Gene Vaccines

Gene Vaccines Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Gene Vaccines book. This book definitely worth reading, it is an incredibly well-written.

Gene Vaccines

Josef Thalhamer,Richard Weiss,Sandra Scheiblhofer
Gene Vaccines Book PDF

Author : Josef Thalhamer,Richard Weiss,Sandra Scheiblhofer
Publisher : Springer Science & Business Media
Page : 332 pages
File Size : 47,5 Mb
Release : 2011-08-31
Category : Medical
ISBN : 9783709104392

Get Book

Gene Vaccines by Josef Thalhamer,Richard Weiss,Sandra Scheiblhofer Pdf

The induction of antigen-specific immune responses after in vivo transfection with expression plasmids has triggered a revolution of vaccine research. After a first hype, evoked by the fascinating options of this method, clinical studies did not reach the ambitious aims and a phase of disillusion ensued. It became obvious that Gene vaccines displayed a weaker immunogenicity in humans than had been observed in the mouse models. Meanwhile these hurdles have been overcome and gene vaccines undergo a renaissance. The present book gives an update of the “world of naked gene vaccines”, namely DNA and RNA vaccines. Its content ranges from general mechanisms, inherent immunostimulatory properties and the vast potential to modulate immune responses, to recent successful clinical studies and approved veterinary gene vaccines. Beyond the state-of-the-art of genetic immunization, the reader will be stimulated with a chapter addressing “burning questions”.

Gene Vaccination: Theory and Practice

Eyal Raz
Gene Vaccination Theory and Practice Book PDF

Author : Eyal Raz
Publisher : Springer Science & Business Media
Page : 182 pages
File Size : 53,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642468674

Get Book

Gene Vaccination: Theory and Practice by Eyal Raz Pdf

Vaccination has been established as an efficient procedure to prevent infections. Over the past few years, a new method of subunit vaccination has attracted the attention of immunologists. Despite its popularity, it is only recently that the basic mechanisms that drive the immune response to the encoded antigen have begun to unfold. The multidisciplinary approach of this book outlines the basic characteristics of gene (DNA) vaccination, the role of APCs or bone marrow derived cells in the induction of the immune response. It points out the potential applications for various infectious and allergic diseases and describes the multifaceted properties of DNA in initiating and determining the subsequent immune responses to the encoded antigen.

Toll-Like Receptors (TLRs) and Innate Immunity

Stefan Bauer,Gunther Hartmann
Toll Like Receptors TLRs and Innate Immunity Book PDF

Author : Stefan Bauer,Gunther Hartmann
Publisher : Springer Science & Business Media
Page : 243 pages
File Size : 55,7 Mb
Release : 2007-12-11
Category : Medical
ISBN : 9783540721673

Get Book

Toll-Like Receptors (TLRs) and Innate Immunity by Stefan Bauer,Gunther Hartmann Pdf

Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention.

DNA Vaccination/Genetic Vaccination

Hilary Koprowski,David B. Weiner
DNA Vaccination Genetic Vaccination Book PDF

Author : Hilary Koprowski,David B. Weiner
Publisher : Springer Science & Business Media
Page : 215 pages
File Size : 51,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642804755

Get Book

DNA Vaccination/Genetic Vaccination by Hilary Koprowski,David B. Weiner Pdf

Genetic / DNA immunization represents a novel approach to vaccine and immune therapeutic development. The direct injec tion of nucleic acid expression cassettes into a living host results in a limited number of its cells becoming factories for production of the introduced gene products. This host-inappropriate gene expression has important immunological consequences, resulting in the specific immune activation of the host against the gene delivered antigen. The recent demonstration by a number of laboratories that the induced immune responses are functional in experimental models against both specific infectious diseases and cancers is likely to have dramatic consequences for the develop ment of a new generation of experimental vaccines and immune therapies. This technology has the potential to enable the pro duction of vaccines and immune-based therapies that are not only effective immunologically but are accessible to the entire world (rather than just to the most developed nations). Vaccine Development Vaccination against pathogenic microorganisms represents one of the most important advances in the history of medicine. Vaccines, including those against polio, measles, mumps, rubella, hepatitis A, hepatitis B, pertussis and other diseases, have dramatically improved and protected more human lives than any other avenue of modern medicine. The vaccine against smallpox, for example, has been so successful that it is now widely believed that this malicious killer, responsible for more deaths in the twentieth century than World Wars I and II combined, has been removed from the face of the earth.

