Lipidomics In Health Disease

Author : Xiangdong Wang,Duojiao Wu,Huali Shen
Publisher : Springer
Page : 204 pages
File Size : 47,7 Mb
Release : 2018-08-30
Category : Science
ISBN : 9789811306204

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Lipidomics in Health & Disease by Xiangdong Wang,Duojiao Wu,Huali Shen Pdf

This volume covers the emerging area of science, Clinical Lipidomics, which is the application of lipidology to the understanding of physiological and pathophysiological changes of lipidomes, with a special focus on lipidomic profiles in human diseases. Lipidomics is widely used to map lipid molecular species in a biological system. Clinical lipidomic analysis has demonstrated the comprehensive characterization of molecular lipids in various severities, durations, and therapies as a critical tool in identification and validation of disease-specific biomarkers. This volume on Clinical Lipidomics will add to the literature and help advance the knowledge of the pathogenesis, diagnosis, prevention and treatment of diseases.

Author : Andres Trostchansky,Homero Rubbo
Publisher : Springer
Page : 198 pages
File Size : 55,5 Mb
Release : 2019-05-28
Category : Medical
ISBN : 9783030114886

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Bioactive Lipids in Health and Disease by Andres Trostchansky,Homero Rubbo Pdf

The purpose of this book is to introduce the readers on the perspective of the role that unsaturated fatty acids and complex lipids play on health and disease. Bioactive lipids can be modified affecting membrane composition, structure and fluidity in addition to changes in cell signaling associated to lipid-protein (membrane receptors) interactions, issues that are addressed by the authors. This book analyzes key topics involving bioactive lipids and their role in normal signaling and the mechanisms of disease. The book navigates from structural studies of oxidized and non-oxidized lipids to the reactions and cell signaling processes that bioactive lipids play in cardiovascular and neurodegenerative diseases. The book contains the recent advances reported in the literature about lipidomics as well as the role that lipid-derived compounds exert on unfolded protein response and lipid metabolism and disease. This book represents a state of the art introduction to lipid metabolism from a biochemical to an in vivo overview being an useful tool for students and investigators. We hope the mechanistic observations on the role of bioactive lipids in health and disease serve a perspective to improve the existing treatments or propose new lipid-based pharmacology

Author : Anonim
Publisher : Elsevier
Page : 296 pages
File Size : 42,7 Mb
Release : 2007-11-09
Category : Science
ISBN : 0080560652

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Lipidomics and Bioactive Lipids: Specialized Analytical Methods and Lipids in Disease by Anonim Pdf

This volume in the well-established Methods in Enzymology series features methods for the study of lipids using mass spectrometry techniques. Articles in this volume cover topics such as Liquid chromatography mass spectrometry for quantifying plasma lysophospholipids: potential biomarkers for cancer diagnosis; Measurement of eicosanoids in cancer tissues; Noninvasive Assessment of the Role of Cyclooxygenases in Cardiovascular Health A Detailed HPLC/MS/MS Method; Lipidomics in Diabetes and the Metabolic Syndrome; LC-MS-MS Analysis of Neutral Eicosanoids; Quantification Of F2-Isoprostanes In Biological Fluids And Tissues As A Measure Of Oxidant Stress; Measurement of Products of Docosahexaenoic Acid Peroxidation, Neuroprostanes, and Neurofurans; Enantiomeric separation of hydroxy and hydroperoxy eicosanoids by chiral column chromatography; Targeted Chiral Lipidomics Analysis by Liquid Chromatography Electron Capture Atmospheric Pressure Chemical Ionization Mass Spectrometry (LC-ECAPCI/MS); Shotgun Lipidomics by Tandem Mass Spectrometry under Data-Dependent Acquisition Control; Identification of Intact Lipid Peroxides by Ag+ Coordination Ionspray Mass Spectrometry (CIS-MS); Quantification of Cardiolipin by Liquid Chromatography Electrospray Ionization Mass Spectrometry.

Author : Xianlin Han
Publisher : John Wiley & Sons
Page : 496 pages
File Size : 42,5 Mb
Release : 2016-04-06
Category : Science
ISBN : 9781119085270

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Lipidomics by Xianlin Han Pdf

Covers the area of lipidomics from fundamentals and theory to applications Presents a balanced discussion of the fundamentals, theory, experimental methods and applications of lipidomics Covers different characterizations of lipids including Glycerophospholipids; Sphingolipids; Glycerolipids and Glycolipids; and Fatty Acids and Modified Fatty Acids Includes a section on quantification of Lipids in Lipidomics such as sample preparation; factors affecting accurate quantification; and data processing and interpretation Details applications of Lipidomics Tools including for Health and Disease; Plant Lipidomics; and Lipidomics on Cellular Membranes

Author : Xianlin Han
Publisher : John Wiley & Sons
Page : 48 pages
File Size : 53,6 Mb
Release : 2016-05-02
Category : Science
ISBN : 9781118893128

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Lipidomics by Xianlin Han Pdf

