Metabolic Basis Of Obesity

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Metabolic Basis of Obesity

Rexford S. Ahima
Metabolic Basis of Obesity Book PDF

Author : Rexford S. Ahima
Publisher : Springer Science & Business Media
Page : 395 pages
File Size : 42,6 Mb
Release : 2010-11-16
Category : Medical
ISBN : 9781441916075

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Metabolic Basis of Obesity by Rexford S. Ahima Pdf

The obesity epidemic has generated immense interest in recent years due to the wide-ranging and significant adverse health and economic consequences that surround the problem. Much attention has been focused on behaviors that lead to obesity, in particular to over consumption of energy-dense food and to sedentary lifestyle. However, obesity is an extremely complex condition with poorly defined pathogenesis. Thanks to greatly enhanced research in the area, the discovery of pathways in the brain and peripheral organs that mediate energy homeostasis has provided a framework for understanding the biological basis of obesity. Metabolic Basis of Obesity adds an important new dimension to the growing literature on obesity by offering a comprehensive review of specifically how metabolic imbalance culminates in obesity. Developed by a team of expert authors, this important title discusses the principles of energy balance, genetics of body weight regulation, hormones and adipokines, and metabolic pathways in the brain, liver, muscle and fat, to name just several of the areas covered. The book also examines the connection between obesity and diabetes, cardiovascular disease and other complications. Current and future diagnostic and treatment strategies are also reviewed. Comprehensive and timely, Metabolic Basis of Obesity is an essential reference for understanding the burgeoning problem of obesity.

Metabolic Basis of Obesity

Rexford S. Ahima
Metabolic Basis of Obesity Book PDF

Author : Rexford S. Ahima
Publisher : Springer
Page : 391 pages
File Size : 48,9 Mb
Release : 2010-11-17
Category : Medical
ISBN : 1441916067

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Metabolic Basis of Obesity by Rexford S. Ahima Pdf

The obesity epidemic has generated immense interest in recent years due to the wide-ranging and significant adverse health and economic consequences that surround the problem. Much attention has been focused on behaviors that lead to obesity, in particular to over consumption of energy-dense food and to sedentary lifestyle. However, obesity is an extremely complex condition with poorly defined pathogenesis. Thanks to greatly enhanced research in the area, the discovery of pathways in the brain and peripheral organs that mediate energy homeostasis has provided a framework for understanding the biological basis of obesity. Metabolic Basis of Obesity adds an important new dimension to the growing literature on obesity by offering a comprehensive review of specifically how metabolic imbalance culminates in obesity. Developed by a team of expert authors, this important title discusses the principles of energy balance, genetics of body weight regulation, hormones and adipokines, and metabolic pathways in the brain, liver, muscle and fat, to name just several of the areas covered. The book also examines the connection between obesity and diabetes, cardiovascular disease and other complications. Current and future diagnostic and treatment strategies are also reviewed. Comprehensive and timely, Metabolic Basis of Obesity is an essential reference for understanding the burgeoning problem of obesity.

Obesity and Metabolism

Márta Korbonits
Obesity and Metabolism Book PDF

Author : Márta Korbonits
Publisher : Karger Medical and Scientific Publishers
Page : 305 pages
File Size : 45,8 Mb
Release : 2008-01-01
Category : Medical
ISBN : 9783805584296

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Obesity and Metabolism by Márta Korbonits Pdf

It has become increasingly difficult to keep up with the growing body of literature on the genetics, metabolic phenotype and treatment of obesity. This volume brings together an array of chapters from many of the foremost authorities and researchers in this area. Key advances in the genetics of obesity are summarized and the effects of obesity in pregnancy, childhood and old age explored. By scrutinizing the hormones and enzymes most recently implicated in the development, maintenance and consequences of obesity, the biochemical and physiological background of the abnormal metabolism of obesity is mapped out. Furthermore, a practical update on clinical approach and treatment of obesity is offered. Finally, the social aspects of obesity and the view of the obese body in art throughout the centuries are reflected. A valuable overview of causes, metabolic disturbances and treatment options, this volume will appeal to those with an interest in clinical as well as pathophysiological and genetic aspects of obesity. Furthermore, it will provide useful reading for scientists and students who would like to broaden and update their knowledge in this area.

