Natural Products In Clinical Trials Volume 2

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Natural Products in Clinical Trials: Volume 2

Atta-ur-Rahman,Shazia Anjum,Hesham R. El-Seedi
Natural Products in Clinical Trials Volume 2 Book PDF

Author : Atta-ur-Rahman,Shazia Anjum,Hesham R. El-Seedi
Publisher : Bentham Science Publishers
Page : 280 pages
File Size : 54,6 Mb
Release : 2020-08-20
Category : Medical
ISBN : 9789811425752

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Natural Products in Clinical Trials: Volume 2 by Atta-ur-Rahman,Shazia Anjum,Hesham R. El-Seedi Pdf

Natural compounds continue to play a key role in drug development. Many clinically approved drugs are either unmodified natural products or their semi-synthetic derivatives. This book series presents reviews of exciting new bioactive natural products that have huge potential as drugs. Each volume presents comprehensive chapters contributed by eminent scientists. The volumes focus on drug candidates which are in the later stages of drug development and are being evaluated in clinical trials. The series, therefore, highlights the importance of natural products in our lives. The second volume covers the following topics: - A review of recent patents and natural products in clinical trials to treat schistosomiasis - Natural products: the new intervention regimen for metabolic disorders - Fluorine-containing drugs and drug candidates derived from natural products - Natural products for the management of cardiovascular diseases - Implication of natural compounds for the prevention of ocular diseases.

Natural Products in Clinical Trials

Atta-ur- Rahman,Shazia Anjum,Hesham El-Seedi
Natural Products in Clinical Trials Book PDF

Author : Atta-ur- Rahman,Shazia Anjum,Hesham El-Seedi
Publisher : Bentham Science Publishers
Page : 253 pages
File Size : 43,8 Mb
Release : 2018-03-03
Category : Medical
ISBN : 9781681082134

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Natural Products in Clinical Trials by Atta-ur- Rahman,Shazia Anjum,Hesham El-Seedi Pdf

Natural products continue to play a key role in drug development. A recent analysis of the drug market in the developed world revealed that 40% of total clinically approved drugs were either unmodified natural products or their semi-synthetic derivatives. This book series focuses on reviews of exciting new bioactive natural products that have huge potential as drugs. It highlights the everlasting importance of natural products in our lives. Each volume brings reviews contributed by eminent scientists in the field. The first volume covers the following topics: - bioactive compounds from marine invertebrates - natural product derived drugs for immunological and inflammatory diseases - clinical trials of curcumin, camptothecin, astaxanthin, and biochanin - antibacterial and antifungal drugs from natural sources - natural products as anti-HIV medicines.

Natural Products in Clinical Trials Volume

Atta-ur Rahman,Shazia Anjum,Hesham El-Seedi
Natural Products in Clinical Trials Volume Book PDF

Author : Atta-ur Rahman,Shazia Anjum,Hesham El-Seedi
Publisher : Unknown
Page : 128 pages
File Size : 47,8 Mb
Release : 2018-03-02
Category : Electronic
ISBN : 1681082144

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Natural Products in Clinical Trials Volume by Atta-ur Rahman,Shazia Anjum,Hesham El-Seedi Pdf

Natural products continue to play a key role in drug development. A recent analysis of the drug market in the developed world revealed that 40% of total clinically approved drugs were either unmodified natural products or their semi-synthetic derivatives. This book series focuses on reviews of exciting new bioactive natural products that have huge potential as drugs. It highlights the everlasting importance of natural products in our lives. Each volume presents comprehensive reviews in cutting edge fields contributed by eminent scientists. The first volume covers the following topics: bioactive compounds from marine invertebrates natural product derived drugs for immunological and inflammatory diseases clinical trials of curcumin, camptothecin, astaxanthin, and biochanin antibacterial and antifungal drugs from natural sources natural products as anti-HIV medicines

Drug Discovery and Development, Volume 2

Mukund S. Chorghade
Drug Discovery and Development Volume 2 Book PDF

Author : Mukund S. Chorghade
Publisher : John Wiley & Sons
Page : 401 pages
File Size : 50,8 Mb
Release : 2007-02-16
Category : Science
ISBN : 9780470085219

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Drug Discovery and Development, Volume 2 by Mukund S. Chorghade Pdf

