Recent Advances In Medicinal Chemistry

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Recent Advances in Medicinal Chemistry

Author : Atta-ur-Rahman,Muhammad Iqbal Choudhary,George Perry
Publisher : Elsevier
Page : 486 pages
File Size : 45,6 Mb
Release : 2015-06-16
Category : Science
ISBN : 9780128039625

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Recent Advances in Medicinal Chemistry by Atta-ur-Rahman,Muhammad Iqbal Choudhary,George Perry Pdf

Originally published by Bentham and now distributed by Elsevier, Recent Advances in Medicinal Chemistry, Volume 1 covers leading-edge research and recent developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. The fourteen updated reviews include unique experimental data and references, and each article highlights an important topic in current medicinal chemistry research. Topics covered include: aureolic acid group of anti-cancer antibiotics and non-steroidal anti-inflammatory drugs; aromatase inhibitors in adjuvant endocrine treatment of early-stage breast cancer in postmenopausal women; Rho GTPases and statins in targeting and developing therapies for tumors; and more. Edited and written by leading experts in medicinal chemistry research Reviews recent advances in the field, including the characterization of inorganic nanomaterials as therapeutic vehicles Covers a variety of topical areas, such as HPLC and in the analysis of tricyclic antidepressants in biological samples, and tannins and their influence on health

Advances in Medicinal Chemistry

Author : B.E. Maryanoff,A.B. Reitz
Publisher : Elsevier
Page : 321 pages
File Size : 47,6 Mb
Release : 1999-04-01
Category : Science
ISBN : 0080526373

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Advances in Medicinal Chemistry by B.E. Maryanoff,A.B. Reitz Pdf

Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.

Recent Advances in Medicinal Chemistry

Author : Atta-ur-Rahman,Muhammad Iqbal Choudhary,George Perry
Publisher : Bentham Science Publishers
Page : 194 pages
File Size : 54,9 Mb
Release : 2015-12-01
Category : Science
ISBN : 9781681081717

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Recent Advances in Medicinal Chemistry by Atta-ur-Rahman,Muhammad Iqbal Choudhary,George Perry Pdf

Recent Advances in Medicinal Chemistry is a book series focused on leading-edge research on developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. The series presents highly cited contributions first published in the impact factor journal Mini-Reviews in Medicinal Chemistry. Contributors to this volume have updated their work with new experimental data and references following their initial research. Each volume highlights a number of important topics in current research in medicinal chemistry. Selected chapters in this volume include: - A brief review of polyphenols as phytotherapeutic agents - Flavonoids in foods and biological samples - Cannabinoid use in treating Parkinson’s Disease symptoms … And much more.

Advances in Medicinal Chemistry Research

Author : Edeildo Ferreira Da Silva, Jr.
Publisher : Unknown
Page : 366 pages
File Size : 47,8 Mb
Release : 2019-10-15
Category : Electronic
ISBN : 1536163686

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Advances in Medicinal Chemistry Research by Edeildo Ferreira Da Silva, Jr. Pdf

