Replicating

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 54,6 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

Get Book

Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Marc Willems
Publisher : Unknown
Page : 250 pages
File Size : 50,6 Mb
Release : 2020-03-03
Category : Electronic
ISBN : 9783750419131

Get Book

Replicating by Marc Willems Pdf

Author : Philip R. Dormitzer,Christian W. Mandl,Rino Rappuoli
Publisher : Springer Science & Business Media
Page : 447 pages
File Size : 50,6 Mb
Release : 2010-11-02
Category : Medical
ISBN : 9783034602778

Get Book

Replicating Vaccines by Philip R. Dormitzer,Christian W. Mandl,Rino Rappuoli Pdf

Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, single-round infectious vaccines and replicon vaccines. This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines.

Author : Kenneth N Kreuzer
Publisher : World Scientific
Page : 438 pages
File Size : 46,7 Mb
Release : 2020-03-16
Category : Science
ISBN : 9789811215711

Get Book

Replicating And Repairing The Genome: From Basic Mechanisms To Modern Genetic Technologies by Kenneth N Kreuzer Pdf

Replicating and Repairing the Genome provides a concise overview of the fields of DNA replication and repair. The book is particularly appropriate for graduate students and advanced undergraduates, and scientists entering the field or working in related fields. The breadth of information regarding DNA replication and repair is vast and often difficult to absorb, with terminology that differs between experimental systems and with complex interconnections of these processes with other cellular pathways. This book provides simple conceptual descriptions of replication and repair pathways using mostly generic protein names, laying out the logic for how the pathways function and highlighting fascinating aspects of the underlying biochemical mechanisms and biology. The book incorporates extensive and informative diagrams and figures, as well as descriptions of a number of carefully chosen experiments that had major influences in the field.The process of DNA replication is explained progressively by starting with the system of a simple bacterial virus that uses only a few proteins, followed by the well-understood bacterial (E coli) system, and then culminating with the more complex eukaryotic systems. In the second half of the book, individual chapters cover key areas of DNA repair — postreplication repair of mismatches and incorporated ribonucleotides, direct damage reversal, excision repair, and DNA break repair, as well as the related areas of DNA damage tolerance (including translesion DNA polymerases) and DNA damage responses. The book closes with chapters that describe the huge impact of DNA replication and repair on aspects of human health and on modern biotechnology.

Author : National Academies of Sciences, Engineering, and Medicine,Policy and Global Affairs,Committee on Science, Engineering, Medicine, and Public Policy,Board on Research Data and Information,Division on Engineering and Physical Sciences,Committee on Applied and Theoretical Statistics,Board on Mathematical Sciences and Analytics,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Division of Behavioral and Social Sciences and Education,Committee on National Statistics,Board on Behavioral, Cognitive, and Sensory Sciences,Committee on Reproducibility and Replicability in Science
Publisher : National Academies Press
Page : 257 pages
File Size : 46,5 Mb
Release : 2019-10-20
Category : Science
ISBN : 9780309486163

Get Book

Reproducibility and Replicability in Science by National Academies of Sciences, Engineering, and Medicine,Policy and Global Affairs,Committee on Science, Engineering, Medicine, and Public Policy,Board on Research Data and Information,Division on Engineering and Physical Sciences,Committee on Applied and Theoretical Statistics,Board on Mathematical Sciences and Analytics,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Division of Behavioral and Social Sciences and Education,Committee on National Statistics,Board on Behavioral, Cognitive, and Sensory Sciences,Committee on Reproducibility and Replicability in Science Pdf

One of the pathways by which the scientific community confirms the validity of a new scientific discovery is by repeating the research that produced it. When a scientific effort fails to independently confirm the computations or results of a previous study, some fear that it may be a symptom of a lack of rigor in science, while others argue that such an observed inconsistency can be an important precursor to new discovery. Concerns about reproducibility and replicability have been expressed in both scientific and popular media. As these concerns came to light, Congress requested that the National Academies of Sciences, Engineering, and Medicine conduct a study to assess the extent of issues related to reproducibility and replicability and to offer recommendations for improving rigor and transparency in scientific research. Reproducibility and Replicability in Science defines reproducibility and replicability and examines the factors that may lead to non-reproducibility and non-replicability in research. Unlike the typical expectation of reproducibility between two computations, expectations about replicability are more nuanced, and in some cases a lack of replicability can aid the process of scientific discovery. This report provides recommendations to researchers, academic institutions, journals, and funders on steps they can take to improve reproducibility and replicability in science.

