Microbial Iron Metabolism

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Microbial Iron Metabolism

J. B. Neilands
Microbial Iron Metabolism Book PDF

Author : J. B. Neilands
Publisher : Academic Press
Page : 616 pages
File Size : 46,8 Mb
Release : 2014-06-28
Category : Science
ISBN : 9781483274812

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Microbial Iron Metabolism by J. B. Neilands Pdf

Microbial Iron Metabolism: A Comprehensive Treatise provides a comprehensive treatment of microbial iron metabolism. It aims to contribute to an increased understanding of the path of iron in microbial species and, eventually, in the plant and animal. The book is organized into five parts. Part I describes some features of iron and its function in the microbial world. These include a historical sketch of the recognition of the importance of iron in cellular physiology; a description of certain physical properties of ferrous and ferric ions; and a list of various known biocoordination derivatives grouped by ligand atom. Metabolism under iron-limited conditions is also examined. Part II presents studies on iron transport, biosynthesis, and storage in microorganisms. Part III examines iron enzymes and proteins, including ferredoxin, rubredoxin, nitrogenase, and hydrogenase. Part IV deals with reactions of inorganic substrates. Part V presents a study on the role of bacterial iron metabolism in infection and immunity.

Military Strategies for Sustainment of Nutrition and Immune Function in the Field

Institute of Medicine,Committee on Military Nutrition Research
Military Strategies for Sustainment of Nutrition and Immune Function in the Field Book PDF

Author : Institute of Medicine,Committee on Military Nutrition Research
Publisher : National Academies Press
Page : 722 pages
File Size : 52,9 Mb
Release : 1999-05-13
Category : Medical
ISBN : 9780309173186

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Military Strategies for Sustainment of Nutrition and Immune Function in the Field by Institute of Medicine,Committee on Military Nutrition Research Pdf

Every aspect of immune function and host defense is dependent upon a proper supply and balance of nutrients. Severe malnutrition can cause significant alteration in immune response, but even subclinical deficits may be associated with an impaired immune response, and an increased risk of infection. Infectious diseases have accounted for more off-duty days during major wars than combat wounds or nonbattle injuries. Combined stressors may reduce the normal ability of soldiers to resist pathogens, increase their susceptibility to biological warfare agents, and reduce the effectiveness of vaccines intended to protect them. There is also a concern with the inappropriate use of dietary supplements. This book, one of a series, examines the impact of various types of stressors and the role of specific dietary nutrients in maintaining immune function of military personnel in the field. It reviews the impact of compromised nutrition status on immune function; the interaction of health, exercise, and stress (both physical and psychological) in immune function; and the role of nutritional supplements and newer biotechnology methods reported to enhance immune function. The first part of the book contains the committee's workshop summary and evaluation of ongoing research by Army scientists on immune status in special forces troops, responses to the Army's questions, conclusions, and recommendations. The rest of the book contains papers contributed by workshop speakers, grouped under such broad topics as an introduction to what is known about immune function, the assessment of immune function, the effect of nutrition, and the relation between the many and varied stresses encountered by military personnel and their effect on health.

Iron Metabolism

Robert Crichton
Iron Metabolism Book PDF

Author : Robert Crichton
Publisher : John Wiley & Sons
Page : 581 pages
File Size : 41,5 Mb
Release : 2016-05-31
Category : Medical
ISBN : 9781118925614

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Iron Metabolism by Robert Crichton Pdf

Iron is indispensable for the growth, development and well-being of almost all living organisms. Biological systems from bacteria, fungi and plants to humans have evolved systems for the uptake, utilisation, storage and homeostasis of iron. Its importance for microbial growth makes its uptake systems a natural target for pathogenic microorganisms and parasites. Uniquely, humans suffer from both iron deficiency and iron overload, while the capacity of iron to generate highly reactive free radicals, causing oxidative stress, is associated with a wide range of human pathologies, including many neurodegenerative diseases. Whereas some essential metal ions like copper and zinc are closely linked with iron metabolism, toxic metals like aluminium and cadmium can interfere with iron metabolism. Finally, iron metabolism and homeostasis are key targets for the development of new drugs for human health. The 4th edition of Iron Metabolism is written in a lively style by one of the leaders in the field, presented in colour and covers the latest discoveries in this exciting area. It will be essential reading for researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and medical sciences. Other interested groups include biological inorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, or of diseases in which iron uptake systems are involved (eg. microbial and fungal infections, cancer, neurodegenerative disorders), and researchers in the pharmaceutical industry interested in developing novel drugs targeting iron metabolism/homeostasis.

