Lassa Fever Epidemiology Immunology Diagnostics And Therapeutics

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Lassa Fever: Epidemiology, Immunology, Diagnostics, and Therapeutics

Robert Garry
Lassa Fever Epidemiology Immunology Diagnostics and Therapeutics Book PDF

Author : Robert Garry
Publisher : Springer Nature
Page : 199 pages
File Size : 44,6 Mb
Release : 2023-07-17
Category : Medical
ISBN : 9783031358074

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Lassa Fever: Epidemiology, Immunology, Diagnostics, and Therapeutics by Robert Garry Pdf

This volume provides a comprehensive and up-to-date overview of the various aspects of Lassa virus (LASV), the causative agent of Lassa fever, a frequently fatal zoonotic disease endemic to West Africa. Compiled by world-leading experts in the field, this book provides an introduction to the 50-year history of Lassa fever research, the genetic diversity of LASV, and its geographic distribution. Subsequent chapters focus on the ecology and epidemiology of LASV, discussing in-depth the interactions of the virus with its hosts - multimammate mice and other rodents - and the interactions between these animal reservoirs and humans. The book also details the many advances in understanding the structural biology and replication of LASV, including new insights into the structure and function of its proteins. These advances in the basic understanding of LASV biology have enabled the development of LASV countermeasures, including sensitive and specific diagnostic assays. Promising drug candidates, including monoclonal antibodies, and vaccines are also discussed. A final and essential chapter addresses current and future clinical practice for clinical management of Lassa fever. This volume is intended for researchers and clinicians in the fields of virology, epidemiology, and microbiology.

Introduction to Medical Immunology

Gabriel Virella
Introduction to Medical Immunology Book PDF

Author : Gabriel Virella
Publisher : Unknown
Page : 672 pages
File Size : 53,6 Mb
Release : 1998
Category : Medical
ISBN : UOM:39015042396716

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Introduction to Medical Immunology by Gabriel Virella Pdf

Introductory textbook for medical students integrating basic and clinical science. This edition is written in outline format.

Nano-Biotechnology for Biomedical and Diagnostic Research

Eran Zahavy,Arie Ordentlich,Shmuel Yitzhaki,Avigdor Shafferman
Nano Biotechnology for Biomedical and Diagnostic Research Book PDF

Author : Eran Zahavy,Arie Ordentlich,Shmuel Yitzhaki,Avigdor Shafferman
Publisher : Springer Science & Business Media
Page : 184 pages
File Size : 41,9 Mb
Release : 2011-11-20
Category : Science
ISBN : 9789400725553

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Nano-Biotechnology for Biomedical and Diagnostic Research by Eran Zahavy,Arie Ordentlich,Shmuel Yitzhaki,Avigdor Shafferman Pdf

The title "Nano Biotechnology for Biomedical and Diagnostics Research" will address research aspects related to nanomaterial in imaging and biological research, nanomaterials as a biosensing tool, DNA nanotechnology, nanomaterials for drug delivery, medicinal and therapeutic application and cytotoxicity of nanomaterials. These topics will be covered by 16 different manuscripts. Amongst the authors that will contribute to the book are major scientific leaders such as S. Weiss - UCLA, I. Willner, and G. Golomb – HUJI, S. Esener - UCSD, E.C. Simmel - Tech. Univ. Munchen, I. Medintz – NRL, N. Hildebrandt - Université Paris and more. The manuscripts in the book intend to present specifically biological, diagnostics and medical problems with their potential solution by nano technology or materials. In this respect this book is unique, since it would arise from the biological problems to the nano technology possible solution and not vice versa.

Hepatitis C Virus: From Molecular Virology to Antiviral Therapy

Ralf Bartenschlager
Hepatitis C Virus From Molecular Virology to Antiviral Therapy Book PDF

Author : Ralf Bartenschlager
Publisher : Springer Science & Business Media
Page : 353 pages
File Size : 50,8 Mb
Release : 2013-03-12
Category : Medical
ISBN : 9783642273407

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Hepatitis C Virus: From Molecular Virology to Antiviral Therapy by Ralf Bartenschlager Pdf

Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted.