From first principles to real-world applications-here is the first comprehensive guide to drug discovery and development Modern drug discovery and development require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines-from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to marketing. Yet surprisingly, until now, there were no authoritative references offering a complete, fully integrated picture of the process. The only comprehensive guide of its kind, this groundbreaking two-volume resource provides an overview of the entire sequence of operations involved in drug discovery and develop-?ment-from initial conceptualization to commercialization to clinicians and medical practitioners. Volume 1: Drug Discovery describes all the steps in the discovery process, including conceptualizing a drug, creating a library of candidates for testing, screening candidates for in vitro and in vivo activity, conducting and analyzing the results of clinical trials, and modifying a drug as necessary. Volume 2: Drug Development delves into the nitty-gritty details of optimizing the synthetic route, drug manufacturing, outsourcing, and marketing-including drug coloring and delivery methods. Featuring contributions from a world-class team of experts, Drug Discovery and Development: Features fascinating case studies, including the discovery and development of erythromycin analogs, Tagamet, and Ultiva (remifentanil) Discusses the discovery of medications for bacterial infections, Parkinson's disease, psoriasis, peptic ulcers, atopic dermatitis, asthma, and cancer Includes chapters on combinatorial chemistry, molecular biology-based drug discovery, genomics, and chemogenomics Drug Discovery and Development is an indispensable working resource for industrial chemists, biologists, biochemists, and executives who work in the pharmaceutical industry.

Natural Products and Cancer Drug Discovery

Frank E. Koehn
Natural Products and Cancer Drug Discovery Book PDF

Author : Frank E. Koehn
Publisher : Springer Science & Business Media
Page : 248 pages
File Size : 49,8 Mb
Release : 2012-11-09
Category : Medical
ISBN : 9781461446545

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Natural Products and Cancer Drug Discovery by Frank E. Koehn Pdf

This volume will cover the natural products as they relate to cancer chemotherapy. The topics will include history and current status , recent launches, new clinical candidates and approved drugs directly derived from natural products, current and future cancer target opportunities for natural products, leveraging natural products as tools for new target generation , new approaches to cancer drug discovery through natural products based lead generation, and enabling technologies which leverage the unique attributes of natural products.

Natural Bio-active Compounds

Mallappa Kumara Swamy,Mohd Sayeed Akhtar
Natural Bio active Compounds Book PDF

Author : Mallappa Kumara Swamy,Mohd Sayeed Akhtar
Publisher : Springer Nature
Page : 492 pages
File Size : 49,6 Mb
Release : 2019-09-19
Category : Science
ISBN : 9789811372056

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Natural Bio-active Compounds by Mallappa Kumara Swamy,Mohd Sayeed Akhtar Pdf

Nature has consistently provided human beings with bioactive compounds that can be used directly as drugs or indirectly as drug leads. Some of the major classes of natural bioactive compounds include phenolics, alkaloids, tannins, saponins, lignin, glycosides, terpenoids, and many more. They possess a broad range of biological activities and are primarily useful in the treatment of various health issues. At the same time, the search for new and novel drugs is never-ending and, despite major advances in synthetic chemistry, nature remains an essential resource for drug discovery. Therefore, more and more researchers are interested in understanding the chemistry, clinical pharmacology, and beneficial effects of bioactive compounds in connection with solving human health problems. This book presents a wealth of information on natural metabolites that have been or are currently being used as drugs or leads for the discovery of new drugs. In addition, it highlights the importance of natural products against various human diseases, and their applications in the drug, nutraceuticals, cosmetics and herbal industries. Accordingly, the book offers a valuable resource for all students, educators, and healthcare experts involved in natural product research, phytochemistry, and pharmacological research.

Clinical Trials

Tom Brody
Clinical Trials Book PDF

Author : Tom Brody
Publisher : Academic Press
Page : 897 pages
File Size : 53,8 Mb
Release : 2016-02-19
Category : Medical
ISBN : 9780128042588

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Clinical Trials by Tom Brody Pdf

Clinical Trials, Second Edition, offers those engaged in clinical trial design a valuable and practical guide. This book takes an integrated approach to incorporate biomedical science, laboratory data of human study, endpoint specification, legal and regulatory aspects and much more with the fundamentals of clinical trial design. It provides an overview of the design options along with the specific details of trial design and offers guidance on how to make appropriate choices. Full of numerous examples and now containing actual decisions from FDA reviewers to better inform trial design, the 2nd edition of Clinical Trials is a must-have resource for early and mid-career researchers and clinicians who design and conduct clinical trials. Contains new and fully revised material on key topics such as biostatistics, biomarkers, orphan drugs, biosimilars, drug regulations in Europe, drug safety, regulatory approval and more Extensively covers the "study schema" and related features of study design Incorporates laboratory data from studies on human patients to provide a concrete tool for understanding the concepts in the design and conduct of clinical trials Includes decisions made by FDA reviewers when granting approval of a drug as real world learning examples for readers