Author : Patrick Hughes,Ellen Fanning,Masamichi Kohiyama
Publisher : Springer Science & Business Media
Page : 429 pages
File Size : 53,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642769887

Get Book

DNA Replication: The Regulatory Mechanisms by Patrick Hughes,Ellen Fanning,Masamichi Kohiyama Pdf

DNA replication is a key event in the cell cycle. Although our knowledge is far from complete and many elusive regulatory mechanisms still remain beyondour grasp, many enzymes and a multiplicity of biochemical mechanisms involved have been discovered. Recent findings in E. coli have confirmed and yet surpassed the original hypothesis of F. Jacob. In yeast and higher eucaryotes, the apparent redundancy in putative origins and initiators has made an estimation of the importance of each identified element difficult to access. In spite of well established methodologies - which are also described in the book - the origin identification in mammalian chromosomes is still a controversial subject. On the other hand, considerable advances have been made in our understanding of virus DNA replication and this continues to deepen and broaden our understanding of the controls of cellular DNA replication.

Author : Robert M. Brosh Jr.
Publisher : MDPI
Page : 368 pages
File Size : 42,7 Mb
Release : 2019-08-27
Category : Science
ISBN : 9783039213894

Get Book

DNA Replication Stress by Robert M. Brosh Jr. Pdf

This Special Issue of International Journal of Molecular Sciences (IJMS) is dedicated to the mechanisms mediated at the molecular and cellular levels in response to adverse genomic perturbations and DNA replication stress. The relevant proteins and processes play paramount roles in nucleic acid transactions to maintain genomic stability and cellular homeostasis. A total of 18 articles are presented which encompass a broad range of highly relevant topics in genome biology. These include replication fork dynamics, DNA repair processes, DNA damage signaling and cell cycle control, cancer biology, epigenetics, cellular senescence, neurodegeneration, and aging. As Guest Editor for this IJMS

Author : Jill Williamson
Publisher : Zonderkidz
Page : 399 pages
File Size : 53,7 Mb
Release : 2012-01-03
Category : Juvenile Fiction
ISBN : 9780310727590

Get Book

Replication by Jill Williamson Pdf

A girl discovers her geneticist father is covering up multiple secrets—all of which are named Jason. Jason 3:3—known as Martyr—always believed his life had purpose. As one of the hundreds of clones living in a closed-off underground facility beneath an Alaskan farm, he has been told his genetics hold the key to saving humanity from an airborne pandemic aboveground, and his purpose will be filled on his upcoming eighteenth birthday. The problem is no such pandemic exists. Unaware of the truth, Martyr wishes for one glimpse of the sky before his expiration date arrives. His escape leads him to the home of one of the scientists, and to Abby Goyer. As she helps Martyr, she can’t help but notice his uncanny resemblance to the high school quarterback. Abby soon uncovers the dark truth behind Jason Farms and her dad’s work, and decides to show Martyr his true value and worth. As Martyr learns the truth behind his existence, he must decide if his God-given purpose is connected to the farm, or if it rests in a life with Abby.

