscience: determination of the neuro-proteome, comparative protein expression profiling, post-translational protein modification profiling and mapping protein-protein interactions, to name but a few. Functional Genomics and Proteomics in Clinical Neuroscience will comment on all of these applications, but with an emphasis on protein expression profiling. This book combines the basic methodology of genomics and proteomics with the current applications of such technologies in understanding psychiatric illnesses. * Introduction of basic methodologies in genomics and proteomics and their integration in psychiatry * Development of the text in sections related to methods, application and future directions of these rapidly advancing technologies * Use of actual data to illustrate many principles of functional genomics and proteomics. * Introduction to bioinformatics and database management techniques

Author : Jonathan Pevsner
Publisher : John Wiley & Sons
Page : 1168 pages
File Size : 43,6 Mb
Release : 2015-08-17
Category : Science
ISBN : 9781118581766

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Bioinformatics and Functional Genomics by Jonathan Pevsner Pdf

The bestselling introduction to bioinformatics and genomics – now in its third edition Widely received in its previous editions, Bioinformatics and Functional Genomics offers the most broad-based introduction to this explosive new discipline. Now in a thoroughly updated and expanded third edition, it continues to be the go-to source for students and professionals involved in biomedical research. This book provides up-to-the-minute coverage of the fields of bioinformatics and genomics. Features new to this edition include: Extensive revisions and a slight reorder of chapters for a more effective organization A brand new chapter on next-generation sequencing An expanded companion website, also updated as and when new information becomes available Greater emphasis on a computational approach, with clear guidance of how software tools work and introductions to the use of command-line tools such as software for next-generation sequence analysis, the R programming language, and NCBI search utilities The book is complemented by lavish illustrations and more than 500 figures and tables - many newly-created for the third edition to enhance clarity and understanding. Each chapter includes learning objectives, a problem set, pitfalls section, boxes explaining key techniques and mathematics/statistics principles, a summary, recommended reading, and a list of freely available software. Readers may visit a related Web page for supplemental information such as PowerPoints and audiovisual files of lectures, and videocasts of how to perform many basic operations: www.wiley.com/go/pevsnerbioinformatics. Bioinformatics and Functional Genomics, Third Edition serves as an excellent single-source textbook for advanced undergraduate and beginning graduate-level courses in the biological sciences and computer sciences. It is also an indispensable resource for biologists in a broad variety of disciplines who use the tools of bioinformatics and genomics to study particular research problems; bioinformaticists and computer scientists who develop computer algorithms and databases; and medical researchers and clinicians who want to understand the genomic basis of viral, bacterial, parasitic, or other diseases.

Author : Juan Y. Chiao
Publisher : Elsevier
Page : 328 pages
File Size : 49,5 Mb
Release : 2009-11-25
Category : Science
ISBN : 9780080952215

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Cultural Neuroscience: Cultural Influences on Brain Function by Juan Y. Chiao Pdf

This volume presents recent empirical advances using neuroscience techniques to investigate how culture influences neural processes underlying a wide range of human abilities, from perception and scene processing to memory and social cognition. It also highlights the theoretical and methodological issues with conducting cultural neuroscience research. Section I provides diverse theoretical perspectives on how culture and biology interact are represented. Sections II –VI is to demonstrate how cultural values, beliefs, practices and experience affect neural systems underlying a wide range of human behavior from perception and cognition to emotion, social cognition and decision-making. The final section presents arguments for integrating the study of culture and the human brain by providing an explicit articulation of how the study of culture can inform the study of the brain and vice versa.

