Pathogenesis And Treatment Of Leukemia

Author : Harinder Gill,Yok-Lam Kwong
Publisher : Springer Nature
Page : 665 pages
File Size : 48,7 Mb
Release : 2023-09-27
Category : Medical
ISBN : 9789819938100

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Pathogenesis and Treatment of Leukemia by Harinder Gill,Yok-Lam Kwong Pdf

This book covers a comprehensive update on acute and chronic leukemia. In 54 chapters, authors introduce research progress and clinical trials of acute myeloid leukaemia (AML), acute promyelocytic leukaemia (APL), acute lymphoblastic leukaemia (ALL), myelodysplastic syndrome (MDS), myeloproliferative neoplasm (MPN) and chronic myeloid leukemia (CML). The last decade has seen the integration of genetic and clinical information to determine the prognosis and treatment strategies. This book provides practitioners, researchers and graduate students of Hematology and Hematopathology a comprehensive update on the pathobiology, genomics, classification, diagnosis, monitoring, prognostication and therapy of both acute and chronic leukemias.

Author : Hillard M. Lazarus,Mary J. Laughlin
Publisher : Springer Science & Business Media
Page : 881 pages
File Size : 52,8 Mb
Release : 2010-03-02
Category : Medical
ISBN : 9781597454780

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Allogeneic Stem Cell Transplantation by Hillard M. Lazarus,Mary J. Laughlin Pdf

Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.

Author : Jonathan Edward Brammer,Marco Herling,Anjali Mishra,Wael Jarjour
Publisher : Frontiers Media SA
Page : 111 pages
File Size : 47,9 Mb
Release : 2022-10-18
Category : Medical
ISBN : 9782832502693

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Pathogenesis, Treatment, and Future Directions for Rare T-Cell Leukemias by Jonathan Edward Brammer,Marco Herling,Anjali Mishra,Wael Jarjour Pdf

Author : John W. Rebuck,Frank H. Bethell,Raymond W. Monto
Publisher : Elsevier
Page : 730 pages
File Size : 46,6 Mb
Release : 2013-10-22
Category : Health & Fitness
ISBN : 9781483263755

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The Leukemias: Etiology, Pathophysiology, and Treatment by John W. Rebuck,Frank H. Bethell,Raymond W. Monto Pdf

The Leukemias: Etiology, Pathophysiology, and Treatment documents the proceedings of an International Symposium on The Leukemias: Etiology and Pathophysiology, held at Henry Ford Hospital, Detroit, Michigan, 8-10 March 1956. This volume gives the present complex position of leukemic etiology and pathophysiologic disturbance, a much needed knowledge of detailed leukocytic functions and comprehensive thought on the therapy of the leukemias. It also establishes a basis of comparison with the earlier works of Downey and Forkner in this field in the late thirties and thus makes it possible to see with some clarity the extent of progress made. The volume contains 39 papers organized into nine parts. The papers in Part I focus on the leukemic cell, its structure, and antigenicity. Part II presents studies on genetic and environmental factors in the transmission of leukemia. Part III examines the radiation biology of leukocytes. Part IV focuses on the leukemias and the malignant lymphomas while Part V deals with leukocytic physiology. Part VI covers the metabolism of amino and nucleic acids in the leukemias. Part VII takes up further biochemical considerations in the leukemias. Part VIII contains papers that examine nucleic acids as the target for chemotherapy. Part IX presents a round-table discussion on therapy.

Author : Severo Vecchione
Publisher : Nova Biomedical Books
Page : 0 pages
File Size : 43,6 Mb
Release : 2011-10
Category : Lymphoblastic leukemia
ISBN : 161470872X

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Acute Lymphoblastic Leukemia by Severo Vecchione Pdf

Acute lymphoblastic leukaemia (ALL) is a malignant disorder of the bone marrow in which a lymphoid precursor cell becomes genetically altered resulting in dysregulated proliferation and clonal expansion of neoplastic cells. It is the most common malignancy in children, representing nearly one third of all paediatric cancers. In this book, the authors present topical research in the study of acute lymphoblastic leukaemia including genome wide association studies in paediatric acute lymphoblastic leukaemia; mice deficient for the Slp65 signalling protein which is a model for ALL; histone deacetylase inhibitors and maintenance therapy in Ph negative adult acute lymphoblastic leukaemia.

