Oxidative Stress And Signal Transduction

Author : H.J. Forman,Enrique Cadenas
Publisher : Springer Science & Business Media
Page : 484 pages
File Size : 51,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461559818

Get Book

Oxidative Stress and Signal Transduction by H.J. Forman,Enrique Cadenas Pdf

In the past few years there has been the increased recognition that the effects of oxidative stress are not limited to the damage of cellular constituents. There is now evidence that reactive oxygen species (ROS) can alter cell function by acting upon the intermediates, or second messengers, in signal transductions. Such effects on signaling mechanisms probably account for the role of oxidative stress in inflammation, aging, and cancer. This volume brings together internationally recognized researchers in both the major areas covered by the book, oxidative stress and signal transduction. The work is organized in three sections. The first deals with the immediate cellular responses to oxidative stress and the production of second messengers. The second details the connection between second messengers and the gene. The third part looks more closely at the level of the gene.

Author : H.J. Forman,Enrique Cadenas
Publisher : Springer
Page : 475 pages
File Size : 52,8 Mb
Release : 2011-10-08
Category : Science
ISBN : 1461559820

Get Book

Oxidative Stress and Signal Transduction by H.J. Forman,Enrique Cadenas Pdf

In the past few years there has been the increased recognition that the effects of oxidative stress are not limited to the damage of cellular constituents. There is now evidence that reactive oxygen species (ROS) can alter cell function by acting upon the intermediates, or second messengers, in signal transductions. Such effects on signaling mechanisms probably account for the role of oxidative stress in inflammation, aging, and cancer. This volume brings together internationally recognized researchers in both the major areas covered by the book, oxidative stress and signal transduction. The work is organized in three sections. The first deals with the immediate cellular responses to oxidative stress and the production of second messengers. The second details the connection between second messengers and the gene. The third part looks more closely at the level of the gene.

Author : H.J. Forman,J.M. Fukuto,M. Torres
Publisher : Springer Science & Business
Page : 411 pages
File Size : 43,8 Mb
Release : 2007-05-08
Category : Science
ISBN : 9780306484124

Get Book

Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles by H.J. Forman,J.M. Fukuto,M. Torres Pdf

Henry Jay Forman, Jon Fukuto and Martine Torres "Research is to see what everybody else has seen and to think what nobody else has thought. " -- Albert Szent-Gyorgyi Several years ago, one of us put together a book that dealt with various aspects of oxidative stress and introduced the concept of signal transduction by oxidants. Since then, the interest in the mechanisms by which reactive oxygen and nitrogen species (ROS/RNS) can modulate the cell’s response has tremendously grown, paralleling the intense efforts towards identifying new signaling pathways in which phosphorylation/dephosphorylation events take center stage. Evidence is now mounting that production of these species by the cells is required for their function from growth to apoptosis and numerous signaling pathways have been identified where the participation of ROS and RNS is apparent (see Chapters 11-14, 16 and 18). Thus, the field is no more limited to the group of free radical aficionados who have pioneered this area of research but has now gone mainstream. While it is satisfactory for those of us who have been working on this topic for a long time, it has the risk of becoming the “fashionable” motto where those molecules, still mysterious to some, become responsible for everything and anything.

Author : Terry D. Hinds, Jr,David E. Stec,Barbara Wegiel
Publisher : Frontiers Media SA
Page : 206 pages
File Size : 47,9 Mb
Release : 2021-10-21
Category : Science
ISBN : 9782889715275

Get Book

Oxidative Stress, Antioxidants, Transcription Factors, and Assimilation of Signal Transduction Pathways in Obesity-Related Disorders by Terry D. Hinds, Jr,David E. Stec,Barbara Wegiel Pdf

Topic Editors Terry Hinds and David Stec have submitted patents related to bilirubin and obesity related disorders. The other Topic Editor declare no potential conflicts of interest with regards to the Research Topic subject.

Author : Tahira Farooqui,Akhlaq A. Farooqui
Publisher : John Wiley & Sons
Page : 433 pages
File Size : 42,8 Mb
Release : 2011-10-24
Category : Science
ISBN : 9781118148112

Get Book

Oxidative Stress in Vertebrates and Invertebrates by Tahira Farooqui,Akhlaq A. Farooqui Pdf

This volume presents a unique comparative treatment of the role oxidative stress plays in vertebrates and invertebrates in multiple organ systems with regards to cell death, development, aging, and human diseases, and anti-oxidant therapy. It offers comprehensive reviews of the current understanding of oxidative stress-mediated physiology and pathology as well as directions for future research. It also provides current information on the role of oxidative stress in neurodegenerative diseases, cardiovascular diseases, and various types of cancer mediated by oxidative stress.

