Rna Interference From Biology To Therapeutics

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RNA Interference from Biology to Therapeutics

Kenneth A. Howard
RNA Interference from Biology to Therapeutics Book PDF

Author : Kenneth A. Howard
Publisher : Springer Science & Business Media
Page : 348 pages
File Size : 48,8 Mb
Release : 2012-10-19
Category : Medical
ISBN : 9781461447436

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RNA Interference from Biology to Therapeutics by Kenneth A. Howard Pdf

The enormous potential of siRNA as a therapeutic has led to an explosion of interest from the scientific community. There has been intense interest from Big Pharma to capitalise on this new technology but the fact remains that delivery is a key determinant in realizing the full clinical potential of RNA interference. There is an urgent need for better delivery methods to take this technology forward. This book addresses the role of different RNAi molecules in cellular processes as rational for diagnostic and therapeutic approaches. This book will cover RNAi therapeutic design to optimize siRNA potency and reduce off-target effects and current delivery technologies to overcome both intracellular and extracellular barriers. The reader will gain an insight into RNA interference from the cellular mechanisms to screening to siRNA design right through to diagnostic and therapeutic applications.

RNA Technologies and Their Applications

Volker A. Erdmann,Jan Barciszewski
RNA Technologies and Their Applications Book PDF

Author : Volker A. Erdmann,Jan Barciszewski
Publisher : Springer Science & Business Media
Page : 460 pages
File Size : 41,9 Mb
Release : 2010-09-02
Category : Medical
ISBN : 9783642121685

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RNA Technologies and Their Applications by Volker A. Erdmann,Jan Barciszewski Pdf

RNA technologies are the driving forces of modern medicine and biotechnology. They combine the fields of biochemistry, chemistry, molecular biology, cell biology, physics, nanotechnology and bioinformatics. The combination of these topics is set to revolutionize the medicine of tomorrow. After more than 15 years of extensive research in the field of RNA technologies, the first therapeutics are ready to reach the first patients. Thus we are witnessing the birth of a very exciting time in the development of molecular medicine, which will be based on the methods of RNA technologies. This volume is the first of a series. It covers various aspects of RNA interference and microRNAs, although antisense RNA applications, hammerhead ribozyme structure and function as well as non-coding RNAs are also discussed. The authors are internationally highly respected experts in the field of RNA technologies.

Advanced Delivery and Therapeutic Applications of RNAi

Kun Cheng,Ram I. Mahato
Advanced Delivery and Therapeutic Applications of RNAi Book PDF

Author : Kun Cheng,Ram I. Mahato
Publisher : John Wiley & Sons
Page : 660 pages
File Size : 47,9 Mb
Release : 2013-04-19
Category : Science
ISBN : 9781118610732

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Advanced Delivery and Therapeutic Applications of RNAi by Kun Cheng,Ram I. Mahato Pdf

Commonly used by researchers to develop technologies for modifying and studying genetic process, RNA interference (RNAi) has many potential uses in medicine, biotechnology, and functional genomics. This book covers all essential aspects involved in the development of RNAi therapeutics, providing detailed guidance on the challenges and opportunities of bringing RNAi technologies from bench to clinic. It explores the design and mechanism of RNAi molecules, delivery strategies, and therapeutic applications in various diseases. Preclinical, regulatory, market, and intellectual aspects of RNAi technologies are also covered.

Cellular RNA Interference Mechanisms

Dirk Grimm
Cellular RNA Interference Mechanisms Book PDF

Author : Dirk Grimm
Publisher : Academic Press
Page : 264 pages
File Size : 52,6 Mb
Release : 2011-08-26
Category : Medical
ISBN : 9780124157958

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Cellular RNA Interference Mechanisms by Dirk Grimm Pdf

This volume explores some of the most exciting recent advances in basic research on cellular RNA interference mechanisms and how this knowledge is leading to advances in the various fields. This series provides a forum for discussion of new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields

RNA Interference and Cancer Therapy

Lekha Dinesh Kumar
RNA Interference and Cancer Therapy Book PDF

Author : Lekha Dinesh Kumar
Publisher : Humana
Page : 416 pages
File Size : 47,7 Mb
Release : 2019-05-17
Category : Medical
ISBN : 1493992198

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RNA Interference and Cancer Therapy by Lekha Dinesh Kumar Pdf

This comprehensive volume collects a repertoire of techniques for the adoption and exploitation of RNA interference (RNAi) as a fertile strategy to develop the bio-drugs of future in the vital field of cancer research. Exploring the immense ‘bench to bedside’ potential of RNAi as a therapeutic molecule, the book focuses many of its chapters on nanoparticle-based targeted deliveries, including aptamers, as well as techniques for using RNAi technology to combat various cancers in preclinical studies. Each of the 26 chapters is authored by the pioneers in the respective areas and thus provides a practical and empirical account of the techniques that could be used as benchmark tools in the area of cancer research. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and essential, RNA Interference and Cancer Therapy: Methods and Protocols provides the necessary guidance for both novice and professional researchers who intend to discover and innovate newer means of using RNAi technology to combat cancer, one of the greatest scourges of human health.