DNA Vaccines

Douglas B. Lowrie,Robert Whalen
DNA Vaccines Book PDF

Author : Douglas B. Lowrie,Robert Whalen
Publisher : Springer Science & Business Media
Page : 530 pages
File Size : 52,5 Mb
Release : 2008-02-01
Category : Medical
ISBN : 9781592596881

Get Book

DNA Vaccines by Douglas B. Lowrie,Robert Whalen Pdf

The field of DNA vaccines has undergone explosive growth in the last few years. As usual, some historical precursors of this approach can be d- cerned in the scientific literature of the last decades. However, the present state of affairs appears to date from observations made discreetly in 1988 by Wolff, Malone, Felgner, and colleagues, which were described in a 1989 patent and published in 1990. Quite surprisingly, they showed that genes carried by pure plasmid DNA and injected in a saline solution, hence the epithet “naked DNA,” could be taken up and expressed by skeletal muscle cells with a low but reproducible frequency. Such a simple methodology was sure to spawn many applications. In a separate and important line of experimentation, Tang, De Vit, and Johnston announced in 1992 that it was indeed possible to obtain humoral immune responses against proteins encoded by DNA delivered to the skin by a biolistic device, which has colloquially become known as the “gene gun. ” The year 1993 saw the publication of further improvements in the me- ods of naked DNA delivery and, above all, the first demonstrations by several groups of the induction of humoral and cytotoxic immune responses to viral antigens expressed from injected plasmid DNA. In some cases, protection against challenge with the pathogen was obtained. The latter result was - questionably the touchstone of a method of vaccination worthy of the name.

Genetic Immunization

Adrian Bot,Constantin A. Bona
Genetic Immunization Book PDF

Author : Adrian Bot,Constantin A. Bona
Publisher : Springer Science & Business Media
Page : 185 pages
File Size : 43,7 Mb
Release : 2013-03-14
Category : Medical
ISBN : 9781475731637

Get Book

Genetic Immunization by Adrian Bot,Constantin A. Bona Pdf

Wolf's discovery demonstrating that a reporter gene is expressed in myocytes subsequent to injection of naked DNA, was exploited by immunologists and vaccinologists to develop a new generation of vaccines. This observation galvanized the research and in a short lapse of time, an oceanic volume of knowledge has been accumulated. The research carried out in a variety of animal models showed the efficacy of genetic immunization against viruses, bacteria, and some parasites by the ability to induce a strong priming effect resulting from long-lasting persistence of plasmid as episomes. Furthermore, it was demonstrated that newborn or infant immune unresponsiveness to classical vaccines can be corrected by genetic immunization. The applications of genetic immunization for prophylaxis of infections was extended to immunotherapy, namely, cancerous, auto immune, and allergic diseases. Immunologists have provided pertinent information on the cellular basis of the immune responses elicited by genetic immunization, and molecular biologists have established the molecular basis of intrinsic adjuvant properties of plasmids.

DNA Vaccines

Mark W. Saltzman,Hong Shen,Janet L. Brandsma
DNA Vaccines Book PDF

Author : Mark W. Saltzman,Hong Shen,Janet L. Brandsma
Publisher : Springer Science & Business Media
Page : 382 pages
File Size : 45,5 Mb
Release : 2008-02-02
Category : Medical
ISBN : 9781597451680

Get Book

DNA Vaccines by Mark W. Saltzman,Hong Shen,Janet L. Brandsma Pdf

In the early 1990s, almost 200 yr after Edward Jenner demonstrated the effectiveness of the smallpox vaccine, a new paradigm for vaccination emerged. The conventional method of vaccination required delivery of whole pathogens or structural subunits, but in this new approach, DNA or genetic information was administered to elicit an immunological response. Once it was observed that plasmid DNA delivered in vivo led to production of an encoded transgene (1), two ground-breaking studies demonstrated that immunological responses could be generated against antigenic transgenes via plasmid DNA delivered by DNA vaccination (as this approach is called) (2,3). The appe- ance of this new vaccination strategy coincided with advances in molecular biology, which provided new tools to study and manipulate the basic elements of an organism’s genome and also could also be applied to the design and production of DNA vaccines. DNA Vaccines is a major updated and enhancement of the first edition. It reviews state-of-the-art methods in DNA vaccine technology, with chapters describing DNA vaccine design, delivery systems, adjuvants, current appli- tions, methods of production, and quality control. Consistent with the approach of the Methods in Molecular Medicine series, these chapters contain detailed practical procedures on the latest DNA vaccine technology. The enthusiasm for DNA vaccine technology is made clear by the number of research studies published on this topic since the mid-1990s.

