Membrane Lipidomics For Personalized Health

Author : Carla Ferreri,Chryssostomos Chatgilialoglu
Publisher : John Wiley & Sons
Page : 208 pages
File Size : 52,5 Mb
Release : 2015-06-26
Category : Science
ISBN : 9781118683460

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Membrane Lipidomics for Personalized Health by Carla Ferreri,Chryssostomos Chatgilialoglu Pdf

Lipidomics is an important aspect of personalized medicine in relation to nutrition and metabolism. This approach has become important due to the substantial presence of nutraceuticals in the market, since it gives personalized criteria on how to choose the right nutraceutical strategy for both prevention and for quality of life. This multi-disciplinary textbook uses a simple and practical approach to provide a comprehensive overview of lipidomics and their connection with health and nutrition. The text is divided into two parts: - Part 1 outlines the basics of lipidomics and focuses on the biochemical and nutritional aspects with descriptions of the analytical methods employed for the examination of cell membrane fatty acid composition. - Part 2 familiarizes the reader with the use of membrane lipidomic diagnostics in practical health care, using health conditions as examples to introduce the concept of lipidomic profiles in different physiological and pathological situations including prevention. Through the various properties of membrane lipidomics, readers will be able to combine the molecular status of the cell membrane with the evaluation of the subject for personalized nutritional and nutraceutical strategies. Membrane Lipidomics for Personalized Health will be beneficial to biologists, biochemists and medical researchers, as well as health care professionals, pharmacists, and nutritionists seeking in-depth information on the topic.

Author : Carla Ferreri,Chryssostomos Chatgilialoglu
Publisher : John Wiley & Sons
Page : 204 pages
File Size : 55,8 Mb
Release : 2015-08-31
Category : Science
ISBN : 9781118540411

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Membrane Lipidomics for Personalized Health by Carla Ferreri,Chryssostomos Chatgilialoglu Pdf

Lipidomics is an important aspect of personalized medicine in relation to nutrition and metabolism. This approach has become important due to the substantial presence of nutraceuticals in the market, since it gives personalized criteria on how to choose the right nutraceutical strategy for both prevention and for quality of life. This multi-disciplinary textbook uses a simple and practical approach to provide a comprehensive overview of lipidomics and their connection with health and nutrition. The text is divided into two parts: - Part 1 outlines the basics of lipidomics and focuses on the biochemical and nutritional aspects with descriptions of the analytical methods employed for the examination of cell membrane fatty acid composition. - Part 2 familiarizes the reader with the use of membrane lipidomic diagnostics in practical health care, using health conditions as examples to introduce the concept of lipidomic profiles in different physiological and pathological situations including prevention. Through the various properties of membrane lipidomics, readers will be able to combine the molecular status of the cell membrane with the evaluation of the subject for personalized nutritional and nutraceutical strategies. Membrane Lipidomics for Personalized Health will be beneficial to biologists, biochemists and medical researchers, as well as health care professionals, pharmacists, and nutritionists seeking in-depth information on the topic.

Author : Apostolos Kiritsakis,Fereidoon Shahidi
Publisher : John Wiley & Sons
Page : 693 pages
File Size : 47,5 Mb
Release : 2017-08-14
Category : Technology & Engineering
ISBN : 9781119135319

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Olives and Olive Oil as Functional Foods by Apostolos Kiritsakis,Fereidoon Shahidi Pdf

