New Enzymes For Organic Synthesis

Author : Thomas Scheper
Publisher : Springer Science & Business Media
Page : 256 pages
File Size : 49,8 Mb
Release : 1999-04
Category : Science
ISBN : 3540655492

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New Enzymes for Organic Synthesis by Thomas Scheper Pdf

Isolated enzymes are known as useful for synthesising of complex molecules with more and more large scale applications in recent years. These six reviews show different steps in the development of enzymatic syntheses for useful compounds. Screening of novel enzymes, their biochemical characterisation as well as reaction engineering approaches in order to increase their performance are treated in three papers. Then the use of protein design as a tool for the directed improvement of reactivity and selectivity of biocatalysts is described in two reviews. The supply of sufficient quantities of biocatalysts must not be neglected: fluidized bed adsorption as an emerging technology for the simple and fast purification of biomolecules is presented in the light of its potential in large scale supply of enzyme catalysts.

Author : Cheanyeh Cheng
Publisher : John Wiley & Sons
Page : 719 pages
File Size : 46,8 Mb
Release : 2022-02-03
Category : Science
ISBN : 9781118995150

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Enzyme-Based Organic Synthesis by Cheanyeh Cheng Pdf

Enzyme-Based Organic Synthesis An insightful exploration of an increasingly popular technique in organic chemistry In Enzyme-Based Organic Synthesis, expert chemist Dr. Cheanyeh Cheng delivers a comprehensive discussion of the principles, methods, and applications of enzymatic and microbial processes for organic synthesis. The book thoroughly explores this growing area of green synthetic organic chemistry, both in the context of academic research and industrial practice. The distinguished author provides a single point of access for enzymatic methods applicable to organic synthesis and focuses on enzyme catalyzed organic synthesis with six different classes of enzyme. This book serves as a link between enzymology and biocatalysis and serves as an invaluable reference for the growing number of organic chemists using biocatalysis. Enzyme-Based Organic Synthesis provides readers with multiple examples of practical applications of the main enzyme classes relevant to the pharmaceutical, medical, food, cosmetics, fragrance, and health care industries. Readers will also find: A thorough introduction to foundational topics, including the discovery and nature of enzymes, enzyme structure, catalytic function, molecular recognition, enzyme specificity, and enzyme classes Practical discussions of organic synthesis with oxidoreductases, including oxidation reactions and reduction reactions Comprehensive explorations of organic synthesis with transferases, including transamination with aminotransferases and phosphorylation with kinases In-depth examinations of organic synthesis with hydrolases, including the hydrolysis of the ester bond Perfect for organic synthetic chemists, chemical and biochemical engineers, biotechnologists, process chemists, and enzymologists, Enzyme-Based Organic Synthesis is also an indispensable resource for practitioners in the pharmaceutical, food, cosmetics, and fragrance industries that regularly apply this type of synthesis.

Author : Vicente Gotor,Ignacio Alfonso,Eduardo García-Urdiales
Publisher : John Wiley & Sons
Page : 348 pages
File Size : 48,7 Mb
Release : 2008-03-31
Category : Science
ISBN : 3527318259

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Asymmetric Organic Synthesis with Enzymes by Vicente Gotor,Ignacio Alfonso,Eduardo García-Urdiales Pdf

Perfect for biochemists, synthetic and organic chemists, this book covers all important reactions, including C-C coupling reactions, oxidation reactions and many more. Divided into two parts, the first section on methodology presents new innovative methods for enzymatic catalysis optimization, including such new trends as medium engineering, directed evolution and computer-aided prediction of enantioselectivity. The second and main section deals with applications to synthesis, showing important reaction types and their applications. Only those reactions with very high selectivity are presented, allowing readers to improve their own reaction yields.

Author : Karlheinz Drauz,Harald Gröger,Oliver May
Publisher : John Wiley & Sons
Page : 2143 pages
File Size : 49,7 Mb
Release : 2012-03-26
Category : Science
ISBN : 9783527325474

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Enzyme Catalysis in Organic Synthesis, 3 Volume Set by Karlheinz Drauz,Harald Gröger,Oliver May Pdf

This comprehensive three-volume set is the standard reference in the field of organic synthesis, catalysis and biocatalysis. Edited by a highly experienced and highly knowledgeable team with a tremendous amount of experience in this field and its applications, this edition retains the successful concept of past editions, while the contents are very much focused on new developments in the field. All the techniques described are directly transferable from the lab to the industrial scale, making for a very application-oriented approach. A must for all chemists and biotechnologists.