Author : Giuseppe Di Giovanni,Vincenzo Di Matteo,Ennio Esposito
Publisher : Elsevier
Page : 682 pages
File Size : 43,9 Mb
Release : 2008-11-11
Category : Medical
ISBN : 9780444532350

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Serotonin-Dopamine Interaction: Experimental Evidence and Therapeutic Relevance by Giuseppe Di Giovanni,Vincenzo Di Matteo,Ennio Esposito Pdf

This book provides a unique and timely multidisciplinary synthesis of our current knowledge of the anatomy, pharmacology, physiology and behavioral data of the serotonin (5-HT)-dopamine (DA) interactions. Central serotonergic and dopaminergic systems play a critical role in the regulation of normal and abnormal behaviors. Moreover, recent evidence suggests that the dysfunction of the DA and 5-HT neurotransmitter systems contribute to various mental disorders including depression, schizophrenia, drug addiction and Parkinson's disease. This extremely important topic is of wide interest within the scientific community, with relevance not only to specialists but also to general practitioners and students. The book provides a valuable contribution to the debate on new pharmacological approaches for several psychopathological states, with contributions from expert neuroscientists and pharmacologists who comprehensively survey the most significant currently active areas of dopamine/serotonin interactions. * Provides an understanding of the interaction between Serotonin and Dopamine. * Appeals equally to specialists, general practitioners, students and researchers. * Contributes to the debate on new pharmacological approaches to several psychopathological states * Gives a comprehensive anatomical description plus the physiology and pharmacology of dopaminergic and serotonergic systems * Singles out neuropsychiatric and suggests new therapeutic approaches.

Author : Anonim
Publisher : Elsevier
Page : 260 pages
File Size : 41,7 Mb
Release : 2013-09-12
Category : Medical
ISBN : 9780444632883

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The Fine Arts, Neurology, and Neuroscience by Anonim Pdf

This volume on neuroscience, neurology, and the fine arts brings several disciplines together. It presents current thoughts and modern examples about how science, medicine and the arts have interacted in the past and are still converging. This volume specifically explores the history and modern perspective on neurology and neuroscience. This volume explores the history and modern perspective on neurology and neuroscience

Author : Anonim
Publisher : Elsevier
Page : 253 pages
File Size : 44,7 Mb
Release : 2013-12-11
Category : Medical
ISBN : 9780444633873

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Literature, Neurology, and Neuroscience: Neurological and Psychiatric Disorders by Anonim Pdf

This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume on the neurosciences, neurology, and literature vividly shows how science and the humanities can come together --- and have come together in the past. Its sections provide a new, broad look at these interactions, which have received surprisingly little attention in the past. Experts in the field cover literature as a window to neurological and scientific zeitgeists, theories of brain and mind in literature, famous authors and their suspected neurological disorders, and how neurological disorders and treatments have been described in literature. In addition, a myriad of other topics are covered, including some on famous authors whose important connections to the neurosciences have been overlooked (e.g., Roget, of Thesaurus fame), famous neuroscientists who should also be associated with literature, and some overlooked scientific and medical men who helped others produce great literary works (e,g., Bram Stoker's Dracula). There has not been a volume with this coverage in the past, and the connections it provides should prove fascinating to individuals in science, medicine, history, literature, and various other disciplines. This book looks at literature, medicine, and the brain sciences both historically and in the light of the newest scholarly discoveries and insights

Author : Anonim
Publisher : Elsevier
Page : 369 pages
File Size : 52,9 Mb
Release : 2013-11-25
Category : Medical
ISBN : 9780444632753

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Literature, Neurology, and Neuroscience: Historical and Literary Connections by Anonim Pdf

This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume on the neurosciences, neurology, and literature vividly shows how science and the humanities can come together --- and have come together in the past. Its sections provide a new, broad look at these interactions, which have received surprisingly little attention in the past. Experts in the field cover literature as a window to neurological and scientific zeitgeists, theories of brain and mind in literature, famous authors and their suspected neurological disorders, and how neurological disorders and treatments have been described in literature. In addition, a myriad of other topics are covered, including some on famous authors whose important connections to the neurosciences have been overlooked (e.g., Roget, of Thesaurus fame), famous neuroscientists who should also be associated with literature, and some overlooked scientific and medical men who helped others produce great literary works (e,g., Bram Stoker's Dracula). There has not been a volume with this coverage in the past, and the connections it provides should prove fascinating to individuals in science, medicine, history, literature, and various other disciplines. This book looks at literature, medicine, and the brain sciences both historically and in the light of the newest scholarly discoveries and insights

