Inflammation And Stroke

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Inflammation and Stroke

Giora Z. Feuerstein
Inflammation and Stroke Book PDF

Author : Giora Z. Feuerstein
Publisher : Springer
Page : 351 pages
File Size : 54,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783034882972

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Inflammation and Stroke by Giora Z. Feuerstein Pdf

Stroke is a leading cause of death in developed countries. However, current therapeutic strategies for stroke have been largely unsuccessful. One possible explanation is that research and pharmacological management have focused on very early events in brain ischemia. New research has shown that brain ischemia and trauma elicit strong inflammatory reactions driven by both external and brain cells. The recognition of inflammation as a fundamental response to brain ischemia provides novel opportunities for new anti-inflammatory therapies. For the first time, an international body of researchers presents the latest findings about the cellular and humoral aspects of immune and inflammatory reactions in the brain. The work may have an impact on the treatment of neuroinjuries and ancillary brain diseases, and increase the understanding of the roles infections and immune reactions play in the brain milieu.

Neuroinflammation in Stroke

Ulrich Dirnagl,Bernd Elger
Neuroinflammation in Stroke Book PDF

Author : Ulrich Dirnagl,Bernd Elger
Publisher : Springer Science & Business Media
Page : 224 pages
File Size : 44,5 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9783662054260

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Neuroinflammation in Stroke by Ulrich Dirnagl,Bernd Elger Pdf

The successful treatment of acute stroke remains one of the major challenges in clinical medicine. Over the last decades, the understanding of stroke pathophysiology has greatly improved, while the therapeutic options in stroke therapy remain very limited. Today, hyperacute mechanisms of damage, such as excitotoxicity, can be discriminated from delayed ones, such as inflammation and apoptosis. Targeting of inflammation has already been successfully applied in various stroke models, but translation into a clinically efficacious strategy has not been achieved so far. In this book, leading experts in basic cerebrovascular research as well as stroke treatment review the current evidence for and against an important role for inflammation in stroke, and explore the potential of treating or modulating inflammation in stroke therapy.

Inflammation and Stroke

Giora Z. Feuerstein
Inflammation and Stroke Book PDF

Author : Giora Z. Feuerstein
Publisher : Birkhauser Basel
Page : 356 pages
File Size : 45,6 Mb
Release : 2001
Category : Medical
ISBN : 3764365110

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Inflammation and Stroke by Giora Z. Feuerstein Pdf

Stroke is a leading cause of death in developed countries. However, current therapeutic strategies for stroke have been largely unsuccessful. One possible explanation is that research and pharmacological management have focused on very early events in brain ischemia. New research has shown that brain ischemia and trauma elicit strong inflammatory reactions driven by both external and brain cells. The recognition of inflammation as a fundamental response to brain ischemia provides novel opportunities for new anti-inflammatory therapies. For the first time, an international body of researchers presents the latest findings about the cellular and humoral aspects of immune and inflammatory reactions in the brain. The work may have an impact on the treatment of neuroinjuries and ancillary brain diseases, and increase the understanding of the roles infections and immune reactions play in the brain milieu.

Mechanisms of Secondary Brain Damage

A. Baethmann,K. G. Go,A. Unterberg
Mechanisms of Secondary Brain Damage Book PDF

Author : A. Baethmann,K. G. Go,A. Unterberg
Publisher : Springer Science & Business Media
Page : 403 pages
File Size : 49,8 Mb
Release : 2013-03-09
Category : Science
ISBN : 9781468452037

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Mechanisms of Secondary Brain Damage by A. Baethmann,K. G. Go,A. Unterberg Pdf

A distinction between primary and secondary brain damage of vari ous origin, particularly in acute lesions, such as head injury and ische mia is not entirely new. The concept is of practical significance, be cause it is the foremost intention of all clinical efforts to prevent, or at least attenuate the development of secondary sequelae. Primary dam age to nervous elements usually cannot be influenced by treatment. Its prevention is the objective of prophylactic measures. The current volume gathered prominent scientists and clinicians from various fields to pro vide a competent introduction and survey of the various aspects involved in secondary brain damage. It was attempted to provide criteria for the distinction between the primary and secondary phenomena on a morpho logical and functional level, on the basis of the kinetics involved and, most importantly, regarding the different specific manifestations, such as disturbances of microcirculation, aspects of the blood-brain barrier, and of cellular structure and function at a molecular level. Although it was not expected that a grand unifying hypothesis will be reached recon cilable with the many, occasionally opposing views on such a complex subject, nevertheless, the present volume attains an appropriate result. It can best be described as a mosaic of many different pieces which only as an ensemble reflect the current state of the art.