Author : Masahiro Kizaki
Publisher : Springer
Page : 193 pages
File Size : 52,6 Mb
Release : 2015-11-05
Category : Medical
ISBN : 9784431557142

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Molecular Pathogenesis and Treatment of Chronic Myelogenous Leukemia by Masahiro Kizaki Pdf

Molecular Pathogenesis and Treatment of Chronic Myelogenous Leukemia provides a comprehensive understanding of the recent molecular genetics of Chronic Myelogenous Leukemia (CML) and a characterization of the molecular targets for drug development. Included are therapeutic implications, diagnosis, and prognosis for understanding and facilitating daily practice in the management of patients with CML. Understanding of the pathogenesis and therapy of hematological malignancies such as CML has grown significantly in recent years. This development owe much to the progress in molecular biology and now makes a major contribution to diagnosis and to treatment that pharmacologically targets the molecular events of CML. Molecular targeting therapy with newly developed agents such as small molecules and antibodies for hematological malignancies are being discovered after years of research. Some of these, including tyrosine kinase inhibitors such as imatinib, nilotinib, and dasatinib, lead to increased survival rates and improved therapies. With the opinion leaders of basic and clinical research in the field as authors, this book reviews recent advances in the biology of CML.

Author : Ajay Vora
Publisher : Springer
Page : 342 pages
File Size : 46,6 Mb
Release : 2017-04-21
Category : Medical
ISBN : 9783319397085

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Childhood Acute Lymphoblastic Leukemia by Ajay Vora Pdf

This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.

Author : Wolfgang Hiddemann
Publisher : Springer
Page : 92 pages
File Size : 48,5 Mb
Release : 2016-11-14
Category : Medical
ISBN : 9783319267722

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Handbook of Acute Leukemia by Wolfgang Hiddemann Pdf

This book provides an overview of the key developments in both acute lymphocytic leukemia and acute myeloid leukemia with a comprehensive guide to the epidemiology, pathogenesis, etiology, clinical manifestations, classification, diagnosis, and staging as well as the most recent developments in the therapeutic landscape for acute leukemia. The Handbook of Acute Leukemia offers readers a key resource into the future outlook for patients with leukemia and is edited and authored by internationally renowned experts in the field. Leukemia is cancer of the white blood cells and acute leukemia means the condition progresses rapidly and aggressively, requiring immediate treatment. Acute leukemia is classified according to the type of white blood cells that are affected: either lymphocytes and myeloid cells.

Author : Howard Franklin Bunn,Jon C. Aster
Publisher : McGraw Hill Professional
Page : 354 pages
File Size : 44,7 Mb
Release : 2010-12-27
Category : Medical
ISBN : 9780071713788

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Pathophysiology of Blood Disorders by Howard Franklin Bunn,Jon C. Aster Pdf

A concise full-color review of the mechanisms of blood diseases and disorders – based on a Harvard Medical School hematology course 4 STAR DOODY'S REVIEW! "This is a superb book. Deceptively small, yet packs a wallop. The emphasis on principles instead of practice is welcome....The text is clear, concise, and surprisingly approachable for what could have been a very dense and dry discussion. I could not put this book down and read it entirely in one sitting. When was the last time anyone found a hematology textbook so riveting?"--Doody's Review Service Hematological Pathophysiology is a well-illustrated, easy-to-absorb introduction to the physiological principles underlying the regulation and function of blood cells and hemostasis, as well as the pathophysiologic mechanisms responsible for the development of blood disorders. Featuring a strong emphasis on key principles, the book covers diagnosis and management primarily within a framework of pathogenesis. Authored by world-renowned clinician/educators at Harvard Medical School, Hematological Pathophysiology features content and organization based on a hematology course offered to second year students at that school. The book is logically divided into four sections: Anemias and Disorders of the Red Blood Cell, Disorders of Hemostasis and Thrombosis, Disorders of Leukocytes, and Transfusion Medicine; it opens with an important overview of blood and hematopoietic tissues. Features Succinct, to-the-point coverage that reflects current medical education More than 200 full-color photographs and renderings of disease mechanisms and blood diseases Each chapter includes learning objectives and self-assessment questions Numerous tables and diagrams encapsulate important information Incorporates the feedback of 180 Harvard medical students who reviewed the first draft -- so you know you’re studying the most relevant material possible

Author : Anjali S. Advani,Hillard M. Lazarus
Publisher : Humana Press
Page : 388 pages
File Size : 46,6 Mb
Release : 2010-11-19
Category : Medical
ISBN : 1607617064

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Adult Acute Lymphocytic Leukemia by Anjali S. Advani,Hillard M. Lazarus Pdf

The current explosion of new areas of controversy in the treatment of acute lymphocytic leukemia in adults and young adults makes this comprehensive book a much needed reference for hematologists and oncologists. This book assembles leading authorities from around the globe to cover the full spectrum of ALL subtypes and their treatments. Specific topics of discussion include indications for allogeneic bone marrow transplant in first complete remission, the role of minimal residual disease in making treatment decisions, the treatment of young adults, and the treatment of Philadelphia chromosome positive ALL with the advent of the tyrosine kinase inhibitors. This is the first book to focus exclusively on the adult ALL patient. It provides a complete overview of diagnosis, molecular pathogenesis, evaluation, and treatment for this important patient population.