Iron Metabolism

Robert Crichton
Iron Metabolism Book PDF

Author : Robert Crichton
Publisher : John Wiley & Sons
Page : 576 pages
File Size : 40,5 Mb
Release : 2016-03-30
Category : Medical
ISBN : 9781118925638

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Iron Metabolism by Robert Crichton Pdf

Iron is indispensable for the growth, development and well-being of almost all living organisms. Biological systems from bacteria, fungi and plants to humans have evolved systems for the uptake, utilisation, storage and homeostasis of iron. Its importance for microbial growth makes its uptake systems a natural target for pathogenic microorganisms and parasites. Uniquely, humans suffer from both iron deficiency and iron overload, while the capacity of iron to generate highly reactive free radicals, causing oxidative stress, is associated with a wide range of human pathologies, including many neurodegenerative diseases. Whereas some essential metal ions like copper and zinc are closely linked with iron metabolism, toxic metals like aluminium and cadmium can interfere with iron metabolism. Finally, iron metabolism and homeostasis are key targets for the development of new drugs for human health. The 4th edition of Iron Metabolism is written in a lively style by one of the leaders in the field, presented in colour and covers the latest discoveries in this exciting area. It will be essential reading for researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and medical sciences. Other interested groups include biological inorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, or of diseases in which iron uptake systems are involved (eg. microbial and fungal infections, cancer, neurodegenerative disorders), and researchers in the pharmaceutical industry interested in developing novel drugs targeting iron metabolism/homeostasis.

Inorganic Biochemistry of Iron Metabolism

Robert R. Crichton,Johan R. Boelaert
Inorganic Biochemistry of Iron Metabolism Book PDF

Author : Robert R. Crichton,Johan R. Boelaert
Publisher : John Wiley & Sons
Page : 370 pages
File Size : 51,8 Mb
Release : 2001-10-17
Category : Medical
ISBN : 047149223X

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Inorganic Biochemistry of Iron Metabolism by Robert R. Crichton,Johan R. Boelaert Pdf

Iron is of fundamental importance for the growth, development and well being of almost all living organisms. Multiple biological systems have been developed for the uptake, utilisation, storage and homeostasis of iron in microbes, plants and mammals. e.g. Both iron deficiency and iron overload are found extensively in man: the intimate links between iron and oxidative stress are associated with a wide range of pathologies; iron has a well established role in infections by a wide range of microorganisms and parasites; there is a close link between iron requirements and cellular division with implications for cancers and other metals such as copper and zinc are closely linked with iron metabolism. The first edition of this book was published in 1991. Since then the extensive impact of molecular cell biology on the field of iron biochemistry has opened new horizons in our understanding of the transport and storage of iron and of its homeostasis. The explosive use of molecular biological techniques applied to cellular biology of iron metabolism has resulted in a rapid expansion in the literature which has led to the need for this second edition. This second edition also: Introduces many illustrations and colour photos to make the basic concepts far clearer Includes new chapters on iron and cell division and interactions of iron with other metals - particularly copper and zinc Provides additional anecdotes Incorporates an extensive and up-to-date bibliography

Molecular Aspects of Iron Metabolism in Pathogenic and Symbiotic Plant-Microbe Associations

Dominique Expert,Mark R. O'Brian
Molecular Aspects of Iron Metabolism in Pathogenic and Symbiotic Plant Microbe Associations Book PDF

