Next Generation Antidepressants

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Next Generation Antidepressants

Chad E. Beyer,Stephen M. Stahl
Next Generation Antidepressants Book PDF

Author : Chad E. Beyer,Stephen M. Stahl
Publisher : Cambridge University Press
Page : 151 pages
File Size : 49,9 Mb
Release : 2010-05-20
Category : Medical
ISBN : 9781139833035

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Next Generation Antidepressants by Chad E. Beyer,Stephen M. Stahl Pdf

The World Health Organization defines depression as a primary contributor to the global burden of disease and predicts it will become the second leading cause of death by 2020. The need to develop effective therapies has never been so pressing. Current antidepressant drugs have several limitations. This 2010 book looks at the future of mood-disorder research, covering the identification of new therapeutic targets, establishing new preclinical models, new medicinal chemistry opportunities, and fostering greater understanding of genetic influences. These strategies are likely to help build a better picture of the disease process, and lead to new opportunities for patient stratification and treatment. The ultimate goal for this strand of research is to develop more personalized and effective treatments for this chronic and debilitating condition. This is essential reading for all those involved in psychopharmacologic drug development, and mental health clinicians seeking a preview of discoveries soon to influence their practice.

Next Generation Antidepressants

Chad E. Beyer,Stephen M. Stahl
Next Generation Antidepressants Book PDF

Author : Chad E. Beyer,Stephen M. Stahl
Publisher : Cambridge University Press
Page : 151 pages
File Size : 49,7 Mb
Release : 2010-05-20
Category : Medical
ISBN : 9780521760584

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Next Generation Antidepressants by Chad E. Beyer,Stephen M. Stahl Pdf

The future of mood-disorder research: covering identification of new therapeutic targets, preclinical models, and medicinal chemistry opportunities.

The Search for Antidepressants - An Integrative View of Drug Discovery

Andre F. Carvalho,Gislaine Z. Reus,João Quevedo
The Search for Antidepressants An Integrative View of Drug Discovery Book PDF

Author : Andre F. Carvalho,Gislaine Z. Reus,João Quevedo
Publisher : Bentham Science Publishers
Page : 416 pages
File Size : 48,8 Mb
Release : 2017-07-10
Category : Medical
ISBN : 9781681084732

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The Search for Antidepressants - An Integrative View of Drug Discovery by Andre F. Carvalho,Gislaine Z. Reus,João Quevedo Pdf

Major depressive disorder (MDD) is a prevalent, chronic, and recurring mental disorder. This disorder is a leading source of disability worldwide, and is associated with excess mortality rates. Currently approved antidepressants primarily enhance, or otherwise modulate monoaminergic neurotransmission, without curing the disease. Evidence indicates that only one third of patients with MDD achieve remission after treatment with a first-line antidepressant agent. Research in the past two decades has provided valuable insights into the pathophysiological understanding of MDD. However, there is an acknowledged ‘translational gap’ in the field, and few genuinely novel antidepressants have been approved for the treatment of MDD. The Search for Anti Depressants provides readers an in-depth picture of the main pathophysiological mechanisms responsible for the development of MDD in patients. Chapters in the volume focus on possible strategies to spur the discovery of novel antidepressants. This book is an indispensable reference for mental health care providers, students at both under-graduate and graduate levels, and neuroscientists interested in the neurobiology of MDD and recent advances towards the discovery of next generation antidepressants.

Discontinuing Antidepressant Medications

Giovanni Fava
Discontinuing Antidepressant Medications Book PDF

Author : Giovanni Fava
Publisher : Oxford University Press
Page : 193 pages
File Size : 51,9 Mb
Release : 2021-10-28
Category : Medical
ISBN : 9780192896643

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Discontinuing Antidepressant Medications by Giovanni Fava Pdf

