Overexpression And Knockout Of Cytokines In Transgenic Mice

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Overexpression and Knockout of Cytokines in Transgenic Mice

Chaim O. Jacob
Overexpression and Knockout of Cytokines in Transgenic Mice Book PDF

Author : Chaim O. Jacob
Publisher : Academic Press
Page : 216 pages
File Size : 55,6 Mb
Release : 1994-08-12
Category : Juvenile Nonfiction
ISBN : UOM:39015031823753

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Overexpression and Knockout of Cytokines in Transgenic Mice by Chaim O. Jacob Pdf

The intricate ways in which they act, often with the exhibition of pleiotropic or synergistic effects, make the study of cytokine biology complicated, and the results potentially ambiguous using conventional systems. As a consequence, many investigators are now utilizing the powerful tools of transgenic technology to address some of these questions.

Cytokine Knockouts

Scott K. Durum,Kathrin Muegge
Cytokine Knockouts Book PDF

Author : Scott K. Durum,Kathrin Muegge
Publisher : Springer Science & Business Media
Page : 498 pages
File Size : 40,7 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9781475727531

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Cytokine Knockouts by Scott K. Durum,Kathrin Muegge Pdf

My personal history in the field of cytokines had an initial period of several years during which my student and then colleague, Werner Muller, tried in vain to attract me to them. My interest always vanished when I was confronted with complex data pointing to func tional redundancy of cytokines in cell culture systems. When gene targeting in the mouse germline became possible, this frustration came to an end. We and others immediately embarked on analyzing the in vivo function of cytokines and the problem of functional redundancy with this powerful new approach. The early cytokine gene knockouts performed by colleagues in Wiirzburg (IL-2) and by ourselves (IL-4 and IL-l 0) seemed to give clear answers and at the same time led to surprises: Each of these cytokines apparently had its own special and irreplaceable function, and this function could be quite distinct from what had been anticipated from functional experiments in vitro. Al though the latter finding is of course a wonderful incentive for fur ther research, the former is pleasing in a general sense since it highlights the value of each of those one hundred thousand genes or so in our genome, cherished by evolution to become respectable mem bers of the community. Even in the present era of "genomics" there will be no way around the careful functional analysis of each gene by itself.

Cytokine Knockouts

Giamila Fantuzzi
Cytokine Knockouts Book PDF

Author : Giamila Fantuzzi
Publisher : Springer Science & Business Media
Page : 471 pages
File Size : 40,5 Mb
Release : 2003-07-30
Category : Medical
ISBN : 9781592594054

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Cytokine Knockouts by Giamila Fantuzzi Pdf

Carrying on the high standards of the much praised first edition (Durum and Muegge, Cytokine Knockouts, 1998), Giamila Fantuzzi and a panel of experts have generated completely new chapters to reflect the use of many novel mouse strains and the hundreds of recent studies on cytokine physiology. Comprehensive reviews of the numerous often-surprising results obtained using cytokine knockout mice are provided, along with much important information about cytokine biology and physiology. For those not familiar with cytokine research, the authors present a critical discussion of the advantages and disadvantages of using cytokine knockout mice in various fields of research.

Cytokines and Cytokine Receptors

Constantin A. Bona,Jean-Pierre Revillard
Cytokines and Cytokine Receptors Book PDF

Author : Constantin A. Bona,Jean-Pierre Revillard
Publisher : CRC Press
Page : 864 pages
File Size : 42,7 Mb
Release : 2003-09-02
Category : Science
ISBN : 9780203305133

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Cytokines and Cytokine Receptors by Constantin A. Bona,Jean-Pierre Revillard Pdf

The field of cytokine research is expanding at a rapid pace Contributions from the major leading groups in the world on the structure and biological properties of cytokine and cytokine receptors, as well as integrated reviews on cytokines in various physiological and pathological conditions were presented in three issues of International Reviews of Immunology This collection of articles provided a unique source of information However, important discoveries are emerging very rapidly and some of the reviews written in 1997 are already outdated In this book, the editors assemble reviews that have been updated by their authors to include all the recent publications and unpublished data from the authors' laboratories This volume should serve as an excellent reference source for all those concerned by the multiple faces of cytokines in basic research and in the clinic

