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Guidelines For The Management Of Non Transfusion Dependent Thalassaemia Ntdt Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Guidelines For The Management Of Non Transfusion Dependent Thalassaemia Ntdt book. This book definitely worth reading, it is an incredibly well-written.
Author : Ali Taher,Khaled Musallam,Maria-Domenica Cappellini
Publisher : Unknown
Page : 114 pages
File Size : 51,6 Mb
Release : 2017
Category : Iron deficiency anemia
ISBN : 996371711X
Author : Sue Pavord,Beverley Hunt
Publisher : Cambridge University Press
Page : 128 pages
File Size : 41,5 Mb
Release : 2010-04-15
Category : Medical
ISBN : 9781139487092
Obstetric hematology is a fast-growing area of medicine covering the diagnosis and management of hematological problems of pregnancy. Comprehensive in approach, The Obstetric Hematology Manual addresses the many hematological conditions that can cause serious problems in pregnancy, delivery and the post-partum period for both mother and baby. Written by a team of international authorities, this text provides up-to-date, evidence-based guidelines on best care, as well as sound advice based on the experience and opinion of experts. Where appropriate, basic principles are discussed to clarify the rationale for management, and systems and procedures for disease prevention are highlighted. Many conditions and cases are discussed, including venous thromboembolism, pre-eclampsia, anemia, thrombocytopenia and inherited disorders. This book will appeal to both trainees and practitioners in obstetrics, obstetric medicine, obstetric anesthesia and hematology. It is also an accessible text for midwives, nurses, and laboratory staff.
Author : Maria-Domenica Cappellini
Publisher : Unknown
Page : 128 pages
File Size : 43,5 Mb
Release : 2008
Category : Electronic
ISBN : 9963623700
Author : Chaim Hershko
Publisher : Springer Science & Business Media
Page : 275 pages
File Size : 54,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461505938
Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5).
Author : Anjana Munshi
Publisher : BoD – Books on Demand
Page : 198 pages
File Size : 53,8 Mb
Release : 2015-11-11
Category : Medical
ISBN : 9789535121985
The book, Inherited Hemoglobin Disorders, describes the genetic defects of hemoglobins, disease complications, and therapeutic strategies. This book has two distinct sections. The first theme includes seven chapters devoted to the types of hemoglobinopathies, mutation spectrum, diagnostic methods, and disease complications, and the second theme includes three chapters focusing on various treatment strategies. The content of the chapters presented in the book is guided by the knowledge and experience of the contributing authors. This book serves as an important resource and review to the researchers in the field of hemoglobinopathies.
Author : Ali Taher
Publisher : Elsevier Health Sciences
Page : 128 pages
File Size : 45,5 Mb
Release : 2018-03-07
Category : Medical
ISBN : 9780323583091
This issue of Hematology/Oncology Clinics, edited by Dr. Ali Taher, focuses on Thalassemia. Topics include, but are not limited to, Molecular basis and genetic modifiers; Evolving spectrum of epidemiology; Clinical classification; Ineffective erythropoiesis, anemia and iron overload; Hypercoagulability and vascular disease; Clinical complications and their management; Transfusion and iron chelation therapy; Hematopoietic Stem Cell Transplantation in Thalassemia; Gene therapy and genome editing; Emerging therapies; Quality of life; Advances in understanding pathophysiology and treatment of fertility, pregnancy, and prenatal diagnosis in Thalassemia; and MRI for iron overload.
Author : Stephan Lobitz,Jacques Elion,Raffaella Colombatti,Elena Cela
Publisher : MDPI
Page : 160 pages
File Size : 54,5 Mb
Release : 2019-10-07
Category : Medical
ISBN : 9783039216147
Newborn Screening for Sickle Cell Disease and other Haemoglobinopathies is a Special Issue of the International Journal of Neonatal Screening. Sickle cell disease is one of the most common inherited blood disorders, with a huge impact on health care systems due to high morbidity and high mortality associated with the undiagnosed disease. Newborn screening helps to make the diagnosis early and to prevent fatal complications and diagnostic odysseys. This book gives an overview of diagnostic standards in newborn screening for sickle cell disease and examples of existing newborn screening programs.