Uncommon Causes of Stroke

Julien Bogousslavsky,Louis R. Caplan
Uncommon Causes of Stroke Book PDF

Author : Julien Bogousslavsky,Louis R. Caplan
Publisher : Cambridge University Press
Page : 418 pages
File Size : 47,9 Mb
Release : 2001-05-24
Category : Medical
ISBN : 0521771455

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Uncommon Causes of Stroke by Julien Bogousslavsky,Louis R. Caplan Pdf

An essential resource for diagnosis and treatment of stroke patients outside the usual clinical categories.

Cerebral Ischemic Reperfusion Injuries (CIRI)

Weijian Jiang,Wengui Yu,Yan Qu,Zhongsong Shi,Benyan Luo,John H. Zhang
Cerebral Ischemic Reperfusion Injuries CIRI Book PDF

Author : Weijian Jiang,Wengui Yu,Yan Qu,Zhongsong Shi,Benyan Luo,John H. Zhang
Publisher : Springer
Page : 259 pages
File Size : 47,7 Mb
Release : 2018-06-29
Category : Medical
ISBN : 9783319901947

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Cerebral Ischemic Reperfusion Injuries (CIRI) by Weijian Jiang,Wengui Yu,Yan Qu,Zhongsong Shi,Benyan Luo,John H. Zhang Pdf

This volume is focused on subjects related to cerebral ischemia and reperfusion injuries after acute stroke. All chapters are selected from the Sixth Elite Stroke meeting named Pangu Stroke Conference and written by members of world leading laboratories of stroke studies. The contents cover both clinical and bench studies, from basic components of cerebral arterial system to clinical reperfusion injury cases, from reperfusion caused programmed cell death and astrocyte activation to oxidative stress and nitric oxide after reperfusion, from extracellular matrix and inflammation to a role of diabetes after reperfusion, from small artery disorders to collateral circulation and blood pressure control after reperfusion. Wei-Jian Jiang, Chairman of New Era Stroke Care and Research Institute of PLA Rocket Force General Hospital, Beijing, China. Wengui Yu, Professor and Director of Comprehensive Stroke & Cerebrovascular Center, University of California, Irvine Yan Qu, Professor and Director of Neurosurgery at the Second Affiliated Hospital of Air Force Medical University, Xi’an, China. Zhongsong Shi, Professor of Neurosurgery at Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Ben-yan Luo, Professor and Chair of Neurology at the First Affiliated Hospital of Zhejiang University. John H. Zhang, Professor of Anesthesiology and Physiology at Loma Linda University School of Medicine, Loma Linda, CA, USA.

Neuroinflammation

Mario Di Napoli,Francesca Papa
Neuroinflammation Book PDF

Author : Mario Di Napoli,Francesca Papa
Publisher : Unknown
Page : 0 pages
File Size : 53,8 Mb
Release : 2008
Category : Cerebral ischemia
ISBN : 1606920308

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Neuroinflammation by Mario Di Napoli,Francesca Papa Pdf

Ischemic stroke is a devastating clinical event. Increasing evidence suggests that inflammatory mechanisms are involved in the progression of post ischemic-induced brain injury. Cerebral ischemia is accompanied by a marked inflammatory reaction that is initiated by ischemia-induced expression of cytokines, adhesion molecules, and other inflammatory mediators, including prostanoids, extracellular proteases, reactive oxygen species and nitric oxide, leading to the accumulation of inflammatory cells, such as leukocytes and microglia. The inflammatory reaction, which has a rapid onset and continues after the stroke, is thought to acutely contribute to the evolution of tissue injury. Many compounds have been identified in cerebral ischemia, which are known to promote and sustain inflammatory responses. Better understanding of the role of the post ischemic-induced inflammatory response and its potential for modulation might have profound implications for patient treatment. Pre-clinical studies suggest that interventions that are aimed at attenuating such inflammation reduce the progression of brain damage that occurs during the late stages of cerebral ischemia. In particular, strategies that block the activity of inflammation-related enzymes reduce ischemic damage with an extended therapeutic window. In this review, a summary of the available literature on the inflammatory responses after cerebral ischemia and ischemic stroke is presented along with discussion of some of the emerging opportunities for potential therapeutic strategies. Although at the moment, clinical trials using anti-inflammatory strategies did not show benefit in patients with ischemic stroke, there is a strong rationale for continuing to explore the efficacy of anti-inflammatory therapies in the treatment of the late stages of cerebral ischemia. It is plausible that in the near future, additional strategies using neuroprotective drug cocktails that target inflammation could offer exciting new promise in the therapeutic approach to ischemic stroke.