Advances in Medicinal Chemistry Research is a book addressed to undergraduate and postgraduate students, where recent advances in the discovery and development of effective agents against the most remarkable wide-reaching diseases are presented, divided into seven chapters. This first edition of Advances in Medicinal Chemistry Research offers insights into medicinal chemistry that arguably have the most significant impact on our lives than any other. It draws together research on therapeutic agents from natural, synthetic, and virtual screening sources as starting points for the design of drugs against obesity, multidrug-resistant bacteria, neglected tropical diseases, Alzheimer, and cancer. From the prediction of promising hits and identification of active compounds to the extraction of more complex molecules, this book explores a range of essential topics to support the development of novel, economical, and efficacious therapeutics for these diseases, which currently affect a billion people worldwide. Beginning with an overview of obesity, showing the current research landscape, the books shows the importance of natural and synthetic products as promising anti-obesity agents. Subsequently, the medicinal chemistry of modulation of bacterial resistance is presented, focusing on the MFS, RND, ABC, and MATE superfamilies. The book goes on to discuss such topics as antituberculosis, antileishmanial, and anti-hepatitis thiophene-containing compounds, under the medicinal chemistry point of view. Also, potent human glutaminyl cyclase inhibitors are deeply discussed and displayed as hopeful anti-Alzheimer's agents. The last three chapters are focused on the development of researches involving new anticancer agents, initializing with LBDD, SBDD, QSAR, and QM/MM methods applied to the identification of novel promising anticancer compounds. Moreover, IDO1 inhibitors are exhaustively explored and analyzed as a new promise for the immunotherapy of cancer. Finally, a great update on Eg5 kinesin inhibitors is provided, exploring different chemical classes of synthetic and natural compounds, including miscellanea as a new approach for Eg5 inhibition. Combining the expertise of researchers from around the world, this volume aims to support and encourage researches for the development of novel, safe, and active agents against lipase enzyme, bacteria, neglected tropical diseases, Alzheimer, and cancer. The clear narrative truly engages the reader, holding their attention right from the opening of a chapter, and maintaining interest and understanding as a chapter leads into more complex material. Advances in Medicinal Chemistry Research is a book that reviews ongoing developments and recent cutting-edge advances in medicinal chemistry of the most relevant diseases found nowadays, underlining how medicinal chemistry research continues to make significant contributions to the discovery and development of new therapeutic entities. Key Features â¢Chapters written by active specialists and leading experts deeply engaged in the research field of most deadly and limiting diseases for drug discovery. â¢Draws together cutting-edge research advances in medicinal chemistry focused at the obesity, multidrug-resistant microorganisms, Alzheimer, and cancer in a single volume. â¢Highlights the future potential of researches for the medicinal chemistry of most impactful diseases today. â¢Contents addressed to medicinal chemistry, biochemistry, biology, and pharmacy students, professors, and researchers.

The Practice of Medicinal Chemistry

Author : Camille Georges Wermuth,David Aldous,Pierre Raboisson,Didier Rognan
Publisher : Elsevier
Page : 903 pages
File Size : 40,6 Mb
Release : 2015-07-01
Category : Science
ISBN : 9780124172135

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The Practice of Medicinal Chemistry by Camille Georges Wermuth,David Aldous,Pierre Raboisson,Didier Rognan Pdf

The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research An image bank is available for instructors at www.textbooks.elsevier.com

Progress in Medicinal Chemistry

Author : Anonim
Publisher : Elsevier
Page : 276 pages
File Size : 42,8 Mb
Release : 1975-01-01
Category : Medical
ISBN : 0080862594

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Progress in Medicinal Chemistry by Anonim Pdf

Progress in Medicinal Chemistry

Progress in Medicinal Chemistry

Author : Anonim
Publisher : Elsevier
Page : 260 pages
File Size : 41,9 Mb
Release : 2016-02-01
Category : Science
ISBN : 9780444637420

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Progress in Medicinal Chemistry by Anonim Pdf

Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume includes chapters covering recent advances in cancer therapeutics, fluorine in medicinal chemistry, a perspective on the next generation of antibacterial agents derived by manipulation of natural products, a new era for Chagas Disease drug discovery? and imaging in drug development. Extended timely reviews of topics in medicinal chemistry Targets and technologies relevant to the discovery of tomorrow’s drugs Analyses of successful drug discovery programmes

Lead Molecules from Natural Products

Author : Anonim
Publisher : Elsevier
Page : 448 pages
File Size : 44,5 Mb
Release : 2006-07-07
Category : Science
ISBN : 0080459331

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Lead Molecules from Natural Products by Anonim Pdf

Lead Molecules from Natural Products: Discovery and New Trends provides the reader with a thorough overview of current discoveries and trends in Natural Products research. This book consists of 22 chapters from well known scientists all over the world, with topics ranging from Natural Product Chemistry and Phytochemistry in their most basic form, to Molecular Biology and in silico drug design. Contributors describe their own laboratory experiences, revealing their findings, the legal issues encountered. The chapters, all of equally high quality, summarize years of extensive research in each area, and provide insight in the new themes of natural product research. The information will help to predict promising leads, useful for physicians in the treatment of different diseases and disease manifestations. * Explains the effects of plant extracts on gene expression profiling. * Details medicinal plant research from around the world * Explores a variety of medicinal uses of plants from traditional remedies, to anti-cancer agents and anti-salmonella agents.