Cellular and Biochemical Mechanisms of Obesity

Paramjit S. Tappia,Bram Ramjiawan,Naranjan S. Dhalla
Cellular and Biochemical Mechanisms of Obesity Book PDF

Author : Paramjit S. Tappia,Bram Ramjiawan,Naranjan S. Dhalla
Publisher : Springer Nature
Page : 420 pages
File Size : 43,8 Mb
Release : 2021-12-15
Category : Medical
ISBN : 9783030847630

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Cellular and Biochemical Mechanisms of Obesity by Paramjit S. Tappia,Bram Ramjiawan,Naranjan S. Dhalla Pdf

Global health has been challenged with the dawning of the era of the obesity epidemic, and thus as a consequence, strategies to reduce obesity have become public health priorities. According to the United Nations, obesity has been identified as a concern for achieving Sustainable Development Goals. Obesity is a serious health problem with an increased risk of several common diseases including diabetes, cardiovascular disease, and cancer. Although the fundamental cause of obesity and overweight is an imbalance between calorie intake and calorie expenditure, the underlying biochemical and metabolic processes that cause obesity are not fully understood. Two earlier volumes dedicated to the subject of obesity, published in the series “Advances in Biochemistry in Health and Disease” focused on the pathophysiology of obesity-induced health complications and the biochemistry of cardiovascular dysfunction in obesity. This book brings together contributions from international experts in the field to describe advancements on the mechanisms leading to development of obesity and related complications. There are 21 chapters in two different parts in this book, comprising of Part I: Pathophysiologic Mechanisms of Obesity (11 chapters) and Part II: Therapeutic Mechanisms of Obesity (10 chapters). This book will serve as a resource and be of interest to health professionals, medical students, fellows, residents and graduate students. It will also evoke innovative research and effective approaches for the prevention of obesity. This volume will accentuate that obesity is a major health hazard in its own right and that appropriate public health measures should be implemented to prevent or reduce or even reverse the impact of this global chronic disease.

The Genetics of Obesity

Claude Bouchard
The Genetics of Obesity Book PDF

Author : Claude Bouchard
Publisher : CRC Press
Page : 262 pages
File Size : 50,8 Mb
Release : 2020-08-11
Category : Medical
ISBN : 9781000141603

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The Genetics of Obesity by Claude Bouchard Pdf

This book provides a comprehensive compilation of the evidence available regarding the role of genetic differences in the etiology of human obesities and their health and metabolic implications. It also identifies the most promising research areas, methods, and strategies for use in future efforts to understand the genetic basis of obesities and their consequences on human health. Leading researchers in their respective fields present contributed chapters on such topics as etiology and the prevalence of obesities, nongenetic determinants of obesity and fat topography, and animal models and molecular biological technology used to delineate the genetic basis of human obesities. A major portion of the book is devoted to human genetic research and clinical observations encompassing adoption studies, twin studies, family studies, single gene effects, temporal trends and etiology heterogeneity, energy intake and food preference, energy expenditure, and susceptibility to metabolic derangements in the obese state. Future directions of research in the field are covered in the book as well.

Overweight and the Metabolic Syndrome:

George A. Bray,Louisiana State University,Donna Ryan
Overweight and the Metabolic Syndrome Book PDF

Author : George A. Bray,Louisiana State University,Donna Ryan
Publisher : Springer Science & Business Media
Page : 347 pages
File Size : 53,7 Mb
Release : 2007-02-16
Category : Medical
ISBN : 9780387321646

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Overweight and the Metabolic Syndrome: by George A. Bray,Louisiana State University,Donna Ryan Pdf

This timely book provides an overview of topics related to obesity. These include associated health risks, childhood obesity, genetics, evaluation, treatment, behavioral strategies, and successes and failures in preventing obesity. The volume covers evaluation guidelines, different approaches to treatment, including diet, exercise, behavior, drugs, and surgery to deal with the current world-wide obesity epidemic.

