Peptide Therapeutics And Peptidomimetic Design

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Peptide and Peptidomimetic Therapeutics

Nir Qvit,Samuel J.S. Rubin
Peptide and Peptidomimetic Therapeutics Book PDF

Author : Nir Qvit,Samuel J.S. Rubin
Publisher : Academic Press
Page : 792 pages
File Size : 50,6 Mb
Release : 2022-09-22
Category : Science
ISBN : 9780128204474

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Peptide and Peptidomimetic Therapeutics by Nir Qvit,Samuel J.S. Rubin Pdf

Peptide and Peptidomimetic Therapeutics: From Bench to Beside offers applied, evidence-based instruction on developing and applying peptide therapeutics in disease treatment, driving drug discovery, and improving patient care. Here, researchers, clinicians and students will find tools to harness the full power of peptides and peptidomimetics and improve bioavailability, stability, efficiency and selectivity of new therapeutics and their application in treatment plans. More than 20 leaders in the field share their approaches for identifying and advancing peptide and peptidomimetic therapeutics. Topics examined run from "bench to bedside," beginning with fundamental peptide science, protein-protein interactions and peptide synthesis. Later chapters examine modes for peptide drug delivery, including cell penetration peptide and peptidomimetic delivery, as well as the targeting of specific disease types, peptide therapeutics as applied to infectious disease, cancer, metabolic disorders, neurodegenerative disorders, and skin disorders, and antiparasitic and immunosuppressive peptidomimetics. Helps researchers and clinicians harness the full of power of peptides and peptidomimetics in their daily work and drug discovery Features chapters running from “bench to bedside , providing a thorough grounding in fundamental peptide science, drug delivery methods, and targeting of specific disease types Features chapter contributions from international leaders in peptide science and drug development

Peptide Therapeutics and Peptidomimetic Design

Juan J. Perez
Peptide Therapeutics and Peptidomimetic Design Book PDF

Author : Juan J. Perez
Publisher : Wiley
Page : 328 pages
File Size : 44,8 Mb
Release : 2015-08-31
Category : Medical
ISBN : 0470937777

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Peptide Therapeutics and Peptidomimetic Design by Juan J. Perez Pdf

By combining interdisciplinary approaches of organic and medicinal chemistry, biophysical methods, and computational chemistry, Peptide Therapeutics and Peptidomimetic Design provides a guide to rational strategies for designing peptidomimetic drugs. Author Juan Perez addresses an active field of biologics research that the pharmaceutical industry and researchers are aggressively moving into, highlighting examples of peptidomimetic drugs as enzyme inhibitors, GPCR ligands, and protein-protein interaction inhibitors.

Peptidomimetics in Organic and Medicinal Chemistry

Antonio Guarna,Andrea Trabocchi
Peptidomimetics in Organic and Medicinal Chemistry Book PDF

Author : Antonio Guarna,Andrea Trabocchi
Publisher : John Wiley & Sons
Page : 334 pages
File Size : 51,6 Mb
Release : 2014-03-14
Category : Science
ISBN : 9781118683149

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Peptidomimetics in Organic and Medicinal Chemistry by Antonio Guarna,Andrea Trabocchi Pdf

A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.

Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery

Henry I. Mosberg,Carrie Haskell-Luevano,Tomi K. Sawyer
Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery Book PDF

Author : Henry I. Mosberg,Carrie Haskell-Luevano,Tomi K. Sawyer
Publisher : MDPI
Page : 406 pages
File Size : 51,9 Mb
Release : 2020-03-13
Category : Medical
ISBN : 9783039282883

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Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery by Henry I. Mosberg,Carrie Haskell-Luevano,Tomi K. Sawyer Pdf

Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery is a book dedicated to Prof. Victor J. Hruby on the occasion of his 80th birthday. This book includes twenty contributions from authors representing diverse multidisciplinary fields of scientific expertise, and is focused on the extraordinary potential of peptides and peptidomimetics as a surging therapeutic modality and as tools for basic research and technology development.