Author : World Health Organization
Publisher : IARC
Page : 360 pages
File Size : 42,9 Mb
Release : 2001
Category : Digestive organs
ISBN : 9283224116

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Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues by World Health Organization Pdf

This is the third volume in the new World Health Organization series on histological and genetic typing of tumours. Tumours of the haematopoietic and lymphoid tissues are covered. This was a collaborative project of the European Association for Haematolpathology and the Society for Haematopathology and others. The WHO classification is based on the principles defined in the Revised European-American Classification of Lymphoid Neoplasms (REAL) classification. Over 50 pathologists from around the world were involved in the project and proponents of all major lymphoma and leukaemia classifications have agreed to accept the WHO as the standard classification of haematological malignancies. So this classification represents the first true world wide concensus of haematologic malignancies. Colour photographs, magnetic resonance and ultrasound images and CT scans are included.

Author : S.H. Faderl,H.M. Kantarjian
Publisher : Springer Science & Business Media
Page : 294 pages
File Size : 41,5 Mb
Release : 2007-11-21
Category : Medical
ISBN : 9783540723042

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Hematologic Malignancies: Acute Leukemias by S.H. Faderl,H.M. Kantarjian Pdf

Better therapy of acute leukemias depends ultimately on better understanding of the distinction between leukemic and normal progenitor cells. This hugely important new book describes the current knowledge of acute leukemia biology and discusses new classification systems that have arisen as a result of emerging insights into pathogenesis. Estey, Faderl and Kantarjian, who all work at the respected Anderson Cancer Center in Houston, Texas, USA, examine in detail advances in the treatment of particular types of acute leukemia. Their book also covers the management of acute leukemia in general as well as the development of new therapies. This book will be extremely useful to clinicians.

Author : Juan Manuel Mejia-Arangure
Publisher : BoD – Books on Demand
Page : 346 pages
File Size : 40,8 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9789535109907

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Clinical Epidemiology of Acute Lymphoblastic Leukemia by Juan Manuel Mejia-Arangure Pdf

This book describes different perspectives of childhood acute lymphoblastic leukemia. The approach includes aspects of molecular epidemiology, particularly molecular features that influence the genesis and prognosis of the disease. Some aspects of the prognosis of lymphoblastic leukemias are very detailed, highlighting the use of molecular biology in the early identification of complications that may occur in diseased patients. The authors of the present book conform a Mexican group who identifies the causes of leukemia, and they summarize their experience in research, results and proposals for future studies. A causal model is included in which the authors hypothesized the origin of acute lymphoblastic leukemias, particularly in children. This hypothesis can be useful to better understand other cancers during childhood. This book will help the reader to identify different molecular aspects involved in leukemia, and its relation to the development and evolution of the disease.

Author : Rüdiger Hehlmann
Publisher : Springer
Page : 255 pages
File Size : 47,5 Mb
Release : 2016-08-17
Category : Medical
ISBN : 9783319331980

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Chronic Myeloid Leukemia by Rüdiger Hehlmann Pdf

This book provides state-of-the-art reviews of key issues and recent developments relating to chronic myeloid leukemia (CML), acquainting the reader with advances in research, treatment, and promotion of public health. Among the management topics addressed are the choices, advantages, and pitfalls of first-, second-, and third-line treatments; the European LeukemiaNet recommendations; management of adverse effects of tyrosine kinase inhibitors (TKI); management of CML blast crisis; management of pregnancy in the context of CML; the role of hematopoietic cell transplantation; the current experience with TKI discontinuation; and the value of interferon α in improving the outcome of TKI treatment. Various aspects of relevance to treatment outcome are discussed, including prognostic scores, molecular monitoring (principles and interlaboratory standardization), and response-related predictors of survival. Furthermore, updates are provided on the increasing prevalence of CML and its implications and on the changing cost of care for CML, taking into account the forthcoming impact of availability of generic imatinib.

Author : Ian Magrath
Publisher : Lippincott Williams & Wilkins
Page : 399 pages
File Size : 45,8 Mb
Release : 1984
Category : Medical
ISBN : 0890049017

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Pathogenesis of Leukemias and Lymphomas by Ian Magrath Pdf