Pseudo Peptides In Drug Discovery

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Pseudo-peptides in Drug Discovery

Peter E. Nielsen
Pseudo peptides in Drug Discovery Book PDF

Author : Peter E. Nielsen
Publisher : John Wiley & Sons
Page : 256 pages
File Size : 43,5 Mb
Release : 2006-03-06
Category : Science
ISBN : 9783527605699

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Pseudo-peptides in Drug Discovery by Peter E. Nielsen Pdf

Peptides are among the most versatile bioactive molecules, yet the do not make good drugs, because they are quickly degraded or modified in the body. To overcome this problem, stable and at the same time biologically active pseudo-peptides have been developed. These novel compounds open up new perspectives in drug design by providing an entire range of highly specific and non-toxic pharmaceuticals. This is the first work devoted to the topic and draws together knowledge gained on different types of peptidomimetics and other pseudo-peptides with drug properties. As such, it includes peptoids, beta-peptides, polyamide DNA binders as well as peptide nucleic acids. The expert authors and editor discuss chemical properties and stability, biological activity and reactivity, as well as practical aspects of synthesis, making this a prime resource for drug developers and bioorganic chemists working with these compounds.

Peptidomimetics in Organic and Medicinal Chemistry

Antonio Guarna,Andrea Trabocchi
Peptidomimetics in Organic and Medicinal Chemistry Book PDF

Author : Antonio Guarna,Andrea Trabocchi
Publisher : John Wiley & Sons
Page : 334 pages
File Size : 48,9 Mb
Release : 2014-03-14
Category : Science
ISBN : 9781118683149

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Peptidomimetics in Organic and Medicinal Chemistry by Antonio Guarna,Andrea Trabocchi Pdf

A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.

Peptide Drug Discovery and Development

Miguel Castanho,Nuno Santos
Peptide Drug Discovery and Development Book PDF

Author : Miguel Castanho,Nuno Santos
Publisher : John Wiley & Sons
Page : 547 pages
File Size : 41,7 Mb
Release : 2011-10-24
Category : Medical
ISBN : 9783527636747

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Peptide Drug Discovery and Development by Miguel Castanho,Nuno Santos Pdf

Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the "bench to bedside" translational approach to drug development. Clearly structured into three major parts, the book stakes out the boundaries of peptide drug development in the preclinical as well as clinical stages. The first part provides a general background and focuses on the characteristic strengths and weaknesses of peptide drugs. The second section contains five cases studies of peptides from diverse therapeutic fields, and the lessons to be learned from them, while the final part looks at new targets and opportunities, discussing several drug targets and diseases for which peptide drugs are currently being developed.

Protein and Peptide Mass Spectrometry in Drug Discovery

Michael L. Gross,Guodong Chen,Birendra Pramanik
Protein and Peptide Mass Spectrometry in Drug Discovery Book PDF

Author : Michael L. Gross,Guodong Chen,Birendra Pramanik
Publisher : John Wiley & Sons
Page : 484 pages
File Size : 49,8 Mb
Release : 2011-09-26
Category : Medical
ISBN : 9781118116548

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Protein and Peptide Mass Spectrometry in Drug Discovery by Michael L. Gross,Guodong Chen,Birendra Pramanik Pdf

The book that highlights mass spectrometry and its application in characterizing proteins and peptides in drug discovery An instrumental analytical method for quantifying the mass and characterization of various samples from small molecules to large proteins, mass spectrometry (MS) has become one of the most widely used techniques for studying proteins and peptides over the last decade. Bringing together the work of experts in academia and industry, Protein and Peptide Mass Spectrometry in Drug Discovery highlights current analytical approaches, industry practices, and modern strategies for the characterization of both peptides and proteins in drug discovery. Illustrating the critical role MS technology plays in characterizing target proteins and protein products, the methods used, ion mobility, and the use of microwave radiation to speed proteolysis, the book also covers important emerging applications for neuroproteomics and antigenic peptides. Placing an emphasis on the pharmaceutical industry, the book stresses practice and applications, presenting real-world examples covering the most recent advances in mass spectrometry, and providing an invaluable resource for pharmaceutical scientists in industry and academia, analytical and bioanalytical chemists, and researchers in protein science and proteomics.