"When I started my residency training program in psychiatry in Italy, more than four decades ago, depression was the psychiatric disorder that particularly attracted my attention. In 1980 I decided to move to United States to further pursue my interest, first in Albuquerque, New Mexico, and then in Buffalo, New York, where I was offered to establish a depression unit. I was convinced that depression was essentially an episodic disorder, that there were powerful remedies against it (antidepressant drugs) and chronicity was essentially a consequence of inadequate diagnosis and treatment. Today, if I think of my views then, I am surprised of my naivete and clinical blindness. We have become aware that depression is essentially a chronic disorder with multiple acute episodes along its course (1). But my view was then shared by almost any expert in the field"--

Rapid Acting Antidepressants

Anonim
Rapid Acting Antidepressants Book PDF

Author : Anonim
Publisher : Academic Press
Page : 404 pages
File Size : 43,6 Mb
Release : 2020-06-29
Category : Medical
ISBN : 9780128201909

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Rapid Acting Antidepressants by Anonim Pdf

The Advances in Pharmacology series presents a variety of chapters from the best authors in the field. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Pharmacogenomics in Psychiatry

M. Schwab,W.P. Kaschka,E. Spina
Pharmacogenomics in Psychiatry Book PDF

Author : M. Schwab,W.P. Kaschka,E. Spina
Publisher : Karger Medical and Scientific Publishers
Page : 148 pages
File Size : 54,5 Mb
Release : 2010-06-25
Category : Medical
ISBN : 9783805594998

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Pharmacogenomics in Psychiatry by M. Schwab,W.P. Kaschka,E. Spina Pdf

In recent years, there have been major developments in the fields of pharmacogenetics and pharmacogenomics, with the potential to make drug treatments in psychiatric medicine more effective. However, improvements in drug efficacy and tolerability, as well as finding the optimal dosage, can only be realized if in vivo mechanisms of drug action and ADME (absorption, distribution, metabolism, excretion) processes (pharmacokinetics) of psychopharmacological agents are better understood. In this volume, current progress and perspectives in pharmacogenetic testing of drug-metabolizing enzymes, drug transporters and other drug targets involved in the response to psychotropic agents are described extensively. This provides a timely overview of what has been achieved in the area of psychiatric pharmacogenomics alongside some promising directions and perspectives for future research.Psychiatrists, general medical doctors as well as pharmacologists and clinical pharmacologists will find new insights into the development and applications of pharmacogenomics in psychiatry.

Major Depressive Disorder

Roger S McIntyre
Major Depressive Disorder Book PDF

Author : Roger S McIntyre
Publisher : Elsevier Health Sciences
Page : 202 pages
File Size : 49,5 Mb
Release : 2019-08-25
Category : Medical
ISBN : 9780323581325

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Major Depressive Disorder by Roger S McIntyre Pdf

Get a quick, expert overview of the key issues surrounding best practices and current consensus on major depressive disorder (MDD). This concise resource by Drs. Roger S. McIntyre, Carola Rong, Mehala Subramaniapillai, and Yena Lee consolidates today’s available information on this complex topic into one convenient resource, making it an ideal, easy-to-digest reference for both psychiatrists and primary care physicians. Covers genetics and epigenetics, brain structural abnormalities, cognition, neuroendocrine alterations, and inflammatory abnormalities as they relate to MDD. Contains chapters on psychiatric comorbidity, pharmacological treatments, neuromodulatory treatments, lifestyle interventions, internet-based/technology-based interventions, and glutamate alterations.

The Emperor's New Drugs

Irving Kirsch
The Emperor s New Drugs Book PDF

Author : Irving Kirsch
Publisher : Random House
Page : 244 pages
File Size : 51,6 Mb
Release : 2009-10-13
Category : Business & Economics
ISBN : 9781409086352

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The Emperor's New Drugs by Irving Kirsch Pdf