Sensory and Metabolic Control of Energy Balance

Wolfgang Meyerhof,Ulrike Beisiegel,Hans-Georg Joost
Sensory and Metabolic Control of Energy Balance Book PDF

Author : Wolfgang Meyerhof,Ulrike Beisiegel,Hans-Georg Joost
Publisher : Springer Science & Business Media
Page : 208 pages
File Size : 55,6 Mb
Release : 2010-09-24
Category : Science
ISBN : 9783642144264

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Sensory and Metabolic Control of Energy Balance by Wolfgang Meyerhof,Ulrike Beisiegel,Hans-Georg Joost Pdf

During the last two decades, the prevalence of obesity has dramatically increased in western and westernized societies. Its devastating health consequences include hypertension, cardiovascular diseases, or diabetes and make obesity the second leading cause of unnecessary deaths in the USA. As a consequence, obesity has a strong negative impact on the public health care systems. Recently emerging scienti?c insight has helped understanding obesity as a complex chronic disease with multiple causes. A multileveled gene–environment interaction appears to involve a substantial number of susceptibility genes, as well as associations with low physical activity levels and intake of high-calorie, low-cost, foods. Unfor- nately, therapeutic options to prevent or cure this disease are extremely limited, posing an extraordinary challenge for today’s biomedical research community. Obesity results from imbalanced energy metabolism leading to lipid storage. Only detailed understanding of the multiple molecular underpinnings of energy metabolism can provide the basis for future therapeutic options. Numerous aspects of obesity are currently studied, including the essential role of neural and endocrine control circuits, adaptive responses of catabolic and anabolic pathways, metabolic fuel sensors, regulation of appetite and satiation, sensory information processing, transcriptional control of metabolic processes, and the endocrine role of adipose tissue. These studies are predominantly fuelled by basic research on mammalian models or clinical studies, but these ?ndings were paralleled by important insights, which have emerged from studying invertebrate models.

Obesity and Diabetes

Anthony H. Barnett,Sudhesh Kumar
Obesity and Diabetes Book PDF

Author : Anthony H. Barnett,Sudhesh Kumar
Publisher : John Wiley & Sons
Page : 324 pages
File Size : 44,8 Mb
Release : 2005-04-08
Category : Medical
ISBN : 9780470011096

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Obesity and Diabetes by Anthony H. Barnett,Sudhesh Kumar Pdf

Obesity has become the most common chronic disease of the present day, with significant increases in prevalence in populations across the world and all age groups. This has resulted in a dramatic increase in obesity-related metabolic and cardiovascular complications, making it an important public health issue. Type 2 diabetes associated with obesity or 'diabesity' is today the most common form of type 2 diabetes. It is also associated with a number of other cardiovascular risk factors, which constitute the metabolic syndrome. Effective management of 'diabesity' is crucial to the reduction of morbidity and premature mortality due to cardiovascular disease. This book comprises chapters written by leading international experts on various aspects of obesity-related diabetes. As a practical reference guide, it is suitable for all professionals with an interest in this field. Emerging problems such as childhood 'diabesity' and the impact of obesity on polycystic ovary syndrome will be of interest not only to paediatricians and endocrinologists, but also to general practitioners and other healthcare professionals. The contemporary approach to the clinical assessment of obesity and its management in both primary and secondary care settings is also described.

Weighing the Options

Institute of Medicine,Committee to Develop Criteria for Evaluating the Outcomes of Approaches to Prevent and Treat Obesity
Weighing the Options Book PDF

Author : Institute of Medicine,Committee to Develop Criteria for Evaluating the Outcomes of Approaches to Prevent and Treat Obesity
Publisher : National Academies Press
Page : 296 pages
File Size : 52,6 Mb
Release : 1995-03-01
Category : Medical
ISBN : 9780309132572

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Weighing the Options by Institute of Medicine,Committee to Develop Criteria for Evaluating the Outcomes of Approaches to Prevent and Treat Obesity Pdf