Immunology, Infection, and Immunity

Gerald Bryan Pier,Jeffrey B Lyczak,Lee M Wetzler
Immunology Infection and Immunity Book PDF

Author : Gerald Bryan Pier,Jeffrey B Lyczak,Lee M Wetzler
Publisher : Unknown
Page : 0 pages
File Size : 48,9 Mb
Release : 2004
Category : Cellular immunity
ISBN : 155581283X

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Immunology, Infection, and Immunity by Gerald Bryan Pier,Jeffrey B Lyczak,Lee M Wetzler Pdf

TEXT WITH CD STUDY GUIDE With a focus on the relatedness of immunology and microbiology, Immunology, Infection, and Immunity covers both the foundation concepts of immunology, among the most exciting in modern biology and medicine, and their application to the real world of diseases and health. This new text combines clear narratives of how the immune system functions relying in many instances on supporting data from experiments. The editors use examples and illustrations depicting basic immunologic processes in conjunction with their role in infectious or other diseases in order to teach both basic and applied aspects of immunology. A chapter on antibody–antigen interactions and measurements of immunologic reactions familiarizes students with the tools of experimental immunology. In addition to an emphasis on infectious diseases, the book focuses strongly on those areas where the immune system does not act when it should – primary and acquired immunodeficiency, and the failure to control cancer – as well as areas where the over–activity or dysregulation of the immune system is a cause of pathology – hypersensitivity reactions, including allergy and asthma, autoimmunity and the unwanted immune responses to transplanted tissues and organs. To bring the full flavor and excitement of immunology to new students, the editors have assembled an outstanding group of contributors with expertise in the multiple areas of immunology who provide the most up–to–date information in this quickly moving field. All of the chapters have standardized thematic and structural aspects to provide critical information in a comprehensive style. Immunology, Infection, and Immunity is ideally suited for upper division and graduate level students as well as medical and dental students with a good background in basic biology, biochemistry, genetics, and cell biology. The text complements traditional views and dogmas about immunology with today′s cutting edge ideas and experimental data describing how the immune system works, some of which are challenging and changing some long–held beliefs about the function of the immune system. Key Features Examines the basic molecular and cellular components of the immune system relative to the pathogenesis and prevention of infectious diseases Concentrates on the way in which the immune system is critical to the pathogenesis and prevention of infectious diseases Focuses on primary and acquired immunodeficiency and immune system dysregulation as causes of pathology Contributions from multiple areas of immunology present current information in a rapidly moving field All chapters have standardized thematic and structural aspects to provide critical information in a comprehensible style Examples and illustrations depict basic immunologic processes in conjunction with their role in infectious or other diseases About the Electronic Study Guide The DLG CD—ROM is an interactive, automated program that organizes each chapter from Immunology, Infection and Immunity into questions, answers, and extensive explanations. The software helps students first through reviewing the book and then helps them quiz themselves and assess their progress. Students can print out or even stop a study session and resume exactly where they left off at their convenience. With the DLG, students will be able to quickly learn new information, retain it longer, and improve their test scores. Students can work at their own pace, measure their performance, and make the most efficient use of their study time. Prepared by Mary J. Ruebush Recommended system requirements: Windows 98/98SE/ME/NT4/2000/XP Pentium Class Processor, 166 MHz or greater 64 MB of RAM 300 MB free disk space Internet connection for registration/activation only

Influenza Virology

Yoshihiro Kawaoka
Influenza Virology Book PDF

Author : Yoshihiro Kawaoka
Publisher : Horizon Scientific Press
Page : 367 pages
File Size : 44,5 Mb
Release : 2006
Category : Medical
ISBN : 1904455069

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Influenza Virology by Yoshihiro Kawaoka Pdf

World renowned scientists critically review the most important issues in this rapidly expanding field.

