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Author : Henry I. Yamamura,S. J. Enna,Michael J. Kuhar
Publisher : Raven Press (ID)
Page : 298 pages
File Size : 43,9 Mb
Release : 1990
Category : Medical
ISBN : UOM:39015017698328
Author : S.H. Parvez,M. Naoi,T. Nagatsu
Publisher : Elsevier
Page : 436 pages
File Size : 53,5 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483290225
This two-part book provides the most advanced biochemical and histochemical analytical methods on neurotransmitters, neuromodulators, and neuropeptides described by international specialists. The biochemical methods include liquid chromatography/electrochemistry, liquid chromatography/fluorescence and chemiluminescence detection, gas chromatography or liquid chromatography with mass spectrometry, and immunoassays. Morphological and physiological methods are also described, including immunohistochemistry, in situ hybridization, in vivo microdialysis, electrophysiological analysis, microwave irradiation, electrophysiological analysis, micro-anatomical dissection, peptide sequence analysis, quantitative autoradiographic analysis, and isolated CNS preparations. The neurotransmitters and neuropeptides include catecholamines, indoleamines, histamine, polyamines, and various neuropeptides, and their related enzymes. The book is the most comprehensive, advanced and versatile volume on the biochemical, morphological and physiological analysis of neurotransmitters and neuropeptides.
Author : Marjorie Ariano
Publisher : John Wiley & Sons
Page : 276 pages
File Size : 42,9 Mb
Release : 1998-07-16
Category : Medical
ISBN : 0471195243
The detection of neurotransmitter receptor locations and distribution densities within the central nervous system and peripheral tissues is receiving intense attention within the neuroscience research community. Neurotransmitter receptors, which receive the chemical signals sent from one neuron to another, are critical links in a highly complex information-processing chain. Pinpointing receptor sites and systems is crucial for understanding neurological function as well as dysfunction. It is also essential for understanding how receptors process information when impacted by such substances as heroin or nicotine, or when affected by neurodegenerative disease. Receptor Localization: Laboratory Methods and Procedures is the first user-friendly guide to the latest techniques and approaches being employed to examine the localization of neurotransmitter receptors in the central nervous system and peripheral tissues. It covers detection methods that are applicable to a wide variety of receptor systems, ranging from genes and ligands to in vito receptors in individuals; and to numerous receptor subtypes, such as nicotine, muscarine, tackykinins, dopamine, adenosine, and GABA. The standard laboratory "recipes" or "tricks" employed in these detection methods are fully discussed, as are the advantages and limitations of each procedure. With contributions from leading experts and extensively illustrated, this book: * Discusses receptor ligand binding methods using irreversible and reversible compounds * Presents antireceptor antisera technology using synthetic peptides and fusion proteins at both the cellular and subcellular resolution levels * Examines molecular assessments of receptors * Describes in situ hybridization, reverse transcriptase-PCR, and fluorescent in situ transcription * Covers new visualization paradigms * Includes physiological analysis of receptor function, cellular detection in the brain slice, and cultured neurons * Discusses the use of PET and SPECT to assess in vivo receptor distributions in animals and humans Receptor Localization: Laboratory Methods and Procedures is an invaluable guide for researchers in the related fields of neurology, biochemistry, and pharmacology. Its lucid descriptions of new detection methods, inclusion of experimental examples, and emphasis on how these experimental approaches are applicable to particular research areas will appeal to both the experienced researcher and novice investigator.
Author : Federico Bermudez-Rattoni
Publisher : CRC Press
Page : 368 pages
File Size : 54,9 Mb
Release : 2007-04-17
Category : Psychology
ISBN : 9781420008418
A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniq
Author : Arne Schousboe,Hans Bräuner-Osborne
Publisher : Springer Science & Business Media
Page : 282 pages
File Size : 49,6 Mb
Release : 2003-12-22
Category : Medical
ISBN : 9781592596720
A powerful collection of readily reproducible cutting-edge techniques for characterizing the ligand or substrate binding of neurotransmitter receptors and transporters. The procedures cover interdisciplinary interactions for monoamine transporters, amino acid transporters, ionotropic receptors, metabotropic glutamate receptors, GABA receptors, and other G protein-coupled receptors. By illuminating how neurons in the central nervous communicate with other, these techniques can lead to the development of novel therapeutic strategies for neurological diseases.
Author : Rafael Luján,Francisco Ciruela
Publisher : Humana Press
Page : 475 pages
File Size : 41,5 Mb
Release : 2018-03-31
Category : Medical
ISBN : 1493979833
Receptor and Ion Channel Detection in the Brain provides state-of-the-art and up-to-date methodological information on molecular, neuroanatomical and functional techniques that are currently used to study neurotransmitter receptors and ion channels in the brain. The chapters have been contributed by world-wide recognized neuroscientists who explain in an easy and detailed way well established and tested protocols embracing molecular, cellular, subcellular, anatomical and electrophysiological aspects of the brain. This comprehensive and practical manual is presented in a simple, step-by-step manner for laboratory use, and also offers unambiguous detail and key implementation advice that proves essential for successful results and facilitate choosing the best method for the target proteins under study. This work serves as a useful guide for young researchers and students in training as well as for neurologists and established scientists who wish to extend their repertoire of techniques.
Author : Thomas C. Südhof,Klaus Starke
Publisher : Springer Science & Business Media
Page : 582 pages
File Size : 52,9 Mb
Release : 2007-12-07
Category : Medical
ISBN : 9783540748052
It has been known for half a century that neurotransmitters are released in preformed quanta, that the quanta represent transmitter-storing vesicles, and that release occurs by exocytosis. The focus of this book is twofold. In the first part, the molecular events of exocytosis are analysed. In the second part of the book, the presynaptic receptors for endogenous chemical signals are presented that make neurotransmitter release a highly regulated process.