Nearly one out of every three adults in America is obese and tens of millions of people in the United States are dieting at any one time. This has resulted in a weight-loss industry worth billions of dollars a year and growing. What are the long-term results of weight-loss programs? How can people sort through the many programs available and select one that is right for them? Weighing the Options strives to answer these questions. Despite widespread public concern about weight, few studies have examined the long-term results of weight-loss programs. One reason that evaluating obesity management is difficult is that no other treatment depends so much on an individual's own initiative and state of mind. Now, a distinguished group of experts assembled by the Institute of Medicine addresses this compelling issue. Weighing the Options presents criteria for evaluating treatment programs for obesity and explores what these criteria meanâ€"to health care providers, program designers, researchers, and even overweight people seeking help. In presenting its criteria the authors offer a wealth of information about weight loss: how obesity is on the rise, what types of weight-loss programs are available, how to define obesity, how well we maintain weight loss, and what approaches and practices appear to be most successful. Information about weight-loss programsâ€"their clients, staff qualifications, services, and success ratesâ€"necessary to make wise program choices is discussed in detail. The book examines how client demographics and characteristicsâ€"including health status, knowledge of weight-loss issues, and attitude toward weight and body imageâ€"affect which programs clients choose, how successful they are likely to be with their choices, and what this means for outcome measurement. Short- and long-term safety consequences of weight loss are discussed as well as clinical assessment of individual patients. The authors document the health risks of being overweight, summarizing data indicating that even a small weight loss reduces the risk of disease and depression and increases self-esteem. At the same time, weight loss has been associated with some poor outcomes, and the book discusses the implications for program evaluation. Prevention can be even more important than treatment. In Weighing the Options, programs for population groups, efforts targeted to specific groups at high risk for obesity, and prevention of further weight gain in obese individuals get special attention. This book provides detailed guidance on how the weight-loss industry can improve its programs to help people be more successful at long-term weight loss. And it provides consumers with tips on selecting a program that will improve their chances of permanently losing excess weight.

Global Health Complications of Obesity

Jahangir Moini,Raheleh Ahangari,Carrie Miller,Mohtashem Samsam
Global Health Complications of Obesity Book PDF

Author : Jahangir Moini,Raheleh Ahangari,Carrie Miller,Mohtashem Samsam
Publisher : Elsevier
Page : 482 pages
File Size : 51,5 Mb
Release : 2020-04-01
Category : Medical
ISBN : 9780128197523

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Global Health Complications of Obesity by Jahangir Moini,Raheleh Ahangari,Carrie Miller,Mohtashem Samsam Pdf

Global Health Complications of Obesity presents a valuable resource for research scientists and clinicians by covering the burden of obesity and related diseases and serving as a starting point for in-depth discussions in academic settings and for obesity-treatment specialists. Obesity is associated with a statistically higher risk of heart disease, hypertension, insulin resistance, type 2 diabetes and many other diseases. This succinct resource focuses on the current data, research and management of obesity. It is essential reading for healthcare professionals, endocrinologists, nutritionists, public health students and medical students. Presents clinical cases, key terms and targeted references Addresses diseases including diabetes, cancer, hypertension, osteoarthritis, fatty liver disease, infertility, renal failure and depression Provides a link to new knowledge that is ideal for both researchers and clinicians

The Metabolic Syndrome and Obesity

George A. Bray
The Metabolic Syndrome and Obesity Book PDF

Author : George A. Bray
Publisher : Springer Science & Business Media
Page : 304 pages
File Size : 47,5 Mb
Release : 2008-01-23
Category : Science
ISBN : 9781597454315

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The Metabolic Syndrome and Obesity by George A. Bray Pdf

This book presents an up-to-date survey of the current scientific understanding of obesity and the metabolic syndrome, as well as an overview of the most significant changes to the field over the past 30 years. The book defines obesity and realistically assesses its prevalence. It further examines and evaluates the success of traditional cognitive behavioral treatment. This volume is a thorough reference for obesity and the metabolic syndrome.