The Ebola Epidemic in West Africa

National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Global Health,Forum on Microbial Threats
The Ebola Epidemic in West Africa Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 137 pages
File Size : 54,5 Mb
Release : 2016-12-30
Category : Medical
ISBN : 9780309450065

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The Ebola Epidemic in West Africa by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Global Health,Forum on Microbial Threats Pdf

The most recent Ebola epidemic that began in late 2013 alerted the entire world to the gaps in infectious disease emergency preparedness and response. The regional outbreak that progressed to a significant public health emergency of international concern (PHEIC) in a matter of months killed 11,310 and infected more than 28,616. While this outbreak bears some unique distinctions to past outbreaks, many characteristics remain the same and contributed to tragic loss of human life and unnecessary expenditure of capital: insufficient knowledge of the disease, its reservoirs, and its transmission; delayed prevention efforts and treatment; poor control of the disease in hospital settings; and inadequate community and international responses. Recognizing the opportunity to learn from the countless lessons of this epidemic, the National Academies of Sciences, Engineering, and Medicine convened a workshop in March 2015 to discuss the challenges to successful outbreak responses at the scientific, clinical, and global health levels. Workshop participants explored the epidemic from multiple perspectives, identified important questions about Ebola that remained unanswered, and sought to apply this understanding to the broad challenges posed by Ebola and other emerging pathogens, to prevent the international community from being taken by surprise once again in the face of these threats. This publication summarizes the presentations and discussions from the workshop.

Coronavirus Disease 2019 (COVID-19)

Shailendra K. Saxena
Coronavirus Disease 2019 COVID 19 Book PDF

Author : Shailendra K. Saxena
Publisher : Springer
Page : 213 pages
File Size : 51,6 Mb
Release : 2021-05-14
Category : Medical
ISBN : 9811548161

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Coronavirus Disease 2019 (COVID-19) by Shailendra K. Saxena Pdf

This book provides a comprehensive overview of recent novel coronavirus (SARS-CoV-2) infection, their biology and associated challenges for their treatment and prevention of novel Coronavirus Disease 2019 (COVID-19). Discussing various aspects of COVID-19 infection, including global epidemiology, genome organization, immunopathogenesis, transmission cycle, diagnosis, treatment, prevention, and control strategies, it highlights host-pathogen interactions, host immune response, and pathogen immune invasion strategies toward developing an immune intervention or preventive vaccine for COVID-19. An understanding of the topics covered in the book is imperative in the context of designing strategies to protect the human race from further losses and harm due to SARS-CoV-2 infection causing COVID-19.

The Arenaviridae

Maria S. Salvato
The Arenaviridae Book PDF

Author : Maria S. Salvato
Publisher : Springer Science & Business Media
Page : 417 pages
File Size : 54,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461530282

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The Arenaviridae by Maria S. Salvato Pdf

In this volume, a distinguished international group of contributors present the latest molecular, organismal, and epidemiological research on arenaviruses. Their work will broaden both the clinician's and the researcher's knowledge of basic mechanisms of immunological tolerance, viral immunosuppression, the nature of protective immune responses to vaccination, and viral effects on cell functions.

Fungal Diseases in Animals

Arti Gupta,Nagendra Pratap Singh
Fungal Diseases in Animals Book PDF

Author : Arti Gupta,Nagendra Pratap Singh
Publisher : Springer Nature
Page : 191 pages
File Size : 46,5 Mb
Release : 2021-06-22
Category : Science
ISBN : 9783030695071

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Fungal Diseases in Animals by Arti Gupta,Nagendra Pratap Singh Pdf

The importance of fungal infections in both human and animals has increased over the last few decades. This book presents an overview of the different categories of fungal infections that can be encountered in animals (including lower vertebrates) originating from environmental sources with or without transmission to humans. In addition, the endemic infections with indirect transmission from the environment, the zoophilic fungal pathogens with near-direct transmission, the zoonotic fungi that can be directly transmitted from animals to humans, mycotoxicoses and antifungal resistance in animals will also be discussed. This book includes case studies and reviews the current state of knowledge on the mechanism of fungal attraction, recognition, infection, extracellular hydrolytic enzymes and pathogenesis of nematophagous fungi. The book also covers diagnostics, fungal formulations, as well as prevention methods. It discusses strategies to access the fungal pathogen groups, metagenomic analyses, genomics, secretomics, metabolomics, proteomics and transcriptomics. In addition, pathogen description, understanding, distribution and recent research results are provided.