Gene Vaccines

Josef Thalhamer,Richard Weiss,Sandra Scheiblhofer
Gene Vaccines Book PDF

Author : Josef Thalhamer,Richard Weiss,Sandra Scheiblhofer
Publisher : Springer
Page : 344 pages
File Size : 52,7 Mb
Release : 2016-05-01
Category : Electronic
ISBN : 3709119294

Get Book

Gene Vaccines by Josef Thalhamer,Richard Weiss,Sandra Scheiblhofer Pdf

This up-to-date volume provides an overview of the world of naked gene vaccines, namely DNA and RNA vaccines. Topics include general mechanisms, inherent immunostimulatory properties, the vast potential to modulate immune responses, and more."

Plasmids for Therapy and Vaccination

Martin Schleef
Plasmids for Therapy and Vaccination Book PDF

Author : Martin Schleef
Publisher : John Wiley & Sons
Page : 307 pages
File Size : 44,5 Mb
Release : 2008-07-11
Category : Science
ISBN : 9783527612840

Get Book

Plasmids for Therapy and Vaccination by Martin Schleef Pdf

This is the first book specializing in plasmids and their biomedical use, including all relevant aspects of production, applications, quality, and regulations. Readers will discover clinical applications for the wide range of preventive and therapeutic applications using plasmid DNA. The book describes modified vector systems based on plasmids, as well as the potency of genomic research and vector design by informatics. Using the example of fish vaccination, the application of DNA vaccination in veterinary health care is reviewed, followed by a detailed overview of plasmid production technology on an industrial scale. Finally, the book considers regulatory and quality assurance aspects of such new drugs plus thire market potential.

Dna Vaccines

Lane Scheiber
Dna Vaccines Book PDF

Author : Lane Scheiber
Publisher : iUniverse
Page : 388 pages
File Size : 40,5 Mb
Release : 2017-07-31
Category : Medical
ISBN : 9781532017223

Get Book

Dna Vaccines by Lane Scheiber Pdf

The world is under constant threat of a virus evolving into a global plague. To this point, there is no direct defense against a widespread viral infection. DNA Vaccines: Design of a Gene to Eradicate HIV offers an innovative and new strategy to combat deadly viral infections. Presented is the discovery of a unique identifier for HIV. Analysis of the transcription and translation mechanisms utilized by cells leads to exploring the function of nuclear transcription factor proteins as intracellular hunter-killer molecules aimed specifically at viral genomes. Utilizing amino acid-to-nucleotide binding characteristics, taking into account Watson-Crick binding, Hoogsteen grove binding, and Vander Waals forces, modifications to existing transcription factors binding sites are undertaken. Transcription factors are altered to specifically target the unique identifier of pathogenic viruses. Binding a transcription factor directly to a viral genome is intended to silence the genome, preventing transcription if embedded in the DNA or interfering with translation if the genome is present in a cells cytoplasm as RNA. This text describes the design of an intracellular courier gene technology to make cells defensible against HIV and other lethal pathogenic viral threats.

Adverse Effects of Vaccines

Institute of Medicine,Board on Population Health and Public Health Practice,Committee to Review Adverse Effects of Vaccines
Adverse Effects of Vaccines Book PDF

Author : Institute of Medicine,Board on Population Health and Public Health Practice,Committee to Review Adverse Effects of Vaccines
Publisher : National Academies Press
Page : 894 pages
File Size : 45,8 Mb
Release : 2012-04-26
Category : Medical
ISBN : 9780309214353

Get Book

Adverse Effects of Vaccines by Institute of Medicine,Board on Population Health and Public Health Practice,Committee to Review Adverse Effects of Vaccines Pdf

In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children. Adverse Effects of Vaccines reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma. Adverse Effects of Vaccines will be of special interest to the National Vaccine Program Office, the VICP, the Centers for Disease Control and Prevention, vaccine safety researchers and manufacturers, parents, caregivers, and health professionals in the private and public sectors.

