Translational Research In Stroke

Author : Paul A. Lapchak,Guo-Yuan Yang
Publisher : Springer
Page : 581 pages
File Size : 50,6 Mb
Release : 2017-12-20
Category : Medical
ISBN : 9789811058042

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Translational Research in Stroke by Paul A. Lapchak,Guo-Yuan Yang Pdf

This book mainly discusses the current status of stroke transnational research and allows the reader to understand the interplay of common comorbidities in the stroke population such as diabetes and hypertension, and provides insight into stroke targets to promote cell survival, angiogenesis, neurogenesis, and most importantly, functional recovery after stroke. Throughout the world, stroke is still a leading cause of mortality and morbidity; each year approximately 15 million people worldwide suffer from stroke. Stroke is now the leading cause of death and disability in China. Large communities of stroke survivors are eagerly awaiting scientific advances in transnational stroke research that would offer neuroprotective therapeutics for acute stroke management, or rehabilitation and regenerative strategies utilizing novel stem cell-based approaches. While research is ongoing, the Editors have compiled this volume to help the further understanding of the pathophysiology of stroke and to review and identify future potential biomarkers. The book is written for students, researchers and physicians in neurosciences, neurology and neuroradiology.

Author : Paul A. Lapchak,John H. Zhang
Publisher : Springer Science & Business Media
Page : 926 pages
File Size : 45,5 Mb
Release : 2012-03-23
Category : Medical
ISBN : 9781441995292

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Translational Stroke Research by Paul A. Lapchak,John H. Zhang Pdf

This volume sets a basis for effective translational research. Authored by experts in the field of translational stroke research, each chapter specifically addresses one or more components of preclinical stroke research. The emphasis is placed on target identification and drug development using state-of-the-art in vitro and in vivo assays, in combination with in vitro toxicology assays, AMDE and clinical design.

Author : Paul A. Lapchak,杨国源
Publisher : Unknown
Page : 581 pages
File Size : 42,7 Mb
Release : 2018
Category : Cerebrovascular disease
ISBN : 731318932X

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Translational Research in Stroke by Paul A. Lapchak,杨国源 Pdf

Author : Paul A. Lapchak,John H. Zhang
Publisher : Springer
Page : 541 pages
File Size : 55,7 Mb
Release : 2017-11-04
Category : Medical
ISBN : 9783319666792

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Cellular and Molecular Approaches to Regeneration and Repair by Paul A. Lapchak,John H. Zhang Pdf

This book discusses recent advances in the field of translational stroke research. The editors have designed the book to provide new insight into the importance of regeneration and repair mechanisms for stroke victims. The editors have brought together a talented group of international stroke researchers and clinicians to contribute to this volume, which is written for students, researchers and physicians in biotechnology, neurosciences, neurology, neuroradiology and neurosurgery. Throughout the world, stroke is still a leading cause of mortality and morbidity; there are 152,000 strokes in the United Kingdom, 62,000 in Canada, and approximately 15 million people worldwide. Large communities of stroke survivors are eagerly awaiting scientific advances in translational stroke research related to regeneration and recovery of function that would offer new therapeutics for rehabilitation and regeneration utilizing novel stem cell and molecular-based approaches. This volume will allow the reader to undersnd the future of stroke treatment from its inception in the laboratory through to clinical trial design. The reader will learn about the recent advances made in these areas related to basic and applied stroke research and their translational potential. Dr. Paul A. Lapchak is Professor of Neurology and Director of Translational Research in the Departments of Neurology & Neurosurgery at Cedars-Sinai Medical Center in Los Angeles CA, USA. Dr. Lapchak is an internationally recognized expert conducting translational drug development research for ischemic and hemorrhagic stroke. Dr. John H. Zhang is Professor of Anesthesiology, Neurosurgery, Neurology, and Physiology, and Director, Center for Neuroscience Research at Loma Linda University School of Medicine, Loma Linda, CA, USA. Dr. Zhang is an internationally recognized expert working on drug development for hemorrhagic stroke.

Author : Paul A. Lapchak,John H. Zhang
Publisher : Springer
Page : 795 pages
File Size : 54,8 Mb
Release : 2017-01-12
Category : Medical
ISBN : 9783319453453

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Neuroprotective Therapy for Stroke and Ischemic Disease by Paul A. Lapchak,John H. Zhang Pdf

A critical and comprehensive look at current state-of-the-art scientific and translational research being conducted internationally, in academia and industry, to address new ways to provide effective treatment to victims of ischemic and hemorrhagic stroke and other ischemic diseases. Currently stroke can be successfully treated through the administration of a thrombolytic, but the therapeutic window is short and many patients are not able to receive treatment. Only about 30% of patients are "cured" by available treatments. In 5 sections, the proposed volume will explore historical and novel neuroprotection mechanisms and targets, new and combination therapies, as well as clinical trial design for some of the recent bench-side research.