Bioassay Methods in Natural Product Research and Drug Development

Lars Bohlin,Jan G. Bruhn
Bioassay Methods in Natural Product Research and Drug Development Book PDF

Author : Lars Bohlin,Jan G. Bruhn
Publisher : Springer Science & Business Media
Page : 222 pages
File Size : 40,5 Mb
Release : 1999-01-31
Category : Medical
ISBN : 079235480X

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Bioassay Methods in Natural Product Research and Drug Development by Lars Bohlin,Jan G. Bruhn Pdf

Bioassay Methods in Natural Product Research and Drug Development contains the proceedings from the Phytochemical Society of Europe's very successful symposium on this topic, held August 24-27, 1997 in Uppsala, Sweden. In this volume, leading academic and industrial scientists discuss novel methods for assaying natural products to find new structure-activity relationships. Of key importance in this process is the availability and reliability of specific bioassay methods, but chapters also discuss chemical and biological diversity and how to dereplicate natural product extracts to increase efficiency in lead discovery. Anti-tumor, HIV-inhibitory, antiprotozoal, anti-infective and immunomodulatory natural products are discussed. Various industrial projects are presented for the first time. This volume bridges the gap between academic and industrial research and scientists, and should be required reading in drug companies and faculties of pharmacy, as well as serving scientists in pharmacognosy, pharmacology, phytochemistry, natural products and drug discovery.

Global Clinical Trials

Richard Chin,Menghis Bairu
Global Clinical Trials Book PDF

Author : Richard Chin,Menghis Bairu
Publisher : Academic Press
Page : 522 pages
File Size : 45,7 Mb
Release : 2011-05-06
Category : Science
ISBN : 012381538X

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Global Clinical Trials by Richard Chin,Menghis Bairu Pdf

This book will explore the great opportunities and challenges which exist in conducting clinical trials in developing countries. By exploring the various regulations specific to the major players and providing insight into the logistical challenges including language barriers, this book provides a working tool for clinical researchers and administrators to navigate the intricacies of clinical trials in developing countries. Important topics such as ethical issues will be handled very carefully to highlight the significant differences of conducting this work in various jurisdictions. Overall, it will present a clear and comprehensive guide to the ins-and-outs of clinical trials in various countries to assist in design, development, and effectiveness of these trials. Contributors include high-profile, respected figures who have paved the way for clinical trials in developing countries Provides hands-on tools for regulatory and legal requirements and qualification, design, management, and reporting Case studies outline successes, failures, lessons learned and prospects for future collaboration Includes country-specific guidelines for the most utilized countries Foreword by David Feigel, former Head of CDRH at FDA

Natural Products

Lixin Zhang,Arnold L. Demain
Natural Products Book PDF

Author : Lixin Zhang,Arnold L. Demain
Publisher : Springer Science & Business Media
Page : 380 pages
File Size : 42,5 Mb
Release : 2007-11-17
Category : Medical
ISBN : 9781592599769

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Natural Products by Lixin Zhang,Arnold L. Demain Pdf

A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.

Natural Products

Karen Shapiro
Natural Products Book PDF

Author : Karen Shapiro
Publisher : American Pharmacists Association (APhA)
Page : 264 pages
File Size : 46,5 Mb
Release : 2006
Category : Medical
ISBN : UOM:39015064117537

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Natural Products by Karen Shapiro Pdf

This text is intended for use in the classroom and as a reference for the practising professional. Selected natural products represent those commonly in use today and most likely to be encounted by health professionals.

Nutraceuticals and Natural Product Pharmaceuticals

Charis M. Galanakis
Nutraceuticals and Natural Product Pharmaceuticals Book PDF

Author : Charis M. Galanakis
Publisher : Academic Press
Page : 366 pages
File Size : 43,5 Mb
Release : 2019-08-04
Category : Technology & Engineering
ISBN : 9780128175163

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Nutraceuticals and Natural Product Pharmaceuticals by Charis M. Galanakis Pdf

