Systems Biology Of Micrornas In Cancer

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Systems Biology of MicroRNAs in Cancer

Ulf Schmitz,Olaf Wolkenhauer,Julio Vera-González
Systems Biology of MicroRNAs in Cancer Book PDF

Author : Ulf Schmitz,Olaf Wolkenhauer,Julio Vera-González
Publisher : Springer Nature
Page : 321 pages
File Size : 45,5 Mb
Release : 2022-11-09
Category : Medical
ISBN : 9783031083563

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Systems Biology of MicroRNAs in Cancer by Ulf Schmitz,Olaf Wolkenhauer,Julio Vera-González Pdf

This book provides an update on the latest development in the field of microRNAs in cancer research with an emphasis on translational research. Since the early 2000s, microRNAs have been recognized as important and ubiquitous regulators of gene expression. Soon it became evident that their deregulation can cause human diseases including cancer. This book focuses on the emerging opportunities for the application of microRNA research in clinical practice. In this context, computer models are presented that can help to identify novel biomarkers, e.g. in circulating microRNAs, and tools that can help to design microRNA-based therapeutic interventions. Other chapters evaluate the role of microRNAs in immunotherapy, immune responses and drug resistance. Covering key topics on microRNAs in cancer research this book is a valuable resource for both emerging and established microRNA researchers who want to explore the potential of microRNAs as therapeutic targets or co-adjuvants in cancer therapies.

MicroRNA Cancer Regulation

Ulf Schmitz,Olaf Wolkenhauer,Julio Vera
MicroRNA Cancer Regulation Book PDF

Author : Ulf Schmitz,Olaf Wolkenhauer,Julio Vera
Publisher : Springer Science & Business Media
Page : 352 pages
File Size : 49,8 Mb
Release : 2013-02-03
Category : Medical
ISBN : 9789400755901

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MicroRNA Cancer Regulation by Ulf Schmitz,Olaf Wolkenhauer,Julio Vera Pdf

This edited reflects the current state of knowledge about the role of microRNAs in the formation and progression of solid tumours. The main focus lies on computational methods and applications, together with cutting edge experimental techniques that are used to approach all aspects of microRNA regulation in cancer. We are sure that the emergence of high-throughput quantitative techniques will make this integrative approach absolutely necessary in the near future. This book will be a resource for researchers starting out with cancer microRNA research, but is also intended for the experienced researcher who wants to incorporate concepts and tools from systems biology and bioinformatics into his work. Bioinformaticians and modellers are provided with a general perspective on microRNA biology in cancer, and the state-of-the-art in computational microRNA biology.

MicroRNA and Cancer

Wei Wu
MicroRNA and Cancer Book PDF

Author : Wei Wu
Publisher : Humana Press
Page : 273 pages
File Size : 51,6 Mb
Release : 2016-08-23
Category : Medical
ISBN : 1493957740

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MicroRNA and Cancer by Wei Wu Pdf

The tiny microRNAs (miRNAs) can have huge impacts on the regulation of a variety of genes and play crucial roles in the fundamental cellular processes. Recent miRNA studies change the landscape of cancer genetics by scrutinizing the alterations of genome-wide miRNA expressions in most common cancers and their regulatory functions during the development of cancer. The connections between miRNAs and cancer are widespread enough to warrant more comprehensive investigations in the systems biology perspective. In MicroRNA and Cancer: Methods and Protocols, internationally renowned experts provide the latest miRNA knowledge, the various techniques and methodologies currently available for cancer research application. Ranging from the fundamental concepts to practical applications, this book presents: • Overview of microRNA biogenesis, computational prediction of new miRNAs in the cancer genome, and miRNA-based therapeutic approaches for cancer treatment • Detailed experimental protocols in miRNA detection with novel and high-throughput technology, miRNA library cloning, miRNA epigenetic regulation, and miRNA pathway study • Stepwise computational and bioinformatic procedures for miRNA complex networks in cancer genomes with a variety of softwares and programs • Cross-cited notes on troubleshooting and avoiding known pitfalls Authoritative and cutting-edge, MicroRNA and Cancer: Methods and Protocols serves researchers with the basic principles of experimental and computational methods for microRNA study in cancer research and provides a firm grounding for those who wish to further develop their own applications and tailor them to their own specific research needs.