Covers the area of lipidomics from fundamentals and theory to applications Presents a balanced discussion of the fundamentals, theory, experimental methods and applications of lipidomics Covers different characterizations of lipids including Glycerophospholipids; Sphingolipids; Glycerolipids and Glycolipids; and Fatty Acids and Modified Fatty Acids Includes a section on quantification of Lipids in Lipidomics such as sample preparation; factors affecting accurate quantification; and data processing and interpretation Details applications of Lipidomics Tools including for Health and Disease; Plant Lipidomics; and Lipidomics on Cellular Membranes

Author : Carla Ferreri,Chryssostomos Chatgilialoglu
Publisher : John Wiley & Sons
Page : 208 pages
File Size : 47,5 Mb
Release : 2015-07-02
Category : Science
ISBN : 9781118682753

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Membrane Lipidomics for Personalized Health by Carla Ferreri,Chryssostomos Chatgilialoglu Pdf

Lipidomics is an important aspect of personalized medicine in relation to nutrition and metabolism. This approach has become important due to the substantial presence of nutraceuticals in the market, since it gives personalized criteria on how to choose the right nutraceutical strategy for both prevention and for quality of life. This multi-disciplinary textbook uses a simple and practical approach to provide a comprehensive overview of lipidomics and their connection with health and nutrition. The text is divided into two parts: - Part 1 outlines the basics of lipidomics and focuses on the biochemical and nutritional aspects with descriptions of the analytical methods employed for the examination of cell membrane fatty acid composition. - Part 2 familiarizes the reader with the use of membrane lipidomic diagnostics in practical health care, using health conditions as examples to introduce the concept of lipidomic profiles in different physiological and pathological situations including prevention. Through the various properties of membrane lipidomics, readers will be able to combine the molecular status of the cell membrane with the evaluation of the subject for personalized nutritional and nutraceutical strategies. Membrane Lipidomics for Personalized Health will be beneficial to biologists, biochemists and medical researchers, as well as health care professionals, pharmacists, and nutritionists seeking in-depth information on the topic.

Author : Lawrence J. Berliner,Narasimham L. Parinandi
Publisher : Springer Nature
Page : 237 pages
File Size : 51,7 Mb
Release : 2020-08-08
Category : Science
ISBN : 9783030473181

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Measuring Oxidants and Oxidative Stress in Biological Systems by Lawrence J. Berliner,Narasimham L. Parinandi Pdf

This book describes the methods of analysis and determination of oxidants and oxidative stress in biological systems. Reviews and protocols on select methods of analysis of ROS, RNS, oxygen, redox status, and oxidative stress in biological systems are described in detail. It is an essential resource for both novices and experts in the field of oxidant and oxidative stress biology.

Author : Alex Sevanian
Publisher : The American Oil Chemists Society
Page : 272 pages
File Size : 43,6 Mb
Release : 1988
Category : Science
ISBN : 0935315187

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Lipid Peroxidation in Biological Systems by Alex Sevanian Pdf

Author : Fong-Fu Hsu
Publisher : Humana
Page : 314 pages
File Size : 55,8 Mb
Release : 2022-05-20
Category : Science
ISBN : 1071614126

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Mass Spectrometry-Based Lipidomics by Fong-Fu Hsu Pdf

This detailed volume covers conventional MS-based “shotgun lipidomics” by which samples are introduced by infusion or loop injection, as well as LC-MS-based lipidomics, which are becoming increasingly important due to the ever-increasing demand for a complete and precise lipid analysis of the complex and diversified lipids in nature. The volume features protocols applying chemical reactions, the on-line photochemical reactions combined with various MS methods for comprehensive characterization of various lipid classes, and quantification of specific and rare lipids. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Mass Spectrometry-Based Lipidomics: Methods and Protocols serves as an invaluable guide for biochemists and mass spectroscopists who are interested in lipid studies.

Author : Michael G. Katze,Marcus J. Korth,G. Lynn Law,Neal Nathanson
Publisher : Academic Press
Page : 366 pages
File Size : 42,5 Mb
Release : 2015-12-30
Category : Science
ISBN : 9780128011744

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Viral Pathogenesis by Michael G. Katze,Marcus J. Korth,G. Lynn Law,Neal Nathanson Pdf

Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized. The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interaction networks, and the role of host genetics in determining disease outcome. In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology. Covers all aspects of viral infection, including viral entry, replication, and release, as well as innate and adaptive immunity and viral pathogenesis Provides a fresh perspective on the approaches used to understand how viruses cause disease Features molecular profiling techniques, whole genome sequencing, and innovative computational methods Highlights the use of contemporary approaches and the insights they provide to the field

Author : LERAY Claude
Publisher : Lavoisier
Page : 354 pages
File Size : 54,9 Mb
Release : 2013-04-04
Category : Lipids
ISBN : 9782743064914

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Les lipides – nutrition et santé by LERAY Claude Pdf