Antibodies and Their Role in Therapeutics

Roohi Bansal
Antibodies and Their Role in Therapeutics Book PDF

Author : Roohi Bansal
Publisher : Roohi Bansal
Page : 390 pages
File Size : 50,9 Mb
Release : 2021-12-04
Category : Electronic
ISBN : 9355781601

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Antibodies and Their Role in Therapeutics by Roohi Bansal Pdf

Beginning with the structure, types, functions, and gene organization of antibodies, the book aims to shine a detailed light on the monoclonal antibodies (often referred to as mAbs) that have revolutionized the fields of therapeutics and diagnostics. The book describes the different ways of generating chimeric, humanized, and fully human monoclonal antibodies, emphasizing phage display, hybridoma, and rDNA technology. In addition, the book focuses on the various recombinant antibody formats in detail: Drug conjugates: Antibody-drug conjugates (ADCs), Immunotoxins (Recombinant, Humanized and Fully Human) and Antibody-antibiotic conjugate (AAC) Bispecific antibodies: scFv based (BiTE, DARTs and TandAbs) and Full-length IgG based Abzymes and Antibody-directed enzyme prodrug therapy (ADEPT) Fc-fusion proteins Single-domain antibodies (VHH and IgNAR sdAb) The book discusses the various therapeutic applications of monoclonal antibodies, along with the immunogenicity issues. The book also covers the modes of administration and side effects of monoclonal antibodies, along with the challenges and issues faced while developing a monoclonal antibody into a therapeutic agent. Modifications introduced by the researchers to decrease the immunogenicity issues and increase the efficacy of therapeutic mAbs are also described. The book is an invaluable resource for researchers and students in biology and medicine, biotechnology, immunology, genetics, molecular biology, and anyone interested in antibody engineering.

Nonhuman Primates I

Thomas C. Jones,Ulrich Mohr,Ronald D. Hunt
Nonhuman Primates I Book PDF

Author : Thomas C. Jones,Ulrich Mohr,Ronald D. Hunt
Publisher : Springer
Page : 0 pages
File Size : 45,6 Mb
Release : 2011-12-15
Category : Medical
ISBN : 3642849083

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Nonhuman Primates I by Thomas C. Jones,Ulrich Mohr,Ronald D. Hunt Pdf

The International Life Sciences Institute (ILSI) was estab lished in 1978 to stimulate and support scientific research and educational programs related to nutrition, toxicology, and food safety, and to encourage cooperation in these programs among scientists in universities, industry, and government agencies to assist in the resolution of health and safety issues. To supplement and enhance these efforts, ILSI has made a major commitment to supporting programs to harmonize toxicologic testing, to advance a more uniform interpreta tion of bioassay results worldwide, to promote a common understanding of lesion classifications, and to encourage wide discussion of these topics among scientists. The Mo nographs on the Pathology of Laboratory Animals are de signed to facilitate communication among those involved in the safety testing of foods, drugs, and chemicals. The complete set will cover all organ systems and is intended for use by pathologists, toxicologists, and others con cerned with evaluating toxicity and carcinogenicity stu dies. The international nature of the project - as reflected in the composition of the editorial board and the diversity of the authors and editors -strengthens our expectations that understanding and cooperation will be improved worldwide through the series. Alex Malaspina President International Life Sciences Institute Preface This book, on Nonhuman Primates, is the eleventh volume of a set pre pared under the sponsorship of the International Life Sciences Institute (ILSI).