RNA Interference Technology

Krishnarao Appasani
RNA Interference Technology Book PDF

Author : Krishnarao Appasani
Publisher : Cambridge University Press
Page : 564 pages
File Size : 45,6 Mb
Release : 2005-01-17
Category : Science
ISBN : 1139442651

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RNA Interference Technology by Krishnarao Appasani Pdf

RNA Interference (RNAi) technology has rapidly become one of the key methods used in functional genomics. RNAi is used to block the expression of genes and create phenotypes that can potentially yield clues about the function of these genes. In the postgenomic era, the elucidation of the physiological function of genes has become the rate-limiting step in the quest to develop 'gene-based drugs' and RNAi could potentially play a pivotal role in the validation of such novel drugs. In this overview, the basic concepts and applications of RNAi biology are discussed. Leading experts from both academia and industry have contributed to this invaluable reference. The volume is forwarded by Andrew Fire, one of the winners of the 2006 Nobel Prize for the discovery of RNA Interference.

RNA Interference and CRISPR Technologies

Mouldy Sioud
RNA Interference and CRISPR Technologies Book PDF

Author : Mouldy Sioud
Publisher : Unknown
Page : 486 pages
File Size : 52,6 Mb
Release : 2020
Category : Gene expression
ISBN : 107160290X

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RNA Interference and CRISPR Technologies by Mouldy Sioud Pdf

This volume explores the uses of RNAi and CRISPR interferences as a general method for inhibiting gene expression, with focus on their biological functions, design, chemical modifications, delivery, and preclinical/clinical applications. In addition to relevant backgrounds, the chapters in this book discuss simple and accurate protocols dealing with the latest advances in RNAi and CRISPR applications and look at how these methods differ from one another. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, RNA Interference and CRISPR Technologies: Technical Advances and New Therapeutic Opportunities is a valuable resource for any scientist, teachers, graduate student, postdoc, and clinician interested in this field. This book also benefits anyone in research and development in biotech and pharmaceutical companies who want to understand more about these technologies, and their applications in biology and medicine. .

RNA Silencing

Esra Galun
RNA Silencing Book PDF

Author : Esra Galun
Publisher : World Scientific
Page : 469 pages
File Size : 43,5 Mb
Release : 2005
Category : Science
ISBN : 9789812562067

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RNA Silencing by Esra Galun Pdf

This book focuses on an emerging, central issue in molecular genetics and the development of eukaryotes: the control of gene expression by small species of RNA. As an exciting new field of endeavor, it is the first book by a single author to deal comprehensively with RNA silencing.The book provides the historical background of the field preceding the seminal work by Fire and associates in 1998 on the impact of small double-stranded RNA on the expression of nematode genes, which is considered the beginning of RNA silencing research. RNA silencing is described in a wide range of plants and animals including protozoa, simple metazoa, insects, non-mammalian vertebrates, and mammals. In each case the experimental results are provided with the accompanying background and with illustrations. There is also an appendix on the prospective use of RNA silencing in gene therapy, which is intended as a guide for investigators wishing to explore this possibility.

Therapeutic Applications of RNAi

John F. Reidhaar-Olson,Cristina M. Rondinone
Therapeutic Applications of RNAi Book PDF

Author : John F. Reidhaar-Olson,Cristina M. Rondinone
Publisher : Humana Press
Page : 0 pages
File Size : 51,6 Mb
Release : 2011-12-01
Category : Medical
ISBN : 1617794945

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Therapeutic Applications of RNAi by John F. Reidhaar-Olson,Cristina M. Rondinone Pdf

The phenomenon of RNA interference has rapidly moved from groundbreaking scientific discovery to promising therapeutic approach. However, even as RNAi-based drugs enter the clinic, significant challenges remain, particulary in the area of delivery. Therapeutic Applications of RNAi provides detailed protocols in key areas of current focus, including testing of delivery vehicles, identification of appropriate model systems, and evaluation of the effects of RNAi in vivo. Produced by a team of internationally renowned authors, the volume describes the therapeutic applications of RNAi and potential pitfalls in oncology, viral infections and CNS disease, using a variety of delivery methods, including liposomes, peptide-based nanoparticles, polycationic polymers, and viral vehicles. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Therapeutic Applications of RNAi is an ideal guide for scientists attempting to solve the numerous challenges in this field and revolutionize the treatment of disease.