The only single-source reference on the science of olives and olive oil nutrition and health benefits Olives and Olive Oil as Functional Foods is the first comprehensive reference on the science of olives and olive oil. While the main focus of the book is on the fruit’s renowned health-sustaining properties, it also provides an in-depth coverage of a wide range of topics of vital concern to producers and researchers, including post-harvest handling, packaging, analysis, sensory evaluation, authentication, waste product utilization, global markets, and much more. People have been cultivating olives for more than six millennia, and olives and olive oil have been celebrated in songs and legends for their life-sustaining properties since antiquity. However, it is only within the last several decades that the unique health benefits of their consumption have become the focus of concerted scientific studies. It is now known that olives and olive oil contain an abundance of phenolic antioxidants, as well as the anti-cancer compounds such as squalene and terpenoids. This centerpiece of the Mediterranean diet has been linked to a greatly reduced risk of heart disease and lowered cancer risk. Bringing together contributions from some of the world’s foremost experts on the subject, this book: Addresses the importance of olives and olive oil for the agricultural economy and the relevance of its bioactive components to human health Explores the role that olive oil plays in reducing oxidative stress in cells-a well-known risk factor in human health Provides important information about new findings on olive oil and lipids which reviews the latest research Explores topics of interest to producers, processors, and researchers, including the fruit’s chemical composition, processing considerations, quality control, safety, traceability, and more Edited by two scientists world-renowned for their pioneering work on olive oil and human health, this book is an indispensable source of timely information and practical insights for agricultural and food scientists, nutritionists, dieticians, physicians, and all those with a professional interest in food, nutrition, and health.

Author : Michal Holcapek,Kim Ekroos
Publisher : John Wiley & Sons
Page : 897 pages
File Size : 51,8 Mb
Release : 2023-03-07
Category : Science
ISBN : 9783527836505

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Mass Spectrometry for Lipidomics by Michal Holcapek,Kim Ekroos Pdf

Mass Spectrometry for Lipidomics All-in-one guide to successful lipidomic analysis, combining the latest advances and best practices from academia, industry, and clinical research Mass Spectrometry for Lipidomics presents a systematic overview of lipidomic analysis, covering established standards of lipid analysis, available technology, and key lipid classes, as well as applications in basic research, medicine, pharma, and the food industry. Through connecting recent technological advances with key application areas, this unique guide bridges the gap between academia and industry by translating the vast body of knowledge that has been gained in the past decade into much-needed practical advice for novices as well as routine users. Edited by the president and vice-president of the International Lipidomics Society with contributions from the top experts in lipid analysis, Mass Spectrometry for Lipidomics covers a wide range of key topics, including: Aspects of sample preparation, separation methods, different mass spectrometry modes, as well as identification and quantitation, including the use of bioinformatics tools for data analysis Identification, quantitation and profiling of lipids in different types of biological samples Analytical approaches for all major classes of biological lipids, from fatty acids to phospholipids to sterols Novel applications in biological research, clinical diagnostics, as well as food and crop science For analytical chemists, biochemists, clinical chemists, and analytical laboratories and hospitals, Mass Spectrometry for Lipidomics presents a comprehensive and authoritative overview of the subject, with unmatched expertise from practicing professionals actively involved in the latest research.

Author : G. Schreier,D. Hayn,A. Eggerth
Publisher : IOS Press
Page : 294 pages
File Size : 46,6 Mb
Release : 2020-06-24
Category : Medical
ISBN : 9781643680859

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dHealth 2020 – Biomedical Informatics for Health and Care by G. Schreier,D. Hayn,A. Eggerth Pdf

Successful digital healthcare depends on the effective flow of a complete chain of information; from the sensor, via multiple steps of processing, to the actuator, which can be anything from a human healthcare professional to a robot. Along this pathway, methods for automating the processing of information, like signal processing, machine learning, predictive analytics and decision support, play an increasing role in providing actionable information and supporting personalized and preventive healthcare concepts in both biomedical and digital healthcare systems and applications. ICT systems in healthcare and biomedical systems and devices are very closely related, and in the future they will become increasingly intertwined. Indeed, it is already often difficult to delineate where the one ends and the other begins. This book presents the intended proceedings of the dHealth 2020 annual conference on the general topic of health Informatics and digital health, which was due to be held in Vienna, Austria, on 19 and 20 May 2020, but which was cancelled due to the COVID-19 pandemic. The decision was nevertheless taken to publish these proceedings, which include the 40 papers which would have been delivered at the conference. The special topic for the 2020 edition of the conference was Biomedical Informatics for Health and Care. The book provides an overview of current developments in health informatics and digital health, and will be of interest to researchers and healthcare practitioners alike.