Biochemical Modulation of Skin Reactions

Agis F. Kydonieus,John J. Wille
Biochemical Modulation of Skin Reactions Book PDF

Author : Agis F. Kydonieus,John J. Wille
Publisher : CRC Press
Page : 352 pages
File Size : 42,8 Mb
Release : 1999-12-15
Category : Medical
ISBN : 0849321174

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Biochemical Modulation of Skin Reactions by Agis F. Kydonieus,John J. Wille Pdf

Like almost every major scientific or medical breakthrough in history, the transdermal delivery of drugs started as only an idea - slowly moving its way from the drawing board to actual testing and eventually approval. Today, there are more than 20 companies involved in transdermal drug delivery. In addition, almost every large pharmaceutical firm has ongoing transdermal delivery programs. But in spite of this effort and after 15 years from the introduction of the Nitroglycerin patch, only six transdermal drugs exist in the marketplace. The practice has been hampered by the fact that most drugs, as well as many excipients used in the manufacture of transdermal patches, cause skin irritation or skin sensitization. Similar problems exist with the application of dermatologicals and cosmetics to skin, which in many cases are equally as severe as those encountered in transdermal delivery. Biochemical Modulation of Skin Reactions: Transdermals, Topicals, Cosmetics presents a series of chapters describing technologies and the practical application of biochemicals which might lead to the reduction or abrogation of these skin reaction. In addition, it addresses those areas of skin immunology and skin sciences that account for the processes that control irritant and allergic contact dermatitis and outlines the numerous cellular and molecular factors involved in the development of irritation and sensitization. Indeed, Biochemical Modulation of Skin Reactions helps serve as a catalyst for further research in the field, allowing for more drugs and cosmetics to be applied to the skin without adverse effects. Features

Eosinophils in Health and Disease

James J. Lee,Helene F. Rosenberg
Eosinophils in Health and Disease Book PDF

Author : James J. Lee,Helene F. Rosenberg
Publisher : Academic Press
Page : 679 pages
File Size : 49,8 Mb
Release : 2012-11-02
Category : Health & Fitness
ISBN : 9780123943859

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Eosinophils in Health and Disease by James J. Lee,Helene F. Rosenberg Pdf

Eosinophils in Health and Disease provides immunology researchers and students with a comprehensive overview of current thought and cutting-edge eosinophil research, providing chapters on basic science, disease-specific issues, therapeutics, models for study and areas of emerging importance.

Principles of Cancer Biotherapy

Robert K. Oldham,Robert O. Dillman
Principles of Cancer Biotherapy Book PDF

Author : Robert K. Oldham,Robert O. Dillman
Publisher : Springer Science & Business Media
Page : 743 pages
File Size : 46,6 Mb
Release : 2009-08-29
Category : Medical
ISBN : 9789048122899

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Principles of Cancer Biotherapy by Robert K. Oldham,Robert O. Dillman Pdf

At the time of the first edition of Principles of Cancer Biotherapy in 1987, this book represented the first comprehensive textbook on biological therapy. In 1991, when the second edition was published, there was still some doubt on the part of many oncologists and cancer researchers as to the therapeutic value of these new approaches. By 2003 and the fourth edition, it was generally agreed that biopharmaceuticals were producing major opportunities for new cancer therapies. Cancer biotherapy has now truly matured into the fourth modality of cancer treatment. This fifth revised edition describes the tremendous progress that has been made in recent years using biologicals in cancer treatment. This book summarizes an evolving science and a rapidly changing medical practice in biotherapy. In this new millennium, it is now possible to envision a much more diversified system of cancer research and treatment that will afford greater opportunities for a patient’s personalized cancer treatment. This was first envisioned in the 1987 initial edition of this textbook and is now a “new” and popular approach to cancer treatment. Some forms of cancer biotherapy use the strategy of tumor stabilization and control through continued biological therapy, akin to the use of insulin in the treatment of diabetes. This textbook illustrates new methods of thinking and new strategies for control of cancer. It is always difficult to move from past dogma to future opportunity, but this fifth edition of Principles of Cancer Biotherapy illustrates why it is so important to the patients for researchers and clinicians to explore and quickly apply these new opportunities in cancer biotherapy.