Peptide Therapeutics

Seetharama D. Jois
Peptide Therapeutics Book PDF

Author : Seetharama D. Jois
Publisher : Springer Nature
Page : 321 pages
File Size : 53,7 Mb
Release : 2022-09-26
Category : Medical
ISBN : 9783031045448

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Peptide Therapeutics by Seetharama D. Jois Pdf

This book explains how peptide-based drug design works, what steps are needed to develop a peptide-based therapeutic, and challenges in synthesis as well as regulatory issues. It covers the design concept of peptide therapeutics from fundamental principles using structural biology and computational approaches. The chapters are arranged in a linear fashion. A fresh graduate or a scientist who works on small molecules can use this to follow the design and development of peptide therapeutics to use as understanding the basic concepts. Each chapter is written by experts from academia as well as industry. Rather than covering extensive literature, the book provides concepts of design, synthesis, delivery, as well as regulatory affairs and manufacturing of peptides in a systematic way with examples in each case. The book can be used as a reference for a pharmaceutical or biomedical scientist or graduate student who wants to pursue their career in peptide therapeutics. Some chapters will be written as a combination of basic principles and protocol so that scientists can adopt these methods to their research work. The examples provided can be used to perform peptide formulation considerations for the designed peptides. The book has nine chapters, and each chapter can be read as an independent unit on a particular concept.

Peptide and Protein Design for Biopharmaceutical Applications

Knud Jensen
Peptide and Protein Design for Biopharmaceutical Applications Book PDF

Author : Knud Jensen
Publisher : John Wiley & Sons
Page : 306 pages
File Size : 40,6 Mb
Release : 2009-09-01
Category : Science
ISBN : 0470749717

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Peptide and Protein Design for Biopharmaceutical Applications by Knud Jensen Pdf

Peptides serve as effective drugs in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this researchers are developing new methods to create ‘tailor-made’ peptides and proteins with improved pharmacological properties. Design of Peptides and Proteins provides an overview of the experimental and computational methods for peptide and protein design, with an emphasis on specific applications for therapeutics and biomedical research. Topics covered include: Computer modeling of peptides and proteins Peptidomimetics Design and synthesis of cyclic peptides Carbohydrates in peptide and protein design De novo design of peptides and proteins Medical development applications An extended case study – the design of insulin variants Design of Peptides and Proteins presents the state-of-the-art of this exciting approach for therapeutics, with contributions from international experts. It is an essential resource for academic and industrial scientists in the fields of peptide and protein drug design, biomedicine, biochemistry, biophysics, molecular modelling, synthetic organic chemistry and medicinal/pharmaceutical chemistry.

Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery: A Themed Issue Honoring Professor Victor J. Hruby on the Occasion of His 80th Birthday

Carrie Haskell-Luevano,Tomi Sawyer,Henry Mosberg
Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery A Themed Issue Honoring Professor Victor J Hruby on the Occasion of His 80th Birthday Book PDF

Author : Carrie Haskell-Luevano,Tomi Sawyer,Henry Mosberg
Publisher : Unknown
Page : 406 pages
File Size : 50,5 Mb
Release : 2020
Category : Medicine (General)
ISBN : 3039282891

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Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery: A Themed Issue Honoring Professor Victor J. Hruby on the Occasion of His 80th Birthday by Carrie Haskell-Luevano,Tomi Sawyer,Henry Mosberg Pdf

Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery is a book dedicated to Prof. Victor J. Hruby on the occasion of his 80th birthday. This book includes twenty contributions from authors representing diverse multidisciplinary fields of scientific expertise, and is focused on the extraordinary potential of peptides and peptidomimetics as a surging therapeutic modality and as tools for basic research and technology development.