Author : Anonim
Publisher : Newnes
Page : 405 pages
File Size : 46,7 Mb
Release : 2012-12-31
Category : Science
ISBN : 9780444595454

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Functional Neural Transplantation III by Anonim Pdf

This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on Functional Neural Transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery. Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Author : Anonim
Publisher : Elsevier
Page : 513 pages
File Size : 42,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9780444594549

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The Neurobiology of Circadian Timing by Anonim Pdf

Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future researchChapters are extensively referenced to provide readers with a comprehensive list of resources on the topics coveredAll chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Author : Anonim
Publisher : Elsevier
Page : 376 pages
File Size : 42,7 Mb
Release : 2011-04-21
Category : Science
ISBN : 9780444538857

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Gene Expression to Neurobiology and Behaviour by Anonim Pdf

How does the genome, interacting with the multi-faceted environment, translate into the development by which the human brain achieves its astonishing, adaptive array of cognitive and behavioral capacities? Why and how does this process sometimes lead to neurodevelopmental disorders with a major, lifelong personal and social impact? This volume of Progress in Brain Research links findings on the structural development of the human brain, the expression of genes in behavioral and cognitive phenotypes, environmental effects on brain development, and developmental processes in perception, action, attention, cognitive control, social cognition, and language, in an attempt to answer these questions. Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Author : Anonim
Publisher : Elsevier
Page : 273 pages
File Size : 54,8 Mb
Release : 2012-10-16
Category : Medical
ISBN : 9780444543004

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Down Syndrome: From Understanding the Neurobiology to Therapy by Anonim Pdf

Down syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of chromosome 21 (HSA21) producing deregulated gene expression in brain that gives raise to subnormal intellectual functioning. The topic of this volume is of broad interest for the neuroscience community, because it tackles the concept of neurogenomics, that is, how the genome as a whole contributes to a neurodevelopmental cognitive disorders, such as DS, and thus to the development, structure and function of the nervous system. This volume of Progress in Brain Research discusses comparative genomics, gene expression atlases of the brain, network genetics, engineered mouse models and applications to human and mouse behavioral and cognitive phenotypes. It brings together scientists of diverse backgrounds, by facilitating the integration of research directed at different levels of biological organization, and by highlighting translational research and the application of the existing scientific knowledge to develop improved DS treatments and cures. Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Author : Christine E. Kasper, PhD, RN, FAAN, FACSM
Publisher : Springer Publishing Company
Page : 300 pages
File Size : 40,9 Mb
Release : 2015-04-24
Category : Medical
ISBN : 9780826129222

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Annual Review of Nursing Research, Volume 33, 2015 by Christine E. Kasper, PhD, RN, FAAN, FACSM Pdf

This groundbreaking annual review has provided nearly three decades of knowledge, insight, and research on topics critical to the field of nursing. The 33rd volume delivers the most current research on traumatic brain injury (TBI) with a focus on its implications for improving health and wellbeing. The book examines promising new interventions for individuals suffering from TBI with supporting research about their efficaciousness. Invited experts--highly respected nurse scientists working in a variety of TBI-related arenas--stress outcomes and symptom development post-TBI. The Review encompasses current military research on TBI along with animal models in TBI research. It addresses the relationship of sleep disorders to TBI-related PSTD; biomarkers related to recovery from TBI; genomics, transciptomics, and epigenomics; cerebral perfusion pressure and intracranial pressure in TBI; and an informatics system for TBI research. Also covered are TBI in pediatrics and in caregiver research. Additionally, the Review also provides a unique literature review of under-reported research. Key Topics Military Research on TBI Animal Models in TBI Research PSTD and Sleep Post-TBI Biomarkers Related to Recovery Post-TBI Genomics, Transcriptomics, and Epigenomics in TBI Research Common Data Elements and Federal Interagency Traumatic Brain Injury: Research Informatics System for TBI Research Cerebral Perfusion Pressure and Intracranial Pressure in TBI TBI in Pediatrics TBI in Caregiver Research