Systems Biology in Cancer Research and Drug Discovery

Asfar S Azmi
Systems Biology in Cancer Research and Drug Discovery Book PDF

Author : Asfar S Azmi
Publisher : Springer Science & Business Media
Page : 424 pages
File Size : 41,8 Mb
Release : 2012-09-29
Category : Medical
ISBN : 9789400748187

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Systems Biology in Cancer Research and Drug Discovery by Asfar S Azmi Pdf

Systems Biology in Cancer Research and Drug Discovery provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology (i) in understanding aberrant signaling in cancer (ii) in identifying biomarkers and prognostic markers especially focused on angiogenesis pathways (iii) in unwinding microRNAs complexity and (iv) in anticancer drug discovery and in clinical trial design. This book reviews the state-of-the-art knowledge and touches upon cutting edge newer and improved applications especially in the area of network modeling. It is aimed at an audience ranging from students, academics, basic researcher and clinicians in cancer research. This book is expected to benefit the field of translational cancer medicine by bridging the gap between basic researchers, computational biologists and clinicians who have one ultimate goal and that is to defeat cancer.

MicroRNAs in Cancer

César López-Camarillo,Laurence A. Marchat
MicroRNAs in Cancer Book PDF

Author : César López-Camarillo,Laurence A. Marchat
Publisher : CRC Press
Page : 428 pages
File Size : 46,5 Mb
Release : 2013-02-22
Category : Science
ISBN : 9781466576766

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MicroRNAs in Cancer by César López-Camarillo,Laurence A. Marchat Pdf

MicroRNA (miRNA) biology is a cutting-edge topic in basic as well as biomedical research. This is a specialized book focusing on the current understanding of the role of miRNAs in the development, progression, invasion, and metastasis of diverse types of cancer. It also reviews their potential for applications in cancer diagnosis, prognosis, and therapeutic targets as well as the potential use in translational medicine. Chapters present comprehensive and expert perspectives on the roles of miRNAs in most common cancers from bench to bedside applications and are written by an international team of renowned experts in the field.

MicroRNA Profiling in Cancer

Yuriy Gusev
MicroRNA Profiling in Cancer Book PDF

Author : Yuriy Gusev
Publisher : CRC Press
Page : 257 pages
File Size : 44,8 Mb
Release : 2019-09-06
Category : Medical
ISBN : 9789814267540

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MicroRNA Profiling in Cancer by Yuriy Gusev Pdf

This book presents current advances in the emerging interdisciplinary field of microRNA research of human cancers from a unique perspective of quantitative sciences: bioinformatics, computational and systems biology, and mathematical modeling. This volume contains adaptations and critical reviews of recent state-of-the-art studies, ranging from technological advances in microRNA detection and profiling, clinically oriented microRNA profiling in several human cancers, to a systems biology analysis of global patterns of microRNA regulation of signaling and metabolic pathways. Interactions with transcription factor regulatory networks and mathematical modeling of microRNA regulation are also discussed.

MicroRNA in Cancer

Suresh Alahari
MicroRNA in Cancer Book PDF

Author : Suresh Alahari
Publisher : Springer Science & Business Media
Page : 149 pages
File Size : 53,5 Mb
Release : 2012-08-01
Category : Medical
ISBN : 9789400746558

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MicroRNA in Cancer by Suresh Alahari Pdf

The field of microRNA biology is really emerging in the last couple of years. Several investigators highlighted the importance of miRNAs in cancer. Although there is so much literature on microRNAs exist, a comprehensive book is still not available. Thus this book will be a great use to the scientists in the field of cancer biology. In addition, this book will be a good source of information for undergraduate, graduate students who want to develop their research careers in cancer biology.

MiRNomics

Malik Yousef,Jens Allmer
MiRNomics Book PDF

Author : Malik Yousef,Jens Allmer
Publisher : Unknown
Page : 333 pages
File Size : 54,5 Mb
Release : 2014
Category : RNA
ISBN : 1627037489

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MiRNomics by Malik Yousef,Jens Allmer Pdf

In miRNomics: MicroRNA Biology and Computational Analysis, expert researchers in the field present an overview of the current state of the art and aim to put the respective areas of research into a larger perspective. These include methods and techniques ranging from miRNA biogenesis, their biological function, computational analyses to their medical implications and applications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, miRNomics: MicroRNA Biology and Computational Analysis seeks to aid scientists in the further study into miRNA research and statistics.