Author : Xiangdong Wang,Duojiao Wu,Huali Shen
Publisher : Springer
Page : 0 pages
File Size : 52,5 Mb
Release : 2018-12-29
Category : Science
ISBN : 9811344639

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Lipidomics in Health & Disease by Xiangdong Wang,Duojiao Wu,Huali Shen Pdf

This volume covers the emerging area of science, Clinical Lipidomics, which is the application of lipidology to the understanding of physiological and pathophysiological changes of lipidomes, with a special focus on lipidomic profiles in human diseases. Lipidomics is widely used to map lipid molecular species in a biological system. Clinical lipidomic analysis has demonstrated the comprehensive characterization of molecular lipids in various severities, durations, and therapies as a critical tool in identification and validation of disease-specific biomarkers. This volume on Clinical Lipidomics will add to the literature and help advance the knowledge of the pathogenesis, diagnosis, prevention and treatment of diseases.

Author : Shen Hu
Publisher : Springer Nature
Page : 317 pages
File Size : 43,5 Mb
Release : 2021-04-01
Category : Medical
ISBN : 9783030516529

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Cancer Metabolomics by Shen Hu Pdf

Cancer metabolomics is a rapidly evolving field that aims for a comprehensive dissection of the metabolic phenotypes and functional network of metabolites in human cancers. State of the art metabolomics tools have been developed and applied to studying cancer metabolism and developing metabolic targets for improved diagnosis, prognosis and therapeutic treatment of human cancers. Chapters are written by subject experts in the field of cancer metabolomics with cross-disciplinary contributions. Coverage includes advanced metabolomics technologies and methodologies, including chemical isotope labelling liquid chromatography - mass spectrometry, capillary ion chromatography - mass spectrometry, 2-D gas chromatography – mass spectrometry, capillary electrophoresis – mass spectrometry, nuclear magnetic resonance spectroscopy, shotgun lipidomics, tracer-based metabolomics, microbial metabolomics, mass spectrometry imaging for single cell metabolomics and functional metabolomics. In addition, the book highlights new discoveries in cancer metabolism such as hypoxia inducible factor pathway, isocitrate dehydrogenase 1 mutation and oncometabolites. Finally, contributors focus on the translational applications of metabolomics in human cancers such as glioma, head and neck cancer, and gastric cancer. This new volume will be a unique reference source for cancer researchers and promote applications of metabolomics in understanding cancer metabolism.

Author : Chryssostomos Chatgilialoglu
Publisher : MDPI
Page : 300 pages
File Size : 48,6 Mb
Release : 2020-03-25
Category : Technology & Engineering
ISBN : 9783039283927

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Biomimetic Radical Chemistry and Applications by Chryssostomos Chatgilialoglu Pdf

The enormous importance of free radical chemistry for a variety of biological events, including ageing and inflammation, has attracted a strong interest in understanding the related mechanistic steps at the molecular level. Modelling the free radical chemical reactivity of biological systems is an important research area. When studying free-radical-based chemical mechanisms, biomimetic chemistry and the design of established biomimetic models come into play to perform experiments in a controlled environment that is suitably designed to be in strict connection with cellular conditions. This Special Issue gives the reader a wide overview of biomimetic radical chemistry, where molecular mechanisms have been defined and molecular libraries of products are developed to also be used as traces for the discovery of some relevant biological processes. Several subjects are presented, with 12 articles and 6 reviews written by specialists in the fields of DNA, proteins, lipids, biotechnological applications, and bioinspired synthesis, having “free radicals” as a common denominator.