Author : Lester Packer,Karel W.A. Wirtz
Publisher : Springer Science & Business Media
Page : 461 pages
File Size : 53,8 Mb
Release : 2013-06-29
Category : Science
ISBN : 9783642796753

Get Book

Signalling Mechanisms — from Transcription Factors to Oxidative Stress by Lester Packer,Karel W.A. Wirtz Pdf

A NATO Advanced Study Institute on "Molecular Mechanisms of Transcellular Signaling: from the Membrane to the Gene" was held on the Island of Spetsai, Greece, from August 15- 27, 1994. The aim of this Institute was to bring together researchers in the field of signal transduction mechanisms, transcription factors and gene regulation with those actively involved in studies on the implications of oxygen radicals and antioxidant defence mechanisms for cell function. As diverse as these fields may be, the emergence of their interconnection during the course of the Institute was an eye-opener for students and lecturers alike. 2 Presentations and discussions focussed on the role of Ca +, G-proteins, protein kinase C and phospholipases in signaling mechanisms. These broad principles were extended to transcription factors and gene regulation with an emphasis on the steroid hormone receptor superfamily and NFKB. Basic principles of free radical formation and antioxidant action (vitamin E and C) were presented and discussed in connection with effects on signaling pathways. This book present the content of the major lectures and a selection of the most relevant posters. These proceedings offer a comprehensive account of the most important topics discussed at the Institute. The book is intended to make the proceedings accessible to a large audience.

Author : Junji Yodoi
Publisher : CRC Press
Page : 366 pages
File Size : 52,6 Mb
Release : 1999-03-29
Category : Science
ISBN : 0824719611

Get Book

Redox Regulation of Cell Signaling and Its Clinical Application by Junji Yodoi Pdf

Presents recent developments in the rapidly expanding field of redox regulation research. The book examines insights into intracellular communication and new techniques for diagnosing and treating diseases associated with oxidation and reduction. It focuses on important cellular mechanisms, such as redox reactions related to thioredoxin (TRX)/adult T-cell leukemia-derived factor (ADF).

Author : Luis A. del Río,Alain Puppo
Publisher : Springer Science & Business Media
Page : 245 pages
File Size : 48,5 Mb
Release : 2009-06-22
Category : Science
ISBN : 9783642003905

Get Book

Reactive Oxygen Species in Plant Signaling by Luis A. del Río,Alain Puppo Pdf

Oxygen (O ) appeared in significant amounts in the Earth’s atmosphere over 2. 2 2 billion years ago, largely due to the evolution of photosynthesis by cyanobacteria (Halliwell 2006). The O molecule is a free radical, as it has two impaired electrons 2 that have the same spin quantum number. This spin restriction makes O prefer to 2 accept its electrons one at a time, leading to the generation of the so-called reactive oxygen species (ROS). The chemical nature of these species dictates that they can create damage in cells. This has contributed to the creation of the “oxidative stress” concept; in this view, ROS are unavoidable toxic products of O metabolism and 2 aerobic organisms have evolved antioxidant defences to protect against this tox- ity (Halliwell 1981; Fridovich 1998). Indeed, even in present-day plants, which are full of antioxidants, much of the protein synthetic activity of chloroplasts is used to replace oxidatively damaged D1 and other proteins (Halliwell 2006). Yet, the use of the “oxidative stress” term implies that ROS exert their effects through indiscriminate widespread inactivation of cellular functions. In this context, ROS must not be able to react with lipids, proteins or nucleic acids in order to avoid any damage to vital cellular components. However, genetic evidence has suggested that, in planta, purely physicoche- cal damage may be more limited than previously thought (Foyer and Noctor 2005).

Author : C. Pasquier
Publisher : Birkhäuser
Page : 355 pages
File Size : 45,5 Mb
Release : 2013-03-08
Category : Medical
ISBN : 9783034874243

Get Book

Oxidative Stress, Cell Activation and Viral Infection by C. Pasquier Pdf

Since the appearance of photosynthesis on our planet, all living organisms have been facing a new abundant, extremely reactive element, oxygen. This element is used for the synthesis of highly energetic compounds, but can also generate molecules capable of damaging constituents of living structures, including proteins, nucleic acids and lipids. It is therefore no surprise that all biological organisms have evolved multiple and sophisticated ways to reduce the detrimental effects of oxygen. For cells and tissues of highly organized animals, particularly cells of the immune system, superoxidation products play an important role, via oxidative stress, in activation, inflammation and viral and bacterial infections. We must be grateful to Drs. C. Pasquier, C. Auclair, L. Packer and R. Olivier for having brought together many specialists in an international meeting held in Paris in March 1993, at the Ministry of Research. This book comprises an impressive amount of recent knowledge, a real mine for the reader in this fast developing field of research. Furthermore, we should not forget that this basic research may lead in the future to new therapeutic approaches to the most important pathologies of the latter part of this century, including AIDS.