Systems Biology and the Challenge of Deciphering the Metabolic Mechanisms Underlying Cancer

Osbaldo Resendis-Antonio,Christian Diener
Systems Biology and the Challenge of Deciphering the Metabolic Mechanisms Underlying Cancer Book PDF

Author : Osbaldo Resendis-Antonio,Christian Diener
Publisher : Frontiers Media SA
Page : 144 pages
File Size : 52,7 Mb
Release : 2017-11-23
Category : Electronic
ISBN : 9782889453337

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Systems Biology and the Challenge of Deciphering the Metabolic Mechanisms Underlying Cancer by Osbaldo Resendis-Antonio,Christian Diener Pdf

Since the discovery of the Warburg effect in the 1920s cancer has been tightly associated with the genetic and metabolic state of the cell. One of the hallmarks of cancer is the alteration of the cellular metabolism in order to promote proliferation and undermine cellular defense mechanisms such as apoptosis or detection by the immune system. However, the strategies by which this is achieved in different cancers and sometimes even in different patients of the same cancer is very heterogeneous, which hinders the design of general treatment options. Recently, there has been an ongoing effort to study this phenomenon on a genomic scale in order to understand the causality underlying the disease. Hence, current “omics” technologies have contributed to identify and monitor different biological pieces at different biological levels, such as genes, proteins or metabolites. These technological capacities have provided us with vast amounts of clinical data where a single patient may often give rise to various tissue samples, each of them being characterized in detail by genomescale data on the sequence, expression, proteome and metabolome level. Data with such detail poses the imminent problem of extracting meaningful interpretations and translating them into specific treatment options. To this purpose, Systems Biology provides a set of promising computational tools in order to decipher the mechanisms driving a healthy cell’s metabolism into a cancerous one. However, this enterprise requires bridging the gap between large data resources, mathematical analysis and modeling specifically designed to work with the available data. This is by no means trivial and requires high levels of communication and adaptation between the experimental and theoretical side of research.

Systems Biology

Mariano Bizzarri
Systems Biology Book PDF

Author : Mariano Bizzarri
Publisher : Springer Nature
Page : 261 pages
File Size : 47,7 Mb
Release : 2024-01-08
Category : Science
ISBN : 9781071635773

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Systems Biology by Mariano Bizzarri Pdf

This second edition volume expands on the previous edition with discussions of the latest advancements and methods used by scientists to study systems biology. The chapters in this book are organized into four parts. Part One looks at models in systems biology and parameters identification such as short peptide analysis, metastasis models, and metabolomics. Part Two covers computational methods in the study of organisms, and cancer non-linear dynamics. Part Three discusses critical transition states across Waddington’s like landscapes such as understanding cell differentiation through single-cell approaches and modeling mammary organogenesis from biological first principles. Part Four talks about specific fields of investigation including inborn errors of metabolism, system biology approach in epithelial-mesenchymal transition, and an approach to understanding how COVID-19 spreads in the population. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Systems Biology, Second Edition is a valuable tool for any researcher looking to learn more about this important and developing field.

An investigation of microRNA target regulation mechanisms using an integrative approach

Ulf Schmitz
An investigation of microRNA target regulation mechanisms using an integrative approach Book PDF

Author : Ulf Schmitz
Publisher : Logos Verlag Berlin GmbH
Page : 192 pages
File Size : 41,8 Mb
Release : 2015-06-29
Category : MicroRNA.
ISBN : 9783832540050

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An investigation of microRNA target regulation mechanisms using an integrative approach by Ulf Schmitz Pdf

This work is a showcase for the integration of systems biology and bioinformatics tools, algorithms and models for deciphering biological phenomena. More specifically, it integrates (i) prediction algorithms for identifying and characterizing molecular interactions, (ii) structural modelling of molecule complexes, (iii) network analysis approaches, and (iv) mathematical modelling and simulation. Two comprehensive workflows are implemented for the analysis of collective target gene regulation by microRNAs and for the prediction of cooperating microRNA pairs and their mutual target genes. In two case studies mechanisms of fine-tuned target gene regulation are revealed for different cellular processes and the phenomenon of cooperative target regulation is identified as frequent mechanism of gene regulation in humans.

miRNA and Cancer

Anonim
miRNA and Cancer Book PDF

Author : Anonim
Publisher : Academic Press
Page : 230 pages
File Size : 55,9 Mb
Release : 2017-09-04
Category : Science
ISBN : 9780128119235