Author : Dominique Expert,Mark R. O'Brian
Publisher : Springer Science & Business Media
Page : 91 pages
File Size : 41,5 Mb
Release : 2012-08-23
Category : Science
ISBN : 9789400752665

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Molecular Aspects of Iron Metabolism in Pathogenic and Symbiotic Plant-Microbe Associations by Dominique Expert,Mark R. O'Brian Pdf

Iron plays a key role in biology as essential cofactor of numerous proteins. However, since it is only slightly soluble its bioavailability can be readily compromised under aerobic conditions. Moreover, due to its ability to catalyze the generation of free radicals, iron can also be toxic. Thus, it doesn’t surprise that living organisms have developed sophisticated means for acquiring iron whilst tightly controlling the intracellular concentrations of this metal in response to environmental conditions. Also, the critical role of iron has long been acknowledged in host vertebrate-parasite relationships where both partners compete for the acquisition of this essential element and activate complex signaling cascades to control their iron homeostasis during infection. Following the great interest that the mechanisms regulating the acquisition of iron and the control of iron homeostasis have generated among researchers studying plant-pathogen and legume-rhizobia interactions, this book offers a comprehensive analysis of irons’ various roles in the plant-microbial associations. The introductory chapter stresses the essentiality of iron in biological systems. The second chapter surveys the abundance of information on iron’s pivotal role in microbial plant pathogenesis and defence. Finally, the third chapter reviews the advances in our understanding of iron metabolism in the rhizobia, soil bacteria able to establish a symbiotic association with legumes and carry out nitrogen fixation. Molecular Aspects of Iron Metabolism in Pathogenic and Symbiotic Plant-Microbe Associations is a valuable resource to microbiologists, pathologists and scientists interested in iron uptake and metabolism in microbial pathogenesis, rhizobia legume associations, and plant physiology and immunity.

Metallomics and the Cell

Lucia Banci
Metallomics and the Cell Book PDF

Author : Lucia Banci
Publisher : Springer Science & Business Media
Page : 642 pages
File Size : 40,5 Mb
Release : 2013-04-18
Category : Science
ISBN : 9789400755611

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Metallomics and the Cell by Lucia Banci Pdf

Metallomics and the Cell provides in an authoritative and timely manner in 16 stimulating chapters, written by 37 internationally recognized experts from 9 nations, and supported by more than 3000 references, several tables, and 110 illustrations, mostly in color, a most up-to-date view of the "metallomes" which, as defined in the "omics" world, describe the entire set of biomolecules that interact with or are affected by each metal ion. The most relevant tools for visualizing metal ions in the cell and the most suitable bioinformatic tools for browsing genomes to identify metal-binding proteins are also presented. Thus, MILS-12 is of relevance for structural and systems biology, inorganic biological chemistry, genetics, medicine, diagnostics, as well as teaching, etc.

Iron Uptake in Bacteria with Emphasis on E. coli and Pseudomonas

Ranjan Chakraborty,Volkmar Braun,Klaus Hantke,Pierre Cornelis
Iron Uptake in Bacteria with Emphasis on E coli and Pseudomonas Book PDF

Author : Ranjan Chakraborty,Volkmar Braun,Klaus Hantke,Pierre Cornelis
Publisher : Springer Science & Business Media
Page : 98 pages
File Size : 48,9 Mb
Release : 2013-02-02
Category : Science
ISBN : 9789400760882

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Iron Uptake in Bacteria with Emphasis on E. coli and Pseudomonas by Ranjan Chakraborty,Volkmar Braun,Klaus Hantke,Pierre Cornelis Pdf