Toole's Cerebrovascular Disorders

E. Steve Roach,Kerstin Bettermann,Jose Biller
Toole s Cerebrovascular Disorders Book PDF

Author : E. Steve Roach,Kerstin Bettermann,Jose Biller
Publisher : Cambridge University Press
Page : 445 pages
File Size : 43,5 Mb
Release : 2010-02-15
Category : Medical
ISBN : 9781139855587

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Toole's Cerebrovascular Disorders by E. Steve Roach,Kerstin Bettermann,Jose Biller Pdf

Toole's Cerebrovascular Disorders was the first modern book devoted to care of the stroke, originally published more than 40 years ago. This is a completely revised and updated sixth edition of the highly respected standard for stroke diagnosis and treatment. Dr James Toole has stayed on as a consultant for the text, and Drs E. Steve Roach, Kerstin Bettermann, and Jose Biller have reworked Dr Toole's book to include chapters on genetics, pregnancy-related stroke, and acute treatments. The practical focus of the book has not changed, retaining its emphasis on bedside diagnosis and treatment. Easily accessible both for stroke specialists and residents, the sixth edition has been modernized to keep pace with the rapid expansion of knowledge in stroke care and includes evidence-based recommendations, the latest technology and imaging, and risk factors. The text is supplemented with more than 200 images, many in color.

Mechanisms of Neuroinflammation

Gonzalo Emiliano Aranda Abreu
Mechanisms of Neuroinflammation Book PDF

Author : Gonzalo Emiliano Aranda Abreu
Publisher : BoD – Books on Demand
Page : 320 pages
File Size : 46,8 Mb
Release : 2017-08-23
Category : Medical
ISBN : 9789535134510

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Mechanisms of Neuroinflammation by Gonzalo Emiliano Aranda Abreu Pdf

"Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of suitable therapies that revert the neuronal inflammation and thus prevent further damage to the nervous system.

Advancement in the Pathophysiology of Cerebral Stroke

Ranjana Patnaik,Amit Kumar Tripathi,Ashish Dwivedi
Advancement in the Pathophysiology of Cerebral Stroke Book PDF

Author : Ranjana Patnaik,Amit Kumar Tripathi,Ashish Dwivedi
Publisher : Springer
Page : 0 pages
File Size : 41,9 Mb
Release : 2019-05-23
Category : Medical
ISBN : 9811314527

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Advancement in the Pathophysiology of Cerebral Stroke by Ranjana Patnaik,Amit Kumar Tripathi,Ashish Dwivedi Pdf

This book provides detailed and comprehensive mechanistic insights of the various risk factors that lead to the ischemic stroke and the novel therapeutic interventions against it. The first section discusses the different ischemic cerebral stroke-induced inflammatory pathways and dysfunctionality of blood-brain barrier. The later sections of the book deals with the role of endoplasmic reticulum stress and mitophagy in cerebral stroke and introduces the different neuroimaging techniques such as Computed tomography (CT), Magnetic resonance imaging (MRI), Positron emission tomography (PET) and Single-Photon emission computed tomography (SPECT) that are used to identify the arterial blockages. The final section comprises of chapters that focus on various neuroprotective strategies and emerging therapeutic interventions for combating stroke pathophysiology. The chapters cover the role of stem cell therapy, the therapeutic effect of low-frequency electromagnetic radiations (LF-EMR), and implications of non-coding RNAs such as micro-RNAs as the biomarkers for diagnosis, prognosis, and therapy in ischemic stroke.