Everyone knows that antidepressant drugs are miracles of modern medicine. Professor Irving Kirsch knew this as well as anyone. But, as he discovered during his research, there is a problem with what everyone knows about antidepressant drugs. It isn't true. How did antidepressant drugs gain their reputation as a magic bullet for depression? And why has it taken so long for the story to become public? Answering these questions takes us to the point where the lines between clinical research and marketing disappear altogether. Using the Freedom of Information Act, Kirsch accessed clinical trials that were withheld, by drug companies, from the public and from the doctors who prescribe antidepressants. What he found, and what he documents here, promises to bring revolutionary change to the way our society perceives, and consumes, antidepressants. The Emperor's New Drugs exposes what we have failed to see before: depression is not caused by a chemical imbalance in the brain; antidepressants are significantly more dangerous than other forms of treatment and are only marginally more effective than placebos; and, there are other ways to combat depression, treatments that don't only include the empty promise of the antidepressant prescription. This is not a book about alternative medicine and its outlandish claims. This is a book about fantasy and wishful thinking in the heart of clinical medicine, about the seductions of myth, and the final stubbornness of facts.

Drug-Induced Liver Injury

Anonim
Drug Induced Liver Injury Book PDF

Author : Anonim
Publisher : Academic Press
Page : 288 pages
File Size : 43,5 Mb
Release : 2019-07-13
Category : Medical
ISBN : 9780128173176

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Drug-Induced Liver Injury by Anonim Pdf

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Fluoxetine

Graziano Pinna
Fluoxetine Book PDF

Author : Graziano Pinna
Publisher : Unknown
Page : 412 pages
File Size : 42,7 Mb
Release : 2015-04-01
Category : Electronic
ISBN : 1634820762

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Fluoxetine by Graziano Pinna Pdf

Fluoxetine, best known by the trade name Prozac®, unlike other psychotropic drugs whose effects were serendipitously stumbled upon, was the first developed for a precise mechanism of action, that is, the ability to selectively inhibit serotonin reuptake, based upon the theory that increasing the availability of serotonin would treat major depression. Once approved by the FDA in 1987, fluoxetine quickly became the most prescribed psychotropic drug worldwide and its success in improving mood disorders has triggered the development of a large number of congener molecules, commonly known as SSRIs after their purported mechanism of action. However, a quarter of a century after its development, the idea that fluoxetine asserts its positive behavioral effect through inhibition of serotonergic reuptake is not firmly established. This book reviews several preclinical and clinical reports suggesting that the pharmacological effects of fluoxetine may be mediated by means other than the regulation of serotonin, including the regulation of gene expression, modifying epigenetic mechanisms as well as modifying microRNAs. One of the most prominent mechanisms for the therapeutic relevance of fluoxetine relates to influencing neuroplasticity by enhancing neurotropic factors, including BDNF signaling and altering adult neurogenesis. The ability of fluoxetine to rapidly increase neurosteroid levels accounts for the fast anxiolytic effects of this drug. Fluoxetine action at sigma-1 receptor or modulating glutamatergic neurotransmission as well as the combination of fluoxetine with other psychotropic drugs is discussed in relation to its therapeutic effects. While fluoxetine was primarily prescribed as an antidepressant, this drug currently represents a treatment of choice for a broad spectrum of psychiatric disorders, including post-traumatic stress disorder and a range of anxiety disorders. This drug even possesses analgesic actions and is a valuable therapy for stroke. This book also highlights emerging evidence on the gender-specific effects of fluoxetine, its potential adverse features, including its addiction liability in combination with psychostimulants, and the impact of perinatal fluoxetine exposure.

Clinical Psychopharmacology

Nassir Ghaemi
Clinical Psychopharmacology Book PDF

Author : Nassir Ghaemi
Publisher : Oxford University Press, USA
Page : 601 pages
File Size : 47,7 Mb
Release : 2019-01-04
Category : Medical
ISBN : 9780199995486

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Clinical Psychopharmacology by Nassir Ghaemi Pdf

Clinical Psychopharmacology offers a comprehensive guide to clinical practice that explores two major aspects of the field: the clinical research that exists to guide clinical practice of psychopharmacology, and the application of that knowledge with attention to the individualized aspects of clinical practice. The text consists of 50 chapters, organized into 6 sections, focusing on disease-modifying effects, non-DSM diagnostic concepts, and essential facts about the most common drugs. This innovative book advocates a scientific and humanistic approach to practice and examines not only the benefits, but also the harms of drugs. Providing a solid foundation of knowledge and a great deal of practical information, this book is a valuable resource for practicing psychiatrists, psychiatric nurse practitioners, medical students and trainees in psychiatry, as well as pharmacists.