Iron is essential for the growth of most bacteria because it serves as a cofactor for vital enzymes and for the components of the electron transport chain. Moreover, Iron plays an important role in bacterial pathogenicity; in fact, the iron transport systems in bacteria works as target for designing novel antibiotics. Because iron is not soluble under aerobic conditions, bacteria have had to find ways to overcome iron deficiency. One of them is producing an iron-chelating small organic molecule called siderophore. Indeed, most bacteria and fungi produce structurally and chemically diverse siderophores which are transported back to the cytoplasm using complex energy dependent transport systems. Escherichia coli and Pseudomonas were the first ones to be tested; however, nowadays iron transport systems have been investigated in many other bacteria. Iron Uptake in Bacteria with Emphasis on E. coli and Pseudomonas reviews the recent advancements in the field of iron transport systems in bacteria. Chapter 1 is dedicated to Dr. Dick van der Helm’s contribution to the field of siderophore biology. It then describes and discusses the structural advances in the components and the mechanism of siderophore mediated iron transport systems in E.coli. Chapter 2 details the variety of iron transport and iron regulatory systems of both gram negative and gram positive bacteria. Finally, chapter 3 describes the iron transport systems of Pseudomonas. This book is aimed at researchers in the fields of iron metabolism in multiple organisms, and to those who are interested in studying iron transport systems of bacteria. It appeals also to scientists researching structure and function relationship of proteins.

Iron Chelation in Plants and Soil Microorganisms

Larry Barton
Iron Chelation in Plants and Soil Microorganisms Book PDF

Author : Larry Barton
Publisher : Academic Press
Page : 507 pages
File Size : 46,9 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323147835

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Iron Chelation in Plants and Soil Microorganisms by Larry Barton Pdf

Iron Chelation in Plants and Soil Microorganisms provides an introduction to the basic biological processes of plants that require iron and those affected by iron deficiency. The book aims to stimulate research in the area of iron metabolism in plants and plant-associated microorganisms. The book is organized into three parts. Part I provides an overview of research methods used in the study of iron chelation relevant to plant biology. Key topics covered include microbial siderophores, phytosiderophores, and plant and microbial ferritins. Part II discusses the molecular approach to iron chelation, which includes molecular biology, enzymology, and iron uptake activities. Part III addresses various physiological and chemical characteristics of the iron stress response. This book was written for scientists involved in plant physiology, agronomy, phytopathology, plant control, and soil microbiology. It may also be of interest to those studying soil chemistry, plant-mineral relationships, horticulture, in vivo and in vitro iron measurements, and microbial ecology. In addition, the book can serve as reference for specialty courses and laboratories conducting research on iron nutrition in plants as well as individuals engaged in iron-related research.

Iron Nutrition in Plants and Rhizospheric Microorganisms

Larry L. Barton,Javier Abadia
Iron Nutrition in Plants and Rhizospheric Microorganisms Book PDF

Author : Larry L. Barton,Javier Abadia
Publisher : Springer Science & Business Media
Page : 500 pages
File Size : 44,7 Mb
Release : 2007-08-20
Category : Medical
ISBN : 1402066236

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Iron Nutrition in Plants and Rhizospheric Microorganisms by Larry L. Barton,Javier Abadia Pdf

This book provides a comprehensive review on the status of iron nutrition in plants. It contains updated reviews of most relevant issues involving Fe in plants and combines research on molecular biology with physiological studies of plant-iron nutrition. It also covers molecular aspects of iron uptake and storage in Arabidopsis and transmembrane movement and translocation of iron in plants. This book should serve to stimulate continued exploration in the field.

Handbook of Microbial Iron Chelates

Gunther Winkelmann
Handbook of Microbial Iron Chelates Book PDF

Author : Gunther Winkelmann
Publisher : CRC Press
Page : 376 pages
File Size : 46,8 Mb
Release : 1991-06-14
Category : Science
ISBN : 0849329663

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Handbook of Microbial Iron Chelates by Gunther Winkelmann Pdf

Handbook of Microbial Iron Chelates emphasizes the various microbial compounds and synthetic analogues functioning as siderophores in microbes and as potential drugs in human iron metabolism. There are chapters describing the isolation, chemical characterization, synthesis and physicochemical properties of microbial iron chelates. Other chapters deal with the physiology and genetics of transport and receptors involved in iron uptake. Chemists, biologists, biochemists, pharmacologists, and medical doctors interested in the general aspects of iron metabolism, siderophores, receptors, and iron complex formation should consider this book a rich information source.