Author : Proceedings of the National Academy of Sciences
Publisher : National Academies Press
Page : 303 pages
File Size : 42,5 Mb
Release : 2002-09-18
Category : Science
ISBN : 9780309074247

Get Book

Links Between Recombination and Replication by Proceedings of the National Academy of Sciences Pdf

There has been a sea change in how we view genetic recombination. When germ cells are produced in higher organisms, genetic recombination assures the proper segregation of like chromosomes. In the course of that process, called meiosis, recombination not only assures segregation of one chromosome of each type to progeny germ cells, but also further shuffles the genetic deck, contributing to the unique inheritance of individuals. In a nutshell, that is the classical view of recombination. We have also known for many years that in bacteria recombination plays a role in horizontal gene transfer and in replication itself, the latter by establishing some of the replication forks that are the structural scaffolds for copying DNA. In recent years, however, we have become increasingly aware that replication, which normally starts without any help from recombination, is a vulnerable process that frequently leads to broken DNA. The enzymes of recombination play a vital role in the repair of those breaks. The recombination enzymes can function via several different pathways that mediate the repair of breaks, as well as restoration of replication forks that are stalled by other kinds of damage to DNA. Thus, to the classical view of recombination as an engine of inheritance we must add the view of recombination as a vital housekeeping function that repairs breaks suffered in the course of replication. We have also known for many years that genomic instability--including mutations, chromosomal rearrangements, and aneuploidy--is a hallmark of cancer cells. Although genomic instability has many contributing causes, including faulty replication, there are many indications that recombination, faulty or not, contributes to genome instability and cancer as well. The (Nas colloquium) Links Between Recombination and Replication: Vital Roles of Recombination was convened to broaden awareness of this evolving area of research. Papers generated by this colloquium are published here. To encourage the desired interactions of specialists, we invited some contributions that deal only with recombination or replication in addition to contributions on the central thesis of functional links between recombination and replication. To aid the nonspecialist and specialist alike, we open the set of papers with a historical overview by Michael Cox and we close the set with a commentary on the meeting and the field by Andrei Kuzminov.

Author : Daniel L. Kaplan
Publisher : Springer
Page : 563 pages
File Size : 40,8 Mb
Release : 2016-02-11
Category : Medical
ISBN : 9783319246963

Get Book

The Initiation of DNA Replication in Eukaryotes by Daniel L. Kaplan Pdf

​Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells. The process of DNA replication needs to be precisely regulated to ensure that replication of the genome is complete and accurate, but that re-replication does not occur. Errors in DNA replication can lead to genome instability and cancer. The process of replication initiation is of paramount importance, because once the cell is committed to replicate DNA, it must finish this process. A great deal of progress has been made in understanding how DNA replication is initiated in eukaryotic cells in the past ten years, but this is the first one-source book on these findings. The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells. While the concept of replication initiation is simple, its elaborate regulation and integration with other cell processes results in a high level of complexity. This book will cover how the position of replication initiation is chosen, how replication initiation is integrated with the phases of the cell cycle, and how it is regulated in the case of damage to DNA. It is the cellular protein machinery that enables replication initiation to be activated and regulated. We now have an in-depth understanding of how cellular proteins work together to start DNA replication, and this new resource will reveal a mechanistic description of DNA replication initiation as well.

Author : A. De Recondo
Publisher : Springer Science & Business Media
Page : 361 pages
File Size : 52,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468443974

Get Book

New Approaches in Eukaryotic DNA Replication by A. De Recondo Pdf

DNA replication in eukaryotes is an important field, particular ly because of its direct impact on the study of cancer. The under standing of molecular mechanisms of replication and their regulation should allow a better comprehension of the alterations that lead to the proliferation of tumor cells and to error-prone repair in cells exposed to radiation or chemical carcinogens. During the last several years, many enzymes and proteins which participate in replication of DNA in eukaryotic cells have been identified, isolated and characterized. New concepts in chromatin structure have refocused attention on the study of replication of DNA complexed with his tones and non-histone chromosomal proteins. However, progress has been noticeably slower than for prokaryotes, essentially because of the difficulty in genetic analysis of eukaryo tic DNA replication. In June 1980, a workshop was organized in Cargese, Corsica (France) to facilitate exchanges of information between workers spe cializing in prokaryotes and those specializing in eukaryotes, and to allow discussion of new experimental approaches. With this in mind, special interest has been taken in the origin and termination of chromosome cycles and how they are controlled.