Author : Punam Malik,John Tisdale
Publisher : Springer
Page : 248 pages
File Size : 47,6 Mb
Release : 2017-11-09
Category : Medical
ISBN : 9781493972999
Hemoglobin defects, specifically sickle cell disease & thalassemia, combined, constitute the most common monogenic disorders in the world. In fact, nearly 2% of the world’s population carries a globin gene mutation. The transfer of the corrective globin gene through the HSC compartment by allogeneic HSC transplantation (HSCT) has already proven curative in both SCD and thalassemia patients, and provides the proof of concept that genetic manipulation of the defective organ might be equally therapeutic. However, procedural toxicities and the requirement of an HLA-matched sibling donor limit this approach to a fraction of affected individuals. The editors review the progress & the state of the field in HSCT for hemoglobinopathies & shed light on the major changes expected in the next decade. Although allogeneic HSCT is a curative option, it is limited by the availability of matched donors, which are often available only to 15-20% of patients. An alternative to allogeneic HS CT is genetic correction of autologous HSCs, to overcome donor availability & immune side effects. This Book reviews the progress made on additive gene therapy approaches & the current state of the field. Finally, targeted genetic correction is emerging as a novel therapeutic strategy in the hemoglobinopathies. Although ideal, the inefficiency of targeted correction was rate limiting for translation of this technology to the clinic. With advancements in zinc finger nucleases and TALE endonuclease mediated targeted correction, correction frequencies in hematopoietic stem cells is now reaching levels that may become clinically relevant. Furthermore, the ability to generate autologous embryonic stem cell like cells from primary somatic cells (skin fibroblasts or hematopoietic cells) of the affected individual has allowed for the potential application of genetic correction strategies.This Book reviews upcoming genetic strategies to reactivate fetal hemoglobin production and research advances.
Author : Corey S. Scher,Alan David Kaye,Henry Liu,Seth Perelman,Sarah Leavitt
Publisher : Springer Nature
Page : 469 pages
File Size : 40,7 Mb
Release : 2021-03-12
Category : Medical
ISBN : 9783030592950
This comprehensive book is written to inform and improve outcomes of patients in need of blood management during surgical procedures. Information is presented in an accessible format, allowing for immediate use in clinical practice. Beginning with an overview of the history of blood transfusions, early chapters present the foundational information needed to comprehend information in later chapters. Nuanced procedures, drugs, and techniques are covered, including new biologicals to assist clotting and blood substitutes. Further discussions focus on potential complications seen in blood transfusions, such as diseases of the coagulation system, pathogen transmissions, and acute lung injuries. Chapters also examine the complexities of treating specific demographics, of which include the geriatric patient and patients suffering from substance abuse. Essentials of Blood Product Management in Anesthesia Practice is an invaluable guide for anesthesiologists, surgeons, trauma physicians, and solid organ transplant providers.
Author : Lee Goldman,Kathleen A. Cooney
Publisher : Elsevier Health Sciences
Page : 4183 pages
File Size : 53,6 Mb
Release : 2023-07-15
Category : Medical
ISBN : 9780323930857
For more than 95 years, Goldman-Cecil Medicine has been the authoritative source for internal medicine and the care of adult patients. Every chapter is written by acclaimed experts who, with the oversight of our editors, provide definitive, unbiased advice on the diagnosis and treatment of thousands of common and uncommon conditions, always guided by an understanding of the epidemiology and pathobiology, as well as the latest medical literature. But Goldman-Cecil Medicine is not just a textbook. It is designed to optimize electronic searches that will rapidly take you to exactly the information you are seeking. Throughout the lifetime of each edition, periodic updates continually include the newest information from a wide range of journals. Furthermore, Goldman-Cecil Medicine is available for all users of ClinicalKey, Elsevier’s full library of subspecialty textbooks that can be accessed by readers who may want even more in-depth information. More than 400 chapters authored by a veritable "Who’s Who" of modern medicine A practical, templated organization with an emphasis on up-to-date, evidence-based references New chapters on Population Health, Effects of Climate Change on Health, Bradycardias, Transgender Medicine, Whipple Disease, Covid-19 Virology and Pathobiology, Covid-19 Epidemiology/Clinical Manifestations/Diagnosis/Community Prevention, COVID-19 Treatment and Vaccination, Polyomaviruses, and more Thousands of algorithms, figures, and tables that make its information readily accessible Over 100 supplementary videos, heart sounds, and key references Available in print and on a variety of electronic devices Continuously updated by Lee Goldman, MD
Author : Brian I. Carr
Publisher : Springer Nature
Page : 408 pages
File Size : 51,8 Mb
Release : 2021-09-22
Category : Medical
ISBN : 9783030787370
This book aims to illuminate the causes, incidence, and treatments of Hepatocellular Carcinoma(HCC) or liver cancer in the politically important and societally diverse region of the Middle East. Taking a flexible and inclusive view, it examines the influences of geography, crops and diet, ethnicity, and local behavior on both diagnosis and outcomes of this disease. Understanding the different causes of liver cancer enables effective strategies for both prevention and early diagnosis while knowledge of the different treatment modalities, their uses and limitations, availability and costs, works to inform rational treatment provision and selection. Divided into four sections, this book considers the causes and clinical syndromes associated with HCC, provides a detailed overview of clinical HCC and treatment modalities, describes country-specific clinical HCC experience and practice, and considers future needs and the potential for HCC collaborations across the region. Liver Cancer in the Middle East is a useful resource for clinicians seeking insight into the second highest cause of death from cancer worldwide, governments planning social and medical services for their peoples, as well as for international aid agencies prioritizing donations.