Inflammatory Mechanisms in Allergic Diseases

Burton Zweiman,Lawrence B. Schwartz
Inflammatory Mechanisms in Allergic Diseases Book PDF

Author : Burton Zweiman,Lawrence B. Schwartz
Publisher : CRC Press
Page : 604 pages
File Size : 55,9 Mb
Release : 2023-01-06
Category : Medical
ISBN : 9781000893762

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Inflammatory Mechanisms in Allergic Diseases by Burton Zweiman,Lawrence B. Schwartz Pdf

Contains patterns of allergic reactivity for disorders such as asthma, atopic dermatitis, urticaria, and anaphylaxis. Written by leading experts in the field, Inflammatory Mechanisms in Allergic Diseases covers non-anaphylactic drug disorders; synthesis and formation of IgE antibodies; new treatments using allergenic peptides, immunostimulatory oligonucleotides, and pharmacogenomics;recent advances targeting effector mechanisms; hypersensitivity reactions to drugs and more! With over 3100 references, tables, drawings, and micrographs, Inflammatory Mechanisms in Allergic Diseases is an essential reference for allergists, pulmonologists, immunologists, dermatologists, ophthalmologists, otolaryngologists, internists, pediatricians, family practitioners, and medical students in these disciplines.

Congestive Heart Failure

Jeffrey D. Hosenpud,Barry H. Greenberg
Congestive Heart Failure Book PDF

Author : Jeffrey D. Hosenpud,Barry H. Greenberg
Publisher : Lippincott Williams & Wilkins
Page : 1487 pages
File Size : 49,7 Mb
Release : 2007
Category : Medical
ISBN : 9780781762854

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Congestive Heart Failure by Jeffrey D. Hosenpud,Barry H. Greenberg Pdf

Written by recognized leaders in the field, Congestive Heart Failure, Third Edition is a comprehensive, state-of-the-art reference on all basic and clinical aspects of heart failure. Coverage includes an entire section on pharmacologic therapy and a twenty-chapter section on clinical approaches to acute and chronic heart failure. This edition has new chapters on impact and treatment of comorbidities, prevention of sudden cardiac death, rationale for use of anticoagulants, ultrafiltration, use of mechanical devices, and gene and cell therapy. Readers will find up-to-date information on genetics, surgical therapies, ventricular synchronization, defibrillator therapy, mechanical approaches to atrial fibrillation, left ventricular assist devices, ventricular support and ventricular remodeling surgery, and myocardial regeneration/cell transplantation.

The Role of Inflammatory Mediators in the Failing Heart

Douglas L. Mann
The Role of Inflammatory Mediators in the Failing Heart Book PDF

Author : Douglas L. Mann
Publisher : Springer Science & Business Media
Page : 111 pages
File Size : 45,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461514497

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The Role of Inflammatory Mediators in the Failing Heart by Douglas L. Mann Pdf

Although clinicians have recognized the importance of inflammatory mediators in the pathogenesis of heart disease for well over 200 years, it has taken nearly as many years for clinicians and scientists to focus on the basic biological mechanisms by which inflammatory mediators contribute to the pathogenesis of cardiac disease states. Over the past decade there has been increasing interest in the potential role that inflammatory mediators, play in a variety of cardiac disease states, including chronic heart failure. The Role of Inflammatory Mediators in the Failing Heart provides a state-of-the-art review on inflammatory mediators and the failing heart. This book will serve both as a useful introduction to the field, as well as an update for those interested in the role of inflammatory mediators and the failing heart.

Animal Models of T Cell-Mediated Skin Diseases

T. Zollner,Harald Renz,Khusru Asadullah
Animal Models of T Cell Mediated Skin Diseases Book PDF

Author : T. Zollner,Harald Renz,Khusru Asadullah
Publisher : Springer Science & Business Media
Page : 302 pages
File Size : 49,6 Mb
Release : 2007-01-19
Category : Science
ISBN : 9783540268116

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Animal Models of T Cell-Mediated Skin Diseases by T. Zollner,Harald Renz,Khusru Asadullah Pdf

Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The "50th International Workshop of the Ernst Schering Research Foundation" focussed on "Animal Models of T Cell-Mediated Skin Diseases". Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character. The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery.