Author : Azzam A. Maghazachi
Publisher : Frontiers Media SA
Page : 110 pages
File Size : 53,8 Mb
Release : 2017-09-18
Category : Electronic book
ISBN : 9782889452880

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Immunomodulatory Effects of Drugs for Treatment of Immune-Related Diseases by Azzam A. Maghazachi Pdf

More than 90% of diseases possess immunological abnormalities. Disorders such as inflammation, hypersensitivity, autoimmunity and immunodeficiency are simple examples of how the immune system misinterprets its surroundings and goes awry. Multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel diseases, among many others are manifestations of immune cells attacking normal tissues. On the other hand, damping the immune system leads to diseases such as cancer, AIDS, and severe combined immunodeficiency. The last ten years witnessed an explosion in developing drugs that target the immune system. Several novel monoclonal antibodies have been approved for treatment of various diseases confirming that personalized medicine approach is robust in combating diseases. Hence, the future holds great promise for using personalized and targeted medicine rather than generalized medications that, in most circumstances, proven to be ineffective and characteristically exert side effects. Approaches such as generating novel adjuvants that can stimulate the immune system without harmful side effects, targeting inflammatory cytokines and chemokines, harnessing and activating innate immune cells such as natural killer cells or dendritic cells, are examples of future approaches to treat autoimmune diseases, AIDS, and various forms of cancer resulting from chronic inflammation. More recently, targeting immune checkpoint molecules have shown therapeutic response against lung cancer and melanoma. Identifying molecules involved in autophagy is another example of how personalized medicine might help treat patients with refractory asthma and autoimmune diseases. This topic introduces the reader to these novel approaches of manipulating the immune system and developing targeted therapeutic strategies for treatment of various diseases.

Author : Abhai Kumar,Debasis Bagchi
Publisher : CRC Press
Page : 631 pages
File Size : 45,8 Mb
Release : 2021-01-07
Category : Health & Fitness
ISBN : 9781000282740

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Antioxidants and Functional Foods for Neurodegenerative Disorders by Abhai Kumar,Debasis Bagchi Pdf

Neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are a growing problem across the world’s aging population. Oxidative stress in the brain plays a central role in a common pathophysiology of these diseases. This book presents scientific research on the potential of antioxidant therapy in the prevention and treatment of neurodegenerative disorders. This book outlines the roles of oxidative stress and diabetes mellitus in neurodegeneration, describes the molecular mechanisms of neurodegenerative disorders including the roles of environmental pollutants and inflammatory responses, and explores mitochondrial dysfunction. It then describes the protective abilities of antioxidants – including vitamin D, tocotrienol and coenzyme Q10 – against neurodegeneration. The book demonstrates the therapeutic potential of ketogenic diets, and highlights the roles of medicinal plants, phytopharmaceuticals, traditional medicines and food nutrients in neuroprotection. Key Features: Explains damage caused by numerous neurodegenerative disorders and the possible protection offered by antioxidants and functional foods. Describes molecular mechanisms of neurodegeneration by oxidative stress, advancing age, diabetes and mitochondrial dysfunctions. Demonstrates protection offered by nutraceuticals, antioxidants, botanical extracts and functional foods. The book contains twenty-three chapters divided into six sections written by leading researchers. This book is essential reading for health professionals, dietitians, food and nutrition scientists and anyone wanting to improve their knowledge of etiology of neurodegenerative diseases.

Author : Ronald Ross Watson,Fabien De Meester
Publisher : Academic Press and AOCS Press
Page : 0 pages
File Size : 52,7 Mb
Release : 2015-12-04
Category : Technology & Engineering
ISBN : 1630670367

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Handbook of Lipids in Human Function by Ronald Ross Watson,Fabien De Meester Pdf

Handbook of Lipids in Human Function: Fatty Acids presents current research relating to health issues whose impact may be modified by adopting personalized diets and lifestyle interventions of the consumption of fatty acids. Addressing cardiovascular and neurological diseases as well as cancer, obesity, inflammatory conditions, and lung disease, the authors correlate lipid sources with specific conditions, providing important insights into preventative as well as response-based actions designed to positively impact health outcomes. The material is presented in 29 chapters and brings together the research and work of an international team of experts. designed to bridge the gap between traditional approaches to dietary interventions and leading edge integrated health strategies, Handbook of Lipids in Human Function: Fatty Acids is a valuable resource for researchers and clinicians.