Advances in Triazole Chemistry

Author : Tahir Farooq
Publisher : Elsevier
Page : 266 pages
File Size : 42,9 Mb
Release : 2020-11-28
Category : Science
ISBN : 9780128171141

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Advances in Triazole Chemistry by Tahir Farooq Pdf

Advances in Triazole Chemistry reviews the ever-widening scope of triazole chemistry. Triazole is an exceptional structural motif with a range of applications across scientific disciplines, including materials science, organocatalysis, agrochemicals, and medicinal chemistry. These many applications of different classes of triazoles have promoted the development of a range of synthetic strategies over the past few years, which are presented here along with recent and ecofriendly methods for the synthesis of all types of triazoles. The book also reviews the recent notable applications in chemical ligation, peptidomimetics, carbohydrate chemistry, nanotechnology, and polymer and materials science. This comprehensive resource is ideal for researchers using triazoles in various disciplines, as well as chemists working in the pharmaceutical, polymer, and agrochemical industries. Includes coverage of the role triazoles play in DNA synthesis Features comprehensive information on 1,2,3-triazoles and 1,2,4-triazoles and their subclasses, synthesis, and applications Serves as an ideal reference for researchers and chemists interested in using triazole chemistry for functionalization, modification, and development of target products

Handbook of Research on Medicinal Chemistry

Author : Debarshi Kar Mahapatra,Sanjay Kumar Bharti
Publisher : Taylor & Francis
Page : 648 pages
File Size : 41,9 Mb
Release : 2017-11-20
Category : Medical
ISBN : 9781771885454

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Handbook of Research on Medicinal Chemistry by Debarshi Kar Mahapatra,Sanjay Kumar Bharti Pdf

This valuable new book, Handbook of Research on Medicinal Chemistry: Innovations and Methodologies, presents some of the latest advancements in the various fields of combinatorial chemistry, drug discovery, biochemical aspects, pharmacology of medicinal agents, current practical problems, and nutraceuticals. The editors keep the drug molecule as the central component of the volume and aim to explain the associated features essential to exhibiting pharmacological activity. With a unique combination of chapters in biology, clinical aspects, biochemistry, synthetic chemistry, medicine and technology, the volume provides broad exposure to the essential aspect of pharmaceuticals. The volume many important aspects of medicinal chemistry, including techniques in drug discovery pharmacological aspects of natural products chemical mediators: druggable targets advances in medicinal chemistry The field of medicinal chemistry is growing at an unprecedented pace, and this volume takes an interdisciplinary approach, covering a range of new research and new practices in the field. The volume takes into account the latest therapeutic guidelines put forward by the World Health Organization and the U.S Food and Drug Administration.. Topics include: drug design drug discovery natural products and supplements and nutraceuticals pharmaceutical approaches to sexual dysfunction drug resistance parasites new natural compounds and identification of new targets stereochemistry aspects in medicinal chemistry common drug interactions in daily practices Handbook of Research on Medicinal Chemistry: Innovations and Methodologies will be a valuable addition to the bookshelves of pharmaceutical scientists and faculty as well as for industry professionals.

Drug Discovery and Development

Author : Vishwanath Gaitonde,Partha Karmakar,Ashit Trivedi
Publisher : BoD – Books on Demand
Page : 166 pages
File Size : 53,9 Mb
Release : 2020-03-11
Category : Medical
ISBN : 9781789239751

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Drug Discovery and Development by Vishwanath Gaitonde,Partha Karmakar,Ashit Trivedi Pdf

The process of drug discovery and development is a complex multistage logistics project spanned over 10-15 years with an average budget exceeding 1 billion USD. Starting with target identification and synthesizing anywhere between 10k to 15k synthetic compounds to potentially obtain the final drug that reaches the market involves a complicated maze with multiple inter- and intra-operative fields. Topics described in this book emphasize the progresses in computational applications, pharmacokinetics advances, and molecular modeling developments. In addition the book also contains special topics describing target deorphaning in Mycobacterium tuberculosis, therapy treatment of some rare diseases, and developments in the pediatric drug discovery process.