Author : Springer
Publisher : Unknown
Page : 948 pages
File Size : 50,9 Mb
Release : 2012-03-27
Category : Electronic
ISBN : 1441995315

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Translational Stroke Research by Springer Pdf

Author : Bridget Martinez
Publisher : Royal Society of Chemistry
Page : 366 pages
File Size : 51,8 Mb
Release : 2017-11-23
Category : MEDICAL
ISBN : 9781782629504

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Acute Brain Impairment by Bridget Martinez Pdf

Author : Daniel Laskowitz,Gerald Grant
Publisher : CRC Press
Page : 412 pages
File Size : 52,8 Mb
Release : 2015-12-01
Category : Medical
ISBN : 9781498766579

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Translational Research in Traumatic Brain Injury by Daniel Laskowitz,Gerald Grant Pdf

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

Author : Kiyohiro Houkin,Koji Abe,Satoshi Kuroda
Publisher : Springer
Page : 156 pages
File Size : 47,7 Mb
Release : 2017-01-06
Category : Medical
ISBN : 9784431560593

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Cell Therapy Against Cerebral Stroke by Kiyohiro Houkin,Koji Abe,Satoshi Kuroda Pdf

This book presents comprehensive reviews for both translational research and clinical trials on cell therapy for stroke. Cerebral stroke is still a leading cause of death and disability. However, despite intensive research, few treatment options are available. The therapeutic potential of cell transplantation has been studied for various pathological conditions of the central nervous system (CNS) including traumatic brain injury, traumatic spinal cord injury, degenerative disease, demyelinating disease and ischemic stroke, as the injured neural tissue in the CNS has only a limited regenerative capacity. Recently, a growing body of evidence in this field suggests that cell transplantation holds great potential as a form of stroke therapy. The authors, who are experts in the field of neurosurgery, review and discuss optimal cell sources and various issues involved in translational research; further, they outline ongoing clinical trials in Japan.

Author : Giuseppe Micieli,Diana Amantea
Publisher : CRC Press
Page : 542 pages
File Size : 55,6 Mb
Release : 2014-08-27
Category : Medical
ISBN : 9781466594975

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Rational Basis for Clinical Translation in Stroke Therapy by Giuseppe Micieli,Diana Amantea Pdf

Stroke remains one of the major causes of death and long-term disability worldwide. Currently, the only approved therapy for the acute treatment of this disease is thrombolysis, a strategy that can only be applied to a small percentage of patients due to its narrow therapeutic window. Unfortunately, during the last years numerous promising drugs that showed neuroprotection in the experimental setting failed to translate into the clinic because of their toxicity or lack of efficacy. Researchers in the field now face the crucial need to develop effective stroke therapies and successfully translate novel strategies into the clinical setting. Rational Basis for Clinical Translation in Stroke Therapy presents the most recent promising preclinical approaches and the most updated clinical evidence for treating stroke patients. By bringing together the experience of accomplished stroke researchers and clinicians, the book is a useful tool for improving the treatment and management of stroke patients. The book describes current approaches for the management of stroke patients including thrombolysis and mechanical recanalization procedures as well as other clinically relevant topics such as diagnosis, imaging, risk factors, and prevention. Also described are emerging interventions based on the use of stem cells, botulinum toxin, and antidepressants which complement emergency stroke treatment and conventional rehabilitation procedures. Clinical approaches are integrated with the most promising therapeutic opportunities based on targeting the immune system, hypothermia, and postconditioning. The book also covers issues related to the improvement of R&D strategies in stroke therapeutics, aimed at the implementation of preclinical approaches with stroke model guidelines and at the optimization of clinical trial design. This volume is a reference for all those interested in the rational development of novel stroke therapeutics.

Author : Jun Chen,Xiaoming Hu,Mary Stenzel-Poore,John H. Zhang
Publisher : Springer Science & Business Media
Page : 386 pages
File Size : 42,6 Mb
Release : 2013-11-09
Category : Medical
ISBN : 9781461489153

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Immunological Mechanisms and Therapies in Brain Injuries and Stroke by Jun Chen,Xiaoming Hu,Mary Stenzel-Poore,John H. Zhang Pdf

Recent research has revealed the importance of immunological mechanisms and inflammation in delaying damage and/or promoting repair after an acute injury to the central nervous system. This book provides a comprehensive and up-to-date overview of the role of immunological mechanisms and therapies for treating acute neurological injuries such as cerebral ischemia, hemorrhage, and brain and spinal cord trauma. In several sections, the contributing authors provide a review of immunological mechanisms involved in neurological injury and of various translational and clinical research aimed at harnessing those mechanisms for better patient outcomes.​