Peptide-based Drug Discovery

Ved Srivastava
Peptide based Drug Discovery Book PDF

Author : Ved Srivastava
Publisher : Royal Society of Chemistry
Page : 589 pages
File Size : 43,8 Mb
Release : 2017-06-26
Category : Science
ISBN : 9781782627326

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Peptide-based Drug Discovery by Ved Srivastava Pdf

With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies. What does it take to develop a peptide-based medicine? What are the key challenges and how are they overcome? What are emerging therapeutics for peptide modalities? This book answers these questions with a holistic story from molecules to medicine, combining the themes of design, synthesis and clinical applications of peptide-based therapeutics and biomarkers. Chapters are written and edited by leaders in the field from industry and academia and they cover the pharmacokinetics of peptide therapeutics, attributes necessary for commercially successful metabolic peptides, medicinal chemistry strategies for the design of peptidase-resistant peptide analogues, disease classes for which peptide therapeutic are most relevant, and regulatory issues and guidelines. The critical themes covered provide essential background information on what it takes to develop peptide-based medicine from a chemistry perspective and views on the future of peptide drugs. This book will be a valuable resource not only as a reference book for the researcher engaged in academic and pharmaceutical setting, from basic research to manufacturing and from organic chemistry to biotechnology, but also a valuable resource to graduate students to understand discovery and development process for peptide-based medicine.

Peptide Chemistry and Drug Design

Ben M. Dunn
Peptide Chemistry and Drug Design Book PDF

Author : Ben M. Dunn
Publisher : John Wiley & Sons
Page : 8 pages
File Size : 47,6 Mb
Release : 2015-03-09
Category : Medical
ISBN : 9780470317617

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Peptide Chemistry and Drug Design by Ben M. Dunn Pdf

This book focuses on peptides as drugs, a growing area of pharmaceutical research and development. It helps readers solve problems of discovering, developing, producing, and delivering peptide-based drugs. • Identifies promising new areas in peptide drug discovery • Includes chapters on discovery from natural sources, metabolic modification, and drug delivery • Overviews separation methods and techniques for analysis, bond formation, and purification • Offers readers both a professional reference and a text or resource for graduate-level students

Peptide Therapeutics

Ved Srivastava
Peptide Therapeutics Book PDF

Author : Ved Srivastava
Publisher : Royal Society of Chemistry
Page : 572 pages
File Size : 45,6 Mb
Release : 2019-08-28
Category : Science
ISBN : 9781788014335

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Peptide Therapeutics by Ved Srivastava Pdf

Peptide therapy has become a key strategy in innovative drug development, however, one of the potential barriers for the development of novel peptide drugs in the clinic is their deficiencies in clearly defined chemistry, manufacturing and controls (CMC) strategy from clinical development to commercialization. CMC can often become a rate-limiting step due to lack of knowledge and lack of a formal policy or guidelines on CMC for peptide-based drugs. Regulators use a risk-based approach, reviewing applications on a case-by-case basis. Peptide Therapeutics: Strategy and Tactics for Chemistry, Manufacturing, and Controls covers efficient manufacturing of peptide drug substances, a review of the process for submitting applications to the regulatory authority for drug approval, a holistic approach for quality attributes and quality control from a regulatory perspective, emerging analytical tools for the characterisation of impurities, and the assessment of stability. This book is an essential reference work for students and researchers, in both academia and industry, with an interest in learning about CMC, and facilitating development and manufacture of peptide-based drugs.