Author : Animesh Goswami,Jon D. Stewart
Publisher : Academic Press
Page : 438 pages
File Size : 40,8 Mb
Release : 2015-09-06
Category : Science
ISBN : 9780124115422

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Organic Synthesis Using Biocatalysis by Animesh Goswami,Jon D. Stewart Pdf

Organic Synthesis Using Biocatalysis provides a concise background on the application of biocatalysis for the synthesis of organic compounds, including the important biocatalytic reactions and application of biocatalysis for the synthesis of organic compounds in pharmaceutical and non-pharmaceutical areas. The book provides recipes for carrying out various biocatalytic reactions, helping both newcomers and non-experts use these methodologies. It is written by experts in their fields, and provides both a current status and future prospects of biocatalysis in the synthesis of organic molecules. Provides a concise background of the application of biocatalysis for the synthesis of organic compounds Expert contributors present recipes for carrying out biocatalytic reactions, including subject worthy discussions on biocatalysis in organic synthesis, biocatalysis for selective organic transformation, enzymes as catalysis for organic synthesis, biocatalysis in Industry, including pharmaceuticals, and more Contains detailed, separate chapters that describe the application of biocatalysis

Author : C.H. Wong,G.M. Whitesides
Publisher : Elsevier
Page : 389 pages
File Size : 45,5 Mb
Release : 2013-10-22
Category : Science
ISBN : 9780080505824

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Enzymes in Synthetic Organic Chemistry by C.H. Wong,G.M. Whitesides Pdf

This book covers the most recent development of enzymatic organic synthesis, with particular focus on the use of isolated enzymes. It is organized into one introductory chapter dealing with the characteristics of enzymes as catalysts, and five chapters dealing with different types of chemical transformations. Methods for enzyme immobilization and stabilizaton, the use of enzymes in extreme environments, and the alteration of enzyme properties by chemical modification and site-directed mutagenesis for synthetic purposes are covered.

Author : Thomas Scheper
Publisher : Springer
Page : 248 pages
File Size : 43,8 Mb
Release : 2014-01-15
Category : Electronic
ISBN : 3662125927

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New Enzymes for Organic Synthesis by Thomas Scheper Pdf

Isolated enzymes are known as useful for synthesising of complex molec ules with more and more large scale applications in recent years. Thes e six reviews show different steps in the development of enzymatic syn theses for useful compounds. Screening of novel enzymes, their biochem ical characterisation as well as reaction engineering approaches in or der to increase their performance are treated in three papers. Then th e use of protein design as a tool for the directed improvement of reac tivity and selectivity of biocatalysts is described in two reviews. Th e supply of sufficient quantities of biocatalysts must not be neglecte d: fluidized bed adsorption as an emerging technology for the simple a nd fast purification of biomolecules is presented in the light of its potential in large scale supply of enzyme catalysts.

Author : Ari Koskinen,A. Klibanov
Publisher : Springer Science & Business Media
Page : 338 pages
File Size : 44,6 Mb
Release : 1995-12-31
Category : Science
ISBN : 0751402591

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Enzymatic Reactions in Organic Media by Ari Koskinen,A. Klibanov Pdf

The outlook of organic synthesis has changed many times during its tractable history. The initial focus on the synthesis of substances typical of living matter, exemplified by the first examples of organic chemistry through the synthesis of urea from inorganic substances by Liebig, was accepted as the birth of organic chemistry, and thus also of organic synthesis. Although the early developments in organic synthesis closely followed the pursuit of molecules typical in nature, towards the end of the 19th century, societal pressures placed higher demands on chemical methods appropriate for the emerging age of industrialization. This led to vast amounts of information being generated through the discovery of synthetic reactions, spectroscopic techniques and reaction mechanisms. The basic organic functional group transformations were discovered and improved during the early part of this century. Reaction mechanisms were elucidated at a growing pace, and extremely powerful spectroscopic tools, such as infrared, nuclear magnetic resonance and mass spectrometry were introduced as everyday tools for a practising organic chemist. By the 1950s, many practitioners were ready to agree that almost every molecule could be syn thesized. Some difficult stereochemical problems were exceptions; for example Woodward concluded that erythromycin was a "hopelessly complex target". This frustration led to a hectic phase of development of new and increasingly more ingenious protecting group strategies and functional group transformations, and also saw the emergence of asymmetric synthesis.