Platform Technologies in Drug Discovery and Validation

Author : Anonim
Publisher : Academic Press
Page : 690 pages
File Size : 47,6 Mb
Release : 2017-11-21
Category : Medical
ISBN : 9780128130704

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Platform Technologies in Drug Discovery and Validation by Anonim Pdf

Platform Technologies in Drug Discovery and Validation, Volume 50, the latest release in the Annual Reports in Medicinal Chemistry series, provides timely and critical reviews of important topics in medicinal chemistry, with an emphasis on emerging topics in the biological sciences. Topics covered in this new volume include DELT, Oligos: ASO, siRNA, CRISPR, Micro-fluidic chemistry, High throughput screening, Kinase-centric computational drug development, Virtual Screening, Phenotypic screening, PROTACS, Chemical Biology, Fragment-based lead generation, Antibody-Drug Conjugates, Antibody-recruiting small molecules, Deuteration, and Peptides. Unique for its treatment of platform technologies for medicinal chemistry and target validation Provides a single, rich volume that summaries a broad spectrum of expertise relevant to the field Presents state-of-the-art summaries of platform technologies

Medicinal Chemistry Advances

Author : Federico G. de las Heras,Salvador Vega
Publisher : Pergamon
Page : 536 pages
File Size : 41,9 Mb
Release : 1981
Category : Medical
ISBN : UOM:39015018141286

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Medicinal Chemistry Advances by Federico G. de las Heras,Salvador Vega Pdf

Medicinal Chemistry Advances covers the proceedings of the Seventh International Symposium on Medicinal Chemistry. The book reviews the papers presented in the symposium. The main topics that this book covers are nucleosides in chemotherapy; theoretical approaches to medicinal chemistry; platelets and antithrombotic agents; receptors; antiviral agents; antilipidemic agents; respiratory system; central nervous system; enzyme inhibitors; and bioactive peptides. Chemists, pharmacologists, biochemists, physicians and other professionals and researchers concerned with the development of pharmaceuti ...

Perspectives in Medicinal Chemistry

Author : Bernard Testa
Publisher : Wiley-VCH
Page : 672 pages
File Size : 47,9 Mb
Release : 1993-03-25
Category : Science
ISBN : UOM:39015029715136

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Perspectives in Medicinal Chemistry by Bernard Testa Pdf

A broad overview of the latest advances in medicinal chemistry. Emphasis is placed on - drug design - new therapeutic agents - treatment of major diseases, such as AIDS and malaria. The book discusses recently discovered targets for drug action. It also takes a look at the theoretical and experimental tools which have fostered our understanding of the molecular mechanisms of drug action.

Medicinal Chemistry of Nucleic Acids

Author : Lihe Zhang,Zhen Xi,Jyoti Chattopadhyaya
Publisher : John Wiley & Sons
Page : 477 pages
File Size : 46,7 Mb
Release : 2011-08-10
Category : Medical
ISBN : 9781118092811

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Medicinal Chemistry of Nucleic Acids by Lihe Zhang,Zhen Xi,Jyoti Chattopadhyaya Pdf

Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry—a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids—such as the new advances in genome sequencing, and the processes for creating RNA interference (RNAi) based drugs—to assist pharmaceutical researchers in removing roadblocks that hinder their ability to predict drug efficacy. Offering the latest cutting-edge science in this growing field, Medicinal Chemistry of Nucleic Acids includes: In-depth coverage of the development and application of modified nucleosides and nucleotides in medicinal chemistry A close look at a large range of current topics on nucleic acid chemistry and biology Essential information on the use of nucleic acid drugs to treat diseases like cancer A thorough exploration of siRNA for RNAi and the regulation of microRNA, non-coding RNA (ncRNA), a newly developing and exciting research area Thorough in its approach and promising in its message, Medicinal Chemistry of Nucleic Acids probes the new domains of pharmaceutical research—and exposes readers to a wealth of new drug discovery opportunities emerging in the dynamic field of nucleic acid chemistry.