Peptide and Peptidomimetic Therapeutics

Nir Qvit,Samuel J.S. Rubin
Peptide and Peptidomimetic Therapeutics Book PDF

Author : Nir Qvit,Samuel J.S. Rubin
Publisher : Academic Press
Page : 792 pages
File Size : 48,5 Mb
Release : 2022-09-22
Category : Science
ISBN : 9780128204474

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Peptide and Peptidomimetic Therapeutics by Nir Qvit,Samuel J.S. Rubin Pdf

Peptide and Peptidomimetic Therapeutics: From Bench to Beside offers applied, evidence-based instruction on developing and applying peptide therapeutics in disease treatment, driving drug discovery, and improving patient care. Here, researchers, clinicians and students will find tools to harness the full power of peptides and peptidomimetics and improve bioavailability, stability, efficiency and selectivity of new therapeutics and their application in treatment plans. More than 20 leaders in the field share their approaches for identifying and advancing peptide and peptidomimetic therapeutics. Topics examined run from "bench to bedside," beginning with fundamental peptide science, protein-protein interactions and peptide synthesis. Later chapters examine modes for peptide drug delivery, including cell penetration peptide and peptidomimetic delivery, as well as the targeting of specific disease types, peptide therapeutics as applied to infectious disease, cancer, metabolic disorders, neurodegenerative disorders, and skin disorders, and antiparasitic and immunosuppressive peptidomimetics. Helps researchers and clinicians harness the full of power of peptides and peptidomimetics in their daily work and drug discovery Features chapters running from “bench to bedside , providing a thorough grounding in fundamental peptide science, drug delivery methods, and targeting of specific disease types Features chapter contributions from international leaders in peptide science and drug development

Cyclic Peptides

Jesko Koehnke,James Naismith,Wilfred A van der Donk
Cyclic Peptides Book PDF

Author : Jesko Koehnke,James Naismith,Wilfred A van der Donk
Publisher : Royal Society of Chemistry
Page : 392 pages
File Size : 41,9 Mb
Release : 2017-12-15
Category : Science
ISBN : 9781782625285

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Cyclic Peptides by Jesko Koehnke,James Naismith,Wilfred A van der Donk Pdf

This book provides the reader with a comprehensive view of the state-of-the-art of cyclic peptides, from construction to utility in biology and drug discovery.

Peptide and Protein Design for Biopharmaceutical Applications

Knud Jensen
Peptide and Protein Design for Biopharmaceutical Applications Book PDF

Author : Knud Jensen
Publisher : John Wiley & Sons
Page : 306 pages
File Size : 51,7 Mb
Release : 2009-09-01
Category : Science
ISBN : 0470749717

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Peptide and Protein Design for Biopharmaceutical Applications by Knud Jensen Pdf

Peptides serve as effective drugs in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this researchers are developing new methods to create ‘tailor-made’ peptides and proteins with improved pharmacological properties. Design of Peptides and Proteins provides an overview of the experimental and computational methods for peptide and protein design, with an emphasis on specific applications for therapeutics and biomedical research. Topics covered include: Computer modeling of peptides and proteins Peptidomimetics Design and synthesis of cyclic peptides Carbohydrates in peptide and protein design De novo design of peptides and proteins Medical development applications An extended case study – the design of insulin variants Design of Peptides and Proteins presents the state-of-the-art of this exciting approach for therapeutics, with contributions from international experts. It is an essential resource for academic and industrial scientists in the fields of peptide and protein drug design, biomedicine, biochemistry, biophysics, molecular modelling, synthetic organic chemistry and medicinal/pharmaceutical chemistry.

Practical Medicinal Chemistry with Macrocycles

Eric Marsault,Mark L. Peterson
Practical Medicinal Chemistry with Macrocycles Book PDF

Author : Eric Marsault,Mark L. Peterson
Publisher : John Wiley & Sons
Page : 617 pages
File Size : 45,6 Mb
Release : 2017-09-12
Category : Science
ISBN : 9781119092568

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Practical Medicinal Chemistry with Macrocycles by Eric Marsault,Mark L. Peterson Pdf

Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts. Provides needed background to build a program in macrocycle drug discovery –design criteria, macrocycle profiles, applications, and limitations Features chapters contributed from leading international figures involved in macrocyclic drug discovery efforts Covers design criteria, typical profile of current macrocycles, applications, and limitations

Peptide Libraries

Ratmir Derda
Peptide Libraries Book PDF

Author : Ratmir Derda
Publisher : Humana
Page : 0 pages
File Size : 46,6 Mb
Release : 2016-09-24
Category : Science
ISBN : 1493946420

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Peptide Libraries by Ratmir Derda Pdf

This volume provides an overview of modern and emerging methods for production, analysis, and utility of peptide libraries. Chapter focus on methods and techniques for synthesis, genetic expression, hybrid synthesis-expression, examples of modern utility of these libraries, de novo discovery of reactions, hybrid organic-inorganic materials and, emerging tools for the analysis of these libraries by method of genetic selection and next-generation sequencing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Peptide Libraries: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies.

