Protein Based Therapeutics

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Protein Therapeutics, 2 Volume Set

Tristan Vaughan,Jane Osbourn,Bahija Jallal
Protein Therapeutics 2 Volume Set Book PDF

Author : Tristan Vaughan,Jane Osbourn,Bahija Jallal
Publisher : John Wiley & Sons
Page : 762 pages
File Size : 40,7 Mb
Release : 2017-12-04
Category : Medical
ISBN : 9783527340866

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Protein Therapeutics, 2 Volume Set by Tristan Vaughan,Jane Osbourn,Bahija Jallal Pdf

In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal chemists and drug developers of all trades. Following an introduction tracing the rapid development of the protein therapeutics market over the last decade, all currently used therapeutic protein scaffolds are surveyed, from human and non-human antibodies to antibody mimetics, bispecific antibodies and antibody-drug conjugates. This ready reference then goes on to review other key aspects such as pharmacokinetics, safety and immunogenicity, manufacture, formulation and delivery. The handbook then takes a look at current key clinical applications for protein therapeutics, from respiratory and inflammation to oncology and immune-oncology, infectious diseases and rescue therapy. Finally, several exciting prospects for the future of protein therapeutics are highlighted and discussed.

Therapeutic Proteins

Vladimir Voynov,Justin A. Caravella
Therapeutic Proteins Book PDF

Author : Vladimir Voynov,Justin A. Caravella
Publisher : Humana Press
Page : 516 pages
File Size : 46,7 Mb
Release : 2016-05-01
Category : Medical
ISBN : 1493959492

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Therapeutic Proteins by Vladimir Voynov,Justin A. Caravella Pdf

Emphasizing the newest developments in the field, this volume presents detailed methodswith added emphasison therapeutic protein discovery. It features key tips and valuable implementation advice to ensure successful results."

Protein Therapeutics

Zuben E. Sauna,Chava Kimchi-Sarfaty
Protein Therapeutics Book PDF

Author : Zuben E. Sauna,Chava Kimchi-Sarfaty
Publisher : Springer
Page : 182 pages
File Size : 48,9 Mb
Release : 2017-07-19
Category : Science
ISBN : 9783319418186

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Protein Therapeutics by Zuben E. Sauna,Chava Kimchi-Sarfaty Pdf

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors

Protein-based Therapeutics

Dev Bukhsh Singh,Timir Tripathi
Protein based Therapeutics Book PDF

Author : Dev Bukhsh Singh,Timir Tripathi
Publisher : Springer Nature
Page : 387 pages
File Size : 53,6 Mb
Release : 2023-03-01
Category : Psychology
ISBN : 9789811982491

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Protein-based Therapeutics by Dev Bukhsh Singh,Timir Tripathi Pdf

This book provides an overview of the essential characteristics and clinical applications of therapeutic proteins against human diseases, including cancers, immune disorders, infections, and other diseases. It presents the latest advancements in protein engineering techniques for producing desirable therapeutic proteins. The book also covers the strategies used to formulate and deliver systemic therapeutic proteins, approved protein therapeutics and their targets, and pharmacogenetic biomarkers. Further, it discusses challenges associated with the clinical implications of therapeutic proteins, including safety, immunogenicity, protein stability, degradation, and efficacy. It illustrates the development of biosimilar antibodies, optimization strategies for producing biobetter antibodies, and presents fundamental concepts about biosuperior therapeutics. Lastly, it includes a discussion about protein-based vaccines against bacterial and viral infections.

Characterization of Protein Therapeutics using Mass Spectrometry

Guodong Chen
Characterization of Protein Therapeutics using Mass Spectrometry Book PDF

Author : Guodong Chen
Publisher : Springer Science & Business Media
Page : 404 pages
File Size : 55,9 Mb
Release : 2014-07-08
Category : Science
ISBN : 9781441978622

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Characterization of Protein Therapeutics using Mass Spectrometry by Guodong Chen Pdf

This book highlights current approaches and future trends in the use of mass spectrometry to characterize protein therapies. As one of the most frequently utilized analytical techniques in pharmaceutical research and development, mass spectrometry has been widely used in the characterization of protein therapeutics due to its analytical sensitivity, selectivity, and specificity. This book begins with an overview of mass spectrometry techniques as related to the analysis of protein therapeutics, structural identification strategies, quantitative approaches, followed by studies involving characterization of process related protein drug impurities/degradants, metabolites, higher order structures of protein therapeutics. Both general practitioners in pharmaceutical research and specialists in analytical sciences will benefit from this book that details step-by-step approaches and new strategies to solve challenging problems related to protein therapeutics research and development.

