Gadd45 Stress Sensor Genes

Author : M. Raza Zaidi,Dan A. Liebermann
Publisher : Springer Nature
Page : 159 pages
File Size : 52,8 Mb
Release : 2022-05-04
Category : Medical
ISBN : 9783030948047

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Gadd45 Stress Sensor Genes by M. Raza Zaidi,Dan A. Liebermann Pdf

This second edition is fully updated throughout and covers the emerging evidence that indicates that the Gadd45 family of proteins plays a unique and critical role as sensors of stress, including genotoxic, physiological, and oncogenic stress. It sheds light on the complex cellular stress response, encompassing myriad molecular pathways with a plethora of regulators and effectors. The GADD45 stress response genes encode small (18 kd) nuclear/cytoplasmic proteins. These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. Despite marked similarities, Gadd45 genes are regulated differentially and exhibit functional diversity. Gadd45 proteins respond to physiological and oncogenic stress, and are implicated in cell cycle arrest, DNA demethylation and repair, apoptosis, cell survival, genomic stability, and inflammation. The purpose of this book is to provide a comprehensive overview of the unique global role that Gadd45 proteins play as stress sensors and the molecular pathways involved.

Author : Dan A. Liebermann,Barbara Hoffman
Publisher : Springer Science & Business Media
Page : 141 pages
File Size : 46,6 Mb
Release : 2013-10-08
Category : Medical
ISBN : 9781461482895

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Gadd45 Stress Sensor Genes by Dan A. Liebermann,Barbara Hoffman Pdf

Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress. The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins). These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity. Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress. Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus. Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved.

Author : Alexander M. Vaiserman,Alexey A. Moskalev,Elena G. Pasyukova
Publisher : Springer
Page : 353 pages
File Size : 40,8 Mb
Release : 2015-06-09
Category : Medical
ISBN : 9783319183268

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Life Extension by Alexander M. Vaiserman,Alexey A. Moskalev,Elena G. Pasyukova Pdf

​This book looks at aging through research on Drosophila, the fruit fly that is one of the most widely used model organisms in bio gerontology. Work in model organisms can expand the theoretical knowledge of aging: it yields valuable insight into the molecular and cellular processes that underlie aging process, and it can perhaps provide new therapeutic targets for the treatment of age-related disorders in humans. Drosophila models have been developed for a large variety of aging-related processes and diseases, and this book provides readers with an overview of current research on the use of the Drosophila model to understand the genetic, molecular and physiological mechanisms that underlie the aging process. Themes of health span, life extension and longevity-associated genes emerge in this collation of international research on Drosophila that is of relevance to geriatrics and gerontology, animal genetics and genomics, and biomedicine. This fascinating, illustrated book will be of interest to a wide audience, ranging from academic researchers to the general reader.

Author : Timothy W Bredy
Publisher : Academic Press
Page : 180 pages
File Size : 49,8 Mb
Release : 2016-12-23
Category : Science
ISBN : 9780128017814

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DNA Modifications in the Brain by Timothy W Bredy Pdf

DNA Modifications in the Brain: Neuroepigenetic Regulation of Gene Expression begins with an historical overview of the early discoveries surrounding DNA methylation in the mammalian brain and then explores the evidence supporting a role for this epigenetic mechanism in controlling gene expression programs across the lifespan in both normal and diseased states. Chapters describe new directions and technological advances, and provide an overview of what the future holds for this exciting new field. This book is ideal for medical, graduate and advanced undergraduate students, but is also a great resource for researchers who need a broad introduction to the dynamic nature of DNA that sheds light on evolving concepts of gene-environment interaction and their effects on adaptation and neuropsychiatric disease. Provides a comprehensive overview of the many facets of DNA modifications Discusses the impact of this dynamic epigenetic mechanism across brain development and lifespan at behavioral, cognitive, molecular and genetic levels Contains contributions by influential leaders in the field Edited by a Neuroscientist to further promote synthesis between epigenetics, neuroscience, and clinical relevance

Author : Anonim
Publisher : ScholarlyEditions
Page : 1446 pages
File Size : 51,9 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781464964411

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Issues in Medical Chemistry: 2011 Edition by Anonim Pdf

Issues in Medical Chemistry / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Medical Chemistry. The editors have built Issues in Medical Chemistry: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Medical Chemistry in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Medical Chemistry: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Tahira Farooqui,Akhlaq A. Farooqui
Publisher : John Wiley & Sons
Page : 433 pages
File Size : 52,9 Mb
Release : 2011-12-06
Category : Science
ISBN : 9781118001943

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Oxidative Stress in Vertebrates and Invertebrates by Tahira Farooqui,Akhlaq A. Farooqui Pdf

This volume presents a unique comparative treatment of the role oxidative stress plays in vertebrates and invertebrates in multiple organ systems with regards to cell death, development, aging, and human diseases, and anti-oxidant therapy. It offers comprehensive reviews of the current understanding of oxidative stress-mediated physiology and pathology as well as directions for future research. It also provides current information on the role of oxidative stress in neurodegenerative diseases, cardiovascular diseases, and various types of cancer mediated by oxidative stress.