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miRNA and Cancer by Anonim Pdf

miRNA and Cancer, Volume 135, the latest volume in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents original reviews on research bridging oncology and gene expression, and includes specific chapters on Non-coding RNAs as Biomarkers of Cancer, The Enigma of microRNA Regulation in Cancer, Animal Models to Study microRNA functions, Non-coding RNAs and Cancer, microRNAs in Cancer Susceptibility, ts-RNAs versus microRNAs, microRNAs and AML, and microRNAs and Epigenetics. Provides information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike

MicroRNA as Biomarkers in Cancer Diagnostics and Therapy

Lorenzo F. Sempere
MicroRNA as Biomarkers in Cancer Diagnostics and Therapy Book PDF

Author : Lorenzo F. Sempere
Publisher : Unknown
Page : 166 pages
File Size : 52,5 Mb
Release : 2019
Category : Biology (General)
ISBN : 3039212508

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MicroRNA as Biomarkers in Cancer Diagnostics and Therapy by Lorenzo F. Sempere Pdf

This Special Issue celebrates the 25th anniversary of the discovery of the first microRNA. The size of the microRNome and complexity of animal body plans and organ systems suggests a role for microRNAs in cell fate determination and differentiation. More than 2000 sequences have been proposed to represent unique microRNA genes in humans, with an increasing number of mechanistic roles identified in developmental, physiological, and pathological processes. Thus, dysregulation of a few key microRNAs can have a profound global effect on the gene expression and molecular programs of a cell. This great potential for clinical intervention has captured the interest and imagination of researchers in many fields. However, very few fields have been as prolific as the field of cancer research. This Special Issue provides but a glimpse of the large body of literature of microRNA biology in cancer research, containing 4 original research studies and 4 review articles that focus on specific hematologic or solid tumors in disease. Collectively, these articles highlight state-of-the-art approaches and methodologies for microRNA detection in tissue, blood, and other body fluids in a range of biomarkers applications, from early cancer detection to prognosis and treatment response. The articles also address some of the challenges regarding clinical implementation.

MicroRNAs

Krishnarao Appasani
MicroRNAs Book PDF

Author : Krishnarao Appasani
Publisher : Cambridge University Press
Page : 580 pages
File Size : 40,7 Mb
Release : 2009-08-20
Category : Science
ISBN : 0521118557

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MicroRNAs by Krishnarao Appasani Pdf

MicroRNAs (miRNAs) are RNA molecules, conserved by evolution, that regulate gene expressions and their recent discovery is revolutionising both basic biomedical research and drug discovery. Expression levels of MiRNAs have been found to vary between tissues and with developmental stages and hence evaluation of the global expression of miRNAs potentially provides opportunities to identify regulatory points for many different biological processes. This wide-ranging reference work, written by leading experts from both academia and industry, will be an invaluable resource for all those wishing to use miRNA techniques in their own research, from graduate students, post-docs and researchers in academia to those working in R&D in biotechnology and pharmaceutical companies who need to understand this emerging technology. From the discovery of miRNAs and their functions to their detection and role in disease biology, this volume uniquely integrates the basic science with industry application towards drug validation, diagnostic and therapeutic development. Forewords by: Sidney Altman, Yale University, Winner of the Nobel Prize in Chemistry, 1989 and Victor R. Ambros, Dartmouth Medical School, Co-discoverer of MicroRNAs

MicroRNA: Cancer

Gaetano Santulli
MicroRNA Cancer Book PDF

Author : Gaetano Santulli
Publisher : Unknown
Page : 128 pages
File Size : 48,5 Mb
Release : 2015
Category : Electronic
ISBN : 3319237314

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MicroRNA: Cancer by Gaetano Santulli Pdf

This volume thoroughly explores of the functional role of microRNAs in cancer. It not only expertly describes the molecular mechanisms underlying the malignant transformation process but also compiles cutting-edge research on microRNAs in several forms of cancer, including colorectal cancer, pancreatic cancer, leukemia/lymphoma, prostate cancer, lung cancer, ovarian cancer, and bone cancer. Distinguished experts, currently working in prestigious institutions, elegantly discuss these fundamental themes. The text, which opens with a foreword by the renowned Dr. Carlo M. Croce, is enhanced by abundant color photographs, schemes, diagrams, and tables that fully support and complement the content. microRNA: Cancer is an ideal companion to both microRNA: Basic Science and microRNA: Medical Evidence. Taken together, these three books provide a state-of-the-art overview of this rapidly-expanding and fascinating field, from the molecular level to clinical practice. It will be invaluable to medical students, physicians, and researchers, as a complete and unique guide in the exploration of microRNA in basic science, cancer and clinical practice.