Immunology of the Skin

Kenji Kabashima
Immunology of the Skin Book PDF

Author : Kenji Kabashima
Publisher : Springer
Page : 510 pages
File Size : 43,7 Mb
Release : 2016-03-10
Category : Medical
ISBN : 9784431558552

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Immunology of the Skin by Kenji Kabashima Pdf

This book reviews the role of each cell subset in the skin, providing the basics for understanding skin immunology and the mechanisms of skin diseases. The skin is one of the immune organs and is continually exposed to foreign antigens and external stimuli that must be monitored and characterized for possible elimination. Upon exposure to foreign antigens, the skin can elicit a variety of immune responses in harmony with skin components that include keratinocytes, dendritic cell subsets, mast cells, basophils, fibroblasts, macrophages, gamma-delta T cells, neutrophils, myeloid-derived suppressor cells, vascular and lymphatic cells, hair follicles, platelets, and adipose tissues, among others. In the past 10 years, knowledge of immunology has expanded drastically in areas such as innate immunity (Toll-like receptors, C-type lectins), and host defenses to bacteria and viruses, and this increased knowledge has led to the development of more effective treatment of psoriasis and other skin diseases. This book provides updates on the mechanisms of skin diseases including contact dermatitis, atopic dermatitis, psoriasis, urticaria, drug eruption, bullous diseases, anaphylaxis, graft-versus-host disease, rosacea, lymphoma, photodermatology, and collagen vascular diseases. Understanding the basics of skin immunology will help clinicians and dermatologists use new therapeutics such as biologics efficiently. Serving as an intermediary between basic science and clinical medicine, this book gives readers the opportunity to understand and marvel at the mystery and fascination of skin immunology.

Global Health Impacts of Vector-Borne Diseases

National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Global Health,Forum on Microbial Threats
Global Health Impacts of Vector Borne Diseases Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 397 pages
File Size : 51,8 Mb
Release : 2016-10-21
Category : Medical
ISBN : 9780309377591

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Global Health Impacts of Vector-Borne Diseases by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Global Health,Forum on Microbial Threats Pdf

Pathogens transmitted among humans, animals, or plants by insects and arthropod vectors have been responsible for significant morbidity and mortality throughout recorded history. Such vector-borne diseases â€" including malaria, dengue, yellow fever, and plague â€" together accounted for more human disease and death in the 17th through early 20th centuries than all other causes combined. Over the past three decades, previously controlled vector-borne diseases have resurged or reemerged in new geographic locations, and several newly identified pathogens and vectors have triggered disease outbreaks in plants and animals, including humans. Domestic and international capabilities to detect, identify, and effectively respond to vector-borne diseases are limited. Few vaccines have been developed against vector-borne pathogens. At the same time, drug resistance has developed in vector-borne pathogens while their vectors are increasingly resistant to insecticide controls. Furthermore, the ranks of scientists trained to conduct research in key fields including medical entomology, vector ecology, and tropical medicine have dwindled, threatening prospects for addressing vector-borne diseases now and in the future. In June 2007, as these circumstances became alarmingly apparent, the Forum on Microbial Threats hosted a workshop to explore the dynamic relationships among host, pathogen(s), vector(s), and ecosystems that characterize vector-borne diseases. Revisiting this topic in September 2014, the Forum organized a workshop to examine trends and patterns in the incidence and prevalence of vector-borne diseases in an increasingly interconnected and ecologically disturbed world, as well as recent developments to meet these dynamic threats. Participants examined the emergence and global movement of vector-borne diseases, research priorities for understanding their biology and ecology, and global preparedness for and progress toward their prevention, control, and mitigation. This report summarizes the presentations and discussions from the workshop.

Varicella-zoster Virus

Allison Abendroth,Ann M. Arvin,Jennifer F. Moffat
Varicella zoster Virus Book PDF

Author : Allison Abendroth,Ann M. Arvin,Jennifer F. Moffat
Publisher : Springer Science & Business Media
Page : 382 pages
File Size : 55,6 Mb
Release : 2010-09-30
Category : Medical
ISBN : 9783642127281

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Varicella-zoster Virus by Allison Abendroth,Ann M. Arvin,Jennifer F. Moffat Pdf

This book offers a comprehensive review of basic and clinical research on Varicella-zoster Virus, the only human herpesvirus for which vaccines to prevent both primary and recurrent infection are approved.