Author : Ruy Beck,Silvia Guterres,Adriana Pohlmann
Publisher : Springer Science & Business Media
Page : 368 pages
File Size : 48,5 Mb
Release : 2011-04-06
Category : Technology & Engineering
ISBN : 9783642197925

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Nanocosmetics and Nanomedicines by Ruy Beck,Silvia Guterres,Adriana Pohlmann Pdf

The book "Nanocosmetics and nanomedicines: new approaches for skin care” contains a summary of the most important nanocarriers for skin delivery. Although “nanocosmetics” is a subject widely commented in the academy and the beauty industry, a book covering the skin care treatments using nanotechnological approaches with cosmetics and nanomedicines is still missing, therefore the need for this publication. This book is divided in three parts: The first one (Part A) is devoted to a brief review on the main topics related to the skin delivery and to the introduction of the subject “nanocosmetics”. The second part (Part B) presents different types of nanocarriers applied as skin delivery systems for cosmetics or drugs. The last part (Part C) shows a wide range of applications of nanotechnology on the skin care area as well as on dermatocosmetic and dermatological fields.

Author : Anonim
Publisher : ScholarlyEditions
Page : 188 pages
File Size : 50,7 Mb
Release : 2012-12-26
Category : Science
ISBN : 9781481601917

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Cell Cycle Proteins—Advances in Research and Application: 2012 Edition by Anonim Pdf

Cell Cycle Proteins—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cell Cycle Proteins. The editors have built Cell Cycle Proteins—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cell Cycle Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cell Cycle Proteins—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Ramesh C. Gupta
Publisher : Academic Press
Page : 1246 pages
File Size : 53,6 Mb
Release : 2019-02-13
Category : Medical
ISBN : 9780128146569

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Biomarkers in Toxicology by Ramesh C. Gupta Pdf

Biomarkers in Toxicology, Second Edition, is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This revised and completely updated edition includes both vertebrate and non-vertebrate species models for toxicological testing and the development of biomarkers. Divided into several key sections, this reference volume contains new chapters devoted to topics in microplastics, neuroimmunotoxicity and nutraceuticals, along with a look at the latest cutting-edge technologies used to detect biomarkers. Each chapter contains several references to current literature and important resources for further reading. Given this comprehensive treatment, this book is an essential reference for anyone interested in biomarkers across the scientific and biomedical fields. Evaluates the expansive literature, providing one resource covering all aspects of toxicology biomarkers Includes completely revised chapters, along with additional chapters on the newest developments in the field Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation, and much more

Author : Glynis Nicholls,Kuresh Youdim
Publisher : Royal Society of Chemistry
Page : 239 pages
File Size : 53,8 Mb
Release : 2016-08-17
Category : Science
ISBN : 9781782628705

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Drug Transporters by Glynis Nicholls,Kuresh Youdim Pdf

Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. The first volume comprehensively reviewed current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics. In this second volume on Drug Transporters, emphasis is placed on emerging sciences and technologies, highlighting potential areas for future advances within the drug transporter field. The topics covered in both volumes ensure that all relevant aspects of transporters are described across the drug development process, from in silico models and preclinical tools through to the potential impact of transporters in the clinic. Contributions are included from expert leaders in the field, at-the-bench industrial scientists, renowned academics and international regulators. Case studies and emerging developments are highlighted, together with the merits and limitations of the available methods and tools, and extensive references to reviews on specific in-depth topics are also included for those wishing to pursue their knowledge further. As such, this text serves as an essential handbook of information for postgraduate students, academics, industrial scientists and regulators who wish to understand the role of transporters in absorption, distribution, metabolism, and excretion processes. In addition, it is also a useful reference tool on the models and calculations necessary to predict their effect on human pharmacokinetics and pharmacodynamics.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 44,9 Mb
Release : 19??
Category : Electronic
ISBN : 1461464382

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Encyclopedia of Signaling Molecules by Anonim Pdf

Author : Anonim
Publisher : Unknown
Page : 556 pages
File Size : 53,9 Mb
Release : 2008
Category : Cancer
ISBN : NWU:35558005676859

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Cancer Research by Anonim Pdf

Author : Anonim
Publisher : Unknown
Page : 446 pages
File Size : 41,9 Mb
Release : 1998
Category : Gene expression
ISBN : STANFORD:36105029401804

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Gene Expression by Anonim Pdf

Author : Sajal Chakraborti
Publisher : Springer Nature
Page : 4078 pages
File Size : 41,6 Mb
Release : 2022-09-28
Category : Medical
ISBN : 9789811654220

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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects by Sajal Chakraborti Pdf

This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy. ​

Author : Anonim
Publisher : Unknown
Page : 556 pages
File Size : 51,7 Mb
Release : 2008
Category : Biology
ISBN : UIUC:30112086573307

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Experimental Biology and Medicine by Anonim Pdf