Formulation, Characterization, and Stability of Protein Drugs

Rodney Pearlman,Y. John Wang
Formulation Characterization and Stability of Protein Drugs Book PDF

Author : Rodney Pearlman,Y. John Wang
Publisher : Springer Science & Business Media
Page : 432 pages
File Size : 48,5 Mb
Release : 2006-04-11
Category : Medical
ISBN : 9780306474521

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Formulation, Characterization, and Stability of Protein Drugs by Rodney Pearlman,Y. John Wang Pdf

Leading scientists offer detailed profiles of ten protein drugs currently in development. The case histories of these important new compounds are described from the perspective of their formulation, characterization, and stability. This ready reference also features recent data and an abundance of previously unpublished information. The in-depth coverage includes a highly useful compendium of degradation sites occurring in over 70 proteins. An invaluable aid in the rapid identification of potential `hot spots' in proteins, this accessible compilation allows for inspection of the protein's primary structure and preparation of a hydroflex plot.

Recombinant Protein Drugs

P. Buckel
Recombinant Protein Drugs Book PDF

Author : P. Buckel
Publisher : Springer Science & Business Media
Page : 226 pages
File Size : 41,9 Mb
Release : 2001-08-01
Category : Medical
ISBN : 3764359048

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Recombinant Protein Drugs by P. Buckel Pdf

Recombinant protein drugs are intimately associated with the impressive success story of the Biotech Industry during the past thirty years, some of them belonging to the most successful pharmaceutical products. More than thirty different proteins are available for a variety of clinical applications, over 300 proteins are presently being evaluated in clinical trials. In this new volume of the MDT series, historical, technical and clinical aspects of recombinant protein drug discovery and development are presented, covering past, present and future highlights. Leading scientists and co-founders of early Biotech companies describe technical breakthroughs and the fascinating story of pioneering discoveries, as well as the long way of translating them into products and business. Therefore, this book represents an exciting documentation of the beginning of a new era in the pharmaceutical industry. In addition, scientists from basic research, clinic and industry actively involved in new developments discuss...

Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics

Allan Matte
Approaches to the Purification Analysis and Characterization of Antibody Based Therapeutics Book PDF

Author : Allan Matte
Publisher : Elsevier
Page : 222 pages
File Size : 42,8 Mb
Release : 2020-09-07
Category : Business & Economics
ISBN : 9780081030196

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Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics by Allan Matte Pdf

Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book. Covers the vital new area of R&D on therapeutic antibodies Written by leading scientists and researchers Up-to-date coverage and includes a detailed bibliography

Protein Therapeutics

Tristan Vaughan,Jane Osbourn,Bahija Jallal
Protein Therapeutics Book PDF

Author : Tristan Vaughan,Jane Osbourn,Bahija Jallal
Publisher : John Wiley & Sons
Page : 480 pages
File Size : 49,9 Mb
Release : 2017-07-28
Category : Medical
ISBN : 9783527699131

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Protein Therapeutics by Tristan Vaughan,Jane Osbourn,Bahija Jallal Pdf

In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal chemists and drug developers of all trades. Following an introduction tracing the rapid development of the protein therapeutics market over the last decade, all currently used therapeutic protein scaffolds are surveyed, from human and non-human antibodies to antibody mimetics, bispecific antibodies and antibody-drug conjugates. This ready reference then goes on to review other key aspects such as pharmacokinetics, safety and immunogenicity, manufacture, formulation and delivery. The handbook then takes a look at current key clinical applications for protein therapeutics, from respiratory and inflammation to oncology and immune-oncology, infectious diseases and rescue therapy. Finally, several exciting prospects for the future of protein therapeutics are highlighted and discussed.