RNA Interference

Paul H. Johnson
RNA Interference Book PDF

Author : Paul H. Johnson
Publisher : John Wiley & Sons
Page : 375 pages
File Size : 47,6 Mb
Release : 2011-03-01
Category : Medical
ISBN : 9780470934678

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RNA Interference by Paul H. Johnson Pdf

RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.

RNAi Technology

R. K. Gaur,Yedidya Gafni,P. Sharma,V. K. Gupta
RNAi Technology Book PDF

Author : R. K. Gaur,Yedidya Gafni,P. Sharma,V. K. Gupta
Publisher : CRC Press
Page : 380 pages
File Size : 46,6 Mb
Release : 2016-04-19
Category : Science
ISBN : 9781439873250

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RNAi Technology by R. K. Gaur,Yedidya Gafni,P. Sharma,V. K. Gupta Pdf

RNAi technology is used for large-scale screens that systematically shut down each gene in the cell, which can help identify the components necessary for a particular cellular process or an event such as cell division. Exploitation of the pathway is also a promising tool in biotechnology and medicine. Introducing new technology in the study of RNA

Gene Silencing by RNA Interference

Muhammad Sohail
Gene Silencing by RNA Interference Book PDF

Author : Muhammad Sohail
Publisher : CRC Press
Page : 398 pages
File Size : 51,5 Mb
Release : 2004-08-27
Category : Medical
ISBN : 9780203489253

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Gene Silencing by RNA Interference by Muhammad Sohail Pdf

Maximizing the potential of RNA interference in functional genomics - as well as in the development of therapeutics - continues to be at the forefront of biomedical research. Unlike journal articles, Gene Silencing by RNA Interference: Technology and Application combines essential background to the RNAi field with practical techniques designed by r

RNA Interference

Mouldy Sioud
RNA Interference Book PDF

Author : Mouldy Sioud
Publisher : Humana
Page : 0 pages
File Size : 53,8 Mb
Release : 2016-09-22
Category : Medical
ISBN : 1493948911

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RNA Interference by Mouldy Sioud Pdf

RNA Interference: Challenges and Therapeutic Opportunities provides readers with recent advances in siRNA design, delivery, targeting and methods to minimize siRNA’s unwanted effects. Preclinical and clinical use of synthetic siRNAs, the roles of miRNAs in cancer and the promise of extracellular miRNAs for diagnosis are also covered in this meticulous collection, along with novel methods for identifying endogenous siRNAs and the annotation of small RNA transcriptomes. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory. Comprehensive and cutting-edge, RNA Interference: Challenges and Therapeutic Opportunities will aid researchers, clinicians, teachers and biotechnologists interested in the power of RNA-based therapies.

Sirna Design

Debra J. Taxman
Sirna Design Book PDF

Author : Debra J. Taxman
Publisher : Humana Press
Page : 408 pages
File Size : 44,6 Mb
Release : 2016-05-01
Category : Medical
ISBN : 1493959786

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Sirna Design by Debra J. Taxman Pdf

A fresh addition to Springer s successful series Methods in Molecular Biology, this publication updates researchers and technicians with the latest protocols in RNA interference, the gene silencing methodology that is revolutionizing biological research."

RNA Interference (RNAi)

Wiley
RNA Interference RNAi Book PDF

Author : Wiley
Publisher : John Wiley & Sons
Page : 214 pages
File Size : 44,9 Mb
Release : 2013-11-26
Category : Science
ISBN : 9781118829448

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RNA Interference (RNAi) by Wiley Pdf

The 2006 Nobel Prize in Physiology or Medicine was awarded to Andrew Z. Fire and Craig C. Mello for their discovery of RNA interference (RNAi). RNAi is a biological process in which RNA molecules can silence (inhibit) or up- or down-regulate gene expression, typically by causing the destruction of specific messenger RNA (mRNA) molecules. This collection of articles begins with an introduction to RNAi, and proceeds to describe uses of this technology in various approaches to disease treatment, including gene therapy. Several laboratory protocols for silencing genes via RNAi are also provided, as are protocols for down-regulating and then rescuing those down-regulated genes, which demonstrates specificity of the approach. This e-book — a curated collection from eLS, WIREs, and Current Protocols — offers a fantastic introduction to the field of RNA interference for students or interdisciplinary collaborators.