Gene Therapy of Cancer

Stanton L. Gerson,Edmund C. Lattime
Gene Therapy of Cancer Book PDF

Author : Stanton L. Gerson,Edmund C. Lattime
Publisher : Elsevier
Page : 555 pages
File Size : 44,5 Mb
Release : 2002-04-04
Category : Science
ISBN : 9780080491363

Get Book

Gene Therapy of Cancer by Stanton L. Gerson,Edmund C. Lattime Pdf

The Second Edition of Gene Therapy of Cancer provides crucial updates on the basic science and ongoing research in this field, examining the state of the art technology in gene therapy and its therapeutic applications to the treatment of cancer. The clinical chapters are improved to include new areas of research and more successful trials. Chapters emphasize the scientific basis of gene therapy using immune, oncogene, antisense, pro-drug activating, and drug resistance gene targets, while other chapters discuss therapeutic approaches and clinical applications. This book is a valuable reference for anyone needing to stay abreast of the latest advances in gene therapy treatment for cancer. Provides in-depth description of targeted systems and treatment strategies Explains the underlying cancer biology necessary for understanding a given therapeutic approach Extensively covers immune therapeutics of vaccines, cytokines, and peptide-induced responses Presents translational focus with emphasis on requirements for clinical implementation Incorporates detailed illustrations of vectors and therapeutic approaches ideal for classroom presentations and general reference

Canadian Immunization Guide

Canada. Comité consultatif national de l'immunisation,Canada. National Advisory Committee on Immunization
Canadian Immunization Guide Book PDF

Author : Canada. Comité consultatif national de l'immunisation,Canada. National Advisory Committee on Immunization
Publisher : Unknown
Page : 392 pages
File Size : 43,5 Mb
Release : 2006
Category : Immunization
ISBN : 0660193922

Get Book

Canadian Immunization Guide by Canada. Comité consultatif national de l'immunisation,Canada. National Advisory Committee on Immunization Pdf

The seventh edition of the Canadian Immunization Guide was developed by the National Advisory Committee on Immunization (NACI), with the support ofthe Immunization and Respiratory Infections Division, Public Health Agency of Canada, to provide updated information and recommendations on the use of vaccines in Canada. The Public Health Agency of Canada conducted a survey in 2004, which confi rmed that the Canadian Immunization Guide is a very useful and reliable resource of information on immunization.

Genetically Engineered Plants as a Source of Vaccines Against Wide Spread Diseases

Sergio Rosales-Mendoza
Genetically Engineered Plants as a Source of Vaccines Against Wide Spread Diseases Book PDF

Author : Sergio Rosales-Mendoza
Publisher : Springer
Page : 295 pages
File Size : 40,7 Mb
Release : 2014-06-21
Category : Science
ISBN : 9781493908509

Get Book

Genetically Engineered Plants as a Source of Vaccines Against Wide Spread Diseases by Sergio Rosales-Mendoza Pdf

Genetically Engineered Plants as a Source of Vaccines Against Wide Spread Diseases: An Integrated View provides an integrated outlook of the disciplines involved in the development of plant-based vaccines as well as an updated compilation of the successful developments in the field. The volume covers immunological aspects of mucosal vaccine design, molecular approaches to attain high levels of the recombinant antigens, the rationale of using bioreactor to expand plant biomass, and pharmaceutical technology approaches that have been applied to the development of plant-based vaccine formulations. Practical figures and tables are presented to facilitate reading and identification of key points. Perspectives for this field are also discussed. Written by authorities in the field, Genetically Engineered Plants as a Source of Vaccines Against Wide Spread Diseases: An Integrated View is a comprehensive resource for researchers and students interested in plant genetics and breeding, immunology, and genetic engineering.

The Science and Applications of Synthetic and Systems Biology

Institute of Medicine,Board on Global Health,Forum on Microbial Threats
The Science and Applications of Synthetic and Systems Biology Book PDF

Author : Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 570 pages
File Size : 46,8 Mb
Release : 2011-12-30
Category : Science
ISBN : 9780309219396

Get Book

The Science and Applications of Synthetic and Systems Biology by Institute of Medicine,Board on Global Health,Forum on Microbial Threats Pdf

Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.