Solid-Phase Peptide Synthesis

Gregg B. Fields
Solid Phase Peptide Synthesis Book PDF

Author : Gregg B. Fields
Publisher : Academic Press
Page : 828 pages
File Size : 47,8 Mb
Release : 1997-10-21
Category : Medical
ISBN : UVA:X004150724

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Solid-Phase Peptide Synthesis by Gregg B. Fields Pdf

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volumehas been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 275 volumes have been published (all of them still in print) and much of the material is relevant even today-truly an essential publication for researchers in all fields of life sciences. Key Features * Solid-phase peptide synthesis * Applications of peptides for structural and biological studies * Characterization of synthetic peptides

Introduction to Peptide Science

Ian W. Hamley
Introduction to Peptide Science Book PDF

Author : Ian W. Hamley
Publisher : John Wiley & Sons
Page : 240 pages
File Size : 43,8 Mb
Release : 2020-06-08
Category : Science
ISBN : 9781119698180

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Introduction to Peptide Science by Ian W. Hamley Pdf

Provides an interdisciplinary introduction to peptide science, covering their properties and synthesis, as well as many contemporary applications Peptides are biomolecules comprised of amino acids which play an important role in modulating many physiological processes in our body. This book presents an interdisciplinary approach and general introduction to peptide science, covering contemporary topics including their applicability in therapeutics, peptide hormones, amyloid structures, self-assembled structures, hydrogels, and peptide conjugates including lipopeptides and polymer-peptide conjugates. In addition, it discusses basic properties and synthesis clearly and concisely. Taking a logical approach to the subject, Introduction to Peptide Science gives readers the fundamental knowledge that is required to understand the cutting-edge material which comes later in the book. It offers readers in-depth chapter coverage of the basic properties of peptides; synthesis; amyloid and peptide aggregate structures; antimicrobial peptides and cell-penetrating peptides; and peptide therapeutics and peptide hormones. Introduces readers to peptide science, including synthesis and properties Provides unique content covering properties, synthesis, self-assembly, aggregation, and applications Summarizes contemporary topics in an accessible fashion including applications in therapeutics, peptide hormones, amyloid structures, self-assembled structures, hydrogels, and peptide conjugates including lipopeptides Presented at an introductory level for the benefit of students and researchers who are new to the subject Introduction to Peptide Science is an ideal text for undergraduate students of chemistry, biochemistry, and other related biological subjects, and will be a valuable resource for postgraduate students and researchers involved in peptide science and its applications.

DNA-targeting Molecules as Therapeutic Agents

Michael J Waring
DNA targeting Molecules as Therapeutic Agents Book PDF

Author : Michael J Waring
Publisher : Royal Society of Chemistry
Page : 432 pages
File Size : 47,7 Mb
Release : 2018-03-08
Category : Science
ISBN : 9781788014281

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DNA-targeting Molecules as Therapeutic Agents by Michael J Waring Pdf

There have been remarkable advances towards discovering agents that exhibit selectivity and sequence-specificity for DNA, as well as understanding the interactions that underlie its propensity to bind molecules. This progress has important applications in many areas of biotechnology and medicine, notably in cancer treatment as well as in future gene targeting therapies. The editor and contributing authors are leaders in their fields and provide useful perspectives from diverse and interdisciplinary backgrounds on the current status of this broad area. The role played by chemistry is a unifying theme. Early chapters cover methodologies to evaluate DNA-interactive agents and then the book provides examples of DNA-interactive molecules and technologies in development as therapeutic agents. DNA-binding metal complexes, peptide and polyamide–DNA interactions, and gene targeting tools are some of the most compelling topics treated in depth. This book will be a valuable resource for postgraduate students and researchers in chemical biology, biochemistry, structural biology and medicinal fields. It will also be of interest to supramolecular chemists and biophysicists.