Peptide-based Drug Discovery

Ved Srivastava
Peptide based Drug Discovery Book PDF

Author : Ved Srivastava
Publisher : Royal Society of Chemistry
Page : 589 pages
File Size : 46,8 Mb
Release : 2017-06-22
Category : Science
ISBN : 9781788011716

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Peptide-based Drug Discovery by Ved Srivastava Pdf

With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies. What does it take to develop a peptide-based medicine? What are the key challenges and how are they overcome? What are emerging therapeutics for peptide modalities? This book answers these questions with a holistic story from molecules to medicine, combining the themes of design, synthesis and clinical applications of peptide-based therapeutics and biomarkers. Chapters are written and edited by leaders in the field from industry and academia and they cover the pharmacokinetics of peptide therapeutics, attributes necessary for commercially successful metabolic peptides, medicinal chemistry strategies for the design of peptidase-resistant peptide analogues, disease classes for which peptide therapeutic are most relevant, and regulatory issues and guidelines. The critical themes covered provide essential background information on what it takes to develop peptide-based medicine from a chemistry perspective and views on the future of peptide drugs. This book will be a valuable resource not only as a reference book for the researcher engaged in academic and pharmaceutical setting, from basic research to manufacturing and from organic chemistry to biotechnology, but also a valuable resource to graduate students to understand discovery and development process for peptide-based medicine.

Biologically Active Peptides

David B. Weiner,William V. Williams
Biologically Active Peptides Book PDF

Author : David B. Weiner,William V. Williams
Publisher : CRC Press
Page : 382 pages
File Size : 45,7 Mb
Release : 1993-11-04
Category : Medical
ISBN : 0877629358

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Biologically Active Peptides by David B. Weiner,William V. Williams Pdf

Investigation into basic and advanced peptide design, synthesis, evaluation and utilization. New therapeutic approaches from experimental systems.

Peptide Chemistry and Drug Design

Ben M. Dunn
Peptide Chemistry and Drug Design Book PDF

Author : Ben M. Dunn
Publisher : John Wiley & Sons
Page : 8 pages
File Size : 42,8 Mb
Release : 2015-03-09
Category : Medical
ISBN : 9780470317617

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Peptide Chemistry and Drug Design by Ben M. Dunn Pdf

This book focuses on peptides as drugs, a growing area of pharmaceutical research and development. It helps readers solve problems of discovering, developing, producing, and delivering peptide-based drugs. • Identifies promising new areas in peptide drug discovery • Includes chapters on discovery from natural sources, metabolic modification, and drug delivery • Overviews separation methods and techniques for analysis, bond formation, and purification • Offers readers both a professional reference and a text or resource for graduate-level students

De Novo Peptide Design

Vibin Ramakrishnan,Kirti Patel,Ruchika Goyal
De Novo Peptide Design Book PDF

Author : Vibin Ramakrishnan,Kirti Patel,Ruchika Goyal
Publisher : Academic Press
Page : 297 pages
File Size : 47,7 Mb
Release : 2022-09-17
Category : Science
ISBN : 9780323985437

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De Novo Peptide Design by Vibin Ramakrishnan,Kirti Patel,Ruchika Goyal Pdf

De novo Peptide Design: Principles and Applications presents the latest developments in the fields of therapeutic peptides and bio-nanotechnology. The title focuses on the design of peptides, particularly how peptides may be tailored to specific functions. It includes computational and experimental protocols to assist in the design of peptides. Sections cover the basics of protein and peptide structure, modeling and simulation, solid phase peptide synthesis, peptide-based antibiotics, drug delivery, peptide nanomaterials, aromatic interactions directing nano-assembly, protein/peptide aggregation, therapeutic interventions against protein/peptide aggregation diseases, peptide based hydrogels, computational tools and algorithms for peptide design, and experimental protocols in peptide chemistry. In addition, the book covers key aspects in peptide design, providing a solution for researchers working within the 'peptidic universe' to create new therapeutic agents. Gives comprehensive coverage, including peptide design, modeling, synthesis and applications Presents emerging topics in the design of peptide-based therapeutics Details the latest developments in the fields of therapeutic peptides and bio-nanotechnology Considers peptide design and the tailoring of peptides to specific functions Offers computational tools and algorithms for peptide design and experimental protocols for peptide chemistry