Translational Research in Stroke

Paul A. Lapchak,Guo-Yuan Yang
Translational Research in Stroke Book PDF

Author : Paul A. Lapchak,Guo-Yuan Yang
Publisher : Springer
Page : 581 pages
File Size : 55,6 Mb
Release : 2017-12-20
Category : Medical
ISBN : 9789811058042

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Translational Research in Stroke by Paul A. Lapchak,Guo-Yuan Yang Pdf

This book mainly discusses the current status of stroke transnational research and allows the reader to understand the interplay of common comorbidities in the stroke population such as diabetes and hypertension, and provides insight into stroke targets to promote cell survival, angiogenesis, neurogenesis, and most importantly, functional recovery after stroke. Throughout the world, stroke is still a leading cause of mortality and morbidity; each year approximately 15 million people worldwide suffer from stroke. Stroke is now the leading cause of death and disability in China. Large communities of stroke survivors are eagerly awaiting scientific advances in transnational stroke research that would offer neuroprotective therapeutics for acute stroke management, or rehabilitation and regenerative strategies utilizing novel stem cell-based approaches. While research is ongoing, the Editors have compiled this volume to help the further understanding of the pathophysiology of stroke and to review and identify future potential biomarkers. The book is written for students, researchers and physicians in neurosciences, neurology and neuroradiology.

Immunological Mechanisms and Therapies in Brain Injuries and Stroke

Jun Chen,Xiaoming Hu,Mary Stenzel-Poore,John H. Zhang
Immunological Mechanisms and Therapies in Brain Injuries and Stroke Book PDF

Author : Jun Chen,Xiaoming Hu,Mary Stenzel-Poore,John H. Zhang
Publisher : Springer Science & Business Media
Page : 386 pages
File Size : 47,8 Mb
Release : 2013-11-09
Category : Medical
ISBN : 9781461489153

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Immunological Mechanisms and Therapies in Brain Injuries and Stroke by Jun Chen,Xiaoming Hu,Mary Stenzel-Poore,John H. Zhang Pdf

Recent research has revealed the importance of immunological mechanisms and inflammation in delaying damage and/or promoting repair after an acute injury to the central nervous system. This book provides a comprehensive and up-to-date overview of the role of immunological mechanisms and therapies for treating acute neurological injuries such as cerebral ischemia, hemorrhage, and brain and spinal cord trauma. In several sections, the contributing authors provide a review of immunological mechanisms involved in neurological injury and of various translational and clinical research aimed at harnessing those mechanisms for better patient outcomes.​

Textbook of Stroke Medicine

Michael Brainin,Susanne Tabernig,Wolf-Dieter Heiss
Textbook of Stroke Medicine Book PDF

Author : Michael Brainin,Susanne Tabernig,Wolf-Dieter Heiss
Publisher : Cambridge University Press
Page : 425 pages
File Size : 50,5 Mb
Release : 2014-09-11
Category : Medical
ISBN : 9781107047495

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Textbook of Stroke Medicine by Michael Brainin,Susanne Tabernig,Wolf-Dieter Heiss Pdf

Fully revised throughout, the new edition of this concise textbook is aimed at doctors preparing to specialize in stroke care.

Hidden Causes of Heart Attack and Stroke

Christian Wilde
Hidden Causes of Heart Attack and Stroke Book PDF

Author : Christian Wilde
Publisher : Unknown
Page : 0 pages
File Size : 44,8 Mb
Release : 2003-04
Category : Health & Fitness
ISBN : 0972495908

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Hidden Causes of Heart Attack and Stroke by Christian Wilde Pdf

Written to empower you to interface intelligently with your doctors in protecting yourself and your family from America's number one killer. Written in everyday language, this book prepares you to discuss the cutting edge blood tests for C-reactive protein, inherited and acquired hidden risk factors and how to neutralize them by natural means. Rarely has a book drawn such enthusiastic endorsements from leaders in cardiology, even recommended for doctors. HEA000000

Inflammation and the Microcirculation

D. Neil Granger,Elena Senchenkova
Inflammation and the Microcirculation Book PDF

Author : D. Neil Granger,Elena Senchenkova
Publisher : Morgan & Claypool Publishers
Page : 99 pages
File Size : 45,6 Mb
Release : 2010
Category : Medical
ISBN : 9781615041657

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Inflammation and the Microcirculation by D. Neil Granger,Elena Senchenkova Pdf

The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References