Emerging Nanotechnologies for Diagnostics, Drug Delivery and Medical Devices

Ashim K Mitra,Kishore Cholkar,Abhirup Mandal
Emerging Nanotechnologies for Diagnostics Drug Delivery and Medical Devices Book PDF

Author : Ashim K Mitra,Kishore Cholkar,Abhirup Mandal
Publisher : William Andrew
Page : 416 pages
File Size : 40,7 Mb
Release : 2017-02-13
Category : Medical
ISBN : 9780323429979

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Emerging Nanotechnologies for Diagnostics, Drug Delivery and Medical Devices by Ashim K Mitra,Kishore Cholkar,Abhirup Mandal Pdf

Emerging Nanotechnologies for Diagnostics, Drug Delivery and Medical Devices covers the modern micro and nanotechnologies used for diagnosis, drug delivery, and theranostics using micro, nano, and implantable systems. In-depth coverage of all aspects of disease treatment is included. In addition, the book covers cutting-edge research and technology that will help readers gain knowledge of novel approaches and their applications to improve drug/agent specificity for diagnosis and efficient disease treatment. It is a comprehensive guide for medical specialists, the pharmaceutical-industry, and academic researchers discussing the impact of nanotechnology on diagnosis, drug delivery, and theranostics. Gives readers working in immunology, drug delivery, and medicine a greater awareness on how novel nanotechnology orientated methods can help improve treatment Provides readers with backgrounds in nanotechnology, chemistry, and materials science an understanding on how nanotechnology is used in immunology and drug delivery Includes focused coverage of the use of nanodevices in diagnostics, therapeutics, and theranostics not offered by other books

Antibody Drug Discovery

Clive R. Wood
Antibody Drug Discovery Book PDF

Author : Clive R. Wood
Publisher : World Scientific
Page : 490 pages
File Size : 43,9 Mb
Release : 2012
Category : Medical
ISBN : 9781848166288

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Antibody Drug Discovery by Clive R. Wood Pdf

Antibody-based therapeutics are a central driver of the success of biopharmaceuticals. The discovery technology of this field is isolated to a limited number of centers of excellence in industry and academia. The objective of this volume is to provide a series of guides to those evaluating and preparing to enter particular areas within the field. Each chapter is written with a historical perspective that sets into context the significance of the key developments, and with the provision of “points to consider” for the reader as a value-added feature of the volume. All contributors are experts in their fields and have played pivotal roles in the creation of the technology.

Production of Plasma Proteins for Therapeutic Use

Joseph Bertolini,Neil Goss,John Curling
Production of Plasma Proteins for Therapeutic Use Book PDF

Author : Joseph Bertolini,Neil Goss,John Curling
Publisher : John Wiley & Sons
Page : 518 pages
File Size : 48,8 Mb
Release : 2012-12-26
Category : Medical
ISBN : 9780470924310

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Production of Plasma Proteins for Therapeutic Use by Joseph Bertolini,Neil Goss,John Curling Pdf

Sets forth the state of the science and technology in plasma protein production With contributions from an international team of eighty leading experts and pioneers in the field, Production of Plasma Proteins for Therapeutic Use presents a comprehensive overview of the current state of knowledge about the function, use, and production of blood plasma proteins. In addition to details of the operational requirements for the production of plasma derivatives, the book describes the biology, development, research, manufacture, and clinical indications of essentially all plasma proteins with established clinical use or therapeutic potential. Production of Plasma Proteins for Therapeutic Use covers the key aspects of the plasma fractionation industry in five sections: Section 1: Introduction to Plasma Fractionation initially describes the history of transfusion and then covers the emergence of plasma collection and fractionation from its earliest days to the present time, with the commercial and not-for-profit sectors developing into a multi-billion dollar industry. Section 2: Plasma Proteins for Therapeutic Use contains 24 chapters dedicated to specific plasma proteins, including coagulation factors, albumin, immunoglobulin, and a comprehensive range of other plasma-derived proteins with therapeutic indications. Each chapter discusses the physiology, biochemistry, mechanism of action, and manufacture of each plasma protein including viral safety issues and clinical uses. Section 3: Pathogen Safety of Plasma Products examines issues and procedures for enhancing viral safety and reducing the risk of transmissible spongiform encephalopathy transmission. Section 4: The Pharmaceutical Environment Applied to Plasma Fractionation details the requirements and activities associated with plasma collection, quality assurance, compliance with regulatory requirements, provision of medical affairs support, and the manufacture of plasma products. Section 5: The Market for Plasma Products and the Economics of Fractionation reviews the commercial environment and economics of the plasma fractionation industry including future trends, highlighting regions such as Asia, which have the potential to exert a major influence on the plasma fractionation industry in the twenty-first century.

ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins

Honghui Zhou,Frank-Peter Theil
ADME and Translational Pharmacokinetics Pharmacodynamics of Therapeutic Proteins Book PDF

Author : Honghui Zhou,Frank-Peter Theil
Publisher : John Wiley & Sons
Page : 472 pages
File Size : 45,9 Mb
Release : 2015-10-26
Category : Medical
ISBN : 9781118898802

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ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins by Honghui Zhou,Frank-Peter Theil Pdf

With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. • Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs • Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective • Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines • Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan • Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain

Fusion Protein Technologies for Biopharmaceuticals

Stefan R. Schmidt
Fusion Protein Technologies for Biopharmaceuticals Book PDF

Author : Stefan R. Schmidt
Publisher : John Wiley & Sons
Page : 995 pages
File Size : 44,6 Mb
Release : 2013-01-28
Category : Medical
ISBN : 9781118354582

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Fusion Protein Technologies for Biopharmaceuticals by Stefan R. Schmidt Pdf

The state of the art in biopharmaceutical FUSION PROTEIN DESIGN Fusion proteins belong to the most lucrative biotech drugs—with Enbrel® being one of the best-selling biologics worldwide. Enbrel® represents a milestone of modern therapies just as Humulin®, the first therapeutic recombinant protein for human use, approved by the FDA in 1982 and Orthoclone® the first monoclonal antibody reaching the market in 1986. These first generation molecules were soon followed by a plethora of recombinant copies of natural human proteins, and in 1998, the first de novo designed fusion protein was launched. Fusion Protein Technologies for Biopharmaceuticals examines the state of the art in developing fusion proteins for biopharmaceuticals, shedding light on the immense potential inherent in fusion protein design and functionality. A wide pantheon of international scientists and researchers deliver a comprehensive and complete overview of therapeutic fusion proteins, combining the success stories of marketed drugs with the dynamic preclinical and clinical research into novel drugs designed for as yet unmet medical needs. The book covers the major types of fusion proteins—receptor-traps, immunotoxins, Fc-fusions and peptibodies—while also detailing the approaches for developing, delivering, and improving the stability of fusion proteins. The main body of the book contains three large sections that address issues key to this specialty: strategies for extending the plasma half life, the design of toxic proteins, and utilizing fusion proteins for ultra specific targeting. The book concludes with novel concepts in this field, including examples of highly relevant multifunctional antibodies. Detailing the innovative science, commercial realities, and brilliant potential of fusion protein therapeutics, Fusion Protein Technologies for Biopharmaceuticals is a must for pharmaceutical scientists, biochemists, medicinal chemists, molecular biologists, pharmacologists, and genetic engineers interested in determining the shape of innovation in the world of biopharmaceuticals.

Immunogenicity of Proteins Used as Therapeutics

Amy Rosenberg,Zuben E. Sauna,Bernard Maillere,Susan Richards,Elizabeth C. Jury
Immunogenicity of Proteins Used as Therapeutics Book PDF

Author : Amy Rosenberg,Zuben E. Sauna,Bernard Maillere,Susan Richards,Elizabeth C. Jury
Publisher : Frontiers Media SA
Page : 328 pages
File Size : 45,8 Mb
Release : 2020-12-28
Category : Medical
ISBN : 9782889662883

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Immunogenicity of Proteins Used as Therapeutics by Amy Rosenberg,Zuben E. Sauna,Bernard Maillere,Susan Richards,Elizabeth C. Jury Pdf

Topic Editor Susan Richards is an employee of Sanofi and owns stock in the corporation. Topic Editor Bernard Maillere declares economic support from pharmaceutical companies (Novartis, Sanofi, and UCB) in the frame of collaborations aiming to evaluate the recognition by human T cells of therapeutic proteins and antibodies.