Pharmacokinetics and Adverse Effects of Drugs

Ntambwe Malangu
Pharmacokinetics and Adverse Effects of Drugs Book PDF

Author : Ntambwe Malangu
Publisher : BoD – Books on Demand
Page : 164 pages
File Size : 48,5 Mb
Release : 2018-05-23
Category : Medical
ISBN : 9781789231380

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Pharmacokinetics and Adverse Effects of Drugs by Ntambwe Malangu Pdf

This book is a fruit of a collaborative work from several international scientists. It will be a useful resource for researchers, students, and clinicians. Each individual chapter could serve as a prescribed reading for postgraduate students and clinicians specializing in and practicing clinical pharmacology and toxicology, pharmacotherapy and pharmacotherapeutics, pharmacovigilance, and toxicovigilance, as well as those involved in clinical research, drug discovery, and development. Every chapter in this book discusses and provides illustrations on the theme discussed based on authors' understanding and experience while summarizing existing knowledge. In doing so, each chapter provides a new insight that would benefit a novice as well as a seasoned reader in understanding the pharmacokinetic mechanisms and risk factors involved in the occurrence of adverse effects of drugs.

Antidepressants: Past, Present and Future

Sheldon H. Preskorn,Christina Y. Stanga,John P. Feighner,Ruth Ross
Antidepressants Past Present and Future Book PDF

Author : Sheldon H. Preskorn,Christina Y. Stanga,John P. Feighner,Ruth Ross
Publisher : Springer Science & Business Media
Page : 615 pages
File Size : 46,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642185007

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Antidepressants: Past, Present and Future by Sheldon H. Preskorn,Christina Y. Stanga,John P. Feighner,Ruth Ross Pdf

A comprehensive review of the current status of antidepressants - how we arrived at this point in their evolution and where we are going in both the near and the long term. It employs both a scientific and historical approach to accomplish these goals. This volume is intended for practitioners who use antidepressants on a daily basis in their practice as well as for the student and researcher. Each will find that it provides a comprehensive and logical approach to this important group of medications. This book is being published as we mark the end of the first 50 years of the modern antidepressant era.

Coming of Age on Zoloft

Katherine Sharpe
Coming of Age on Zoloft Book PDF

Author : Katherine Sharpe
Publisher : Harper Collins
Page : 247 pages
File Size : 48,8 Mb
Release : 2012-06-05
Category : Biography & Autobiography
ISBN : 9780062059741

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Coming of Age on Zoloft by Katherine Sharpe Pdf

A compelling and troubling exploration of a generation raised on antidepressants, and a book that combines expansive interviews with substantive research-based reporting, Coming of Age on Zoloft is a vitally important and immediately engrossing study of one of America’s most pressing and omnipresent issues: our growing reliance on prescription drugs. Katherine Sharpe, the former editor of Seed magazine’s ScienceBlogs.com, addresses the questions that millions of young men and women are struggling with. “Where does my personality end and my prescription begin?” “Do I have a disease?” “Can I get better on my own?” Combining stout scientific acumen with first-person experience gained through her own struggle with antidepressants, Sharpe leads the reader through a complex subject, a guide towards a clearer future for all.

Magnesium in the Central Nervous System

Robert Vink,Mihai Nechifor
Magnesium in the Central Nervous System Book PDF

Author : Robert Vink,Mihai Nechifor
Publisher : University of Adelaide Press
Page : 354 pages
File Size : 49,8 Mb
Release : 2011
Category : Medical
ISBN : 9780987073051

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Magnesium in the Central Nervous System by Robert Vink,Mihai Nechifor Pdf

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.