Author : K.B. Storey,J.M. Storey
Publisher : Elsevier
Page : 312 pages
File Size : 51,5 Mb
Release : 2001-07-19
Category : Science
ISBN : 0080539963

Get Book

Protein Adaptations and Signal Transduction by K.B. Storey,J.M. Storey Pdf

This volume of Cell and Molecular Responses to Stress has two broad themes: an examination of selected protein adaptations that support stress tolerance and an analysis of signal transduction systems, those critical links between the perception of stress and the activation of the coordinated metabolic responses that ensure survival. Several chapters deal with adaptive responses to environmental cold temperature and highlight novel advances in mammalian hibernation, low temperature enzyme function, cold-shock and antifreeze proteins, and freezing survival. Other chapters stretch out to explore biochemical responses to diverse stresses including water stress, mechanical stress, nutrient availability, oxygen limitation and oxidative stress. The integral roles of protein kinases, transcription factors, oxygen free radicals, and oxygen-sensitive ion channels in the detection and mediation of stress responses are explored. The multiplicity of responses is emphasized and shows us the vast potential of cells and organisms to respond to innumerable stresses, great and small, and the regulatory principles and mechanisms that are used to allow life to adapt and endure in every environment on Earth. Featuring: A discussion of new advances in understanding protein adaptations that support organismal survival of stress. State-of-the-art analysis of key components of cellular signal transduction pathways including protein kinases and calcium and the control, integration and action of signal transduction pathways in response to stresses including mechanical stress, nutrient availability, oxidative stress.

Author : Tammy M. Bray,Norberta W. Schoene
Publisher : Unknown
Page : 156 pages
File Size : 51,9 Mb
Release : 2000
Category : Active oxygen in the body
ISBN : STANFORD:36105110510257

Get Book

Models and Methods in Cell Signaling and Gene Expression by Tammy M. Bray,Norberta W. Schoene Pdf

Author : Lester Packer
Publisher : Unknown
Page : 456 pages
File Size : 42,7 Mb
Release : 1995-06-22
Category : Technology & Engineering
ISBN : 0387591273

Get Book

Signalling Mechanisms from Transciption Factors to Oxidative Stress by Lester Packer Pdf

Author : John T. Hancock,Myra E. Conway
Publisher : Humana
Page : 0 pages
File Size : 49,8 Mb
Release : 2019-05-31
Category : Science
ISBN : 1493994611

Get Book

Redox-Mediated Signal Transduction by John T. Hancock,Myra E. Conway Pdf

This volume explores the scope of the cellular redox analysis and the importance of not being limited by frequently changing and evolving technology. The chapters in this book cover a wide range of topics such as redox components in animal and plant cells and the role of reactive oxygen species, reactive nitrogen species, and hydrogen sulphide in cell signaling; measuring modifications using Flow Cytometry, ELISA assays, and Western blot analysis; measurement of oxidative stress in mitochondira and biological systems; and the use of the genetically encoded fluorescent probe HyPer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and informative, Redox-Mediated Signal Transduction: Methods and Protocols, Second Edition is a valuable resource for both novice and expert researchers who want to expand their studies into new areas and new systems in the evolving redox field.

Author : Zigang Dong,Young-Joon Surh
Publisher : CRC Press
Page : 504 pages
File Size : 53,6 Mb
Release : 2008-09-26
Category : Medical
ISBN : 9780849381492

Get Book

Dietary Modulation of Cell Signaling Pathways by Zigang Dong,Young-Joon Surh Pdf

A consequence of rapid progress in the science of nutrigenomics and nutrigenetics is the substantial accumulation of data covering nutrienal modulation of gene expression at the cellular and subcellular levels. Current research is increasingly focused on the role of nutrition and diet in modifying oxidative damage in the progression of disease. Die

Author : Dirk Inze
Publisher : CRC Press
Page : 417 pages
File Size : 54,5 Mb
Release : 2001-10-18
Category : Science
ISBN : 9780203303146

Get Book

Oxidative Stress in Plants by Dirk Inze Pdf

Plants depend on physiological mechanisms to combat adverse environmental conditions, such as pathogen attack, wounding, drought, cold, freezing, salt, UV, intense light, heavy metals and SO2. Many of these cause excess production of active oxygen species in plant cells. Plants have evolved complex defense systems against such oxidative stress. The