Mitochondria The Cell Powerhouse And Nexus Of Stress

Author : Sabzali Javadov,Andrey V. Kuznetsov
Publisher : Frontiers E-books
Page : 122 pages
File Size : 48,5 Mb
Release : 2014-09-23
Category : Biology (General)
ISBN : 9782889192830

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Mitochondria: the cell powerhouse and nexus of stress by Sabzali Javadov,Andrey V. Kuznetsov Pdf

Mitochondrion, a sub-cellular organelle originated from primary endosymbiosis, plays a vital role in energy metabolism of eukaryotic cells. The transfer of electrons through the electron transport chain (ETC) to molecular oxygen accompanied by the extrusion of protons from the matrix generate an electrochemical gradient across the inner mitochondrial membrane (IMM) that is used for ATP synthesis by oxidative phosphorylation. Despite many aspects of ATP synthesis have been delineated, regulatory mechanisms responsible for energy synthesis and transfer still remain to be uncovered. In addition to energy function, mitochondria play a crucial role in cell metabolism under both physiological and pathological conditions through their participation in many intracellular signaling pathways. Studies over the last 30 years provide strong evidence that mitochondria are the nexus of various stresses which initiate cell death through apoptosis, oncosis, necrosis and autophagy depending on the severity of the stress and cellular energy status. The release of several pro-apoptotic proteins such as cytochrome c, Smac/DIABLO, AIF, endonuclease G from intermembrane space initiates both caspase-dependent and caspase-independent apoptosis. The formation of the mitochondrial permeability transition pore in the IMM promotes cell death mostly through necrosis whereas a mild stress activates autophagy. Due to their critical roles in both cell death and survival mitochondria have been widely considered as an important target for various pharmacological and conditional therapeutic approaches. Currently, a large number of mitochondria-targeted agents are suggested to prevent (in ischemia reperfusion injury, cardiovascular, neurodegenerative and other diseases) or stimulate (in various cancers) cell death. This Research Topic focuses on the role of mitochondria in the regulation of cell metabolism and signaling under physiological and pathological conditions. Studies performed on cultured cells and isolated organs/tissues using different animal and cellular models of various diseases are also included and discussed.

Author : Loveleen Gaur,Arun Solanki,Samuel Fosso Wamba,Noor Zaman Jhanjhi
Publisher : CRC Press
Page : 282 pages
File Size : 42,6 Mb
Release : 2021-10-18
Category : Computers
ISBN : 9781000462982

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Advanced AI Techniques and Applications in Bioinformatics by Loveleen Gaur,Arun Solanki,Samuel Fosso Wamba,Noor Zaman Jhanjhi Pdf

The advanced AI techniques are essential for resolving various problematic aspects emerging in the field of bioinformatics. This book covers the recent approaches in artificial intelligence and machine learning methods and their applications in Genome and Gene editing, cancer drug discovery classification, and the protein folding algorithms among others. Deep learning, which is widely used in image processing, is also applicable in bioinformatics as one of the most popular artificial intelligence approaches. The wide range of applications discussed in this book are an indispensable resource for computer scientists, engineers, biologists, mathematicians, physicians, and medical informaticists. Features: Focusses on the cross-disciplinary relation between computer science and biology and the role of machine learning methods in resolving complex problems in bioinformatics Provides a comprehensive and balanced blend of topics and applications using various advanced algorithms Presents cutting-edge research methodologies in the area of AI methods when applied to bioinformatics and innovative solutions Discusses the AI/ML techniques, their use, and their potential for use in common and future bioinformatics applications Includes recent achievements in AI and bioinformatics contributed by a global team of researchers

Author : José Marín-García
Publisher : Springer Science & Business Media
Page : 495 pages
File Size : 50,6 Mb
Release : 2012-11-19
Category : Medical
ISBN : 9781461445999

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Mitochondria and Their Role in Cardiovascular Disease by José Marín-García Pdf

Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significant advances in the field of mitochondrial cardiovascular medicine. The book begins with a general introduction to mitochondria, followed by laboratory methods to study the structure and function of the organelle, regulation of replication and biogenesis, and the mechanisms and functional consequences of mitophagia and mitochondrial dynamics. Subsequent chapters deal with mitochondrial oxidative stress and the role that the organelle plays in cell signaling and cell death. Discussions will be undertaken on the biochemistry of mitochondrial cell signaling, including the nature of the proteins engaged in these processes, many of them only recently discovered. Later chapters examine the role of mitochondria and mitochondrial abnormalities in cardiovascular diseases, including their diagnosis, therapeutic options currently available, animal models of mitochondrial disease, and new frontiers in mitochondria cardiovascular medicine, including areas of research that are relatively new or developing, such as proteomics, next generation sequencing, and systems biology.