Author : Ole G. Mouritsen
Publisher : Springer Science & Business Media
Page : 276 pages
File Size : 49,6 Mb
Release : 2006-03-30
Category : Science
ISBN : 9783540270768

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Life - As a Matter of Fat by Ole G. Mouritsen Pdf

Presents a multi-disciplinary perspective on the physics of life and the particular role played by lipids and the lipid-bilayer component of cell membranes. Emphasizes the physical properties of lipid membranes seen as soft and molecularly structured interfaces. By combining and synthesizing insights obtained from a variety of recent studies, an attempt is made to clarify what membrane structure is and how it can be quantitatively described. Shows how biological function mediated by membranes is controlled by lipid membrane structure and organization on length scales ranging from the size of the individual molecule, across molecular assemblies of proteins and lipid domains in the range of nanometers, to the size of whole cells. Applications of lipids in nano-technology and biomedicine are also described.

Author : LERAY Claude
Publisher : Lavoisier
Page : 334 pages
File Size : 41,6 Mb
Release : 2013-04-04
Category : Electronic
ISBN : 9782743064914

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Les lipides – nutrition et santé by LERAY Claude Pdf

Les substances lipidiques ont longtemps été négligées par les physiologistes, mais des recherches épidémiologiques les ont récemment portées sur le devant de la scène, notamment au travers de leur intérêt dans les domaines de la nutrition et surtout de la santé chez l’Homme. Outre leur importance énergétique, les lipides interviennent dans de nombreux mécanismes cellulaires dont les dérèglements peuvent conduire à des pathologies parfois graves. En effet, en plus de leur impact sur les maladies métaboliques, les systèmes cardiovasculaire et immunitaire et les processus de cancérisation, le système nerveux central peut lui aussi être altéré à des degrés divers par une carence ou un déséquilibre entre les constituants lipidiques ingérés. Après quelques rappels historiques sur la découverte des lipides et leur utilisation, une première partie décrit les principaux lipides présents dans notre ration alimentaire. Puis, les besoins avérés ou éventuels de l’Homme en divers acides gras, stérols et vitamines appartenant au groupe des lipides, sont passés en revue. Enfin, l’impact des principaux lipides sur des pathologies naguère encore peu explorées sous cet aspect est exposé en détail. Les lipides – Nutrition et santé présente, de façon synthétique, un très large panorama de toutes les facettes des lipides, des acides gras aux corps gras les moins abondants, mais tout aussi importants pour l’équilibre de notre organisme. Il permet aux spécialistes de revisiter les principales sources de lipides présentes dans notre alimentation en insistant sur leur production et leur composition. Cet ouvrage s’adresse aux chercheurs, médecins généralistes et spécialistes, diététiciens et étudiants évoluant dans de nombreux domaines tels que la biologie cellulaire, la nutrition ou encore la pharmacologie.

Author : Lawrence J. Berliner,Narasimham L. Parinandi
Publisher : Springer Nature
Page : 237 pages
File Size : 49,8 Mb
Release : 2020-08-08
Category : Science
ISBN : 9783030473181

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Measuring Oxidants and Oxidative Stress in Biological Systems by Lawrence J. Berliner,Narasimham L. Parinandi Pdf

This book describes the methods of analysis and determination of oxidants and oxidative stress in biological systems. Reviews and protocols on select methods of analysis of ROS, RNS, oxygen, redox status, and oxidative stress in biological systems are described in detail. It is an essential resource for both novices and experts in the field of oxidant and oxidative stress biology.

Author : Alex Sevanian
Publisher : The American Oil Chemists Society
Page : 272 pages
File Size : 55,7 Mb
Release : 1988
Category : Science
ISBN : 0935315187

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Lipid Peroxidation in Biological Systems by Alex Sevanian Pdf