Author : Ana Catarina Fonseca,José M. Ferro
Publisher : Springer Nature
Page : 339 pages
File Size : 52,9 Mb
Release : 2021-05-04
Category : Medical
ISBN : 9783030707613

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Precision Medicine in Stroke by Ana Catarina Fonseca,José M. Ferro Pdf

This book provides a comprehensive coverage of the state of the art in precision medicine in stroke. It starts by explaining and giving general information about precision medicine. Current applications in different strokes types (ischemic, haemorrhagic) are presented from diagnosis to treatment. In addition, ongoing research in the field (early stroke diagnosis and estimation of prognosis) is extensively discussed. The final part provides an in-depth discussion of how different interdisciplinary areas like artificial intelligence, molecular biology and genetics are contributing to this area. Precision Medicine in Stroke provides a practical approach to each chapter, reinforcing clinical applications and presenting clinical cases. This book is intended for all clinicians that interact with stroke patients (neurologists, internal medicine doctors, general practitioners, neurosurgeons), students and basic researchers.

Author : Weijian Jiang,Wengui Yu,Yan Qu,Zhongsong Shi,Benyan Luo,John H. Zhang
Publisher : Springer
Page : 259 pages
File Size : 48,7 Mb
Release : 2018-06-29
Category : Medical
ISBN : 9783319901947

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Cerebral Ischemic Reperfusion Injuries (CIRI) by Weijian Jiang,Wengui Yu,Yan Qu,Zhongsong Shi,Benyan Luo,John H. Zhang Pdf

This volume is focused on subjects related to cerebral ischemia and reperfusion injuries after acute stroke. All chapters are selected from the Sixth Elite Stroke meeting named Pangu Stroke Conference and written by members of world leading laboratories of stroke studies. The contents cover both clinical and bench studies, from basic components of cerebral arterial system to clinical reperfusion injury cases, from reperfusion caused programmed cell death and astrocyte activation to oxidative stress and nitric oxide after reperfusion, from extracellular matrix and inflammation to a role of diabetes after reperfusion, from small artery disorders to collateral circulation and blood pressure control after reperfusion. Wei-Jian Jiang, Chairman of New Era Stroke Care and Research Institute of PLA Rocket Force General Hospital, Beijing, China. Wengui Yu, Professor and Director of Comprehensive Stroke & Cerebrovascular Center, University of California, Irvine Yan Qu, Professor and Director of Neurosurgery at the Second Affiliated Hospital of Air Force Medical University, Xi’an, China. Zhongsong Shi, Professor of Neurosurgery at Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Ben-yan Luo, Professor and Chair of Neurology at the First Affiliated Hospital of Zhejiang University. John H. Zhang, Professor of Anesthesiology and Physiology at Loma Linda University School of Medicine, Loma Linda, CA, USA.

Author : Richard L. Harvey, MD,Richard F. Macko, MD,Dr. Joel Stein, MD,Carolee J. Winstein, PhD, PT, FAPTA,Richard D. Zorowitz, MD
Publisher : Demos Medical Publishing
Page : 224 pages
File Size : 55,6 Mb
Release : 2008-11-20
Category : Medical
ISBN : 1935281054

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Stroke Recovery and Rehabilitation by Richard L. Harvey, MD,Richard F. Macko, MD,Dr. Joel Stein, MD,Carolee J. Winstein, PhD, PT, FAPTA,Richard D. Zorowitz, MD Pdf

A Doody's Core Title 2012 Stroke Recovery and Rehabilitation is the new gold standard comprehensive guide to the management of stroke patients. Beginning with detailed information on risk factors, epidemiology, prevention, and neurophysiology, the book details the acute and long-term treatment of all stroke-related impairments and complications. Additional sections discuss psychological issues, outcomes, community reintegration, and new research. Written by dozens of acknowledged leaders in the field, and containing hundreds of tables, graphs, and photographic images, Stroke Recovery and Rehabilitation features: The first full-length discussion of the most commonly-encountered component of neurorehabilitation Multi-specialty coverage of issues in rehabilitation, neurology, PT, OT, speech therapy, and nursing Focus on therapeutic management of stroke related impairments and complications An international perspective from dozens of foremost authorities on stroke Cutting edge, practical information on new developments and research trends Stroke Recovery and Rehabilitation is a valuable reference for clinicians and academics in rehabilitation and neurology, and professionals in all disciplines who serve the needs of stroke survivors.

Author : Renée Felice Lyons,Warner, Grace,Atlantic Health Promotion Research Centre
Publisher : Halifax, NS : Atlantic Health Promotion Research Centre
Page : 21 pages
File Size : 43,5 Mb
Release : 2005
Category : Electronic
ISBN : 077038062X

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Demystifying Knowledge Translation for Stroke Researchers : a Primer on Theory and Praxis by Renée Felice Lyons,Warner, Grace,Atlantic Health Promotion Research Centre Pdf