Author : Galanello Renzo,Thalassaemia International Federation
Publisher : Unknown
Page : 190 pages
File Size : 54,8 Mb
Release : 2003
Category : Electronic
ISBN : 9963623395
Volume 1 of the Prevention Book presents the principles of a programme for the prevention of the thalassaemia and other haemoglobin disorders, including a description of the various types of disorders requiring prenatal diagnosis, the strategies used for carrier screening, and a number of annexes listing upto date epidemiological and mutation data on thalassaemia. This book was written for use in combination with Volume 2, which describes many of the laboratory protocols in great detail.
Author : Elizabeth N. Anionwu,Karl Atkin
Publisher : Unknown
Page : 184 pages
File Size : 53,7 Mb
Release : 2001
Category : Ethnic groups
ISBN : UOM:39015054270221
Sickle cell disorder (SCD) and thalassaemia are inherited blood disorders which have only recently gained serious attention among health professionals and policy makers. In this text, Anionwu (nursing, Thames Valley U.) and Atkin (U. of Leeds) explore issues regarding these disorders in the UK, and the broader problems faced by minority ethnic communities in acquiring adequate health care and support. Coverage includes a clinical introduction to haemoglobinopathies; screening and diagnosing within the context of the "new genetics," including associated ethical dilemmas and problems; general problems faced by patients and their families, and their daily coping strategies; current shortfalls in providing care; examples of existing good practice; strategies and struggles from the historical development of haemoglobinopathy services in the UK; and opportunities and threats for the future. c. Book News Inc.
Author : Marwa Zakaria,Tamer Hassan
Publisher : BoD – Books on Demand
Page : 176 pages
File Size : 51,9 Mb
Release : 2020-09-23
Category : Medical
ISBN : 9781838805869
Beta thalassemia is a common blood disorder worldwide. Thousands of infants with beta thalassemia are born each year. This book covers most of the aspects related to this disease and greatly helps in understanding this disease and its complications. Of interest are clinical studies as well as basic and translational research reports regarding pathogenesis, genetics, diagnosis as well as standard and novel therapies. This book intends to provide the reader with a comprehensive overview of today’s practices and tomorrow’s possibilities about beta thalassemia.
Author : Syed A. Abutalib,Jean M. Connors,Margaret V. Ragni
Publisher : Springer
Page : 718 pages
File Size : 47,5 Mb
Release : 2016-08-24
Category : Medical
ISBN : 9783319303529
This book, in Q&A format, addresses a wide range of clinically relevant topics and issues in Nonmalignant Hematology, or “Benign Hematology,” with a view to offering a robust, engaging tool that will assist every hematologist and oncologist (pediatric and adult equally) in making decisions during day-to-day practice. The entire spectrum of the specialty is covered in more than 60 exceptional chapters written by acknowledged authorities in the field. The content is organized into well-designed broad sections on red cell disorders, platelet and coagulation disorders, coagulopathy in systemic diseases, thromboembolic disease and its management (including surgical), immune system and related disorders, hemostasis and thrombosis during pregnancy and in the newborn and elderly, and Transfusion Medicine. A key aspect of the book is the opportunity it affords expert physicians to express well-reasoned opinions regarding complex issues in Nonmalignant Hematology. Readers will find that it provides a practical and immediately applicable compendium of answers to often complex and vexing questions. It will appeal to residents, fellows, house officers and more experienced practitioners around the globe.