Nutraceuticals and Natural Product Pharmaceuticals analyzes the nutraceutical and pharmaceutical research published over the last decade, paying particular attention to applications and recovery effects. The book emphasizes the great need for both nutritionists and pharmacologists to understand how these drugs can benefit human health. Topics explore innovative sources, bioavailability, pharmacokinetics, translating novel pathways and mechanisms of action into their clinical use, personalized nutrition and natural product medicine, the convergence between nutraceuticals and western medicine, interactions between drugs, nutrients, the microbiome and lifestyles, industrial applications and commercialization, metabolomics, nano-delivery systems and function, and more. Nutritionists and pharmacists working with natural products, food scientists, nutrition researchers and those interested in the development of innovative products, nutraceuticals, pharmaceuticals and functional foods are sure to benefit from this thorough resource. Connects research from the nutraceutical and pharmaceutical industries Promotes further communication and cooperation between pharmacologists and nutritionists by analyzing nutraceutical and pharmaceutical research in particular applications and recovery efforts Explores the health effects of target compounds and the development of applications in both sectors

Anticancer Plants: Natural Products and Biotechnological Implements

Mohd Sayeed Akhtar,Mallappa Kumara Swamy
Anticancer Plants Natural Products and Biotechnological Implements Book PDF

Author : Mohd Sayeed Akhtar,Mallappa Kumara Swamy
Publisher : Springer
Page : 564 pages
File Size : 49,9 Mb
Release : 2018-07-02
Category : Science
ISBN : 9789811080647

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Anticancer Plants: Natural Products and Biotechnological Implements by Mohd Sayeed Akhtar,Mallappa Kumara Swamy Pdf

This volume provides summarized scientific evidence of the different classes of plant-derived phytocompounds, their sources, chemical structures, anticancer properties, mechanisms of action, methods of extraction, and their applications in cancer therapy. It also discusses endophyte-derived compounds as chemopreventives to treat various cancer types. In addition, it provides detailed information on the enhanced production of therapeutically valuable anticancer metabolites using biotechnological interventions such as plant cell and tissue culture approaches, including in vitro-, hairy root- and cell-suspension culture; and metabolic engineering of biosynthetic pathways. Anticancer Plants: Natural Products and Biotechnological Implements – Volume 2” explores the natural bioactive compounds isolated from plants as well as fungal endophytes, their chemistry, and preventive effects to reduce the risk of cancer. Moreover, it highlights the genomics/proteomics approaches and biotechnological implementations. Providing solutions to deal with the challenges involved in cancer therapy, the book benefits a wide range of readers including academics, students, and industrial experts working in the area of natural products, medicinal plant chemistry, pharmacology, and biotechnology.

Coronavirus Drug Discovery

Chukwuebuka Egbuna
Coronavirus Drug Discovery Book PDF

Author : Chukwuebuka Egbuna
Publisher : Elsevier
Page : 384 pages
File Size : 47,9 Mb
Release : 2022-07-07
Category : Science
ISBN : 9780323955751

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Coronavirus Drug Discovery by Chukwuebuka Egbuna Pdf

Coronavirus Drug Discovery, Volume Two: Antiviral Agents from Natural Products and Nanotechnological Applications presents detailed information on drug discovery against COVID-19. Sections in this volume present chapters that focus on the various antiviral agents from natural products that have the propensity to be used as chemical scaffolds for the development of drugs against COVID-19. Also captured are the dietary sources of antioxidant bioactives that may help boost the immune system for the management of COVID-19. Other chapters describe the application of nanotechnology for efficient and effective delivery of drugs against COVID-19. Written by global team of experts, this book is an excellent resource for drug developers, medicinal chemists, pharmaceutical companies in R&D and research institutes in both academia and industry. Presents the various antiviral bioactive compounds from natural products Discusses the roles of antioxidant in the prevention and management of COVID-19 Details the application of nanotechnology for efficient and effective drug delivery

Frontiers in Clinical Drug Research - Anti-Cancer Agents

Atta-ur-Rahman
Frontiers in Clinical Drug Research Anti Cancer Agents Book PDF

Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
Page : 273 pages
File Size : 42,9 Mb
Release : 2015-07-09
Category : Science
ISBN : 9781681080727

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Frontiers in Clinical Drug Research - Anti-Cancer Agents by Atta-ur-Rahman Pdf

Frontiers in Clinical Drug Research - Anti-Cancer Agents should prove to be a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field. The chapters featured in each volume are written by leading experts in oncology and clinical pharmacology. The eBook series is essential reading for all scientists involved in clinical drug research who wish to keep abreast of rapid and important developments in the development of anti-cancer agents. The contents of this volume include reviews on dendrimers for anti-cancer drug delivery, treatment methods for advanced cutaneous squamous cell carcinoma, targeting heat shock proteins for cancer treatment, Bayesian systems for optimizing treatment protocols in oncology and much more.