Nutrition and Metabolism

Christos S. Mantzoros
Nutrition and Metabolism Book PDF

Author : Christos S. Mantzoros
Publisher : Springer Science & Business Media
Page : 423 pages
File Size : 43,6 Mb
Release : 2009-04-20
Category : Medical
ISBN : 9781603274531

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Nutrition and Metabolism by Christos S. Mantzoros Pdf

Nutrition and Metabolism: Underlying Mechanisms and Clinical Consequences brings together internationally recognized experts to comprehensively review our current understanding of how nutrition interacts with the genetic substrate as well as environmental-exogenous factors, including physical activity or the lack thereof, to result in insulin resistance and the metabolic syndrome. After presenting the scope of the problem, the first major part of the book is devoted to genetics and pathophysiology, the second part of the book presents the public health perspective of the most prevalent problems associated with nutrition and the metabolic syndrome, whereas the third major part of the book focuses on clinical assessment and management of the main disease states associated with inappropriate nutrition and the metabolic syndrome. Finally, general information useful for both clinicians and researchers alike is presented in the Appendix. Nutrition and Metabolism: Underlying Mechanisms and Clinical Consequences offers the reader an up-to-date and authoritative review of the major scientific and clinical aspects of the overlapping areas between nutrition and metabolism.

Metabolic Syndrome and Obesity in Childhood and Adolescence

W. Kiess,M. Wabitsch,C. Maffeis,A.M. Sharma
Metabolic Syndrome and Obesity in Childhood and Adolescence Book PDF

Author : W. Kiess,M. Wabitsch,C. Maffeis,A.M. Sharma
Publisher : Karger Medical and Scientific Publishers
Page : 202 pages
File Size : 42,8 Mb
Release : 2015-01-27
Category : Medical
ISBN : 9783318027990

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Metabolic Syndrome and Obesity in Childhood and Adolescence by W. Kiess,M. Wabitsch,C. Maffeis,A.M. Sharma Pdf

Despite the fact that the prevalence of obesity in early childhood has been stable and is no longer increasing in many developed and industrialized countries, the incidence of both obesity and full-blown metabolic syndrome in children and adolescents is still very high. Obesity is a major disease burden in all societies and needs to be prevented early in life. New approaches are eagerly sought and absolutely necessary. This book presents a comprehensive and state-of-the-art summary of current and new knowledge in this critical field. Crucial issues such as nutrition and genetics are described in detail. In addition, new ideas such as e-health and the consequences of urban living conditions are explored. Last but not least, modern treatment concepts and prevention even at an early age are competently discussed. Offering a valuable update on new developments in obesity research and the treatment in children and adolescents, this book is essential reading for all pediatricians and health-care professionals who look after young patients on a regular basis.

ABC of Obesity

Naveed Sattar,Mike Lean
ABC of Obesity Book PDF

Author : Naveed Sattar,Mike Lean
Publisher : John Wiley & Sons
Page : 64 pages
File Size : 40,9 Mb
Release : 2009-04-08
Category : Medical
ISBN : 9781444312706

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ABC of Obesity by Naveed Sattar,Mike Lean Pdf

Obesity is a hugely expensive and increasing problem worldwide,leading to disability, reproductive problems, depression andaccelerated metabolic and vascular diseases in a large proportionof men, women and children. The ABC of Obesity is a newguide which will aid its effective management, addressing issuessuch as dieting, exercise, self esteem, drug treatment and surgery.Recent evidence is used to highlight frequent problems, successfultreatment options, and the most common causes. Written by leading experts, this is a widely accessible text andan indispensable guide for all general practitioners, juniordoctors, nurses, and other healthcare professionals who areinvolved in the treatment and research of this commoncondition.

Obesity and Energy Metabolism

National Institutes of Health (U.S.)
Obesity and Energy Metabolism Book PDF

Author : National Institutes of Health (U.S.)
Publisher : Unknown
Page : 28 pages
File Size : 51,7 Mb
Release : 1979
Category : Energy metabolism
ISBN : MINN:319510028579400

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Obesity and Energy Metabolism by National Institutes of Health (U.S.) Pdf

Abstract: A comprehensive yet uncomplicated discussion of obesity is presented for the average adult as part of a series called "Medicine for the Layman." Although the specific causes of obesity are unknown, many factors, such as genetics and environment, influence the condition. More is known about the health consequences of obesity in terms of increased risk of diabetes, cardiovascular diseases and emotional stress. Obesity is defined; the functions of the human body which help determine the numbers and size of fat cells in adipose tissue (hypertrophic and hyperplastic obesity) are described. The balance of caloric intake and energy expenditure for each individual is emphasized. Further research needs are identified. The information is reinforced by a question and answer section and color cartoons.