Author : Samarjit Das,Eleonora Leucci,Eric Barrey,Nina Entelis,John Hollander,Veronica Andrea Burzio
Publisher : Frontiers Media SA
Page : 128 pages
File Size : 48,7 Mb
Release : 2022-09-30
Category : Science
ISBN : 9782832501313

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Role of Mitochondria-Associated Non-Coding RNAs in Intracellular Communication by Samarjit Das,Eleonora Leucci,Eric Barrey,Nina Entelis,John Hollander,Veronica Andrea Burzio Pdf

Author : Bryan P. Bergeron
Publisher : Prentice Hall Professional
Page : 472 pages
File Size : 48,9 Mb
Release : 2003
Category : Computers
ISBN : 0131008250

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Bioinformatics Computing by Bryan P. Bergeron Pdf

Comprehensive and concise, this handbook has chapters on computing visualization, large database designs, advanced pattern matching and other key bioinformatics techniques. It is a practical guide to computing in the growing field of Bioinformatics--the study of how information is represented and transmitted in biological systems, starting at the molecular level.

Author : Nitish Kumar
Publisher : Springer Nature
Page : 338 pages
File Size : 53,9 Mb
Release : 2024-06-29
Category : Electronic
ISBN : 9783031536885

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Heavy Metal Remediation by Nitish Kumar Pdf

Author : Niels Olsen Saraiva Camara,Jose C Alves-Filho,Pedro Manoel Mendes de Moraes-Vieira,Vinicius Andrade-Oliveira
Publisher : Springer Nature
Page : 285 pages
File Size : 55,5 Mb
Release : 2021-10-21
Category : Medical
ISBN : 9783030866846

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Essential Aspects of Immunometabolism in Health and Disease by Niels Olsen Saraiva Camara,Jose C Alves-Filho,Pedro Manoel Mendes de Moraes-Vieira,Vinicius Andrade-Oliveira Pdf

Immunometabolism has emerged as an intersectional crossroad between metabolism and immune response. Over the past decade, it has become clear that most - if not all - immune cell functions are not separated from cellular metabolism. Although seminal works have addressed the metabolic fate of immune cells during differentiation and function, the physiological status of a given tissue is also dependent on the cell metabolism. The dialogue between immune cells and their microenvironment can also modulate cellular metabolism, which can trigger the onset and progression of a multitude of inflammation-mediated diseases. Thus, uncovering the specific characteristics of the metabolism in different immune cells types and in different conditions, can shed light into the molecular mechanisms of disease and help develop new drugs and therapeutic strategies to treat immune diseases. The edited volume Essentials aspects of Immunometabolism will give the readers a broad view on how metabolic pathways can influence many types of immune cells during activation, differentiation and function, in health and disease. Of note, the structure of the book was created thinking not only on the experienced immunologist but also on undergraduate and graduate students, physicians, and all members of the scientific community interested in this exciting field of research.

Author : Carolyn D. Berdanier
Publisher : CRC Press
Page : 640 pages
File Size : 43,9 Mb
Release : 2005-06-09
Category : Medical
ISBN : 9781420028843

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Mitochondria in Health and Disease by Carolyn D. Berdanier Pdf

It was once assumed that mitochondrial diseases were rare and that few people were affected. As knowledge has grown about these organelles and their function, it became clear that mitochondrial malfunction could be linked to several chronic diseases. Diabetes has been associated with DNA mutation and can cause mutation itself. This text discusses f

Author : Rupert Glasgow
Publisher : BoD – Books on Demand
Page : 262 pages
File Size : 48,9 Mb
Release : 2018-07-10
Category : Philosophy
ISBN : 9783958260788

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Minimal Selfhood and the Origins of Consciousness by Rupert Glasgow Pdf

In Minimal Selfhood and the Origins of Consciousness, R.D.V. Glasgow seeks to ground the logical roots of consciousness in what he has previously called the 'minimal self'. The idea is that elementary forms of consciousness are logically dependent not, as is commonly assumed, on ownership of an anatomical brain or nervous system, but on the intrinsic reflexivity that defines minimal selfhood. The aim of the book is to trace the logical pathway by which minimal selfhood gives rise to the possible appearance of consciousness. It is argued that in specific circumstances it thus makes sense to ascribe elementary consciousness to certain predatory single-celled organisms such as amoebae and dinoflagellates as well as to some of the simpler animals. Such an argument involves establishing exactly what those specific circumstances are and determining how elementary consciousness differs in nature and scope from its more complex manifestations.