Pseudo-peptides in Drug Discovery

Peter E. Nielsen
Pseudo peptides in Drug Discovery Book PDF

Author : Peter E. Nielsen
Publisher : John Wiley & Sons
Page : 260 pages
File Size : 51,5 Mb
Release : 2004-04-02
Category : Science
ISBN : 3527306331

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Pseudo-peptides in Drug Discovery by Peter E. Nielsen Pdf

Peptides are among the most versatile bioactive molecules, yet the do not make good drugs, because they are quickly degraded or modified in the body. To overcome this problem, stable and at the same time biologically active pseudo-peptides have been developed. These novel compounds open up new perspectives in drug design by providing an entire range of highly specific and non-toxic pharmaceuticals. This is the first work devoted to the topic and draws together knowledge gained on different types of peptidomimetics and other pseudo-peptides with drug properties. As such, it includes peptoids, beta-peptides, polyamide DNA binders as well as peptide nucleic acids. The expert authors and editor discuss chemical properties and stability, biological activity and reactivity, as well as practical aspects of synthesis, making this a prime resource for drug developers and bioorganic chemists working with these compounds.

Peptide-based Drug Design

Michael D. Taylor
Peptide based Drug Design Book PDF

Author : Michael D. Taylor
Publisher : Wiley-VCH
Page : 600 pages
File Size : 54,9 Mb
Release : 1995-04-13
Category : Science
ISBN : UOM:39015035752792

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Peptide-based Drug Design by Michael D. Taylor Pdf

Peptide-based drugs resemble natural peptides in their activity and, thus, increased understanding of peptide transport and metabolism permit optimization of the delivery properties of these new therapeutic agents. After an introduction to basic advances in molecular biology, drug metabolism, and drug transport of amino acids and peptides, this volume deals with intestinal peptide transport, liver peptide transport, peptide delivery through the blood-brain barrier, peptide transport in microorganisms, approaches to limiting peptide metabolism, and experimental systems to evaluate peptide transport and metabolism. Annotation copyright by Book News, Inc., Portland, OR

Peptide-Based Drug Design

Laszlo Otvos
Peptide Based Drug Design Book PDF

Author : Laszlo Otvos
Publisher : Humana Press
Page : 0 pages
File Size : 40,7 Mb
Release : 2008-10-09
Category : Medical
ISBN : 1588299902

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Peptide-Based Drug Design by Laszlo Otvos Pdf

Due to their high specificity and low toxicity profile, peptides have once again become central to the development of new drugs. In Peptide-Based Drug Design: Methods and Protocols, expert researchers provide a handbook which offers a selection of research and production tools suitable for transforming a promising protein fragment or stand-alone native peptide into a pharmaceutically acceptable composition. The volume delves into contemporary, cutting-edge subjects such as hit isolation and target validation, computer-aided design, sequence modifications to satisfy pharmacologists, in vivo stability and imaging, and the actual production of difficult sequences. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include readily reproducible, step-by-step laboratory protocols, lists of materials, and the Notes section, which highlights tips on troubleshooting and avoiding known pitfalls. Comprehensive and up-to-date, Peptide-Based Drug Design: Methods and Protocols shows its subject to be an independent science on the rise, and provides scientists with a clear, concise guide for continuing this vital research.

Drug Design

Gerhard Klebe
Drug Design Book PDF

Author : Gerhard Klebe
Publisher : Springer
Page : 0 pages
File Size : 46,6 Mb
Release : 2013-07-10
Category : Medical
ISBN : 3642179061

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Drug Design by Gerhard Klebe Pdf

Unique work on structure-based drug design, covering multiple aspects of drug discovery and development. Fully colored, many images, computer animations of 3D structures (these only in electronic form). Makes the spatial aspects of interacting molecules clear to the reader, covers multiple applications and methods in drug design. Structures by mode of action, no therapeutic areas. Of high relevance for academia and industrial research. Focus on gene technology in drug design, omics-technologies computational methods experimental techniques of structure determination multiple examples on mode of action of current drugs, ADME-tox properties in drug development, QSAR methods, combinatorial chemistry, biologicals, ribosome, targeting protein-protein interfaces.