The Cytokine Handbook

Angus W. Thomson,Michael T. Lotze
The Cytokine Handbook Book PDF

Author : Angus W. Thomson,Michael T. Lotze
Publisher : Gulf Professional Publishing
Page : 878 pages
File Size : 48,7 Mb
Release : 2003
Category : Chemokines
ISBN : 0126896631

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The Cytokine Handbook by Angus W. Thomson,Michael T. Lotze Pdf

The fourth edition of The Cytokine Handbook provides an encyclopedic coverage of the molecules that induce and regulate immune responses. Expanded to two volumes, the scope of the book has been broadened to include a major emphasis on the clinical applications of cytokines. The early chapters discuss individual cytokines, chemokines and receptors. Additional chapters discuss the clinical implications and applications of cytokines, including cytokine gene transfer, antisense therapy and assay systems.

The Cytokine Handbook, Two-Volume Set

Angus W. Thomson,Michael T. Lotze
The Cytokine Handbook Two Volume Set Book PDF

Author : Angus W. Thomson,Michael T. Lotze
Publisher : Elsevier
Page : 1510 pages
File Size : 47,6 Mb
Release : 2003-04-22
Category : Medical
ISBN : 9780080518794

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The Cytokine Handbook, Two-Volume Set by Angus W. Thomson,Michael T. Lotze Pdf

The fourth edition of The Cytokine Handbook provides an encyclopedic coverage of the molecules that induce and regulate immune responses. Now expanded to two volumes, co-edited by Michael T Lotze, and written by over 120 international experts, the scope of the book has been broadened to include a major emphasis on the clinical applications of cytokines. The early chapters discuss individual cytokines, chemokines and receptors. Additional chapters discuss the clinical implications and applications of cytokines, including cytokine gene transfer, antisense therapy and assay systems. This book is essential for researchers and clinicians interested in cytokines, including anyone working in cancer biology, transplantation, infectious diseases, autoimmunity or bioinformatics. Key Features* Covers all main cytokines and chemokines * Written by experts* Up-to-date- includes detailed referencing accessing current, modern literature and reflects the newest findings from the human genome * The new edition has been thoroughly revised and extended (now 2 volumes) as compared to the last edition, including new co-editor (MTL), new authors, new hot topics and new chapters* Includes major emphasis on clinical applications* Extensively illustrated with tables and figures

Animal Models for the Study of Human Disease

P. Michael Conn
Animal Models for the Study of Human Disease Book PDF

Author : P. Michael Conn
Publisher : Academic Press
Page : 1108 pages
File Size : 54,7 Mb
Release : 2013-05-29
Category : Science
ISBN : 9780124159129

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Animal Models for the Study of Human Disease by P. Michael Conn Pdf

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives and animal ethics Covers a broad range of animal models used in research for human disease

Clinical and Basic Immunodermatology

Anthony A. Gaspari,Stephen K. Tyring,Daniel H. Kaplan
Clinical and Basic Immunodermatology Book PDF

Author : Anthony A. Gaspari,Stephen K. Tyring,Daniel H. Kaplan
Publisher : Springer
Page : 895 pages
File Size : 51,7 Mb
Release : 2017-04-24
Category : Medical
ISBN : 9783319297859

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Clinical and Basic Immunodermatology by Anthony A. Gaspari,Stephen K. Tyring,Daniel H. Kaplan Pdf

This updated volume provides a “user-friendly” reference for dermatologists, dermatology residents and students, as well as for health care workers in related fields to better understand immune-mediated skin diseases and their therapies. The focus is on what is needed by the physician/resident or student for betting understanding the pathophysiology of the disease as well as the mechanisms of action of the therapies. The reader can easily read about groups of related diseases as well as groups of related therapies. The level of complexity of the book is such that it has practical applications on a daily basis but can also be used by the resident as a teaching tool and as a handy source of review for the boards. In addition, it can be used the practicing dermatologist to study for recertification. The scope of the book is immunology, immunogenetics, immunopathology and immunopharmacology as they relate to clinical dermatology.