Author : Institute of Medicine,Division of Biobehavioral Sciences and Mental Disorders,Division of Health Sciences Policy,Committee on a National Neural Circuitry Database
Publisher : National Academies Press
Page : 180 pages
File Size : 54,5 Mb
Release : 1991-02-01
Category : Computers
ISBN : 9780309044974
Significant advances in brain research have been made, but investigators who face the resulting explosion of data need new methods to integrate the pieces of the "brain puzzle." Based on the expertise of more than 100 neuroscientists and computer specialists, this new volume examines how computer technology can meet that need. Featuring outstanding color photography, the book presents an overview of the complexity of brain research, which covers the spectrum from human behavior to genetic mechanisms. Advances in vision, substance abuse, pain, and schizophrenia are highlighted. The committee explores the potential benefits of computer graphics, database systems, and communications networks in neuroscience and reviews the available technology. Recommendations center on a proposed Brain Mapping Initiative, with an agenda for implementation and a look at issues such as privacy and accessibility.
Author : Richard E. Brown
Publisher : Cambridge University Press
Page : 434 pages
File Size : 41,8 Mb
Release : 1994-01-27
Category : Science
ISBN : 0521426650
This book is designed as an introductory text in neuroendocrinology; the study of the interaction between the brain and endocrine system and the influence of this on behaviour. The endocrine glands, pituitary gland and hypothalamus and their interactions and hormones are discussed. The action of steroid and thyroid hormone receptors and the regulation of target cell response to hormones is examined. The function of neuropeptides is discussed with respect to the neuroendocrine system and behaviour. The neuroimmune system and lymphokines are described and the interaction between the neuroendocrine and neuroimmune systems discussed. Finally, methods for studying hormonal influences on behaviour are outlined. Each chapter has review and essay questions designed for advanced students and honours or graduate students with a background in neuroscience, respectively.
Author : Robert M. Bradley
Publisher : CRC Press
Page : 0 pages
File Size : 45,5 Mb
Release : 2006-10-04
Category : Science
ISBN : 0849342007
Providing an essential brainstem relay for three cranial nerves, the NST coordinates highly complex sensory information. While other functions of the NST have received attention, its role in gustatory processing has received little. The first reference devoted exclusively to gustatory processing, The Role of the Nucleus of the Solitary Tract in Gustatory Processing offers an in-depth review of one of the most important central relay stations in the brain. Combining widely dispersed research into a comprehensive single volume, it presents a thorough historical background, documents the anatomy of the rostral nucleus of the solitary tract (rNST), and explores the properties of synaptic transmitters and neurons within that tract. The book examines the role of reflex activities and considers factors that influence how gustatory rNST neurons respond to taste stimuli. It describes the development and maturational changes the rNST undergoes and considers the challenge involved with identifying rNST neural circuits. The Role of the Nucleus of the Solitary Tract in Gustatory Processing brings together expert investigators who have contributed substantially to the current knowledge of the anatomy, physiology, and developmental biology of the solitary nucleus. This pertinent work serves as a standard reference for those involved in the field, providing ready access to past investigations and inviting practitioners to create new approaches that will advance knowledge about the central processing of gustatory information.
Author : Gabriel Berstein
Publisher : CRC Press
Page : 440 pages
File Size : 46,5 Mb
Release : 2019-04-24
Category : Medical
ISBN : 1420048511
Covering recently developed methods in membrane-bound receptors, this book emphasizes receptor structure and function, knowledge of which is essential to the study of signal transduction. G Protein-Coupled Receptors has culled contributors from domestic and international sources, providing a broad base of knowledge. Some topics covered are the r
Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1024 pages
File Size : 41,6 Mb
Release : 2024-07-01
Category : Medicine
ISBN : UOM:39015020571850
First multi-year cumulation covers six years: 1965-70.
Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1032 pages
File Size : 52,6 Mb
Release : 1990
Category : Medicine
ISBN : MINN:31951D00422787B
Author : Michael Kapis,Shayne C. Gad
Publisher : CRC Press
Page : 288 pages
File Size : 48,8 Mb
Release : 1993-06-24
Category : Medical
ISBN : 1439810907
Non-Animal Techniques in Biomedical and Behavioral Research and Testing features the contributions of noted experts describing the application of non-animal methods in a wide variety of research and testing situations, including computer modeling/graphics, protein sequence analysis, behavioral analysis, drug design/testing, cosmetic and household products testing, toxicological testing, clinical testing, chemical identification and analysis, and disease investigations. Many of the alternatives covered have applications in behavioral as well as biomedical research and testing. Topics examined include in vitro techniques, molecular genetics, structure-activity relationships, physicochemical methods, computer-assisted drug designs, nutrition, epidemiology, autopsies, neural networks, ethology, image scanning devices, and medical microbiology. Future applications for non-animal methods are also explored. The book will appeal to toxicologists, pharmacologists, cosmetic and household product researchers, epidemiologists, medical microbiologists, biopsychiatrists, biomedical and psychological educators, biochemists, molecular geneticists, and other scientists interested in alternative testing methods.
Author : Yuan Liu,David M. Lovinger
Publisher : CRC Press
Page : 405 pages
File Size : 55,9 Mb
Release : 2002-02-14
Category : Medical
ISBN : 9781420042092
Written by a panel of experts, Methods in Alcohol-Related Neuroscience Research not only provides information of a technical nature but also gives an overview of the many areas in investigating the effects of alcohol on the brain. It gives technical guidance for investigators doing research at the molecular, cellular, systems, and behavioral levels. These techniques include a wide variety of approaches, ranging from gene mapping and examination of molecular interactions of alcohol at the sub-cellular level to recording of neural activities in freely-behaving animals and imaging alcohol effects on the living human brain.