Handbook of Microbial Iron Chelates (1991)

Gunther Winkelmann
Handbook of Microbial Iron Chelates 1991 Book PDF

Author : Gunther Winkelmann
Publisher : CRC Press
Page : 374 pages
File Size : 40,7 Mb
Release : 2017-11-22
Category : Science
ISBN : 9781351362672

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Handbook of Microbial Iron Chelates (1991) by Gunther Winkelmann Pdf

Handbook of Microbial Iron Chelates emphasizes the various microbial compounds and synthetic analogues functioning as siderophores in microbes and as potential drugs in human iron metabolism. There are chapters describing the isolation, chemical characterization, synthesis and physicochemical properties of microbial iron chelates. Other chapters deal with the physiology and genetics of transport and receptors involved in iron uptake. Chemists, biologists, biochemists, pharmacologists, and medical doctors interested in the general aspects of iron metabolism, siderophores, receptors, and iron complex formation should consider this book a rich information source.

Antimicrobial Peptides and Human Disease

William Shafer
Antimicrobial Peptides and Human Disease Book PDF

Author : William Shafer
Publisher : Springer Science & Business Media
Page : 274 pages
File Size : 42,7 Mb
Release : 2006-10-05
Category : Medical
ISBN : 9783540299165

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Antimicrobial Peptides and Human Disease by William Shafer Pdf

Microbes are in our midst soon after birth. Thankfully, the number of harmless (and often beneficial) microbes far outnumber those that would do us harm. Our ability to ward-off pathogens in our environment, including those that can colonize our exterior and/or interior surfaces, depends on the integrative action of the innate and adaptive immunity systems. This volume of CTMI, entitled Antimicrobial Peptides and Human Disease, is dedicated to the role of antimicrobial peptides (AMPs) in the innate host defense system of homo sapiens.

Biochemistry of Nonheme Iron

Anatoly Bezkorovainy
Biochemistry of Nonheme Iron Book PDF

Author : Anatoly Bezkorovainy
Publisher : Springer Science & Business Media
Page : 445 pages
File Size : 52,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468437799

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Biochemistry of Nonheme Iron by Anatoly Bezkorovainy Pdf

Atomic biology has come of age. Interest in the role of chemical elements in life processes has captured the imagination of a wide spectrum of research scientists-ranging from the nutritionist to the biochemist, the inorganic chemist, and even to some biophysicists. This series, Biochemistry of the Elements, is a recognition of this increasing interest. When complete, the books will assemble the hard facts concerning the biochemistry of each element-singly or in a logical grouping. The series will provide a permanent reference for this active and growing field. Each volume shall represent an integrated effort by one or several authors to describe the current knowledge of an element(s) or the methods by which it is studied. Iron is the only element to which we have devoted two volumes, because its biological and chemical role is so versatile and complex. These two volumes will treat the two main structural categories of iron: heme and nonheme iron. In this volume on nonheme iron, the first in the series, Anatoly Bezkorovainy provides what we believe is the most comprehensive treatment of this important topic.

Iron Nutrition in Plants and Rhizospheric Microorganisms

Larry L. Barton,Javier Abadia
Iron Nutrition in Plants and Rhizospheric Microorganisms Book PDF

Author : Larry L. Barton,Javier Abadia
Publisher : Springer Science & Business Media
Page : 483 pages
File Size : 52,5 Mb
Release : 2006-07-25
Category : Science
ISBN : 9781402047435

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Iron Nutrition in Plants and Rhizospheric Microorganisms by Larry L. Barton,Javier Abadia Pdf

This book provides a comprehensive review on the status of iron nutrition in plants. It contains updated reviews of most relevant issues involving Fe in plants and combines research on molecular biology with physiological studies of plant-iron nutrition. It also covers molecular aspects of iron uptake and storage in Arabidopsis and transmembrane movement and translocation of iron in plants. This book should serve to stimulate continued exploration in the field.