Author : Manfred P. Schneider
Publisher : Springer Science & Business Media
Page : 422 pages
File Size : 48,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789400946866

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Enzymes as Catalysts in Organic Synthesis by Manfred P. Schneider Pdf

Proceedings of the NATO Advanced Research Workshop, Reisensburg/Ulm, Donau, Germany, June 16-22, 1985

Author : Karlheinz Drauz,Herbert Waldmann
Publisher : Wiley-VCH
Page : 380 pages
File Size : 42,5 Mb
Release : 2002-07-26
Category : Science
ISBN : UOM:39015051562745

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Enzyme Catalysis in Organic Synthesis by Karlheinz Drauz,Herbert Waldmann Pdf

Organic synthesis with enzymes - the only way This comprehensive set gives reliable answers to all questions on enzyme catalysis - from searching for suitable catalytic systems via choosing the optimal reaction conditions to implementing modern synthesis strategies. The long-awaited new edition has been greatly expanded to include new topics and to reflect the latest research, yet retains the clear and practice-oriented presentation found in the first edition. More than a mere data collection, the three volumes provide synthetic chemists with easy access to all the first-hand information necessary for successfully using enzymes: - the latest synthesis methods - example applications arranged according to reaction type - a table of all the important, commercially available enzymes - comprehensive registers for targeted searching according to enzyme, compound, or reaction - current references to the literature In short, an indispensable reference that should be on the shelf of every modern synthesis laboratory.

Author : Karlheinz Drauz,Herbert Waldmann
Publisher : Unknown
Page : 704 pages
File Size : 55,8 Mb
Release : 2002
Category : Catalysis
ISBN : UOM:39015051562737

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Enzyme Catalysis in Organic Synthesis by Karlheinz Drauz,Herbert Waldmann Pdf

Author : Ruth Porter,Sarah Clark
Publisher : John Wiley & Sons
Page : 192 pages
File Size : 53,7 Mb
Release : 2009-09-14
Category : Science
ISBN : 9780470718629

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Enzymes in Organic Synthesis by Ruth Porter,Sarah Clark Pdf

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Author : Giacomo Carrea,Sergio Riva
Publisher : John Wiley & Sons
Page : 328 pages
File Size : 50,7 Mb
Release : 2008-04-09
Category : Science
ISBN : 9783527621736

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Organic Synthesis with Enzymes in Non-Aqueous Media by Giacomo Carrea,Sergio Riva Pdf

Closing a gap in the literature, this comprehensive book examines and discusses different non-aqueous systems from organic solvents to ionic liquids for synthetic applications, thus opening the door to new successful methods for biocatalytic reactions. It gathers into one handy source the information otherwise widely spread throughout the literature, combining useful background information with a number of synthetic examples, including industrial scale processes for pharmaceutical and fine chemicals. Extremely well structured, the text introduces the fundamentals of non-aqueous enzymology, before going on to new reaction media and synthetic applications using hydrolases and non-hydrolytic enzymes. The one-stop reference for everyone working in this hot field.

Author : Richard B. Silverman
Publisher : Elsevier
Page : 800 pages
File Size : 45,7 Mb
Release : 2002-03-07
Category : Science
ISBN : 9780080513362

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Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition by Richard B. Silverman Pdf

The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed. This is a revised edition of a very successful book, which appeals to both academic and industrial markets. Illustrates the organic mechanism associated with each enzyme-catalyzed reaction Makes the connection between organic reaction mechanisms and enzyme mechanisms Compiles the latest information about molecular mechanisms of enzyme reactions Accompanied by clearly drawn structures, schemes, and figures Includes an extensive bibliography on enzyme mechanisms covering the last 30 years Explains how enzymes can accelerate the rates of chemical reactions with high specificity Provides approaches to the design of inhibitors of enzyme-catalyzed reactions Categorizes the cofactors that are appropriate for catalyzing different classes of reactions Shows how chemical enzyme models are used for mechanistic studies Describes catalytic antibody design and mechanism Includes problem sets and solutions for each chapter Written in an informal and didactic style

Author : Kurt Faber
Publisher : Springer Science & Business Media
Page : 329 pages
File Size : 44,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642974236

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Biotransformations in Organic Chemistry by Kurt Faber Pdf

The use of natural catalysts - enzymes - for the transformation of non-natural is not at all new: they have been used for more man-made organic compounds than one hundred years, employed either as whole cells, cell organelles or isolated enzymes [1]. Certainly, the object of most of the early research was totally different from that of the present day. Thus the elucidation of biochemical pathways and enzyme mechanisms was in the foreground of the reasearch some decades ago. It was mainly during the 1980s that the enormous potential of applying natural catalysts to transform non-natural organic compounds was recognized. What started as a trend in the late 1970s could almost be called a fashion in synthetic organic chemistry in the 1990s. Although the early euphoria during the 'gold rush' in this field seems to have eased somewhat, there is still no limit to be seen for the future development of such methods. As a result of this extensive, recent research, there have been an estimated 5000 papers published on the subject [2]. To collate these data as a kind of 'super-review' would clearly be an impossible task and, furthermore, such a hypothetical book would be unpalatable for the non-expert.