Author : Gregory W. Konat
Publisher : CRC Press
Page : 222 pages
File Size : 50,9 Mb
Release : 2008-06-20
Category : Medical
ISBN : 9781420043198

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Signaling by Toll-Like Receptors by Gregory W. Konat Pdf

The discovery of toll-like receptors (TLRs) spurred the field of innate immunity into a renaissance after many years of neglect. Since then, TLR research has grown at an exponential rate. Taking an integrated methodological approach, Signaling by Toll-Like Receptors offers a comprehensive review of important techniques in molecular biology,

Author : Zhiping Xie
Publisher : Springer Nature
Page : 453 pages
File Size : 41,9 Mb
Release : 2021-07-14
Category : Medical
ISBN : 9789811628306

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Autophagy: Biology and Diseases by Zhiping Xie Pdf

This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 3 focuses on the technical aspects of autophagy research. It is comprised of two parts. The first part discusses the basic process of autophagy, including its overall classification and individual stages in the life cycle of autophagosomes. The second part discusses the tools, strategies, and model systems in current autophagy research, including cell and animal models, detection and manipulation methods, as well as screening, genomic, proteomic and bioinformatic approaches. The book is written and edited by a team of active scientists. It is intended as a practical reference resource for interested researchers to get started on autophagy studies.

Author : Beatrice Morio,Luc Penicaud,Michel Rigoulet
Publisher : Academic Press
Page : 460 pages
File Size : 49,5 Mb
Release : 2019-04-26
Category : Science
ISBN : 9780128117521

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Mitochondria in Obesity and Type 2 Diabetes by Beatrice Morio,Luc Penicaud,Michel Rigoulet Pdf

Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases synthesizes discoveries from laboratories around the world, enhancing our understanding of the involvement of mitochondria in the etiology of diseases, such as obesity and type 2 diabetes. Chapters illustrate and provide an overview of key concepts on topics such as the role of mitochondria in adipose tissue, cancer, cardiovascular comorbidities, skeletal muscle, the liver, kidney, and more. This book is a must-have reference for students and educational teams in biology, physiology and medicine, and researchers. Synthesizes actual knowledge on mitochondrial function Provides an integrated vision of each tissue in the etiology of obesity and type 2 diabetes Identifies the interactive networks that involve alteration in mitochondrial mass and function in disease progression Highlights the role played by mitochondria in the prevention and treatment of obesity and type 2 diabetes

Author : Pramod C. Rath
Publisher : Springer
Page : 0 pages
File Size : 55,8 Mb
Release : 2020-06-27
Category : Medical
ISBN : 9813290048

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Models, Molecules and Mechanisms in Biogerontology by Pramod C. Rath Pdf

The book deals with basic cellular and molecular mechanisms associated with aging. It comprehensively describes the important genetic, epigenetic, biochemical and metabolic regulations during aging, as well as some important age-related diseases.The book is divided into four major sections for easy understanding. It takes the readers through the various aspects of aging in a story-like manner. Certain interventions for healthy aging such as dietary restriction, regular exercise and maintaining a balanced and peaceful life-style are also suggested by the experts. The book would be a companion for both beginners, as well as established researchers in the field. It would be useful for science education, research, clinical approach and policy making.

Author : Shirlynn Spacapan,Stuart Oskamp
Publisher : SAGE Publications, Incorporated
Page : 264 pages
File Size : 55,8 Mb
Release : 1988-12
Category : Psychology
ISBN : UOM:49015000784232

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The Social Psychology of Health by Shirlynn Spacapan,Stuart Oskamp Pdf

A valuable contribution to the burgeoning field of health psychology, The Social Psychology of Health addresses current issues involving psychosocial mediators of health status and health promotion programmes -- the two major features of health psychology. The chapters, based on presentations at the.

Author : Adilson Da Costa
Publisher : Springer Nature
Page : 817 pages
File Size : 43,5 Mb
Release : 2020-02-24
Category : Medical
ISBN : 9783319782652

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Minimally Invasive Aesthetic Procedures by Adilson Da Costa Pdf

Minimally invasive aesthetic procedures are an important part of dermatologists’ day-to-day clinical routine. However, plastic surgeons are also becoming more willing to explore them, and minimally invasive cosmetic and aesthetic procedures are now an established interdisciplinary topic. Minimally Invasive Aesthetic Procedures - A Guide for Dermatologists and Plastic Surgeons addresses the needs of both these specialties. It provides a comprehensive overview of the most relevant and widely used minimally invasive procedures, presented in a practical and straightforward style. Rather than a broad overview of the literature, it offers a step-by-step guide to clinical procedures. Each chapter explores a single clinical procedure, discussing the theoretical basis; the materials needed; the methods and techniques; clinical follow-up; before-and-after illustrations; as well as the side effects and complications and their management. It also includes a summary of tips and relevant references. With more than a hundred procedures presented and discussed in a clinically applicable format, Minimally Invasive Aesthetic Procedures - A Guide for Dermatologists and Plastic Surgeons is a practical manual for all dermatology and plastic surgery practitioners who are interested in aesthetic medicine.