Author : Arthur Kornberg,Tania A. Baker
Publisher : University Science Books
Page : 964 pages
File Size : 54,9 Mb
Release : 2005-06-24
Category : Science
ISBN : 1891389440

Get Book

DNA Replication by Arthur Kornberg,Tania A. Baker Pdf

DNA Replication, second edition, a classic of modernscience, is now back in print in a paperback edition. Kornberg and Baker'sinsightful coverage of DNA replication and related cellular processes have madethis the standard reference in the field.

Author : Bagai,Saroj Kapoor Bagai,Jagan Bandi Reddy,Jeff Tallman
Publisher : Jones & Bartlett Publishers
Page : 651 pages
File Size : 55,9 Mb
Release : 2008-12-08
Category : Computers
ISBN : 9781449613174

Get Book

Sybase 15.0 Replication Server Administration by Bagai,Saroj Kapoor Bagai,Jagan Bandi Reddy,Jeff Tallman Pdf

Sybase 15 Replication Server Administration addresses the needs of a wide range of database professionals, explaining to both beginners and experts how to administer Sybase’s newest Replication Server release. This book examines all the knowledge, background information, and conceptual frameworks needed in order to get started on installing and administering Sybase Replication Server, and explores the world of contemporary cross-platform compatible Sybase Replication Server administration. Learn how to replicate business-critical data; configure database connections and routes; manage replicated tables, stored procedures, and subscriptions; set up a warm standby system; monitor replication performance and tune the database system; provide up-to-the-minute high availability of data; recover from failures and prevent data loss; troubleshoot the replication system.

Author : Bernadette Charron-Bost,Fernando Pedone,Andre Schiper
Publisher : Springer Science & Business Media
Page : 298 pages
File Size : 51,6 Mb
Release : 2010-03-02
Category : Computers
ISBN : 9783642112935

Get Book

Replication by Bernadette Charron-Bost,Fernando Pedone,Andre Schiper Pdf

Consistency models for replicated data /Alan D. Fekete and Krithi Ramamritham --Replication techniques for availability /Robbert van Renesse and Rachid Guerraoui --Modular approach to replication for availability /Fernando Pedone and André Schiper --Stumbling over consensus research: misunderstandings and issues /Marcos K. Aguilera --Replicating for performance: case studies /Maarten van Steen and Guillaume Pierre --A history of the virtual synchrony replication model /Ken Birman --From viewstamped replication to byzantine fault tolerance /Barbara Liskov --Implementing trustworthy services using replicated state machines /Fred B. Schneider and Lidong Zhou --State machine replication with Byzantine faults /Christian Cachin --Selected results from the latest decade of quorum systems research /Michael G. Merideth and Michael K. Reiter --From object replication to database replication /Fernando Pedone and André Schiper --Database replication: a tutorial /Dettina Kemme, Ricardo Jiménez-Peris, Marta Patiño-Martínez, and Gustavo Alonso --Practical database replication /Alfrânio Correia Jr. ... [et al.].

Author : Mischa Gabowitsch
Publisher : Springer
Page : 351 pages
File Size : 41,6 Mb
Release : 2017-12-07
Category : Social Science
ISBN : 9783319650272

Get Book

Replicating Atonement by Mischa Gabowitsch Pdf

This collection examines what happens when one country’s experience of dealing with its traumatic past is held up as a model for others to follow. In regional and country studies covering Argentina, Canada, Japan, Lebanon, Rwanda, Russia, Turkey, the United States and former Yugoslavia, the authors look at the pitfalls, misunderstandings and perverse effects–but also the promise–of trying to replicate atonement. Going beyond the idea of a global or transnational memory, this book examines the significance of foreign models in atonement practices, and analyses the role of national governments, international organisations, museums, foundations, NGOs and public intellectuals in shaping the idea that good practices of atonement can be learned. The volume also demonstrates how one can productively learn from others by appreciating the complex and contested nature of atonement practices such as Germany’s, and also by finding the necessary resources in the history of one’s own country.