Les substances lipidiques ont longtemps été négligées par les physiologistes, mais des recherches épidémiologiques les ont récemment portées sur le devant de la scène, notamment au travers de leur intérêt dans les domaines de la nutrition et surtout de la santé chez l’Homme. Outre leur importance énergétique, les lipides interviennent dans de nombreux mécanismes cellulaires dont les dérèglements peuvent conduire à des pathologies parfois graves. En effet, en plus de leur impact sur les maladies métaboliques, les systèmes cardiovasculaire et immunitaire et les processus de cancérisation, le système nerveux central peut lui aussi être altéré à des degrés divers par une carence ou un déséquilibre entre les constituants lipidiques ingérés. Après quelques rappels historiques sur la découverte des lipides et leur utilisation, une première partie décrit les principaux lipides présents dans notre ration alimentaire. Puis, les besoins avérés ou éventuels de l’Homme en divers acides gras, stérols et vitamines appartenant au groupe des lipides, sont passés en revue. Enfin, l’impact des principaux lipides sur des pathologies naguère encore peu explorées sous cet aspect est exposé en détail. Les lipides – Nutrition et santé présente, de façon synthétique, un très large panorama de toutes les facettes des lipides, des acides gras aux corps gras les moins abondants, mais tout aussi importants pour l’équilibre de notre organisme. Il permet aux spécialistes de revisiter les principales sources de lipides présentes dans notre alimentation en insistant sur leur production et leur composition. Cet ouvrage s’adresse aux chercheurs, médecins généralistes et spécialistes, diététiciens et étudiants évoluant dans de nombreux domaines tels que la biologie cellulaire, la nutrition ou encore la pharmacologie.

Author : Silas G. Villas-Boas,Jens Nielsen,Jorn Smedsgaard,Michael A. E. Hansen,Ute Roessner-Tunali
Publisher : John Wiley & Sons
Page : 339 pages
File Size : 41,7 Mb
Release : 2007-02-16
Category : Science
ISBN : 9780470105504

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Metabolome Analysis by Silas G. Villas-Boas,Jens Nielsen,Jorn Smedsgaard,Michael A. E. Hansen,Ute Roessner-Tunali Pdf

Providing information on the main approaches for the analysis of metabolites, this textbook: Covers basic methodologies in sample preparation and separation techniques, as well as the most recent techniques of mass spectrometry. Differentiates between primary and secondary metabolites. Includes four chapters discussing successful metabolome studies of different organisms. Highlights the analytical challenges of studying metabolites. Illustrates applications of metabolome analysis through the use of case studies.

Author : Ronald Ross Watson,Fabien De Meester
Publisher : Academic Press and AOCS Press
Page : 0 pages
File Size : 52,9 Mb
Release : 2015-12-04
Category : Technology & Engineering
ISBN : 1630670367

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Handbook of Lipids in Human Function by Ronald Ross Watson,Fabien De Meester Pdf

Handbook of Lipids in Human Function: Fatty Acids presents current research relating to health issues whose impact may be modified by adopting personalized diets and lifestyle interventions of the consumption of fatty acids. Addressing cardiovascular and neurological diseases as well as cancer, obesity, inflammatory conditions, and lung disease, the authors correlate lipid sources with specific conditions, providing important insights into preventative as well as response-based actions designed to positively impact health outcomes. The material is presented in 29 chapters and brings together the research and work of an international team of experts. designed to bridge the gap between traditional approaches to dietary interventions and leading edge integrated health strategies, Handbook of Lipids in Human Function: Fatty Acids is a valuable resource for researchers and clinicians.

Author : W. W. Christie,X Han
Publisher : Elsevier
Page : 447 pages
File Size : 48,5 Mb
Release : 2010-01-10
Category : Technology & Engineering
ISBN : 9780857097866

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Lipid Analysis by W. W. Christie,X Han Pdf

This well-known and highly successful book was first published in 1973 and has been completely re-written in subsequent editions (published in 1982 and 2003). This new Fourth Edition has become necessary because of the pace of developments in mass spectrometry of intact lipids, which has given recognition of lipid analysis and ‘lipidomics’ as a distinct science. To bring the book up to date with these developments, author William W. Christie is joined by co-author Xianlin Han. Although devoting considerable space to mass spectrometry and lipidomics, Lipid analysis remains a practical guide, in one volume, to the complexities of the analysis of lipids. As in past editions, it is designed to act as a primary source, of value at the laboratory bench rather than residing on a library shelf. Lipid analysis deals with the isolation, separation, identification and structural analysis of glycerolipids, including triacylglycerols, phospholipids, sphingolipids, and the various hydrolysis products of these. The chapters follow a logical sequence from the extraction of lipids to the isolation and characterization of particular lipid classes and of molecular species of each, and to the mass spectrometric analysis of lipids and lipidomics. The new influence of mass spectrometry is due mainly to the development of electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI). Most emphasis in this book is placed on ESI, which is enabling structural characterization of different lipid classes and the identification of novel lipids and their molecular species.

Author : Thomas Seyfried
Publisher : John Wiley & Sons
Page : 482 pages
File Size : 40,8 Mb
Release : 2012-05-18
Category : Science
ISBN : 9781118310304

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Cancer as a Metabolic Disease by Thomas Seyfried Pdf

The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.